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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : 10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan menerima naskah karya asli (Artikel Penelitian, Artikel Review, dan Studi Kasus), baik eksperimental maupun teoretis, dalam bidang-bidang berikut: Sains dan Kesehatan (Kedokteran, Farmasi, Kesehatan Masyarakat, Keperawatan, Kebidanan, Gizi, dan lain-lain). Tujuan penerbitan Jurnal Sains dan Kesehatan adalah untuk menyediakan informasi ilmiah tentang perkembangan ilmu dan teknologi di bidang Ilmu Pengetahuan dan Kesehatan.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 750 Documents
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Molecular Docking of Secondary Metabolite Compounds of Andrographis Paniculata Plant as Potential Covid-19 Drug Candidate Netty Ino Ishak; Akram La Kilo; Dandi Saputra Halidi; La Ode Aman; Jafar La Kilo; Weny J.A. Musa
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1845

Abstract

The aim of this research was to investigate the interaction between secondary metabolite compounds and the Mpro receptor, which was the main protein in Covid-19. Ligand-receptor interactions were studied using the Molecular Docking method. The validation results indicated that the test ligand Andrographolide had a higher affinity value compared to the standard ligand, with a value of -6.6 kcal/mol compared to the standard ligand's -7.5 kcal/mol. Additionally, the compound 14-Acetyl-3,19-isopropylideneandrographolide, 5,4 dihydroxy-7,8,2',3'-tetramethoxyflavone-5-glucoside had an affinity of -7.5 kcal/mol, Andrographidin A had -7.6 kcal/mol, Andrographiside had -7.7 kcal/mol, Skullcapflavone I had 7.7 kcal/mol, 5-Hydroxy-7,8,2'-trimethoxyflavone-5-glucoside had -7.7 kcal/mol, Apigenin had 7.7 kcal/mol, 5-Hydroxy-7,8-dimethoxyflavone-5-glucoside had -7.8 kcal/mol, Neoandrographolide had -7.8 kcal/mol, Andropanoside had -7.9 kcal/mol, Wogonin-5 glucoside had -8.1 kcal/mol, 5,2',3'-Trihydroxy-7,8-dimethoxyflavone-3'-glucoside had -8.4 kcal/mol, and Bisandrographolide had -8.5 kcal/mol. From the molecular docking results, the secondary metabolite compounds from the Andrographis paniculata plant exhibited significant interactions surpassing the standard ligand N3. Active residue interactions observed included Phe140, Leu141, Asn142, Gly143, His163, Glu166, Gln189, and Thr190. Keywords: Andrographis paniculata; Covid-19 drug; Mpro receptor; molecular docking
Larvicides Activity of Krokot Extract into Aedes aegypti Mortality Fanani, Zaenal; Hidayah, Noor; Yulianti, Nur Fajria
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.1857

Abstract

Dengue Hemorrhagic Fever (DHF) is transmitted by Aedes aegypti, one of controlling vectors which is larvicides. Synthetic larvicides cause several problems so that alternative natural larvicides are used. One of which is the krokot (Portulaca oleracea, L.), the content such as flavonoids, tannins, alkaloids, and saponins can be used as larvicides. This study aims to determine the larvicides activity of krokot extract on mortality of Aedes aegypti. The study was conducted using experimental quantitative research. The study was conducted by pouring the ethanol extract on 25 larvae and repeated 3 times, for 24 hours. The result of larvae mortality test at concentrations of 4%, 5% and 6%, namely 39%, 57% dan 72%. LC50 value from krokot extract on the larvae mortality, that is equal to 9.294%. Based on the study, it can be concluded that the krokot ethanol extract is able to kill 50% of the Aedes aegypti larvae population.   Keywords:          krokot, ethanol extract, Aedes aegypti, mortality
Analisis Kandungan Protein dan Mineral (Fe, Ca, dan Zn) Sup Krim Instan (SKI) untuk Ibu Hamil dalam Mencegah Stunting: Analysis of Protein and Mineral Content (Fe, Ca, and Zn) of Instant Cream Soup (ICS) for Pregnant Women in Preventing Stunting Fahrul Rozi; Chaidir Masyhuri Majiding; Muhammad Nuzul Azhim Ash Siddiq
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1859

