cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rinto Susilo
Contact Email
medicalsains@gmail.com
Phone
+6285691055898
Journal Mail Official
medicalsains@gmail.com
Editorial Address
https://ojs.ummada.ac.id/index.php/iojs/about/editorialTeam
Location
Kab. cirebon,
Jawa barat
INDONESIA
Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 523 Documents
 37   38   39   40   41 
Tectona grandis Linn. : ANTIDIABETIC ACTIVITY OF THE FRACTIONS USING AN IN VIVO APPROACH Nurramadhani ASida; Rifa’atul Mahmudah; Nita Trinovitasari; Nada Shofa; Parawansah; Nuralifah; Abd Rafid; Risma
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1058

Abstract

The exploration of Tectona grandis Linn. from Indonesia, especially its use as an anti-diabetes agent is still quite limited. This study aims to determine the antidiabetic activity of the fractions from Tectona grandis Linn. leaves in male Rattus norvegicus. The animal blood glucose level was measured first as T0, then the animals were injected with streptozotocin (STZ) 40 mg/Kg BW to induce diabetes mellitus (DM), and then the blood was collected to determine the blood glucose level (T1). The animal was divided into six groups, namely normal group (NC) without treatment, positive control (K+) (DM+glibenclamide 5 mg), negative control (K-) (DM+NaCMC 0.5%), fractions group (DM+nHexane fraction (P1), DM+chloroform fraction (P2), and DM+ethyl acetate fraction (P3), each dose 300 mg/kg BW). The duration of treatment was 7 days, and at the end of treatment, the blood glucose levels were determined. The T0, T1, and T2 are analyzed using One-Way ANOVA and post-hoc LSD. The results obtained that the K+, P3, P2, and P1 groups were able to reduce the animals' blood glucose levels significantly (p<0.05), with the blood glucose levels are 97.01; 110.96; 129.38; and 111.46 mg/dL, respectively. The percentage of reduction in blood glucose level shows that the K+ group has the highest percentage at 66.8%, followed by the P3 group at 64.0%. The n-hexane, chloroform, and ethyl acetate fractions showed similar effectiveness to glibenclamide in reducing blood glucose levels statistically (p>0.05). Consequently, Tectona grandis Linn ...
THE APOPTOSIS INDUCTION OF Zingiber oficinale ETHANOLIC EXTRACT-Treated HeLa (HUMAN CERVICAL CANCER) CELLS AND ACTIVE COMPOUND PROFILING USING GAS CHROMATOGRAPHY/MASS SPECTROMETRY Laela Hayu Nurani; Siti Rofida; Dwi Utami; Citra Ariani Edityaningrum; Any Guntarti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1059

Abstract

Cervical cancer accounts for the highest percentage of cancer-related deaths in Indonesia, accounting for nearly 60% of all cancer cases.  Therefore, research into the anticancer mechanisms needs to be conducted.  The ethanolic extract of Zingiber officinale (EEZO) contains zingiberene, a chemical known for its anticancer activity. Understanding the mechanism underlying the apoptosis-inducing effects is crucial. This study aimed to elucidate the apoptotic pathway and analyze the gas chromatography/mass spectrometry (GC/MS) profile of EEZO cells. The research commenced with the maceration of Zingiber officinale rhizomes using 75% ethanol to obtain EEZO. Apoptosis assays were conducted on both a negative control group and an EEZO-treated group of HeLa cells (cervical cancer cells). The apoptotic mechanism was evaluated using forward scattered light-side scattered light (FSC-SSC), fluorescein isothiocyanate (FTIC), and phycoerythrin (PE) flow cytometry. Apoptotic results were analyzed by comparing the control and EEZO samples, which revealed the number of viable cells, apoptotic cells, and cells in the sub-G1 phase. The major constituent of EEZO, which is expected to be a potent apoptosis inducer, was detected using GC/MS. The FSC-SSC results indicated a lower number of viable cells in the EEZO-exposed group than in the control group. FTIC results demonstrated that EEZO significantly increased apoptotic cell death, increasing from 68 to 1537 cells. PE flow cytometry revealed an elevated sub-G1 cell population, indicating the induction of apoptosis by EEZO. GC/MS analysis revealed five dominant components in EEZO, which had the potential to induce apoptosis: L-borneol, zingiberene, farnesol, beta-sesquiphellandrene, and alpha-curcumene ...  
ARTICLE REVIEW: UTILIZATION OF CURCUMIN AS AN ANTI-CANCER AGENT Abdul Mulki Irpani; Deden Indra Dinata; Garnadi Jafar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1062

