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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : 10.25026/jtpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Tropical Pharmacy and Chemistry is a Six monthly (June and December), international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry publishes manuscripts (Original research Article, review articles, Mini-reviews, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics & Biopharmaceutics, Novel &Targeted Drug Delivery, Nanotechnology & Nanomedicine, Pharmaceutical Chemistry, Pharmacognosy & Ethnobotany, Phytochemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Pharmacogenomics, Pharmacovigilance, Natural Product Research, Drug Regulatory Affairs, Case Study & Full clinical trials, Biomaterials & Bioactive polymers, Analytical Chemistry, Organic Chemistry, Physical Pharmacy, Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 298 Documents
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Potential and Constraints of Biopharmaceutical Plants in East Kalimantan Province Junaidin Junaidin; Supriatno Salam; Erwin Samsul
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.350

Abstract

Biopharmaceutical plants (drugs) in East Kalimantan Province have tremendous potential for the Farmers' Economy in particular and the Economy of Society in general. Farmers have not felt this potential because it faces existing obstacles. In this study, the Pharmaceutical Business Laboratory, Faculty of Pharmacy, Mulawarman University, will be analyzed for its role in finding solutions to existing obstacles. Research results are expected to be helpful in terms of the resource-advantage theory and in terms of Implications that can be done by Stakeholders, which aim that the potential of Biopharmaceutical Crops can bring the welfare of Farmers and Communities.
Antibacterial Activity of Salam (Syzygium polyanthum) Leaves 70% Ethanolic Extract on Staphylococcus aureus and Staphylococcus epidermidis Ayu Nala El Muna Haerussana; Wulan Putri Dwiastuti; Cindi Arwan Sukowati
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 4 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i4.352

Abstract

Indonesia has a high diversity of potential medicinal plants, which are the second-largest number of indigenous medicinal plants in the world. Syzygium polyanthum, known as Indonesian Bay Leaf or Salam, easily found, widely used in Indonesia as a spice in cooking and traditional medicine. Salam contains secondary metabolites such as flavonoids, alkaloids, tannins, essential oils, sesquiterpenes, triterpenes, phenols, steroids, and saponins. Staphylococcus aureus and Staphylococcus epidermidis are the main bacteria that cause commensal infection and the most common nosocomial infections. This study aims to know the antibacterial activity of the Salam ethanolic extract against Staphylococcus aureusand Staphylococcus epidermidis bacteria. Salam leaves were extracted by 70% ethanol in the maceration method. Antibacterial activity was conducted by the disk diffusion method. The extract exhibits moderate activity (10.51±0.3 mm) at 75% of concentration and low activity (3.69±0.4 mm) at 100% of concentration against Staphylococcus aureus and Staphylococcus epidermidis respectively. The test showed that salam leaves extract had antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis.
Identification and Determination of Berberine from Arcangelisia Flava, East Borneo Riski Sulistiarini
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 4 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i4.372

Abstract

Berberine is a compound that has various benefits but also has dangerous toxic effects. In Indonesia, the Regulation of the Head of the Food and Drug Supervisory Agency No. 10 of 2014 concerning the Prohibition of Producing and Circulating Traditional Medicines and Health Supplements Containing Coptis Sp, Berberis Sp, Mahonia Sp, Chelidonium Majus, Phellodendron Sp, Arcangelica Flava, Tinosporae Radix, and Catharanthus Roseus. Regulation No. 7 of 2018 (BPOM, 2018) also prohibits the presence of berberine in processed food. This research was conducted to determine the content of berberine compounds from the extract and stem fraction of Arcangelisia flava. The research was conducted by identifying the content of berberine by TLC method compared with Rf Berberine sulfate and determination of berberine content by HPLC method (High-Performance Liquid Chromatography) using column C-18 (ODS). Berberine content of methanol extract, n-hexane fraction, ethyl acetate fraction and Arcangelisia Flava methanol-water fraction were 0.0040, respectively; 0.0010; 0.0041, 0.0044%.
Imunomodulator Activity of Three Types “Kayu Kuning” Borneo Dwi Hadi Setya Palupi; Riski Sulistiarini; Vita Olivia Siregar
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.375

