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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : 10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan menerima naskah karya asli (Artikel Penelitian, Artikel Review, dan Studi Kasus), baik eksperimental maupun teoretis, dalam bidang-bidang berikut: Sains dan Kesehatan (Kedokteran, Farmasi, Kesehatan Masyarakat, Keperawatan, Kebidanan, Gizi, dan lain-lain). Tujuan penerbitan Jurnal Sains dan Kesehatan adalah untuk menyediakan informasi ilmiah tentang perkembangan ilmu dan teknologi di bidang Ilmu Pengetahuan dan Kesehatan.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 764 Documents
 48   49   50   51   52 
Front Cover, Editorial Information, Table of Content, Author Guideline, Back Cover Journal Editor
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1753

Abstract

Ketepatan Obat, Dosis, dan Potensi Interaksi Obat pada Pasien Kanker Paru di Rumah Sakit X Jawa Barat Periode 2019-2021: Appropriate Use of Medicines, Doses, and Potential Drug Interactions in Lung Cancer Patients at X Hospital West Java for the 2019-2021 Period Numlil Khaira Rusdi; Evi Novita Sari; Nora Wulandari
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1754

Abstract

Lung cancer is the most common disease found in the world and is one of the biggest causes of mortality in cancer. Lung cancer is the main cause of death from cancer in the male population and also has a fairly high percentage of new cases in the female population. This study aims to analyze the accuracy of chemotherapy regimens and the potential for drug interactions in lung cancer patients at X Hospital West Java for the 2019-2021 period. This study used a descriptive method with a retrospective data collection technique from medical records of lung cancer patients at Hospital X West Java for the 2019-2021 period. The toolkit were NCCN (National Comprehensive Cancer Network) 2021, National Formulary 2019, and Drugs Interaction Checker (www.drugs.com). Based on the drug regimen used, 94 patients (89.52%) got the right medication, and 71 patients (67.62%) got the right dose. The regimen was inappropriate, namely carboplatin-etoposide in 6 patients (54.50%), cisplatin-doxorubicin in 1 patient (9.10%), carboplatin-vinorelbine in 1 patient (9.10%). There were 482 cases of potential drug interactions. Drug interactions occurred at a major significance level was 34 cases (7.05%), a moderate significance level was 425 cases (88.17%) and a minor significance level was 23 cases (4.78%). Keywords: Lung Cancer, medicine, dose, Drug interactions Abstrak Kanker paru merupakan salah satu penyebab kematian terbesar di dunia. Di Indonesia, Kanker paru merupakan jenis kanker dengan kasus baru tertinggi dan penyebab utama kematian pada penduduk laki-laki dan perempuan. Penelitian ini bertujuan untuk menganalisis ketepatan regimen kemoterapi serta potensi interaksi obat pada pasien kanker paru di Rumah Sakit X Jawa Barat periode 2019-2021. Penelitian ini menggunakan metode deskriptif. Pengumpulan data dilakukan secara retrospektif dari data rekam medik pasien kanker paru di Rumah Sakit X Jawa Barat periode 2019-2021. Toolkit yang digunakan NCCN (National Comprehensive Cancer Network) 2021, Formularium Nasional (Fornas) 2019, dan Drugs Interaction Checker yaitu www.drugs.com. Berdasarkan regimen obat yang digunakan terdapat 94 pasien (89,52%) tepat obat, dan 71 pasien (67,62%) tepat dosis. Hasil penelitian menunjukan regimen yang tidak tepat yaitu carboplatin-etoposid 6 pasien (54,50%), cisplatin-doxorubicin 1 pasien (9,10%), carboplatin-vinorelbin 1 pasien (9,10%). Dari total keseluruhan pasien terdapat potensi interaksi obat sebanyak 482 kasus. Interaksi obat yang terjadi pada tingkat signifikansi mayor sebanyak 34 kasus (7,05%), tingkat signifikansi moderat sebanyak 425 kasus (88,17%) dan tingkat signifikansi minor 23 kasus (4,78%). Kata Kunci: Kanker Paru, Obat, dosis, Interaksi obat
The Problematic of Medicinal Plant: Negative effect of Catha Edulis (Khat) Abuse and Its Potential Benefits Muflihah Rizkawati; Ulfatun Nisa; Widhi Astana; Leonny Dwi Rizkita
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1756

