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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : 10.25026/jtpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Tropical Pharmacy and Chemistry is a Six monthly (June and December), international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry publishes manuscripts (Original research Article, review articles, Mini-reviews, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics & Biopharmaceutics, Novel &Targeted Drug Delivery, Nanotechnology & Nanomedicine, Pharmaceutical Chemistry, Pharmacognosy & Ethnobotany, Phytochemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Pharmacogenomics, Pharmacovigilance, Natural Product Research, Drug Regulatory Affairs, Case Study & Full clinical trials, Biomaterials & Bioactive polymers, Analytical Chemistry, Organic Chemistry, Physical Pharmacy, Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 298 Documents
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Aktivitas Sediaan Gel Antiseptik Tangan Berbahan Aktif Ekstrak Fraksi Etanol Daun Sungkai (Peronema canencens Jack.) terhadap Beberapa Bakteri Patogen Arsyik Ibrahim; Indah Woro Utami; Risna Agustina
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.94

Abstract

Penelitian Aktivitas Sediaan Gel Antiseptik Tangan Berbahan Aktif Ekstrak Fraksi Etanol Daun Sungkai (Peronema Canencens Jack.) telah dilakukan. Penelitian ini bertujuan mengetahui aktivitas antiseptik fraksi daun Sungkai (P. canescens. Jack) secara in vitro terhadap beberapa bakteri patogen dalam sediaan gel antiseptic tangan dan mengetahui konsentrasi terbaik fraksi etanol daun Sungkai (P. canencens Jack.) dalam sediaan gel antiseptik tangan terhadap masing-masing strain mikroba patogen. Bahan uji diperoleh dengan fraksinasi ekstrak fraksi etanol daun sungkai, selanjutnya formulasikan ke dalam basis gel antiseptic, diuji aktivitasnya terhadap beberapa bakteri pathogen dan menentukan konsentrasi terbaik fraksi etanol daun Sungkai (P. canencens Jack.) dalam sediaan gel antiseptik tangan terhadap bakteri Escherichia coli, Salmonella thyposa, Staphylococcus aureu, Bacillus subtilis. Metode pengujian antibakteri mengunakan uji difusi padat secara in vitro. Hasil penelitian menunjukan konsentrasi fraksi etanol dalam sediaan gel antiseptik aktif terhadap bakteri Escherichia coli, Salmonella thyposa, Staphylococcus aureus dan Bacillus subtillis. Konsentrasi terbaik ekstrak etanol dalam sediaan gel antiseptik adalah 4% efektif menghambat/membunuh ke tiga bakteri uji. Kata kunci : P. canencens Jack, Gel antiseptik, E. coli, S. thyposa, S. aureus, B. subtlisABSTRACTA research which antiseptic hand gel preparations containing the active leaf extract fraction ethanol Sungkai (Peronema canencens Jack.) has been done. This study aims to know is antiseptic activity Sungkai leaf fraction (P. canescens. Jack) in vitro against to several microbial pathogens in the preparation of antiseptic hand gel, and to know determine the best concentration of ethanol fraction Sungkai leaf in the preparation of antiseptic gel hands each strain of pathogenic bacteria. Test materials obtained by fractionation of the ethanol extract of the leaf fraction Sungkai, further formulated into a gel base antiseptic, tested its activity against several bacterial pathogens, and determine the best concentration of ethanol fraction Sungkai leaf in the preparation of antiseptic hand gel against Staphylococcus aureus, Salmonella thyposa, Escherichia coli and Bacillus subtilis bacteria. Antibacterial testing using method in vitro solid diffusion test. The results showed the concentration of ethanol fraction in gel dosage of active antiseptic against Staphylococcus aureus, Salmonella thyposa, Escherichia coli and Bacillus subtilis bacteria. The best concentration of ethanol extract in the preparation of antiseptic gel was 4% effective at inhibiting or kill the to three bacteria. Keywords: P. canencens Jack, antiseptic gel, E. coli, S. thyposa, dan S. aureu, B. subtllis
Formulasi dan Optimasi Basis Gel HPMC (Hidroxy Propyl Methyl Cellulose) dengan Berbagai Variasi Konsentrasi Mirhansyah Ardana; Vebry Aeyni; Arsyik Ibrahim
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.95