Abstract

The immune system is a system that plays a role in maintaining the integrity of the body against the dangers that various foreign objects can cause. Immunomodulators are substances or substances that can change/modify the immune system. Empirically, Kayu Kuning or Yellow Wood is used as a cleaner for post-partum conditions. Yellow wood in East Kalimantan is the name for three species, namely Arcangelisia Flava, Fibraurea tinctoria, and Coscinium fensteratum. With the approach of improving the immune system and metabolism, immunomodulatory tests carried out on three types of yellow wood found in Borneo Island. The immunomodulatory activity of Yellow wood steam extract in the non-specific immune response test used phagocytic index and organ index parameters where BALB/c female mice were randomly divided into 16 treatment groups which included a normal group, an immunostimulant comparison group (Levamisole 2.5 mg/kg body weight), an immunosuppressant comparison group (Methylprednisolone 40mg/kg BW), a test extract group with a dose of 100 mg/kg body weight, for the ethanolic extracts of A. Flava, F. tinctoria and C. fenestratum, respectively. Based on the study results, it means that the methanol extract of A. Flava methanol extract had immunostimulating activity, while the methanol extract of F. tinctoria and C. fenestratum showed an immunosuppressant effect
Formulation of Silver Nanoparticle Mouthwash and Testing of Antibacterial Activity Against Staphylococcus aureus Rahmi Annisa; Begum Fauziyah; Dewi Sinta Megawati; Firdausi Zahrah
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.386

Abstract

Silver Nanoparticles (AgNP) are silver particles of no more than 100 nm in size. Silver nanoparticles have antimicrobial characteristics and have been applied to various fields as antibacterial agents. This study aims to formulate and examine the antibacterial activity in preparing silver nanoparticle mouthwash on Staphylococcus aureus. The silver nanoparticles are synthesized using a chemical reduction method, of which the wavelength is then characterized using UV-Vis spectrophotometry, and the PSA instrument is used for particle size. Silver nanoparticles are formulated for a mouthwash with various concentrations such as 0%, 60%, 70%, and 80% consecutively as formula 1, 2, 3, and 4. The observation is then performed on the organoleptic, pH, stability, and bacterial activity of the Staphylococcus aureus using the disk diffusion method. The study results indicate that the preparation of silver nanoparticle mouthwash has a good organoleptic; the average pH of formula 1, 2, 3, and 4 consecutively is 3.40, 3.40, 3.46, and 3.54; however, it is not stable during the storage stage. The result of the antibacterial activity test on Staphylococcus aureus bacteria shows that formula 2 has the most oversized average inhibition zone diameter that is 13.14±0.31 mm compared to formulas 1, 3, and 4, namely 5.20±0.44; 12.40±0.74; and 8.40±0.89 mm. The active formula of mouthwash preparation to inhibit the growth of Staphylococcus aureus bacteria is formula 2.
Physicochemical Parameters and Purification of Pulp Effluent (Black Liquor) Oluwatosin Shokunbi; R.O Omenka
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.394

Abstract

Pulp and paper Industry poses a great significant problem in Environmental pollution and they consume high energy, water and resources. The present study was undertaken to purify pulp effluent (black liquor) using sand bed filters and adsorption method (Activated Carbon). The physicochemical parameters carried out were pH, colour, temperature, turbidity, total alkalinity (TA), total hardness (TH), chemical oxygen demand (COD), total suspended solids (TSS), total solids (TS) and total dissolved solids (TDS) using standard methods by American Public Health Association (APHA). The results obtained for black liquor and treated effluent were; colour (dark brown), pH (11.59 & 9.14), temperature (31 & 30 ), turbidity (1.78 &0.77 NTU), TA (10,000mg/L & 300mg/L), TH (325 mg/L & 220 mg/L), COD (2663 mg/L & 174.85 mg/L), TSS (0.09 mg/L & 0.00 mg/L), TS (0.9 mg/L & 0.17 mg/L), TDS (1354 mg/L) respectively. Highly significant differences were found between the effluent and treated water. The results indicated that pulp and paper Industrial effluents are highly polluted and can be toxic or harmful to human beings when released into water bodies without being treated.
Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active Principle Nelly Tagnin Nkuete; Sandra Leila Nnanga; Stephanie Tamdem Guetchueng; Nga Nnanga; Joseph Ngoupayo
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.404

Abstract

The increase incidence of fungal infections, the resistance of fungal strains to existing drugs and the toxicity assimilated to long term usage of antifungal drugs as prompted the search of new alternative from natural source. In this study we have evaluated the antifungal properties of the essential oil of the rhizome of Z. officinale, a plant known for its various biological properties and used in food industry as spice. An antifungal ointment with Z. officinale essential oil as active principle was also formulated and its antifungal properties evaluated. GC/MS analysis identified Zingiberene (22.36%), 1.8-cineole (15.54%), geranial (11.91%), camphene (11.09%) and geraniol (8.75%) as the main constituents of Z. officinale essential oil obtained by hydrodistillation. The oil showed a significant antifungal activity against clinical isolate of Candida krusei with MIC 800 ppm by microdilution method. The formulated ointment containing 10 % glycerol, 60 % vaseline, 8 % hydrosol, 20% lanolin and 2% Zingiber officinale essential oil (Formule E1) was found to follow pharmaceutical standards according to European Pharmacopeia and also showed good antifungal properties
6,7-dimethoxydihydrocoumarin Compound from Ethyl Acetate Extracts from Steambarks Dysoxylum Alliaceum and Cytotoxic Activity Against P-388 Ois Nurcahyanti; Kartika Rahma
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 2 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i2.405