Abstract

Catha edulis (khat), belongs to a group of psychotropic plants, which has an amphetamine-like structure and contains many catin and cation. The plant contains hallucinogenic compounds and known for its calming effect. The excessive catin contained inside the fresh leave of khat could potentially induce a plenty of side effects especially when the leaves are directly consumed and uncooked. The side effects vary according to how long the plant has been consumed, started from local organ disruption to cardiovascular complication such as increased blood pressure to myocardial infarction. In the contrary, positive effects of the composition of khat have also been reported such as anti-inflammatory effect, antidiabetic, anticancer, immunomodulatory and increased improvement in respiratory diseases. Although myriad studies have been conducted to examine the best benefit obtained from the such plant, the legal issue on its utilization is still questionable. Therefore, khat consumption must be maintained with a proper and strong regulation to lessen the negative impacts. However, studies on the potency of khat are still ongoing. The literature review was written based on various books, journals, and search databases in Pubmed, Medline, Cochrane and Google Scholar to show the positive and negative effects of the habit in consuming khat.
Pengaruh Motivasi terhadap Kinerja Perawat di Rumah Sakit: The Effect of Motivation on Nurse Performance in the Hospital Azzilla Nur Layli; Chriswardani Suryawati; Wulan Kusumastuti
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1758

Abstract

Content Nurses are one of the professions that have the most human resources in hospitals which is 50% and has an important role in the provision of health services. A work boost is needed in hopes of improving and delivering optimal performance. Providing work motivation is a way to improve performance in nurses and encourage to carry out activities in order to achieve their goals and to meet their needs. Without motivation, the task carried out will not be carried out according to the standards because what has become his motive and motivation in working is not fulfilled. From 10 motivational variables, found 9 variables that can affect the performance of nurses in the hospital include achievement, self-employment, responsibility, development of individual potential, policy and administration, incentives/salaries, working relationships, working conditions, and quality of supervision. Incentive/salary variables are more dominant to influence motivation towards hospital nurse performance. Keywords: Motivation, Job Performance, Nurse   Abstrak Perawat adalah salah satu profesi yang memiliki sumber daya manusia paling  besar di rumah sakit yaitu sebesar 50% dan memiliki peranan penting dalam pemberian pelayanan kesehatan. Dorongan kerja sangat diperlukan dengan harapan dapat meningkatkan dan mewujudkan kinerja yang optimal. Memberikan motivasi kerja merupakan cara untuk meningkatkan kinerja pada perawat serta mendorong untuk melaksanakan kegiatan agar mencapai tujuan serta dapat memenuhih kebutuhannya. Tanpa motivasi, tugas yang dilaksanakan tidak akan dijalani sesuai standar sebab apa yang telah menjadi motif dan motivasinya dalam bekerja tidak terpenuhi. Dari 10 variabel motivasi, ditemukan bahwa 9 variabel mempengaruhi kinerja perawat di rumah sakit diantaranya adalah prestasi, pekerjaan itu sediri, tanggung jawab, pengembangan potensi individu, kebijakan dan administrasi, insentif/gaji, hubungan kerja, kondisi kerja, dan kualitas supervisi. Variabel insentif/gaji lebih dominan untuk mempengaruhi motivasi terhadap kinerja perawat. Kata Kunci: Motivasi, Kinerja, Perawat
The Impact of Covid-19 Pandemic on the Livestock Subsector Hamdi Mayulu; Endang Sawitri; Irsan Tricahyadinata
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1760

Abstract

The Covid-19 pandemic had an impact on human activities and all sectors globally. This study aims to review the impact of the pandemic on livestock products. Furthermore, data were collected from several literature, websites, national, and international news, relevant to current policies and conditions. The impact on the livestock sub-sector is not measured and includes a decrease in purchasing power and demand for livestock products such as meat, milk, and eggs, decreased profitability, hampered distribution of production inputs such as feed and medicine affect the increasing production costs, veterinary services limitation, hinder the livestock animal and product distribution, disruption on marketing and business downturn. Meanwhile, the positive impact is that farmers created an online-based digital innovation, known as e-commerce, involving product marketing, business, and product diversification. The Government also plays a vital role in demand and price stabilization, which ensures the supply chain sustainability of the products. Therefore, the livestock business can keep running sustainably, especially during the pandemic.
Aktivitas Antioksidan serta Uji Flavonoid Total Ekstrak Etanol dan Fraksi Etil Asetat Batang Saluang Belum (Luvunga sarmentosa (Blume) Kurz.): Antioxidant Activity and Total Flavonoid Content of Ethanol Extracts and Ethil Acetate Fractions of Saluang Belum Stem (Luvunga sarmentosa (Blume) Kurz.) Muliani, Putri Sari; Hadi, Samsul; Wathan, Nashrul
Jurnal Sains dan Kesehatan Vol. 6 No. 3 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i3.1761