Abstract

Stunting is still a global health problem in the world, as well as in Indonesia. Preventive efforts are needed to reduce the prevalence of stunting in Indonesia, because the impact of stunting is very detrimental to the development of a country. In the short term, stunting causes disturbances in physical, brain, cognitive, and metabolic development. In the long term, stunting causes reduction in cognitive abilities, increases the risk of child mortality and morbidity, decreases productivity and income in adults. Therefore, the development of ICS is needed as a reference for pregnant women supplementation. ICS must contain protein and minerals (Fe, Ca, and Zn) to have an effect on stunting. This study aims to analyze the protein and mineral content (Fe, Ca, and Zn) of ICS. Protein content was analyzed using Kjeldahl method, while mineral content was analyzed using AAS method. All protein and mineral content data were tested differently using two-way ANOVA. In conclusion, there is no significant difference between the formulas in terms of protein content. There was an interaction between factor A and factor B on the content of Fe and Ca, and there was an effect of 0% and 5% maltodextrin on the Zn content of ICE. Keywords: Stunting, ICS, Protein, Mineral Abstrak Stunting masih menjadi permasalahan kesehatan global di dunia, begitupun di Indonesia. Prevalensinya akhir-akhir ini bersifat fluktuatif. Dibutuhkan upaya preventif untuk menurunkan prevalensi stunting di Indonesia, karena dampak dari stunting sangat merugikan bagi perkembangan suatu negara. Pada jangka pendek stunting menyebabkan gangguan perkembangan fisik, otak, kognitif, dan metabolisme tubuh. Pada jangka panjang stunting menyebabkan berkurangnya kemampuan kognitif, peningkatan risiko mortalitas dan morbiditas anak, penurunan produktivitas, dan penurunan pendapatan pada orang dewasa. Oleh karena itu, pengembangan produk Sup Krim Instan (SKI) diperlukan sebagai referensi suplementasi makanan bagi ibu hamil untuk pencegahan stunting sejak dini. SKI harus mengandung protein dan mineral (Fe, Ca, dan Zn) agar dapat memberikan efek terhadap stunting. Penelitian ini bertujuan untuk menganalisis kandungan protein dan mineral (Fe, Ca, dan Zn) SKI. Kandungan protein dianalisis menggunakan metode Kjeldahl, sedangkan kandungan mineral dianalisis menggunakan metode AAS. Seluruh data kandungan protein dan mineral diuji beda menggunakan two-way ANOVA. Sebagai kesimpulan, tidak terdapat perbedaan yang signifikan antar formula terhadap kandungan protein. Terdapat interaksi faktor A dan faktor B terhadap kandungan Fe dan Ca, serta terdapat pengaruh pemberian maltodekstrin 0% dan 5% terhadap kandungan Zn SKI. Sebagai saran, produk ini dapat diberikan sebagai suplemen ibu hamil untuk mencegah stunting. Kata Kunci: Stunting, SKI, Protein, Mineral
Uji Reliabilitas the Functional Reach Test untuk Pengukuran Keseimbangan Statis pada Penderita Osteoarthritis Lutut: Reliability Test of the Functional Reach Test for Measuring Static Balance in Patient with Knee Osteoarthritis Dwi Rosella Komalasari; Hafiza Amalia
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1861