Abstract

Dysoxylum is a genus that has a variety of secondary metabolites. Research on various species of this genus is always growing and producing compounds that have interesting structures and activities, until now many compounds of the terpenoid group, chroman alkaloids, limonoids, sesquiterpenes, flavonoids, steroids, protolimonoids and sulfur have been reported. which is very interesting. One of the Dysoxylum species that has a variety of secondary metabolites is D. alliaceum. The purpose of this study was to obtain secondary metabolites of D. alliaceum bark. The bark of D. alliaceum was macerated successively with n-hexane, ethyl acetate and methanol. The ethyl acetate extract was separated and purified by various chromatographic techniques and was characterized using spectroscopic methods including, ultraviolet, infrared, NMR and mass spectroscopy and guided by thin layer chromatographic analysis to obtain the compound 6,7-dimethoxydyhidrocoumarin and the proposed biogenesis. The chemical structure of these compounds has been determined based on the interpretation of spectroscopic data and compared with spectral data from previous studies. Cytotoxic activity test against P-388 MTT leukemia cells obtained an IC50 of 39.210 g/mL and was declared inactive.
HPLC-HRESI-MSn Characterization of Polyphenolic Compounds in the Stem Bark of Chlorophora regia A. Chev (Moraceae) James Oppong-Kyekyeku; Samuel Oppong Bekoe; Edmund Ekuadzi; John Nii Adotey Addotey; Samuel Asare-Nkansah
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 2 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i2.419

Abstract

Isolation and identification of secondary metabolites from medicinal plants could be tedious and time consuming. Therefore, any technique that could be used to confirm the identity of medicinal plant constituents without isolating them will save time and resources. Chlorophora similar to many genera in the Moraceae family have been demonstrated to be rich sources of polyphenolic compounds with important biological activities. The current study was designed to employ HRESI-MSn analyses to qualitatively examine isolated polyphenolic compounds from the stem bark of Chlorophora regia. Based on the HRESI-MSn data obtained, the fragmentation patterns of the compounds under study will be proposed and could be used in their identification in a matrix. Five polyphenolic compounds were successfully isolated and purified using various chromatographic techniques including column chromatography, thin-layer chromatography (TLC) and preparative HPLC. The structures of the isolated compounds were elucidated by in-depth analyses of their 1D and 2D NMR and mass spectroscopic data. HRESI-MS/MS was further used to characterize the isolated compounds. Five polyphenolic compounds including three Diels-Alder type adducts: sanggenon C, kuwanol E and chalcomoracin; two stilbene derivatives: chlorophorin and isochlorophorin were isolated from the stem bark. The tandem MS fragmentation patterns of the compounds in positive mode, were successfully proposed. The fragments obtained and proposed fragmentation patterns of the isolated compounds could be employed qualitatively in the identification of the studied polyphenolic compounds in a matrix.
Molecular Docking Study of Nigella sativa Alkaloid Compounds as the Inhibitor of Papain-Like Protease SARS-CoV-2 Gusnia Meilin Gholam; Iman Akhyar Firdausy
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 1 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i1.420

Abstract

SARS-CoV-2 causes about 66% of China’s Wuhan market workers to experience fever, dry cough, and fatigue. Black cumin (Nigella sativa) is a plant with many benefits to cure many illnesses like hypertension, headache, infection, and inflammation. This study aimed to investigate the inhibition by compounds belonging to the Alkaloid group from Black Cumin Seed to inhibit PLpro activity as a target for SARS-CoV-2. The study used five alkaloid compounds ((2E,4E)-Decadienal, (2E,4Z)-Decadienal, Nigellicine, Nigellidine, and Nigellimine) from the Black cumin seed and a PLpro SARS-CoV-2 receptor (PDB ID: 6WX4). The methods used are ligand and receptor preparation, grid box validation, molecular docking, 2D and 3D visualisation, and data analysis using Gibbs free energy, type of interaction, and contact of amino acid residues data. This study used YASARA structure and BIOVIA Discovery Studio. The results showed that Nigellidine has the highest Gibbs free energy with a -2.67 kcal/mol score, higher than VIR251. PLpro has a catalytic triad at Cys111, His272, and Asp286 residues, the compound that binds to the active site is Nigellicine found at amino acid Cys111 with Pi-Sulfur.

Page 24 of 30 | Total Record : 298

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