Abstract

Saluang belum plant (L. sarmentosa (Blume) Kurz.) is a plant comes from Kalimantan. This plant L. sarmentosa is known to contain flavonoid compounds that have potential antioxidant activity. This study aimed to determine the total flavonoid content and antioxidant activity of the ethanol extract and the ethyl acetate fraction of stem saluang belum L. sarmentosa. Determination of total flavonoid content was determined using colorimetric method with standard quarcetin,10% AlCl3, 5% acetic acid. The antioxidant activity test was carried out using the DPPH method based on the IC50 value. The results showed that the total flavonoid content of saluang belum stems L. sarmentosa for ethanol extract was 3,249 ± 0.002 % w/w equivalent to quarcetin and for the ethyl acetate fraction of saluang belum stems L. sarmentosa namely 2,518 ± 0.0025% w/w quarcetine equivalent. The results of the antioxidant activity test of the ethanol extract and the ethyl acetate fraction of stem saluang belum L. sarmentosa have IC50 values ??of 80.80 ± 1.1313 and 81.73 ± 0.4917 ppm. Based on the IC50 value, the ethanol extract and the ethyl acetate fraction of stem saluang belum L. sarmentosa indicate that they have antioxidant activity which is included in the strong category. Keywords:          Luvunga sarmentosa (Blume.) Kurz, Extract, Fractions, Total Flavonoids, Antioxidant   Abstrak Tumbuhan saluang belum (L. sarmentosa (Blume) Kurz.) berasal dari Kalimantan. Tumbuhan ini diketahui mengandung senyawa flavonoid yang berpotensi memilki aktivitas antioksidan. Penelitian ini bertujuan untuk menetapkan kadar flavonoid total ekstrak etanol dan fraksi etil asetat batang saluang belum L. sarmentosa menggunakan metode spektrofotometri UV-Vis dan menentukan aktivitas antioksidan ekstrak etanol 96% dan fraksi etil asetat batang saluang belum L. sarmentosa yang dilihat berdasarkan nilai Inhibitor Concentration 50 (IC50). Penetapan kadar flavonoid total ditentukan menggunakan metode kolorimetri dengan standar kuarsetin dan reagen AlCl3 10% dan asam asetat 5%. Uji aktivitas antioksidan dilakukan dengan metode DPPH berdasarkan nilai IC50. Hasil penelitian menunjukkan kadar flavonoid total batang saluang belum L. sarmentosa untuk ekstrak etanol 96% yaitu 3,249 ± 0,002 % b/b ekivalen kuarsetin dan untuk fraksi etil asetat batang saluang belum L. sarmentosa yaitu 2,518 ± 0,0025 % b/b ekivalen kuarsetin. Hasil uji aktivitas antioksidan  ekstrak etanol 96% dan fraksi etil asetat batang saluang belum L. sarmentosa  mempunyai nilai IC50 berturut-turut yaitu 80,80 ± 1,1313 dan 81,73 ± 0,4917 ppm. Berdasarkan nilai IC50 yang didapat ekstrak etanol 96% dan fraksi etil asetat batang saluang belum L. sarmentosa menunjukkan bahwa memilki aktivitas antioksidan yang termasuk ke dalam kategori aktif. Kata Kunci:         Saluang belum (Luvunga sarmentosa (Blume) Kurz.), Ekstrak, Fraksi, Flavonoid Total, Antioksidan
Formulasi Sediaan Semisolid Kosmetika Dekoratif Bibir dengan Ekstrak Daun Miana (Plectranthus scutellarioides) sebagai Pewarna Alami Menggunakan Basis Salep Emulsi: Semi Solid Formulation Lips Decorative Cosmetics with Miana Leaf Extract (Plectranthus scutellarioides) as Natural Dye Using the Emulsion Ointment Base Mappapa, Fritlyanti; Rahim, Abdul; Ardana, Mirhansyah; Rusli, Rolan
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.1765

