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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : 10.25026/jtpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Tropical Pharmacy and Chemistry is a Six monthly (June and December), international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry publishes manuscripts (Original research Article, review articles, Mini-reviews, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics & Biopharmaceutics, Novel &Targeted Drug Delivery, Nanotechnology & Nanomedicine, Pharmaceutical Chemistry, Pharmacognosy & Ethnobotany, Phytochemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Pharmacogenomics, Pharmacovigilance, Natural Product Research, Drug Regulatory Affairs, Case Study & Full clinical trials, Biomaterials & Bioactive polymers, Analytical Chemistry, Organic Chemistry, Physical Pharmacy, Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 298 Documents
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The Immunosuppressant Effect Comparation Between Ethyl Acetate and n-Butanol Fractions of Kalanchoe Pinnata (Lmk) Pers In 2,6,10,14 Tetramethylpentadecane-Treated Mice Niken Indriyanti; Joewono Soeroso; Junaidi Khotib
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i1.126

Abstract

Immunosuppressant drugs are the main treatment of lupus patient. The ACR and SLICC treatment guidelines are able to increase the quality of life, but the outcome is not satisfying since the off-label therapy of corticosteroids and cytotoxic drugs give a lot of side effects. Many breakthrough efforts still develop in order to find the safe and effective drugs for lupus, such as finding immunosuppressant drugs from natural resources. One of the potential resources is Kalanchoe pinnata (Lmk) Pers, which have immunosuppressant, anti-inflammatory, antinociceptive, and antioxidant effects. Thus, in the previous study, we found the effect of the aqueous extract of Kalanchoe pinnata (Lmk) Pers is active to repair the lupus manifestation in 2,6,10,14 tetramethylpentadecane (TMPD)-treated mice. Then, this research was focused on the in vivo immunosuppressant effect of a flavonoid-rich fraction of the extract which was consisted of the ethyl acetate (FE) and n-butanol (FB) fractions. The induction method and the extraction procedure were the same as the previous study and then the fractionation was performed by using liquid-liquid extraction. After 2-week treatment of both fractions, we obtained the differences in the total leukocytes, organ indexes, and also the spleen, kidney, and joint structure parameters. The total leukocyte of the FE group was 3,600±264 cells/mm3, which was lower than that in the FB group. The spleen and kidney indexes increased after the administration of FB fraction, while the FE fraction was not. At last, despite the histology observation of spleen resembled mild structural changes differences, the clear differences between both treatment groups occurred in the kidney and joint histology. The differences led to a conclusion that the FE fraction has the better immunosuppressant effect in TMPD-treated mice.
Pemanfaatan Abu Sekam Padi menjadi Katalis Heterogen dalam Pembuatan Biodiesel dari Minyak Sawit Kusyanto Kusyanto; Purwa Aditya Hasmara
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i1.127

Abstract

Berdasarkan data BPS Kaltim (2014) jumlah produksi padi mencapai 432.612 ton/tahun. Produksi padi tersebut menghasilkan sekam padi rata-rata sebesar 20%. Sekam padi masih kurang dimanfaatkan dengan baik sehingga hanya menjadi tumpukan limbah pertanian. Abu sekam padi mengandung senyawa yang dapat digunakan sebagai support katalis yaitu diantaranya SiO2. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan abu sekam padi yang telah dikalsinasi dengan impregnasi KOH sebagai katalis pembuatan biodiesel dari minyak sawit secara konvensional. Sekam padi dikalsinasi pada suhu 500°C selama 3 jam lalu diimpregnasi dengan KOH 1,9 N. Kemudian dibilas dengan aquadest dan dioven hingga beratnya konstan. Transesterifikasi dilakukan pada minyak sawit dengan perbandingan massa terhadap volume minyak (10%, 15%, 20%, 25% v/b). Hasil yang didapatkan, semakin banyak massa katalis yang digunakan, konversi yield yang diperoleh semakin tinggi yaitu mencapai 67%. Viskositas dan densitas memenuhi standar biodiesel. Hasil uji surface area BET diperoleh surface area spesifik sebelum dan sesudah impregnasi berturut-turut adalah 89,937 m2/g dan 5,471 m2/g. Analisa produk dengan menggunakan GC-MS dilakukan untuk mendapatkan jenis methyl ester sterarate, palmitat, dan Linoleat.
Isolasi dan Karakterisasi Fungi Endofit Tanaman Tapak Dara (Catharanthus Roseus) M. Arifuddin; Mahfuzun Bone; Iswahyudi Iswahyudi; Arsyik Ibrahim; Laode Rijai
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i1.128