Abstract

The uncontrolled growth of abnormal cells in one area of the body can spread to other tissues and create more cancer cells, a disease known as cancer. Malignant cancer cells have the potential to become fatal. After cardiovascular disease, cancer is the second most common cause of mortality. Numerous cancer types exist, including stomach, liver, colorectal, lung, breast, and cervical cancers. More than 70% of cancer-related deaths occur in low- and middle-income nations, and the number of cancer-related deaths is predicted to rise steadily, hitting 11.5 million by 2030. Some of the resources utilized to look up information on curcumin's application as an anticancer agent are PubMed, Science Direct, and Google Scholar. Most of the articles that were used were published between 2013 and 2023, or within the last ten years. These journals were found using the following keywords: "Curcumin," "Cancer," "Curcumin as an Anticancer," and "Utilization of Curcumin as an Anticancer Agent." Scholars from many nations have conducted comparable investigations on the application of curcumin as an anticancer agent. Furthermore, it has been established that curcumin directly inhibits cancer cells when used as an anticancer drug. This suggests that curcumin does have anticancer properties. Keywords: Curcumin, Cancer, Curcumin as an Anticancer agent
THE ROLE OF MEDICATION LITERACY IN THE TREATMENT OF HYPERTENSIVE PATIENTS: A REVIEW Okti Ratna Mafruhah; Vita Widyasari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1071

Abstract

Hypertension, or high blood pressure, has become a major contributor to cardiovascular disease globally. Its prevalence continues to increase, necessitating intensive healthcare efforts. Medication literacy, or the skill of understanding and applying medication information, is crucial for chronic patients, including those with hypertension. However, there has been limited research on this topic, highlighting the need for a literature review of the levels and roles of literacy in the therapy of hypertensive patients. This study used a narrative review approach to analyze the findings of articles on medication literacy in hypertensive patients. This study employs a narrative review approach to analyze findings from various journals. The data were derived from articles focusing on medication literacy in hypertensive patients, identified through literature searches on PubMed from 2013 to 2023. The selected articles were published in international journals, have a full text, can provide data on the role of medication literacy in hypertensive patients, and use quantitative, qualitative, or mixed-methods research designs.Two studies included in the review originated from China. Both articles reported low literacy levels among hypertensive patients. Factors, such as education and income, can also influence literacy. These findings underscore the importance of improving medication literacy in hypertension management, emphasizing the need for better education and more effective development strategies. Both articles also emphasized the significance of medication literacy in the context of hypertension management; that is, they highlighted the need for improved medication literacy and provided evidence of the positive impact of medication literacy on blood pressure control...
MISSENSE MUTATIONS IN THE IRAK1 GENE ARE ASSOCIATED WITH AN INCREASED RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS Adnan Adnan; Dyah Aryani Perwitasari; Rita Maliza; Nanik Sulistyani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1073

Abstract

Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation in humans. Missense SNPs can change protein structure and function. This study aimed to determine missense SNPs of the IRAK1 gene that can affect the amino acid sequence and lead to changes in protein structure and function, as well as their relationship as a risk factor for SLE. In this in silico method, several bioinformatics tools have been used to identify missense SNPs, including their properties and impacts, as well as their interaction networks with proteins. The tools used were PolyPhenv2, SIFT, PhD-SNP, PROVEAN, SNAP, Panthers, I-Mutant 3.0, and GeneMania. Four missense SNPs, rs11465830, rs1059702, rs1059703, and 10127175, were obtained from the NCBI SNP database. The SIFT test results showed that all the SNPs were tolerant. In the test results obtained using PolyPhen, the four SNPs were benign. The results of the probe test indicated that the four SNPs were neutral. When tested with SNAP, one SNP was neutral, and three others had an impact. In the PhD-SNP test, all SNPs were neutral. In the panther test, all SNPs were benign. The I-mutant assay showed that the four SNPs could decrease protein stability. Tests with GeneMania have reported that most interactions between genes were between IRAK1 and MYD88, and physical interactions were the most dominant form of interaction. Conclusion. rs10127175, rs11465830, rs1059702, and rs1059703 are missense SNPs in IRAK1, which can disrupt protein stability and be a risk factor for SLE. Keywords: IRAK1, SNP, Missense, Systemic Lupus Erythematosus
ANALGETIC ACTIVITY DETERMINATION OF PAPAYA LEAVES (Carica papaya L.) AND BASIL LEAVES (Ocimum sanctum L.) EXTRACTED USING NATURAL DEEP EUTECTIC SOLVENT Renny Amelia; Yuniarti Falya; Tomi; Daryuti; Eka Umi Barkah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1079