Abstract

Miana leaves (Plectranthus scutellarioides) are one of the plants that have high levels of anthocyanin pigments, so miana leaves have the potential to be used as a natural dye. Lip color is a cosmetic preparation that is used to color the lips with an artistic touch so that it can improve the aesthetics of facial make-up. This research aims to determine the formula for lip color preparations based on emulsion ointment in various concentrations and to determine the physical characteristics of miana leaf extract lip color preparations. This research method was carried out using an extraction process, making lip color preparations using an emulsion ointment base with concentrations of (F1) 5%, (F2) 10%, and (F3) 15%. Apart from that, physical testing of the preparation (organoleptic test, homogeneity, pH, viscosity, spreadability and stickiness), physical stability test of the preparation (freezethaw method) for 24 days, and testing of the acceptability of the preparation (hedonic test method). The results of miana leaf extract lip color preparations produce successive colors of pink, red and dark red. The physical characteristics are that the three preparations produce a semi-solid consistency, have a distinctive rose aroma, are homogeneous, and show pH, viscosity, spreadability and stickiness that meet the range of values ??required pharmaceutically. Apart from that, stability has been met. The acceptability test results showed that the preparation was acceptable for panelists aged 17-23 years.   Keywords:          Miana leaves (Plectranthus scutellarioides), lip coloring, natural dyes   Abstrak Daun miana (Plectranthus scutellarioides) merupakan salah satu tanaman yang memiliki kadar pigmen antosianin yang tinggi sehingga daun miana dapat berpotensi sebagai bahan pewarna alami. Pewarna bibir merupakan sediaan kosmetika yang digunakan untuk mewarnai bibir dengan sentuhan artistic sehingga dapat meningkatkan estetika dalam tata rias wajah. Penelitian ini bertujuan untuk mengetahui formula sediaan pewarna bibir dengan basis salep emulsi dalam berbagai konsentrasi serta mengetahui karakteristik fisik sediaan pewarna bibir ekstrak daun miana. Metode penelitian ini dilakukan dengan proses ekstraksi, pembuatan sediaan pewarna bibir menggunakan basis salep emulsi dengan konsentrasi (F1) 5%, (F2) 10%, dan (F3) 15%. Selain itu, pengujian fisik sediaan (uji organoleptik, homogenitas, pH, viskositas, daya sebar, dan daya lekat), uji stabilitas fisik sediaan (metode freezethaw) selama 24 hari, dan pengujian aseptabilitas sediaan (metode uji hedonik). Hasil sediaan pewarna bibir ekstrak daun miana menghasilkan warna berturut-turut merah muda, merah, dan merah tua. Karakteristik fisik yaitu ketiga sediaan menghasilkan konsistensi semipadat, beraroma khas mawar, homogen, serta menunjukkan pH, viskositas, daya sebar, dan daya lekat yang memenuhi rentang nilai yang dipersyaratkan secara farmasetika. Selain itu, kestabilan telah memenuhi. Hasil uji aseptabilitas menunjukkan sediaan dapat diterima oleh panelis usia 17-23 tahun.   Kata Kunci:         Daun miana (Plectranthus scutellarioides), pewarna bibir, pewarna alami
Distribusi Kasus Celah Bibir dan Langit-Langit Berdasarkan Jenis Kelamin dan Lokasi Celah di Provinsi Kalimantan Timur Tahun 2020-2022: Distribution of Cleft Lip and Palate Based on Gender and Cleft Location in East Kalimantan Province in 2020-2022 Shadrina, Nida Midati; Samad, Syahril; Listiyawati, Listiyawati; Pramasari, Cristiani Nadya; Danial, Danial
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.1777