Abstract

This study aims to determine the diversity of endophytic fungi Tread Dara (Catharanthus roseus) as one of the potential plants that can produce medicinal efficacious compounds. This study includes the isolation and identification of endophytic fungi on Tapak Dara plant using PDA medium. Based on the results obtained 6 endophytic fungal isolates originating from roots and leaves Tread Dara.
Efek Nefroprotektif Kombinasi Ekstrak Daun Gedi Merah dan Daun Kumis Kucing pada Tikus Induksi Etilen Glikol Joni Tandi; Moh. Roem; Yuliet Yuliet
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i1.129

Abstract

Nephroprotective compound is a compound that has the ability to protect the kidneys from kidney disorders caused by free radicals. This research aimed to determine the nephroprotective effect of the combination of Abelmoschus manihot leaves and Orthosiphon stamineus leaves extract as well as to know the effective extract dose combinations as nephroprotective. This research applied Group Random Design with 6 treatment groups consists of 5 tested animals. Group I was normal control. Group II was negative control. All extract groups was given 0,75% of ethylene glycol and 2% of ammonium chloride. Group III was given 100 mg/kg BW of Abelmoschus manihot leaves extract and 200 mg/kg BW of Orthosiphon stamineus leaves extract. Group IV was given 50 mg/kg BW of Abelmoschus manihot leaves extract and 100 mg/kg BW of Orthosiphon stamineus leaves extract. Group V was given 100 mg/kg BW of Abelmoschus manihot leaves extract. Group VI was given 200 mg/kg BW of Orthosiphon stamineus leaves extract. Treatment was given for 14 days and the levels of creatine and urea were measured on day 0, 8 and 15. The results show the nephroprotective effect in all the extract groups, but the most effective one was the group III.
Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico Yurika Sastyarina; Zuhrotun Nafisah; Muhammad Yusuf; Martalena Ramli; Abdul Mutalib; Ukun Soedjanaatmadja
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 1 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i1.130

Abstract

Dendrimers are a class of highly branched synthetic polymers that has spherical form consist of three components: core, branch and terminal functional groups. One of dendrimer that has been commercialized is (Poly)amidoamine (PAMAM). PAMAM dendrimer used as a template in the preparation of gold nanoparticles. This research was studied the streched cavities of (Poly)amidoamine (PAMAM) dendrimer generation 4 using in silico method. Structure of (Poly) amidoamine (PAMAM) dendrimers generation 4 downloaded from Building Toolkit (DBT) Library and before the simulation structure was prepared. Then molecular dynamics simulations run using the AMBER program at 37°C in aqueous conditions. From analysis, obtained that the furthest distance of streched cavities at the closest distance from the core, region between residues 2 and 3 is 23.696 Å and at the terminal region between residues 100 and 122 is 58.045 Å
Prosfektif Metode Sampel Darah Kering dalam Bioanalisis Supandi Supandi
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 3 (2016): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i3.131

Abstract

Biosampling of dried blood spot method became lately very interested in bioanalysis, some of the advantages given in this method compared to conventional venous canulla (venipuncture); less invasive making it more pleasant for the patient or subject, requires small volume, requires simple transportation process and storage did not need special equipment, suod stabilizes analit and reduces risk of infection. The method of dried blood spot is done by invasive light on the finger or heel prick and then spike on filter paper and dried at room temperature or under nitrogen flow with controlled humidity and stored in bag with desiccant packages, than it analyzed using validation bioanalyzing method. Dried blood spot method can be applied on bioanalysis test for pharmacokinetic, toksikokinetic , epidemiologic and Teurapeutic drug monitoring.
Hubungan Jumlah Obat yang Digunakan terhadap Risiko Terjadinya Drug-Related Problems pada Pasien Asma Di Suatu Rumah Sakit Di Surabaya Amelia Lorensia; Rizka I Wijaya
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 3 (2016): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i3.132

