cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rinto Susilo
Contact Email
medicalsains@gmail.com
Phone
+6285691055898
Journal Mail Official
medicalsains@gmail.com
Editorial Address
https://ojs.ummada.ac.id/index.php/iojs/about/editorialTeam
Location
Kab. cirebon,
Jawa barat
INDONESIA
Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 523 Documents
 48   49   50   51   52 
ESTERIFICATION OF CINNAMIC ACID WITH OCTANOL USING ULTRASONIC WAVE ASSISTED BY COUPLING REAGENT AS ANTIERYTHEMA Jeconiah, Daninda; Mutiara, Erlita Verdia; Indriyanti, Erwin; Wildan, Achmad
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1715

Abstract

The n-octyl cinnamate compound, a cinnamate ester, is believed to have antierythema activity. This compound is naturally present in certain plant species; however, its quantity is limited. Steglich esterification can be used to produce n-octyl cinnamate, which involves the reaction of cinnamic acid with n-octanol using n,n'-dicyclohexylcarbodiimide (DCC) as a coupling reagent. Ultrasonic wave-assisted synthesis was performed to reduce the synthesis time and increase the yield of n-octyl cinnamate with time variations of 3, 4, and 5 hours at ± 2°C. The synthesized compounds were characterized by organoleptic properties, solubility, melting point, TLC, FTIR, and GC-MS tests. The synthetic compound occurred as a white powder, yielding 10.1% after an optimal duration of 4 hours. The compound was insoluble in distilled water but soluble in methanol, ethanol, chloroform, ether, and n-hexane. The compound has a melting range of 135.1-145.4°C, and the TLC results obtained different Rf values than the initial compound. FTIR test analysis showed the presence of C=C aromatic, C-H aromatic, C=O ester, C-O ester, C=C aliphatic, and C-H aliphatic group absorption by the n-octyl cinnamate compound. GC-MS analysis revealed a synthetic retention time of 17.193 minutes and an abundance of 35.40%. The antierythema activity of the synthesized n-octyl cinnamate compound was optimal at 100 ppm with a %TE of 1.661, classifying it as an extra protection category.  Keywords: anti-erythema, esterification, ultrasonic waves, n-octyl cinnamate, time.
REVIEW: INTERACTION OF GLIMEPIRIDE WITH HERBAL PLANTS Nurjaman, Jajang; Sulaeman, Agus
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1717

Abstract

Glimepiride is a commonly prescribed oral antidiabetic drug for the management of type 2 diabetes mellitus (T2DM). However, extensive simultaneous use of herbal plants increases the risk of notable interactions between herbs and drugs. This systematic review analyzed the pharmacokinetic and pharmacodynamic interactions between glimepiride and various medicinal plants, based on 20 selected studies published between 2014 and 2024. The results show that several herbs including Berberine hydrochloride, Licorice, Quercetin, Aloe vera, Ocimum sanctum, and Fenugreek can alter glimepiride’s metabolism, enhance its bioavailability, and increase insulin secretion, potentially amplifying its hypoglycemic effect. Although these interactions may improve therapeutic outcomes, they also increase the risk of hypoglycemia, indicating that careful monitoring and professional supervision are essential when using herbal supplements alongside glimepiride.  Keywords: Pharmacokinetic pharmacodynamics, glimepiride interaction, herbal plants.
RATIONALITY AND COST COMPARISON OF OUTPATIENT TYPE 2 DM THERAPY UNDER INA-CBGS: A LITERATURE REVIEW Eka Gumilang, Nurani; Sulaeman, Agus
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1720

Abstract

This literature review evaluates the rationality of Type 2 Diabetes Mellitus (T2DM) therapy and analyzes the cost comparison between treatment expenses and Indonesian Case-Based Groups (INA-CBGs) tariffs for outpatient hospital care. The findings indicate that evidence-based therapy is essential for improving clinical effectiveness and cost efficiency. Several studies have highlighted significant discrepancies between actual outpatient treatment costs and INA-CBGs tariffs, with pharmaceutical expenses being the primary factor contributing to hospital cost deficits. A review was conducted using 11 peer-reviewed studies from 2019 to 2024, selected based on inclusion criteria such as relevance to outpatient T2DM therapy under INA-CBGs, full-text availability, and publication in Indonesian or English language. This review recommends policy adjustments to strengthen a transparent claims system, optimize an evidence-based national formulary, and enhance complication prevention strategies to improve the efficiency of DM management in Indonesia. Keywords: rationality of therapy, Type 2 Diabetes Mellitus, treatment cost, INA-CBGs, hospital, outpatient
A LITERATURE REVIEW: THE IMPACT OF PHARMACIST COUNSELING ON MEDICATION ADHERENCE IN TYPE 2 DIABETES MELLITUS OUTPATIENTS Sulaeman, Agus; Vallini, Lia
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1721