Abstract

Cleft lip and cleft palate are the most common congenital malformations of the head and neck and may be associated with other congenital anomalies. The etiology of cleft lip and/or palate has been studied extensively that this anomaly is multifactorial. Risk factors for clefts include gender, genetic factors, and family history. The clinical presentation of cleft palate varies and can be classified as isolated cleft palate or cleft lip with or without a cleft palate. The disorder may involve the lips, hard palate and/or soft palate, either completely or incompletely, and unilaterally or bilaterally. The purpose of this study is to describe the distribution of cases of cleft lip and/or cleft palate based on gender and cleft location in East Kalimantan Province in 2020-2022. This type of research is a descriptive study with total sampling technique. Data were obtained from patient registration forms based on predetermined inclusion criteria. The results showed that of the 77 samples, cases of clefts were more common in males, namely 52 people (67.53%) and females, namely 25 people (32.47%). The most frequent cleft location on the left unilateral were 36 people (46.75%) compared to the right unilateral of 19 people (24.68%), or bilateral as many as 22 people (28.57%). Based on the results of this study, the distribution of cases of cleft lip and/or cleft palate mostly occurs in males, with the location of the cleft more common in the left unilateral. Keywords:          Cleft Lip and Palate, Gender, Cleft Location   Abstrak Celah bibir serta langit-langit ialah malformasi kongenital kepala dan leher yang paling umum dan mungkin berhubungan dengan anomali kongenital lainnya. Etiologi celah bibir dan/atau langit-langit telah dipelajari secara ekstensif bahwa anomali ini bersifat multifaktorial. Faktor risiko terjadinya celah yaitu seperti, jenis kelamin, faktor genetik, dan riwayat keluarga. Presentasi klinis celah mulut bervariasi dan dapat diklasifikasikan sebagai celah langit-langit terisolasi atau celah bibir dengan ataupun tanpa celah langit-langit. Kelainan tersebut dapat melibatkan bibir, langit-langit keras dan/atau langit-langit lunak, baik secara lengkap atau tidak lengkap, serta unilateral atau bilateral. Tujuan penelitian ini adalah menggambarkan distribusi kasus celah bibir dan/atau celah langit-langit menurut jenis kelamin serta lokasi celah di Provinsi Kalimantan Timur pada tahun 2020-2022. Jenis penelitian ini ialah penelitian deskriptif dengan teknik total sampling. Hasil penelitian memperlihatkan bahwa dari 77 sampel, kasus celah lebih kerap dialami laki-laki yakni 52 orang (67,53%) dan perempuan yakni 25 orang (32,47%). Lokasi celah paling sering terjadi pada unilateral kiri berjumlah 36 orang (46,75%) dibandingkan dengan unilateral kanan sebanyak 19 orang (24,68%), ataupun bilateral sebanyak 22 orang (28,57%). Berdasarkan hasil penelitian ini, distribusi kasus celah bibir dan/atau celah langit-langit sebagian besar terjadi pada laki-laki, dengan lokasi celah lebih sering terjadi pada unilateral kiri. Kata Kunci:         Celah Bibir dan Langit-Langit, Jenis Kelamin, Lokasi Celah
Perbandingan Aktivitas Antioksidan Infusa Simplisia Segar dan Simplisia Kering Daun Buni (Antidesma bunius L. Spreng) dengan Metode DPPH: Comparison of Antioxidant Activity of Infused from Fresh Simplicia and Dried Simplicia of Buni Leaves (Antidesma bunius L. Spreng) with DPPH Method Indah Permata Sari; Agriana Rosmalina Hidayati; Handa Muliasari
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1792