Abstract

Asthma is a chronic inflammatory disorder of the respiratory tract are at risk of polypharmacy, which is associated with an increased risk of drug-related problems (DRPs) and adverse clinical outcomes. This study aimed to analyze the relationship between the amount of drug used with the incidence of DRPs in hospitalized asthma patients. Research were using retrospective methods, by analyzing the medical records of patients undergoing asthma hospitalizations for 2 years. The number of patients analyzed was 60 people. Results of research conducted by the Spearman test for non-parametric tests, show that there is a correlation between the amount of drug to the type of drugs that are less precise DRPs (p <0.05), so that more and more types of drugs used by patients with asthma, the greater the risk of patients getting the drug less appropriate. Therefore it takes the role of pharmacists in monitoring and recommending rational drug for asthma patients who underwent inpatient in a hospital, for treatment obtained by the patient effective and optimal.
Pengaruh Merokok terhadap Keefektivitasan Terapi Hipertensi pada Penderita Hipertensi Perokok Di Empat Puskesmas Tahun 2017 Dna Raras Mardena; Anjar Mahardian Kusuma
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i2.133

Abstract

Hypertension is a chronic condition of the mesh where blood pressure rises above normalized blood pressure. This study aims to measure the effect of smoking on the effectiveness of hypertension therapy in patients with hypertension of smokers at Puskesmas I Sumbang, Puskesmas II Kembaran, Puskesmas Purwokerto Timur I, Puskesmas Purwokerto Selatan 2017. Type of study used prospective cohort, in terms of patient's blood pressure with drug consumption Single 1st, 10th day, 30th day to assess effectiveness. Data were analyzed univariat and bivariate through Chi-square test. The result showed that p> 0,05 that p = 0,361 showed that there was no significant difference in the effectiveness of hypertension therapy between group of non smoker hypertension and smoker hypertension. Does not affect the effectiveness of therapy statistically. Keywords: Hypertension, Effectiveness, Amlodipine, Smoking
Peran Homepharmacycare pada Pasien Diabetes Mellitus Tipe II Prolanis terhadap Tingkat Kepatuhan dan Keberhasilan Terapi Di BP Sentra Medika Lebaksiu Tegal Mita Rodiyatun Najiha; Wahyu Utaminingrum; Much Ilham Novalisa Aji Wibowo
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i2.134

Abstract

Diabetes mellitus disease (DM) is chronic diseases due to the increase of glucose concentration in the body. The compliance and successful treatment of diabetes are needed to prevent complications. The patients’ compliance in using the medicine is an important factor of the successful therapy. One of the most comprehensive interventions for DM patients is Home Pharmacy Care. Objective: This study aims to determine the effect of Home Pharmacy Care role in patients with diabetes mellitus in increasing the compliance and successful therapy. Method: This research is pre experimental research conducted at Bp Sentra Medika Clinic and counseling at home respondents in Lebaksiu ,Tegal with using the method of one group pretest posttest design. Purposive sampling method is used in this research and got 35 respondents. Measurements were made using the MMAS-8 (pretest-postest) and pill count instrument to determine the patient's compliance level and the glucotest to measure the success of therapy characterized by blood sugar levels. Statistics test uses Wilcoxon and Mc Nemar to determine the effect of provision of Home Pharmacy Care intervention on compliace and successful therapy level. The results: showed that a total of 20 patients (57%) comliance to MMAS-8 and pill count scores and a total of 20 patients (57%) of successful treatment were achieved based on controlled blood glucose levels. Conslusion: The statistical test showed that there was a significant difference between before and after intervention marked with the value of p value of both tests was 0,000 so that there is an effect of giving Home Pharmacy Care toward the improvement of compliance and successful therapy. Keywords : diabetes mellitus, homepharmacycare, prolanis, compliance and successful therapy level
Sunscreen Lotion of Miana Leaves (Coleus atropurpureus Benth) Rolan Rusli; Rosniah Rosniah; Aditya Fridayanti
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 5 (2019): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i5.135

Abstract

Sunscreen can protect the skin from the UV radiation. One of the plants that have the potential to be utilized as active ingredients of sunscreen lotion is miana leaves (Coleus atropurpureus Benth). Lotion made in 3 formulas F1, F2 and F3. Lotion tested its stability with a freeze-thaw method, and evaluated organoleptic, homogeneity, pH, viscosity and scatterness and tested sunscreen activity of lotion preparation. The preparation shows good homogeneity, and has oleum rosae odor and a thick consistency with the lotion color is brown (F1), dark brown (F2) and slightly greenish brown (F3). Spreading, viscosity, and pH of the lotion meet the Indonesia Standart requirement. The lotion formula comes in the category of fast tanning (F2) and extra protection (F3) sunscreen.

Page 13 of 30 | Total Record : 298

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