Abstract

Ideal gel formulation can be obtained by formulating some kind of gelling material, but the most important thing to note is the selection of a gelling agent. HPMC (Hidroxy Propyl Methyl Cellulose) is a gelling agent that is commonly used in the production of cosmetics and drugs, because it can producea gel that is clear, easily soluble in water, and has a low toxicity. This study aimed to obtain the concentration of HPMC as a gelling agent that has the physical stability in accordance with the stipulated requirements. Gel formulations made with HPMC concentration variation of 3%, 5% and 7%, further evaluation of physical properties include organoleptic test, homogeneity, dispersive power, pH, and viscosity. Evaluation gel base done for 3 weeks. The results of stability tests show the base gel with a concentration of 7% HPMC has a good standard for viscosity, pH, dispersive power, homogeneity and organoleptic.Key words: Gel, HPMC (hidroxy propyl methyl cellulose), gelling agent.ABSTRAKSediaan gel yang baik dapat diperoleh dengan cara memformulasikan beberapa jenis bahan pembentuk gel, namun yang paling penting untuk diperhatikan adalah pemilihan gelling agent. HPMC (Hidroxy Propyl Methyl Cellulose) merupakan gelling agent yang sering digunakan dalam produksi kosmetik dan obat, karena dapat menghasilkan gel yang bening, mudah larut dalam air, dan mempunyai ketoksikan yang rendah. Penelitian ini bertujuan untuk memperoleh konsentrasi HPMC sebagai gelling agent yang memiliki kestabilan fisika yang sesuai dengan persyaratan yang telah ditetapkan. Formulasi gel dibuat dengan variasi konsentrasi HPMC 3%, 5% dan 7%, selanjutnya dilakukan evaluasi sifat fisika yang meliputiuji organoleptis, homogenitas, daya sebar, pH, dan viskositas. Evaluasi basis gel dilakukan selama 3 minggu. Hasil yang diperoleh dari uji stabilitas menunjukan basis gel dengan konsentrasi HPMC 7% memiliki standar yang baik untuk viskositas, pH, daya sebar, homogenitas dan organoleptis.Kata Kunci : Gel, HPMC (Hidroxy Propyl Methyl Cellulose), gelling agent.
Aktivitas Ekstrak Daun Salam (Eugenia polyantha) sebagai Antiinflamasi pada Tikus Putih (Rattus norvegicus) Risna Agustina; Dewi Tita Indrawati; Muhammad Amir Masruhim
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.96

Abstract

The aim of this study was to determine the anti inflammatory effect of ethanol extract of salam leaves, viewed from decrease paw edema volume rats carrageenan induced 1%. For the anti-inflammatory activity measurement, five different groups were established, three test group, one positive control group and one negative control group. In the test group given the extract of salam leaves, the positive control given Na diklofenak, while the negative control group given Na CMC. Salam leaf extract was administered in three different doses : 50 mg/kgBB, 150 mg/kgBB and 250 mg/kgBB. Each of them were given orally 30 min before carrageenan induced. The paw volume was measured every hour for five hour after injection carrageenan. The results showed that ethanol extract of salam leaves in all doses has anti inflammatory efect on white rats.Keywords: Anti-inflammatory, extract salam leaves, white ratsABSTRAKPenelitian ini bertujuan untuk mengetahui efek antiinflamasi ekstrak etanol daun salam ditinjau dari penurunan volume udem telapak kaki tikus putih jantan yang diinduksi karagenan 1%. Untuk pengukuran aktivitas antiinflamasi digunakan 5 kelompok hewan coba yang berbeda yakni 3 kelompok uji, 1 kelompok kontrol positif dan 1 kelompok kontrol negatif. Pada kelompok uji diberikan ekstrak daun salam, pada kontrol positif diberikan Na diklofenak, sedangkan pada kelompok kontrol negatif diberikan Na CMC. Pemberian ekstrak daun salam dilakukan 3 variasi dosis yaitu dosis 50mg/kgBB, 150mg/kgBB, dan 250mg/kgBB. Bahan uji diberikan secara oral 30 menit sebelum diinduksi dengan 0,1 mL karagenan 1%. Pengukuran volume telapak kaki tikus dilakukan setiap jam selama 5 jam setelah induksi karagenan. Hasil penelitian menunjukkan ekstrak etanol daun salam pada semua variasi dosis memberikan efek antiinflamasi pada tikus putih jantan.Kata kunci: Antiinflamasi, ekstrak daun salam, tikus putih jantan
Evaluasi Formula Krim Minyak Biji Delima (Punica granatum L.) dan Uji Aktivitas Antioksidan dengan Metode β-Carotene Bleaching Nur Mita; Sasanti Tarini D.; Sophi Damayanti
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.97