Abstract

Osteoarthritis (OA) is a chronic degenerative disease characterized damages the cartilage causing swelling, pain, muscle weakness, joint stiffness and reduced postural balance. The Functional Reach Test (FRT) is one of tests that can be used to measure static balance, unfortunately the reliability of FRT in Indonesia has not published as well including in patient with knee OA. The aim of this research is to determine test retest and inter rater reliability of FRT to measure static balance in patients with knee OA. This study used an observational study method with a methodological research approach. There were 58 participants who taken by purposive sampling. This study conducted in test retest and inter rater reliability of FRT. Test retest and inter rater reliability showed high internal consistency (?=0.82, ICC=0.69, p<0.0001, r=0.64) dan (?=0.84, ICC=0.72, p<0.0001, r=0.67). FRT is reliable in terms of test retest and inter rater reliability to measure static balance in patients with knee OA. Keywords: Functional reach test, Knee Osteoarthritis, Realiability   Abstrak Osteoarthritis (OA) adalah penyakit degeneratif kronis ditandai kerusakan tulang rawan pada sendi, menyebabkan bengkak, nyeri, penurunan kekuatan otot, kekakuan sendi serta keseinbangan tubuh yang mengakibatkan peningkatan resiko jatuh. Functional Reach Test (FRT) merupakan salah satu tes yang dapat digunakan untuk memeriksa keseimbangan statis, tetapi laporan tentang reliabilitas tes ini di Indonesia masih sangat terbatas terutama bagi pasien dengan OA lutut. Tujuan penelitian ini untuk mengetahui reliabilitas test retest dan inter rater reliability dengan pada FRT sebagai alat ukur untuk keseimbangan statis pada penderita osteoarthritis lutut. Penelitian ini menggunakan metode observational study dengan pendekatan methodological research. Terdapat 58 responden dalam penelitian ini yang diambil  dengan purposive sampling. Test retest dan inter rater reliability FRT dievaluasi dalam penelitian ini. Hasil Test retest dan inter rater reliability FRT menunjukkan internal consistency tinggi (?=0.82, ICC=0.69, p<0.0001, r=0.64) dan (?=0.84, ICC=0.72, p<0.0001, r=0.67). FRT reliabel dalam hal test retes dan inter rater sebagai alat ukur keseimbangan statis pada penderita osteoarthritis lutut. Kata Kunci: Functional reach test, Osteoarthritis lutut, Reliabilitas
Uji Efektivitas Diuretik Kombinasi Rebusan Rimpang Alang-alang (Imperata cylindrical L.) dan Daun Kumis Kucing (Orthosiphon aristatus Benth.) pada Mencit Jantan (Mus musculus): Diuretic Effectiveness Test of Combination of Alang-alang (Imperata cylindrical L.) and Kumis Kucing Leaves (Orthosiphon aristatus Benth.) Decoction in Male Mice (Mus musculus) Andi Fadillah; Rusdiaman Rusdiaman; Hendra Stevani
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1864

Abstract

Rhizomes of reeds (Imperata cylindrical L.) and leaves of kumis Kucing (Orthosiphon aristatus Benth.) are traditional medicines used as diuretics. The flavonoids contained in these two plants have biological activity as a diuretic. In this study, 15 mice were separated into 5 groups, each containing 3 mice as test subjects. Group 1 was given aquadest. Group 2 was given furosemide 20 mg/kg BW, boiled reeds with a concentration of 60%: 40% cat's whiskers leaves was given to group 3, reed rhizome decoction with a concentration of 50%: 50% cat's whiskers leaves was given to group 4, and group 5 was given reed rhizome decoction with a concentration of 40%: 60% cat whiskers leaves. The treatment group was studied for 4 hours and the volume of urine was recorded every 30 minutes. The results of the study showed that boiled cat's whisker leaf alang-alang rhizomes from the third concentration group had a diuretic effect where the mice excreted urine for the first time in the 60th minute. The group showing positive controls and negative controls excreted urine for the first time at 30 minutes. Keywords:          Diuretics, reeds, cat whiskers, mice   Abstrak Rimpang alang-alang (Imperata cylindrical L.) dan daun kumis kucing (Orthosiphon aristatus Benth.) merupakan salah satu obat tradisional yang digunakan sebagai diuretik. Flavonoid yang terkandung dalam kedua tanaman inilah yang mempunyai aktivitas biologis sebagai diuretik. Pada penelitian ini, 15 ekor mencit dipisahkan menjadi 5 kelompok yang masing-masing berisi 3 ekor mencit sebagai subjek uji. Kelompok 1 diberikan akuades. Kelompok 2 diberikan larutan furosemide 20 mg/kg BB, rebusan alang-alang dengan konsentrasi 60% : 40% daun kumis kucing diberikan pada kelompok 3, rebusan rimpang alang-alang dengan konsentrasi 50% : 50% daun kumis kucing diberikan pada kelompok 4, dan kelompok 5 diberikan rebusan rimpang alang-alang dengan konsentrasi 40%: 60% daun kumis kucing. Kelompok perlakuan tersebut diteliti selama 4 jam dan dicatat volume urin tiap 30 menit. Hasil penelitian menunjukkan bahwa rebusan rimpang alang-alang daun kumis kucing dari ketiga kelompok konsentrasi memiliki efek diuretik dimana mencit mengeluarkan urin pertama kali pada menit ke-60. Kelompok mencit kontrol positif dan kontrol negatif mengeluarkan urin pertama kali pada menit ke-30. Kata Kunci:         Diuretik, alang-alang, kumis kucing, mencit
Sifat Mekanik dan Morfologi Poliblend Polipropilena dengan Poli(&epsilon;-Kaprolakton) yang Disintesis Menggunakan Katalis Zr &beta;-diketonate sebagai Kandidat Material untuk Pembuatan Benang Jahitan Operasi: Mechanical and Morphology Properties of Polyblelend Polypropylene with Poly(&epsilon;-Caprolactone) that Synthesized using Zr &beta;-Diketonate Catalyst as a Material Candidate for the Manufacture of Surgical Sutures Muhammad Yusuf; Mawaddatur Rahmah
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1865