Abstract

Antidesma bunius L. Spreng is one of the plants that can use for antioxidants. The antioxidant activity of buni leaves caused by the presence of flavonoid compounds that potentially scavenge free radicals. This study aimed to identify the flavonoid compounds in buni leaves and compare the antioxidant activity between infusions of dried and fresh simplicia of buni leaves. This research procedure includes the collection of materials, determination of plants, made simplicia and infusions, identification of flavonoid compounds, and quantitative antioxidant activity test using the DPPH free radical method (1,1-diphenyl-2-picrylhydrazyl). The result obtained in the IC50 values from the linear regression equation between % inhibition and the concentration of the test solution. The IC50 values have been analyzed by a non-parametric statistical test with a 95% confidence level. The result of flavonoid identification showed the infusion contains flavonoid. The IC50 values of infusion from dried and fresh simplicia of buni leaves were 197,344±0,819 ppm and 303,646±3,731 ppm. Dried simplicia on antioxidant classification have weak antioxidant activity, while fresh simplicia have very weak antioxidant activity. The infusion from fresh and dried simplicia of buni leaves has significantly different antioxidant activity (p?0,05). Dried simplicia is more recommended for making infusions for an antioxidant. Keywords: Antidesma bunius, antioxidants, infusion   Abstrak Daun buni atau Antidesma bunius L. Spreng merupakan salah satu tanaman yang dapat dimanfaatkan sebagai sumber antioksidan. Tujuan penelitian ini adalah untuk mengidentifikasi kandungan senyawa flavonoid daun buni dan mengetahui perbandingan aktivitas antioksidan sediaan infusa simplisia kering dan simplisia segar daun buni. Prosedur penelitian ini meliputi pengumpulan bahan, determinasi tanaman, pembuatan simplisia, pembuatan infusa, identifikasi senyawa flavonoid, serta uji aktivitas antioksidan secara kuantitatif dengan metode radikal bebas DPPH (1,1-diphenyl-2-picrylhydrazyl). Data yang didapatkan berupa nilai IC50 yang diperoleh dari persamaan regresi linier antara % inhibisi terhadap konsentrasi larutan uji. Nilai IC50 dianalisis dengan uji statistik non parametric dengan taraf kepercayaan 95%. Hasil identifikasi senyawa flavonoid menunjukkan infusa daun buni positif mengandung senyawa flavonoid. Nilai IC50 infusa simplisia segar dan infusa simplisia kering daun buni berturut-turut 303,646±3,731 ppm dan 197,344±0,819 ppm. Infusa simplisia segar memiliki aktivitas antioksidan sangat lemah, sedangkan infusa simplisia kering memiliki aktivitas antioksidan lemah. Infusa simplisia segar dan infusa simplisia kering daun buni memiliki aktivitas antioksidan yang berbeda signifikan (p?0,05). Berdasarkan data yang diperoleh simplisia kering daun buni lebih direkomendasikan dalam pembuatan infusa sebagai antioksidan dibandingkan simplisia segar. Kata Kunci: Daun buni, antioksidan, infusa
Efek Konsumsi Kopi terhadap Kadar MDA (Malondialdehid) Tikus Terpapar Asap Rokok: Effect of Coffee Consumption on the Levels of MDA (Malondialdehyde) in Rats Exposed to Cigarette Smoke Lizma Febrina; Aryanti Aryanti; Rolan Rusli; Laode Rijai
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1797

Abstract

Coffee is the most commonly consumed beverage beside water. In addition to its benefits as a beverage that reduces drowsiness, coffee reportedly possesses a variety of biological activities, including antioxidant activity, antibacterial activity, and antidiabetic activity. To the best of our knowledge, no scientific studies have been published on the ability of coffee to reduce the increase in MDA levels in experimental animals exposed to cigarette smoke. The purpose of this research was to determine the possibility that coffee can indeed reduce MDA levels in animals exposed to cigarette smoke. The coffee used in this study was instant robusta coffee, which had the highest DPPH radical scavenging activity. MDA levels were determined using the TBARS method. Results indicated that coffee could decrease MDA levels by 11.84 percent. This data indicates that coffee can mitigate the negative effects of cigarette smoke exposure. Keywords: Robusta Coffee, Malondialdehyde, Cigarette Smoke Abstrak Kopi merupakan minuman yang paling banyak dikonsumsi setelah air putih. Selain manfaatnya sebagai minuman yang mengurangi rasa kantuk, kopi juga dilaporkan memiliki berbagai aktivitas biologis, seperti aktivitas antioksidan, aktivitas antibakteri serta aktivitas antidiabetes. Namun, sepanjang pengetahuan kami, belum ada laporan ilmiah mengenai kemampuan kopi dalam meredam peningkatan kadar MDA hewan coba yang dipaparkan asap rokok. Tujuan penelitian ini adalah untuk mengetahui kemampuan seduhan kopi dalam mengurangi kadar MDA hewan coba yang dipaparkan asap rokok. Kopi yang digunakan pada penelitian ini adalah kopi instan jenis kopi robusta yang memiliki aktivitas peredaman radikal DPPH yang paling baik. Kadar MDA diukur menggunakan metode TBARS. Didapatkan hasil bahwa seduhan kopi dapat menurunkan kadar MDA sebesar 11,84%. Data ini mengungkapkan kemampuan kopi dalam mengurangi efek negatif dari paparan asap rokok. Kata Kunci: Kopi Robusta, Malondialdehida, Asap Rokok

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