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease with a high prevalence that requires long-term therapeutic management. One of the biggest challenges in managing T2DM is the low level of patient adherence to medication, which can trigger serious complications and increase the economic burden on the healthcare system. Pharmacist counseling plays an important role in improving patient adherence through education, motivation, and support. This study aimed to analyze the effect of pharmacist counseling on medication adherence in T2DM outpatients using data from scientific journals published between 2019 and 2024, sourced from PubMed, ScienceDirect, and Google Scholar. A total of 10 articles were reviewed and selected based on the following inclusion criteria: studies focusing on pharmacist counseling and medication adherence in T2DM outpatients, published in English or Indonesian, and accessible in full text. The study found that various counseling interventions, such as face-to-face education, reminders via short message (SMS), and the use of informational guidance, significantly improved patient adherence, as measured by clinical parameters such as decreased HbA1c levels and improved quality of life. These findings suggest that pharmacist counseling can be an effective approach to improve the success of T2DM therapy while having a positive impact on patients' quality of life. Keywords: Diabetes mellitus, pharmacist counseling, patient compliance, HbA1c, Quality of life, pharmacy education.
ANALYSIS OF CUSTOMER SATISFACTION WITH DELIVERY SERVICE AT APOTEK HABIBI KUNINGAN Jumiati, Juju; Djuniardi, Dede; Hanifah, Rakhmawati; Noviansyah, Ramadhan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1723

Abstract

Improving service quality in the pharmacy business is crucial to attracting customer interest and maintaining customer loyalty. Customer satisfaction is one of the indicators that can be used to measure the success of service quality. This study aimed to determine the effect of delivery service quality on customer satisfaction in Apotek Habibi. This study used a descriptive observational method and a cross-sectional design. Purposive sampling was used, with the Slovin formula used to obtain 83 respondents from a total population of 497 people. Data were collected through a survey of customers who had used the delivery service at least thrice. Service quality was measured using five dimensions of the Servqual method: Tangibles, Reliability, Responsiveness, Assurance, and Empathy. The results show that customers are highly satisfied with delivery service quality, with the highest scores in the Tangibles dimension (92%), Reliability (90%), Responsiveness (90%), Assurance (91%), and Empathy (89%). The Pearson's correlation analysis revealed a significant relationship between service quality and customer satisfaction (r = 0.537, p < 0.05). The Assurance variable emerged as the dominant factor influencing customer satisfaction with a regression coefficient of 10.810. Although customer satisfaction is high, developing a more flexible delivery system and improving promotional information transparency are necessary to maintain and enhance customer satisfaction in the future. This study provides valuable insights for Apotek Habibi to continuously improve service quality to meet customer expectations.  Keywords: Pharmacy, Customer Satisfaction, Delivery Service, Service Quality
ANTIOXIDANT ACTIVITY OF TEGINING GANANG (Senna hirsuta L) LEAF EXTRACT USING DPPH METHOD Hendriyani, Irmatika; Maulida, Meri Kartika; Wahid, Abdul Rahman; Khairi, Widayatul; Sugara, Taufan Hari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1724