Abstract

Natural deep eutectic solvents (NaDES) are obtained from an adequate mixture of hydrogen bond acceptors (HBA) and donors (HBD), which can bond through the interaction of hydrogen bonds to form a eutectic with a low melting point. NADES has been implemented in several studies as an effective extraction method, but it is still not widely used. C. papaya leaves and O. sanctum leaves have been widely known to have various pharmacological activities. The aim of this study was to determine the best analgesic ability of the NADES extract of C. papaya and O. sanctum leaves. The extraction process used was Microwave-Assisted Extraction (MAE). The liquid extract was tested for antioxidant activity and analgesic activity using doses of 600 mg/kgBW, 800 mg/kgBW, and 1000 mg/kgBW. The results show that The IC50 values of the NADES extract of C. papaya and O. sanctum leaves were 920 ppm and 882 ppm, respectively. Both analgetic percentages are equivalent to the positive control starting from a concentration of 800 mg/kgBW, where the analgetic percentage of the NADES extract of papaya leaves and basil leaves is 59.80% and 54.57% respectively that included in weak category. It can be concluded that both NADES extracts of papaya and basil leaves have analgetic capabilities.  Keywords: Natural Deep Eutectic Solvent (NADES), Carica papaya, Ocimum sanctum, analgetic activity.
PHYSICAL AND ACTIVITY ACTIVITY TONER OF ESSENTIAL OIL OF BAY LEAF (SYZYGIUM POLYANTHUM) AGAINST PROPIONIBACTERIUM ACNE Anna Yusuf; Davit Nugraha; Marlina Indriastuti; Siti Rahmah KR; Laela Tri Fadila
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1080

Abstract

Indonesian people have been using natural ingredients for generations as traditional medicines to treat various diseases or as a preventative measure. One of the plants often used is bay leaf (Syzygium polyanthum). Bay leaves (Syzygium polyanthum) contain 0.2% essential oil, with methyl chavicol, eugenol, and citral as the main compounds. The purpose of this study was to determine the physical properties of essential oil toner preparations from bay leaf plants (Syzygium polyanthum) and to understand the activity of the essential oil toner preparation from bay leaf plants (Syzygium polyanthum) against Propionibacterium acnes as an acne treatment. The physical test results produced the following data: organoleptic test, thin liquid form, distinctive bay leaf smell, clear slightly cloudy color, homogeneity test all preparations were homogeneous, pH test for average F0 5.75 ± 0.5016, F1 5.62±0.1039, F2 5.70±0.08083 and F3 5.64±0.05508 all met the requirements in the pH range of 4.5-6.5. ...
DETERMINATION ANTIOXIDANT ACTIVITY, TOTAL PHENOLICS, FLAVONOIDS CONTENT, OF JUNGRAHAB LEAVES (Baeckea frutescens L.) Wahyu Priyo Legowo; Irma Erika Herawati; Lisna Dewi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1082

Abstract

Medicinal plants are widely used to treat various diseases, and one of the reasons for this is the safety of medicinal plants. The active compounds in medicinal plants include phenolics and flavonoids, which are known to have antioxidant activity. Antioxidants play an essential role in the body's defense against various diseases because they prevent the negative effects of free radicals. Jungrahab (Baeckea frutescens L.) is a medicinal plant containing phenolics and flavonoids. This study aimed to determine the antioxidant activity of jungrahab leaf extracts using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method. The results showed the antioxidant activity of the extract, water fraction, ethyl acetate, and n-hexane of jungrahab leaves with IC50 values of 12.62, 61.74, 60.66, and 63.99 ppm, respectively. Meanwhile, jungrahab extract has a total phenolic content of 52.40 mg GAE (Gallic Acid Equivalent)/g and a flavonoid content of 56.72 mg QE (Quercetin Equivalent)/g. Jungrahab extract showed strongest antioxidant category compared to its fractions. Keywords: phenolics content, flavonoids content, antioxidant activity, DPPH, jungrahab
REVIEW: REVIEW ARTICLE LIPID-BASED NANOTECHNOLOGY Garnadi Jafar; R. Awaludin Nazal N; Entris Sutrisno
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1084