Abstract

Minyak biji delima memiliki aktivitas antioksidan kuat, sehingga berpotensi untuk diformulasi menjadi sediaan antioksidan topikal. Tujuan penelitian ini adalah untuk mengevaluasi formula sediaan krim minyak biji delima dan menguji aktivitas antioksidan dari sediaan tersebut. Krim a/m diformulasi menggunakan emulgator Tween 80- Span 80. Evaluasi sediaan meliputi pemeriksaan pH dan viskositas sediaan yang disimpan selama 4 minggu pada suhu kamar, stabilitas fisik dengan metode Freeze Thaw sebanyak 4 siklus dimana 1 siklus terdiri dari 48 jam pada suhu 4°C dan 48 jam pada suhu 40°C. Potensi antioksidan diuji dengan metode β-Carotene Bleaching. Formula krim yang mengandung minyak biji delima 1% stabil secara fisik. Hasil uji efek antioksidan menunjukkan persen penghambatan minyak biji delima murni dan minyak biji delima dalam bentuk krim terhadap penurunan warna β-Carotene berturut-turut adalah 73,41% dan 52,80%. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa aktivitas antioksidan minyak biji delima dalam bentuk krim mengalami penurunan 0,3 kali.Kata kunci: krim, minyak biji delima, antioksidan, β-Carotene BleachingABSTRACTPomegranate seed oil has a potent antioxidant activity that is potential to be formulate into topical antioxidant dosage form. The purpose of this study is to formulate cream of pomegranate seed oil that physically stable, however have antioxidant activity. Cream w/o was formulated using Tween 80 - Span 80 as emulsifier. Evaluation of cream products includes determining pH and viscosity of the preparations stored for 4 weeks at room temperature, physical stability test by Freeze Thaw method which was carried out for 4 cycles in where 1 cycle consists of 48 hours at 4°C and 48 hours at 40°C. Antioxidant activity was tested by β-carotene bleaching method. The results of the research showed that all cream formulas containing pomegranate seed oil 1% were physically stable and can increase the comfortness in use on the skin. The antioxidant test results showed antioxidant activity of pure pomegranate seed oil and pomegranate seed oil as formulated in creams have antioxidant capacity with inhibition percentage of 73.41% and 52.80%, respectively. Based on these results it can be concluded that the antioxidant activity of pomegranate seed oil in cream decreased 0,3 times.Keywords: cream, pomegranate seed oil, antioxidant, β-Carotene Bleaching
Profil Kromatografi Senyawa Aktif Antioksidan dan Antibakteri Fraksi N-Heksana Daun Libo (Ficus variegata Blume) Rolan Rusli; Myra Puspha Hardina; Fairul Muflihah; Agung Rahmadani
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.98

Abstract

Research about chromatographic profile of antioxidant and antibacterial compounds in n-hexane fraction of Libo leaves (Ficus variegata Blume.) has been done in order to know the form of chromatographic profile of antioxidant and antibacterial compounds in n-hexane fraction of Libo leaves. Extraction was done by maceration using methanol. Isolation was done by 2 methods, vacuum liquid chromatography (VLC) then followed by conventional column chromatography. Eluent used are n-hexane-ethyl acetate and methanol-chloroform. The results based on conventional column chromatography are as many as 10 fractions. The fractions are being conducted then by a qualitative testing of the antioxidant activity using DPPH method and antibacterial activity test using bioautography TLC method. The results formed as a chromatographic profile of fraction that contain antioxidant and antibacterial activity, which are as many as 5 fractions (NHB1, NHB3, NHB4, NHC1, NHC3) active as an antioxidant and 4 fractions (NHB1, NHC1, NHC2, NHC3) which are active as an antibacterial. The secondary metabolite contents of the fractions are alkaloid, flavonoid and steroid/terpenoid.
Formulasi Granul Ekstrak Kulit Buah Manggis (Garcinia mangostana. L) Menggunakan Aerosil dan Avicel PH 101 Supomo Supomo; Dayang Bella R.W; Hayatus Sa'adah
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.99