Abstract

Polypropylene (PP) is a type of synthetic polymer that can be used as a surgical suture material. However, PP has a weakness because it is difficult to degrade. This is because PP has low permeability properties, so its resistance to water is very good. In fact, surgical suture threads should have greater permeability properties so that they can be degraded in a controlled manner. To overcome this, PP needs to be mixed with other polymers in order to obtain polyblends that have controlled degradation properties, such as poly(&epsilon;-caprolactone) (PCL). The PCL used in this study was the product of &epsilon;-CL polymerization using a Zr &beta;-diketonate catalyst. This study aims to determine the mechanical and morphological properties of PP/PCL polyblend. The polymer mixing was carried out using a blending technique and solvent evaporation with 5 ratios (w/w): 10/0, 10/1, 10/2, 10/3, and 10/4. The characterization of the mechanical properties was carried out using a tensile test, and the morphological characterization of the polyblend was carried out using scanning electron microscopy (SEM). The best mix compatibility was obtained at a polyblend PP/PCL ratio of 10/4 with a tensile strength value of 9.394 MPa and an elongation value of 15%. This mixture has the maximum mechanical properties compared to other polyblend compositions. Furthermore, based on SEM analysis, it can be seen that there has been a physical interaction between PP and PCL. In addition, the PP/PCL mixture has been successfully carried out, and the resulting polyblend is biocompatible. Keywords: Polypropylene, poly(&epsilon;-caprolactone), polyblend, mechanical properties, morphological properties Abstrak Polipropilena (PP) merupakan salah satu jenis polimer sintetis yang dapat digunakan sebagai bahan benang jahitan operasi. Namun, PP memiliki kelemahan karena sulit terdegradasi. Hal ini disebabkan karena PP memiliki sifat permeabilitas yang kecil sehingga ketahanannya terhadap air sangat baik. Padahal, benang jahitan operasi harusnya memiliki sifat permeabilitas yang lebih besar sehingga dapat terdegradasi secara terkontrol. Untuk mengatasi hal tersebut, PP perlu dicampur dengan polimer lain agar diperoleh poliblend yang memiliki sifat degradasi terkontrol seperti poli(&epsilon;-kaprolakton) (PCL). PCL yang digunakan pada penelitian ini merupakan hasil polimerisasi &epsilon;-CL menggunakan katalis Zr &beta;-diketonat. Penelitian ini bertujuan untuk mengetahui sifat mekanik dan morfologi poliblend PP/PCL. Pencampuran polimer dilakukan menggunakan teknik blending dan penguapan pelarut dengan 5 perbandingan (b/b): 10/0, 10/1, 10/2, 10/3, dan 10/4. Karakterisasi sifat mekanik dilakukan dengan menggunakan uji tarik dan karakterisasi morfologi poliblend dilakukan dengan menggunakan Scanning Electron Microscopy (SEM). Kompatibilitas campuran terbaik diperoleh pada perbandingan poliblend PP/PCL 10/4 dengan nilai kekuatan tarik sebesar 9,394 MPa dan nilai kemuluran sebesar 15%. Campuran ini memiliki sifat mekanik paling maksium dibandingkan komposisi poliblen lainnya. Selanjutnya, berdasarkan analisis SEM dapat diketahui bahwa telah terjadi interaksi fisik antara PP dengan PCL. Selain itu, campuran PP/PCL telah berhasil dilakukan dan poliblend yang dihasilkan bersifat biokompatibel. Kata Kunci: Polipropilena, poli(&epsilon;-kaprolakton), poliblend, sifat mekanik, sifat morfologi
Difusi Polifenol dari Krim Ekstrak Daun Kelor (Moringa oleifera) dengan Peningkat Penetrasi Dimethyl Sulfoxide (DMSO): Diffusion of Polyphenols from Moringa oleifera (Moringa oleifera) Leaf Extract Cream with Dimethyl Sulfoxide (DMSO) Penetration Enhancer Andi Rezki Khaerun Nissa; Arisanty Arisanty; Nurisyah Nurisyah
Jurnal Sains dan Kesehatan Vol. 5 No. 6 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i6.1867