Abstract

Tegining ganang (Senna hirsuta L) is a commodity plants on Lombok Island and is traditionally used to treat minor wounds, severe wounds, and skin infections. This study aimed to evaluate the antibacterial and antioxidant activities of ethanol, ethyl acetate, and n-hexane extracts of Tegining ganang leaves against Staphylococcus aureus and Escherichia coli using the DPPH method. The results showed that the ethyl acetate extract exhibited the highest antibacterial activity. Escherichia coli with an inhibition zone of 8.16 mm. For Staphylococcus aureus, the inhibition zone was 1.16 mm. However, all three extracts demonstrated weak antifungal activity. Phytochemical screening revealed the presence of alkaloids and flavonoids in all the extracts. Additionally, the ethanol and ethyl acetate extracts contained phenolic compounds and tannins, which were absent in the n-hexane extract. In the antioxidant activity assay, the 96% ethanol extract demonstrated excellent antioxidant activity with average absorbance values of 0,496 ± 0,018 at 10 ppm, 0,438 ± 0,008 at 20 ppm, 0,357 ± 0,003 at 30 ppm, and 0,326 ± 0,002 at 40 ppm, resulting in an IC?? value of 16,67 ppm. The ethyl acetate extract had an absorbance of 0,537 ± 0,010 at 10 ppm, 0,487 ± 0,002 at 20 ppm, 0,443 ± 0,011 at 30 ppm, 0,392 ± 0,003 at 40 ppm, and 0,383 ± 0,005 at 50 ppm, with an IC?? of 28,50 ppm ...
REVIEW: ADVERSE DRUG REACTIONS AND PHARMACOKINETIC CHARACTERISTICS OF LINEZOLID AS A THERAPY FOR DRUG RESISTANT TUBERCULOSIS Retnaningsih, Ririn; Susilo, Rinto; Sundhani, Elza
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1735

Abstract

Introduction: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that remains a global health challenge. One of the main problems in TB treatment is the emergence of drug resistance, such as in multidrug-resistant tuberculosis (MDR-TB). Linezolid is a class of oxazolidinones used as second-line therapy in the treatment of drug-resistant TB. However, its use is not free from serious adverse drug reactions such as peripheral neuropathy, myelosuppression, and lactic acidosis. Therefore, understanding the pharmacokinetic profile and adverse drug reactions of linezolid is important to increase the effectiveness of therapy and minimize the risk of toxicity. Objective: This study aimed to evaluate the adverse drug reactions caused by linezolid and analyze its pharmacokinetic characteristics in the treatment of drug-resistant tuberculosis (TB). Methods: This article is a literature review that collects data from national and international scientific sources over the past 10 years (2015-2025), including the addition of comparative studies or meta-analyses, as well as inclusion criteria, such as articles that discuss the pharmacokinetics, adverse drug reactions, and use of linezolid in drug-resistant tuberculosis therapy, either in clinical trials, observational studies, or relevant therapeutic guidelines. Results: Based on the results of various studies, linezolid has an oral bioavailability approaching 100%, which allows oral and intravenous administration with almost equivalent doses. Its pharmacokinetic profile shows an elimination half-life of approximately 5-7 hours, with primary metabolism via nonenzymatic oxidation in the liver and excretion in the urine as inactive metabolites. These characteristics make linezolid a flexible option for drug-resistant tuberculosis therapy..
A STUDY ON THE KNOWLEDGE AND ATTITUDES OF INDONESIAN WOMEN REGARDING MENSTRUAL CUPS AS ENVIRONMENTALLY FRIENDLY MENSTRUAL PRODUCTS Alfiani, Fitri; Yuniko Febby H Fauzia; Azkya, Fharelina N
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1338

Abstract

Inadequate menstrual hygiene can increase the risk of reproductive tract infections, including pelvic inflammatory disease, dysmenorrhea, and infertility. Therefore, the use of safe and effective menstrual products is essential. Currently, disposable pads are widely recognized products. Disposable pad waste is deemed environmentally detrimental, leading to an estimated annual production of 113,000 tons. Menstrual cups are a viable long-term alternative, since they can be reused for up to ten years, effectively prevent leaks, accommodate various activities, and diminish the risk of toxic shock syndrome. Examining Indonesian women's knowledge and attitudes about menstrual cups is crucial, as it substantially aids in advancing the attainment of Sustainable Development Goals (SDGs). Procedure. This was a quantitative study utilizing anonymous web-based questionnaires. Outcomes.  Of the Indonesian women, 75.97% possessed limited knowledge, while only 24.03%weree well-informed about menstruation cups as eco-friendly menstrual devices. 85.06% of Indonesian women were disinclined to utilize menstruation cups, while only 14.94% expressed a willingness to adopt these environmentally friendly menstrual devices. The ?-value was 0.514>0.05, which represents statistical insignificance; hence, knowledge was not associated with attitude.  Keywords: attitude; knowledge; menstrual_cup; menstruation; women_health  
COMPARISON OF TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF PURPLE LEAF EXTRACT (Graptophyllum pictum (L.) Griff.) USING MACERATION AND SOXHLETATION EXTRACTION METHODS Darotulmutmainnah, Azmi; Marini, Marini; Herliningsih, Herlingsih; Handayani, Hana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1608