Abstract

Salah satu tanaman Indonesia yang bisa dimanfaatkan adalah buah manggis (Garcinia mangostana L.). Banyak penelitian yang dilakukan dengan ekstrak kulit manggis terhadap aktivitas farmakologi seperti antiinflamasi, antihistamin, antioksidan dan antimikroorganisme. Variasi pengolahan kulit buah manggis pada masyarakat Indonesia masih terbatas sehingga diperlukan pengembangan dalam bentuk sediaan lain seperti dibuat menjadi granul. Penelitian ini bertujuan untuk mengetahui apakah granul ekstrak kulit buah manggis menggunakan aerosil dan avicel PH 101 memenuhi persyaratan fisik granul yang baik dan untuk mengetahui konsentrasi aerosil dan avicel PH 101 yang memenuhi persyaratan fisik granul ekstrak kulit buah manggis. Penelitian diawali dengan proses ekstraksi simplisia kulit buah manggis secara maserasi dengan menggunakan pelarut etanol 70% dan diuapkan hingga diperoleh ekstrak kental. Pembuatan granul dari ekstrak kulit manggis dilakukan dengan menggunakan kombinasi antara aerosil dan avicel 101 yang divariasikan dalam 4 formula yaitu formula 1 aerosil : avicel 101(0% : 20%), formula 2 aerosil : avicel 101% (20% : 20%), formula 3 aerosil : avicel 101 (0% : 60%) dan formula 4 aerosil : avicel 101 (20% : 60%). Tahap selanjutnya granul hasil dari formulasi dievaluasi sifat fisik granul meliputi uji kandungan lembab, densitas massa, ukuran partikel dan sifat alir. Hasil yang diperoleh dianalisis secara statistik menggunakan analisis variasi (ANAVA). Hasil penelitian menunjukkan dengan konsentrasi avicel 101 : aerosil (20% : 0%) dan konsentrasi avicel 101 : aerosil (60% : 0%) granul ekstrak kulit manggis, memenuhi persyaratan, meliputi uji kandungan lembab, densitas massa, ukuran partikel dan sifat alir. Hal ini menunjukkan bahwa avicel 101 mampu berperan sebagai pengikat yang baik dan kuat sekaligus sebagai penyerap cairan pada granul.Kata Kunci: granul, kulit buah manggis, aerosil, avicel pH 101
Uji Sitotoksik dan Uji Kombinasi Fraksi Etil Asetat Ekstrak Etanol Akar Pasak Bumi (Eurycoma longifolia Jack.,) dan Doksorubisin pada Sel Limfosit Laela Hayu Nurani; Sitarina Widyarini; Ahmad Mursyidi
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.100