Abstract

Moringa leaves are one of the plants that contain polyphenolic compounds so that they have the potential to be made cream preparations. In addition, cream preparations should have substances that are efficacious as penetration into the skin. This study was conducted to find out how DMSO as a penetration enhancer affects the penetration and diffusion of polyphenols in Moringa leaf extract cream. The cream is made with 4 formulations, each formula has DMSO concentration variations of 0%, 15%, 20%, and 25%. Diffusion testing by Moringa leaf cream using Franz Diffusion cells and diffusion membranes in the form of cellophane membranes. Based on the results of the study that F2 with a DMSO concentration of 20% showed the highest diffusion of polyphenols, the highest cumulative amount of penetrated polyphenols and the best polyphenol release profile. The results of statistical analysis using One Way ANOVA show that F2 and F3 have significance (p < 0.05) compared to F0 without penetration. Keywords:          Diffusion Polyphenols, Creams, Moringa Leaves, Penetration Enhancers   Abstrak Daun Kelor merupakan salah satu tanaman yang mengandung senyawa polifenol sehingga berpotensi dibuat sediaan krim. Disamping itu, sediaan krim sepatutnya mempunyai zat yang berkhasiat sebagai penetrasi menembus ke dalam kulit. Penelitian ini dilakukan untuk mengetahui bagaimana DMSO sebagai peningkat penetrasi mempengaruhi penetrasi dan difusi polifenol pada krim ekstrak daun kelor. Krim dibuat dengan 4 formulasi yang tiap formulanya memiliki variasi konsentrasi DMSO 0%, 15%, 20%, dan 25%. Pengujian difusi oleh krim daun kelor menggunakan sel Difusi Franz serta membrane difusi berupa membrane selofan. Berdasarkan hasil penelitian bahwa F2 dengan konsentrasi DMSO 20% menunjukkan difusi polifenol tertinggi, jumlah kumulatif polifenol terpenetrasi tertinggi dan profil pelepasan polifenol terbaik. Hasil analisis statistic menggunakan One Way ANOVA menunjukkan bahwa F2 dan F3 memiliki signifikansi (p < 0,05) dibanding F0 tanpa penetrasi. Kata Kunci:         Difusi Polifenol, Krim, Daun Kelor, Peningkat Penetrasi
Public Acceptance of Utilization of Water Reuse in Community-Based Sanitation Infrastructure (Case Study: Bandung City) Fajar Lizmawan; Dyah Wulandari Putri; Sri Maryati
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1869

Abstract

The difficulty of sustainable development is hampered by water scarcity and increased water demands, particularly in urban areas. Domestic wastewater discharges contaminate surface water bodies, such as the Citarum River. These difficulties, which disproportionately affect low-income populations, contribute to health consequences like diarrhoea and stunting. The Reinvented Toilet Project, a community-based sanitation programme, was put into place in Pasirluyu Village, Bandung, to combat water pollution. In order to lower water demand and sewage generation, it includes water reuse, reusing processed wastewater for other applications. This study assesses Pasirluyu Village infrastructure users' attitudes towards social water reuse. Surveys gathered data on demographics, views on water recycling, and information about sanitary facilities. Spearman correlation tests and descriptive analysis were carried out. The outcomes show that infrastructure users have a positive impression of water reuse. However, some people are hesitant to use reclaimed water for activities that require close personal touch. The relationship between public acceptability of water reuse for flushing toilets and acceptance for other purposes raises the possibility of a cascading expansion of water reuse practises. Keywords: community-based infrastructure, households, water reuse, water reuse aceptance
Studi In Silico Potensi Antikanker Leukemia Limfositik Senyawa Alkaloid Indol terhadap Protein BCL-2: Study of In Silico Anticancer Action Potentials of Lymphocytic Leukemia Indole Alkaloid Compounds Against on BCL-2 Protein Bulan Rosita Sari; Winni Nur Auli; Vita Julia Saputri; Okta Dinata Saputri; Alika Putriyana Boru Tumanggor; Dhea Anggun Ferlinda; Fira Anggraini; Fatonah Fatonah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1880