Abstract

Purple leaves in Indonesia can be used as an anti-inflammatory medication and laxative to treat hemorrhoids, rheumatism, boils, and skin diseases. Purple leaves are also used as free-radical antidotes. This was due to the presence of secondary metabolite compounds in purple leaves. The right extraction method determines the amount of flavonoids that can be extracted and achieves a high flavonoid content. This study aimed to determine the total flavonoid content and antioxidant activity of purple leaves using different extraction methods, namely maceration and Soxhletation. This study employed an experimental method of testing total flavonoid levels using UV-Vis spectrophotometry and antioxidant activity using the DPPH method. The results showed that the maceration method yielded a total flavonoid level of 4,422 ± 0,047 ppm, which was higher than that obtained using the Soxhletation method (1,547 ± 0,027 ppm). In the antioxidant activity test, vitamin C was used as a comparator, with an IC50 of 2.263 ppm (very strong). The IC50 of purple leaf extract using the maceration method was 123,32 ppm (medium), while the soxhletation method yielded an IC50 of 104,42 ppm (medium). This shows that vitamin C has more potent antioxidant activity in counteracting free radicals than purple leaf extract, using maceration and Soxhletation methods. The  results showed a significant difference in total flavonoid levels using different extraction methods, while there was no significant difference in the antioxidant activity of purple leaf extract using maceration and  Soxhletation methods.   Keywords: antioxidant, extraction, flavonoid, maceration, purple leaf, soxhletation  
FORMULATION AND EFFECTIVENESS TEST OF THE WOUND HEALING GEL RED PIDADA FRUIT (Sonneratia Caseolaris) SKIN EXTRACT Rusdeni, Sofia; Rini Dwiastuti; Phebe Hendra; Hasyrul Hamzah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1633

Abstract

Red pidada fruit peel extract gel preparation can increase the efficiency and comfort of topical use because of its activity in the healing of open wounds. The aim of this research was to determine how variations in HPMC levels affect the physical quality and stability of red pidada fruit peel extract gel preparations, using the maceration method to obtain thick extracts and formulations with different HPMC concentrations (1% HPMC, 3% and HPMC 5% formula were tested for physical quality and stability, including the Storage Stability Test for 4 weeks. Effectiveness testing was also carried out in white mice using an incision wound method with a depth of 1.5 mm and macroscopic observation. The effectiveness test concentration was set to 5%. The results of data analysis using the Spss One Way ANOVA test showed that higher HPMC levels resulted in a thicker gel, viscosity, stickiness, spreadability, and higher pH. It can be concluded that the gel formulation that meets the requirements is that formula 2 provides organoleptic test results with a thick green color typical of red pidada, good homogeneity test, spreadability test 5.52 cm, adhesion test 2.61 minutes, viscosity test 2700cCps, pH test 4.92. During storage, the gel exhibited good consistency. The longer the storage time, the closer the pH changes to alkaline values. With the Anova value, there is a significant difference in the three formulas with a value of p=0.005 Keywords: red pidada (Sonneratia caseolaris) fruit peel, wound healing, HPMC, gel

Page 50 of 53 | Total Record : 523

 48   49   50   51   52 

Filter by Year

2016 2025


Reset
Filter By Issues
All Issue Vol 10 No 4 (2025): Forthcoming Issue Vol 10 No 3 (2025) Vol 10 No 2 (2025) Vol 10 No 1 (2025) Vol 9 No 4 (2024) Vol 9 No 3 (2024) Vol 9 No 2 (2024) Vol 9 No 1 (2024) Vol 8 No 4 (2023) Vol 8 No 3 (2023) Vol 8 No 2 (2023) Vol 8 No 1 (2023) Vol 7 No 4 (2022) Vol 7 No 3 (2022) Vol 7 No 2 (2022) Vol 7 No 1 (2022) Vol 6 No 2 (2021) Vol 6 No 1 (2021) Vol 5 No 2 (2021) Vol 5 No 1 (2020) Vol 4 No 2 (2020) Vol 4 No 1 (2019) Vol 3 No 2 (2019) Vol 3 No 1 (2018) Vol 2 No 2 (2018) Vol 2 No 1 (2017) Vol 1 No 2 (2017) Vol 1 No 1 (2016) More Issue