Abstract

Uji efek sitotoksik dan uji kombinasi fraksi etil asetat ekstrak etanol akar pasak bumi (Eurycoma longifolia, Jack.,) dan doksorubisin telah dilakukan terhadap sel normal limfosit secara in vitro. Fraksi etil asetat ekstrak etanol akar pasak bumi dan kombinasinya dengan doksorubisin diuji dengan metode MTT. Prinsip kerja metode MTT adalah dengan mengukur aktivitas dehidrogenase mitokondria pada sel-sel hidup yang memiliki kemampuan untuk mengkonversi MTT menjadi formazan. Pengujian sitotoksik ekstrak fraksinasi dilakukan pada konsentrasi 2000; 1000; 500; 250; 125; 62,5; 31,25 μg/mL dan doksorubisin pada konsentrasi 4; 2; 1; 0,5; 0,25; 0,125; 0,0625 μg/mL. Dari pengujian yang dilakukan diperoleh nilai IC50 fraksi etil asetat ekstrak etanol akar pasak bumi dan doksorubisin terhadap sel limfosit masing-masing 44 μg/mL dan 1,1 μg/mL. Hasil uji kombinasi diperoleh nilai CI (combination index) tertinggi adalah pada konsentrasi kombinasi 22 μg/mL (fraksi etil asetat ekstrak etanol APB) dan 0,5547 μg/mL (doksorubisin) yaitu sbesar 73,282 (CI>1=antagonis). Hasil penelitian menunjukkan fraksi etil asetat ekstrak etanol akar pasak bumi memiliki toksisitas yang lebih rendah dibandingkan doksorubisin dan dapat digunakan untuk kombinasi pada kemoterapi dengan doksorubisin.Kata Kunci : Akar pasak bumi, doksorubisin, uji sitotoksik, uji kombinasi, sel limfosit.ABSTRACTThe cytotoxicity and combination test of ethyl acetate fraction of ethanolic extract of Pasak bumi roots (Eurycoma longifolia Jack.) and doxorubicin have been made to the normal lymphocyte cells in vitro. The tests were carried out by using MTT method. Principle of the MTT method is to measure the mitochondrial dehydrogenase activity in living cells that have the ability to convert MTT into formazan. Cytotoxicity test for fraction performed at concentrations of 2000;1000;500;250;125;62,5;31,25 μg/mL and the concentrations of doxorubicin at 4;2;1;0,5;0,25;0,125;0,0625 μg/mL. From the tests IC50 values obtained ethyl acetate fraction of ethanolic extract of pasak bumi roots and doxorubicin against lymphocyte cells each 44 μg/mL and 1.1 μg/mL. The results of combination index (CI) value is 73,282 (CI>1= antagonist) at concentration of the combination 22 μg/mL for ethyl acetate fraction and 0,5547 for doxorubicin. The Results showed ethyl acetate fraction of ethanolic extract of the pasak bumi roots has lower toxicity than doxorubicin and it can be used for the combination chemotherapy with doxorubicin.Keywords : Pasak bumi roots, doxorubicin, Cytotoxicity test, combination test, lymphocyte cells
Pengaruh Jus Buah Pepaya (Carica papaya L.) terhadap Profil Farmakokinetik Simetidin pada Tikus Putih (Rattus norvegicus) Siti Julaicha; Adam M. Ramadhan; Rolan Rusli
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 3 (2016): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i3.101

Abstract

Drugs used with foods or drinks can affect the drug effects. This study aims to observe the effect of papaya juice (Carica papaya L.) to the pharmacokinetics profile of cimetidine in white rats. The animal were randomly in three group. Group 1 (cimetidine) was given a single oral cimetidine 3,6 mg/200gBW. Group 2 (cimetidine and papaya juice dose I) was given cimetidine 3,6 mg/200gBW together with papaya juice 4,5 g /200gBW. Group 3 (cimetidine and papaya juice dose II) was given cimetidine 3,6 mg/200gBW together with papaya juice 9 g /200gBW. The serial blood was collected for 4 hours on lateralis vein of rats tail. Determination of cimetidine in plasma performed by spectrophotometer UV. The pharmacokinetic parameters of cimetidine were calculated by regresi linear method and recidual method and were analyzed by One Way ANOVA using 95 % confidence interval. Based on research results showed that the group II and group III increased of ka, Cpmaks, tmaks, Cl, AUC and decreased ke, t½ab and t½el. Group III provides the most affect the cimetidine pharmacokinetics profile with decreased absorption and elimination and increased metabolism of cimetidine in rat.
Pengembangan Sistem Nanostructured Lipid Carriers (NLC) Meloxicam dengan Lipid Monostearin dan Miglyol 808 Menggunakan Metode Emulsifikasi Rahmi Annisa; Esti Hendradi; Dewi Melani
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 3 (2016): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i3.102