Abstract

BCL-2 is an anti-apoptotic protein that can inhibit cell death, prolong cell survival time, and turn cells into malignant ones, which is one of the pathways targeted in the development of leukemia therapy by binding and inactivating the BH3 domain pro-apoptotic protein. Indole alkaloids have pharmacological activities and contribute to the development of new drug leads. This study aims to analyze the potential of insilico alkaloids against Bcl-2 in silico. The docking process initiated from preparing the ligand taken from the Pubchem website. The three-dimensional macromolecular structure of the protein used was BCL-2 retrieved from the RCSB Protein Data Bank (www.rcsb.org) with PDB ID number 6O0K. The validation and docking process was carried out using the AutodockTools software program from MGLTools 1.5.6. Chemical bond interaction analysis was carried out using BIOVIA Discovery Studio 2021 Client. The binding energy results from validating the native ligand venetoclax as existing drug is -14.46 kcal/mol. The results obtained from the three ligands, namely aspidodasycarpine, tetrahydroalstonine, and kopsamine have binding energies of -6.76, -7.92, -7.57 kcal/mol respectively. When compared with tetrahydroalstonine which has the smallest value among the three other ligands, it can be concluded that venetoclax is still smaller so that it becomes more potent than tetrahydroalstonine. Keywords:          Indole alkaloids, Cancer, Bcl-2, Docking   Abstrak BCL-2 adalah protein anti-apoptosis yang dapat menghambat kematian sel, memperpanjang waktu hidup sel, dan mengubah sel menjadi ganas, yang merupakan salah satu jalur yang ditargetkan dalam perkembangan terapi penyakit leukemia dengan mengikat serta menonaktifkan protein pro-apoptosis domain BH3. Alkaloid indol memiliki aktivitas farmakologi dan berkontribusi untuk pengembangan lead obat baru, dimana salah satu senyawa yang paling aktif memiliki berbagai aktivitas farmakologi, yaitu antikanker. Penelitian ini bertujuan untuk menganalisis potensi alkaloid indol terhadap Bcl-2 in silico. Proses docking dimulai dari penyiapan ligan yang diambil dari situs web Pubchem. Struktur makromolekul tiga dimensi protein yang digunakan dalam studi docking ini adalah BCL-2 yang diunduh dari RCSB Protein Data Bank (www.rcsb.org) dengan nomor ID PDB 6O0K. Proses validasi dan docking dilakukan menggunakan perangkat lunak program AutodockTools dari MGLTools 1.5.6. Analisis interaksi ikatan kimia dilakukan menggunakan BIOVIA Discovery Studio 2021 Client. Hasil energi ikatan dari validasi ligan bawaan venetoclax sebagai obat yang telah dikembangkan yaitu -14.46 kkal/mol. Diperoleh hasil dari analisis data energi ikatan dari tiga ligan, yaitu aspidodasycarpine, tetrahydroalstonine, dan kopsamine berurutan sebesar -6,76, -7,92, -7,57 kkal/mol. Apabila dibandingkan dengan tetrahydroalstonine yang memiliki nilai paling kecil diantara ketiga ligan lain maka dapat disimpulkan bahwa venetoclax masih lebih kecil sehingga menjadi lebih poten dibandingkan dengan tetrahydroalstonine. Kata Kunci:         Alkaloid indol, Kanker, BCL-2, Docking
The Role of Cathelicidin in Dermatology Skin Apriani, Diana Kurnia; Dwiyana, Reiva Farah; Chaerunisaa, Anis Yohana
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.1883

Abstract

Acne, Atopic Dermatitis, Psoriasis and Rosacea are examples of chronic inflammatory skin conditions. One characteristic of many skin disorders is the dysregulation of innate immunity in the skin. Acne, Atopic Dermatitis, Psoriasis, and Rosacea all have problems with the expression, function, or processing of the key innate immune effector molecule in the skin, cathelicidin LL-37. Cathelicidin induction can be altered to treat Acne and Atopic Dermatitis, which lessens the efficiency of the antimicrobial barrier. However, cathelicidin is overexpressed in Psoriasis and Rosacea. The most recent research on cathelicidin LL-37’s involvement in the etiology of inflammatory skin disorders will be included in this review. Since cathelicidin LL-37 may one day be employed as a therapeutic target, many cutting-edge therapy methods for the disease will be discussed. Keywords:          Antimicrobial Peptide, Cathelicidin, Dermatology Skin

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