Abstract

Nanotechnology is defined as engineering the creation of materials, functions, and devices on the nanometer scale. Nanoscience is increasingly developing and becoming a part of various fields, such as electronics, materials, and biology. Lipid nanoparticles are a major application in nanotechnology. In formulas II and III, smaller results were obtained compared with the other formulas. Based on the results of this study, it can be concluded that the nanostructured lipid carrier system with solid lipid poloxamer and stearic acid with liquid soybean oil lipids obtained good characteristics, and each test met the range. From the explanation above, it can be concluded that lipid-based nanotechnology has great potential in various fields such as medicine, cosmetics, and agriculture. Its use can provide great benefits such as increasing the effectiveness of drug administration, increasing the absorption of nutrients in food, and developing cosmetic products. which one is safer and more effective. To compare several types of nanoparticle methods, such as Liposomes, Neosomes, Etosomes, SLN, and NLC for selection of the lipid base, namely NLC. It is important to ensure that the use and development of this technology are safe and beneficial for humans and the environment. Keywords : Nanotechnology, Nanoparticles, Lipid-Based Nanoparticles
ANALGESIC POWER OF THE INSOLUBLE FRACTION N-HEXANE OF MELINJO LEAVES (Gnetum gnemon L.) IN SWISS MICE (Mus musculus) Deni Firmansyah; Renny Amelia; Sulistiorini Indriaty; Didi Rohadi; Muhammad Yani Zamzam; Rizqia Shafa Fauziah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1087

Abstract

Melinjo (Gnetum gnemon L.) has various secondary metabolites including alkaloids, flavonoids, saponins, and tannins. In its function as an analgesic, flavonoids work to inhibit the cyclooxygenase enzyme which can reduce prostaglandin production and reduce pain. This study aims to determine the analgesic power of the n-hexane insoluble fraction of melinjo leaves (Gnetum gnemon L.) as an effective analgesic tested on male white mice (Mus musculus) and to determine the most effective dose as an analgesic. This research was experimental using test animals of 25 male white mice (Mus musculus) divided into 5 groups each consisting of 5 mice. The negative control group (CMC-Na) was 0.5%, the positive control group Mefenamic acid dose of 65 mg/KgBW, insoluble fraction hexane group (ifh) dose of 50 mg/KgBW, 100 mg/KgBW, 200 mg/KgBW. The chemical stimulus was given a dose of 400 mg/KgBW of acetic acid. The parameter measured was the number of wriggles in male white mice (Mus musculus) every 10 minutes for 60 minutes. The results of the study showed a significant difference between the negative control (CMC-Na 0.5%) and various doses of insoluble fraction hexane group, while the positive control (mefenamic acid 65 mg/KgBW) had no difference with ifh doses of 100 mg/kgBB and 200 mg/KgBW. The percentage of analgesic power of ifh at doses of 50 mg/KgBW, 100 mg/KgBW and 200 mg/KgBW was 26.64%, 57.5%, and 58.56% and the percentage of analgesic power of mefenamic acid was 69.67% ...

Page 39 of 53 | Total Record : 523

 37   38   39   40   41 

Filter by Year

2016 2025


Reset
Filter By Issues
All Issue Vol 10 No 4 (2025): Forthcoming Issue Vol 10 No 3 (2025) Vol 10 No 2 (2025) Vol 10 No 1 (2025) Vol 9 No 4 (2024) Vol 9 No 3 (2024) Vol 9 No 2 (2024) Vol 9 No 1 (2024) Vol 8 No 4 (2023) Vol 8 No 3 (2023) Vol 8 No 2 (2023) Vol 8 No 1 (2023) Vol 7 No 4 (2022) Vol 7 No 3 (2022) Vol 7 No 2 (2022) Vol 7 No 1 (2022) Vol 6 No 2 (2021) Vol 6 No 1 (2021) Vol 5 No 2 (2021) Vol 5 No 1 (2020) Vol 4 No 2 (2020) Vol 4 No 1 (2019) Vol 3 No 2 (2019) Vol 3 No 1 (2018) Vol 2 No 2 (2018) Vol 2 No 1 (2017) Vol 1 No 2 (2017) Vol 1 No 1 (2016) More Issue