Abstract

The aim this study was to determine the effect of Monostearin and Miglyol 808 lipid ratio in NLC system formulation resulting in physicochemical characteristics, release rate, and penetration rate. The NLC making was done by using emulsification method. In the formulation of NLC meloxicam, 3 different lipid ratios were used, including ratios of 6:4, 7:3, 8:2. Meloxicam served as active ingredient, monostearin served as solid lipid, miglyol 808 served as a liquid lipid, and tween 80 was surfactant. NLC meloxicam physicochemical characteristics include tests of organoleptic, pH, viscosity, particle size, particle morphology and entrapment efficiency. NLC meloxicam belongs to semisolid preparations with pH value range of 5,72-5,87. Increasing viscosity of NLC system are cause by increase of solid lipid. The measurement results of particle size of three different lipid formulas indicated that the lipid particle size was <1000 nm. Test of NLC particle morphology by using Transmission Electron Microscopy (TEM) indicated the spherical particle shape (round). Entrapment efficiency test of all NLC-lipid compositions revealed quite high result (> 80%). The determination of release rate (flux) and penetration rate (flux) was conducted by using Franz diffusion cells with a cellophane membrane for the release and Wistar rat’s skin membrane for the penetration. The release rate values of three NLC meloxicam formulas showed p value (sig) 0,005, while the penetration rate obtained p value (sig) 0,091. Keywords: NLC, meloxicam, physicochemical characterization, release rate and penetration rate
Perubahan Profil Farmakokinetika Ibuprofen yang Diberikan dengan Kombinasi Vitamin C pada Tikus Putih (Rattus Norvegicus L.) Sattrio Desrianto Prabowo; Arsyik Ibrahim; Riski Sulistiarini
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 3 (2016): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i3.103

Abstract

Ibuprofen is one of the NSAID (NonSteroid Anti Inflamation Drug) drugs that has been widely used as antipyretic agent, analgesic dan anti-inflamation. Vitamin C is an important nutrient for the body and has been widely used to maintain health. Earlier study indicate patterns of interaction between vitamin C and NSAID drugs. The aims of this research were to study the influence of vitamin C to the pharmacokinetics profile of ibuprofen. The study was conducted using 9 rats rats, divided into 3 groups (n=3 per group). Each group was treated the following treatment : control ibuprofen (ibuprofen 7.2 mg/200 gBW), dose 1 group (ibuprofen 7,2 mg/200 gBW, and vitamin C 4,5 mg/200 gBW), and dose 2 group (ibuprofen 7,2 mg/200 gBW and vitamin C 9 mg/200 gBW). Blood sampling is done from the vein of rat’s tail at minutes 15, 30, 45, 60, 75, 90, 120, 180, 240, 300 and 360. The quantitation of ibuprofen in plasma was determined by UV spectrophotometer at maximum wavelength. Result showed that vitamin C changed the absorption of ibuprofen by prolonged the maximum plasma concentration time, reduce maximum levels of ibuprofen and vitamin C also changed the elimination of ibuprofen by prolonged the elimination time. Keywords: Ibuprofen, Vitamin C, Pharmacokinetics ABSTRAK Ibuprofen merupakan salah satu obat golongan NSAID (Non Steroid Anti-Inflamation Drug) yang secara luas digunakan oleh masyarakat sebagai antipiretik, analgesik, dan anti-inflamasi. Vitamin C merupakan nutrisi penting bagi tubuh yang dikonsumsi secara luas oleh masyarakat untuk menjaga kesehatan. Penelitian awal menunjukkan bahwa terdapat pola akan kemungkinan teradinya interaksi antara vitamin C dengan obat golongan NSAID. Tujuan penelitian ini adalah mempelajari pengaruh vitamin C terhadap profil farmakokinetika ibuprofen. Uji dilakukan dengan membagi 9 ekor tikus dalam 3 kelompok (tiap kelompok 3 ekor). Tiap kelompok diberi perlakuan sebagai berikut: kontrol ibuprofen (ibuprofen 7,2 mg/200 gBB), dosis 1 (ibuprofen 7,2 mg/200 gBB dan vitamin C 4,5 mg/200 gBB), dan dosis 2 (ibuprofen 7,2 mg/200 gBB dan vitamin C 9 mg/200 gBB). Pengambilan cuplikan darah dilakukan dari vena ekor tikus pada menit ke- 15, 30, 45, 60, 75, 90, 120, 180, 240, 300 dan 360. Kadar ibuprofen dalam plasma diukur menggunakan spektrofotometer UV - Vis pada panjang gelombang maksimum. Hasil penelitian menunjukkan bahwa vitamin C dapat mempengaruhi absorpsi ibuprofen dengan memperpanjang waktu konsentrasi plasma mencapai maksimum, menurunkan kadar maksimum ibuprofen dalam darah, dan vitamin C juga mempengaruhi eliminasi ibuprofen dengan memperpanjang waktu eliminasi ibuprofen Kata Kunci: Ibuprofen, Vitamin C, Farmakokinetik

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