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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : 10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan menerima naskah karya asli (Artikel Penelitian, Artikel Review, dan Studi Kasus), baik eksperimental maupun teoretis, dalam bidang-bidang berikut: Sains dan Kesehatan (Kedokteran, Farmasi, Kesehatan Masyarakat, Keperawatan, Kebidanan, Gizi, dan lain-lain). Tujuan penerbitan Jurnal Sains dan Kesehatan adalah untuk menyediakan informasi ilmiah tentang perkembangan ilmu dan teknologi di bidang Ilmu Pengetahuan dan Kesehatan.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 750 Documents
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Formulasi Serbuk Effervescent Limbah Tulang Ikan Bandeng (Chanos chanos) sebagai Supplement Kalsium Tulang: Formulation Effervescent Powder form of Milk Fish (Chanos chanos) Bone Waste as a Calcium Supplement Hilmiati Wahid; Andi Juaela Yustisi; Prayitno Prayitno; Aninditya Dwi Lestari Amir
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1955

Abstract

Milkfish fish bone (Chanos chanos) is a fish with a high calcium consumption of 23.99%. This high level of calcium means that the waste of milkfish bones can be used as a bone supplement in the form of effervescent powder. to meet the intake of calcium supplements in maintaining health. This study aims to determine the physical and chemical stability of the effervescent powder from milkfish bone waste. The research method was calcium from milkfish bone meal analyzed using an Atomic Absorption Spectrophotometer and made in the form of effervescent powder with concentrations of 800 mg, 900 mg and 1000 mg. Examination of the preparations included organoleptic tests, pH tests, water content tests, flow rate tests, hedonic tests. The results for the organoleptic test did not change. The results of the solubility test, flow rate, pH test, water content test experienced an increase in value before and after the cycling test. The results of the F2 hedonic test favored the shape and color. It can be concluded that the calcium concentration of fish bone powder is 243121 mg/kg. Milkfish bone powder can be formulated in the form of effervescent powder as a bone calcium supplement that is physically and chemically stable Kata Kunci:         Waste of Milkfish Bones, Effervescent Powder, Calcium   Abstrak Tulang ikan Bandeng (Chanos chanos) adalah ikan konsumsi berkalsium tinggi sebesar 23,99%. Tingginya kadar kalsium ini sehingga limbah tulang ikan bandeng dapat dimanfaatkan menjadi suplemen tulang dalam bentuk serbuk effervescent. untuk memenuhi asupan supplement kalsium dalam menjaga kesehatan. Penelitian ini bertujuan untuk mengetahui sediaan serbuk effervesent limbah tulang ikan bandeng yang stabil secara fisika dan kimia. Metode penelitian yaitu kalsium tepung tulang ikan bandeng dianalisis menggunakan Spektrofotometer Serapan Atom dan dibuat dalam bentuk sediaan serbuk effervescent dengan konsentrasi 800 mg, 900 mg dan 1000 mg. Pemeriksaan terhadap sediaan meliputi uji organoleptik, uji pH, uji kadar air, uji kecepatan alir, uji hedonik. Hasil penelitian untuk uji organoleptik tidak mengalami perubahan. Hasil uji waktu larut, kecepatan alir, uji pH, Uji Kadar air mengalami peningkatan nilai sebelum dan sesudah cycling test. Hasil uji hedonik F2 disukai dari bentuk dan warna. Dapat disimpulkan konsentrasi kalsium serbuk tulang ikan sebesar 243121 mg/kg. Serbuk tulang ikan bandeng dapat diformulasikan dalam bentuk sediaan serbuk effervescent sebagai supplement kalsium tulang yang stabil secara fisika dan kimia. Kata Kunci:         Limbah Tulang Ikan Bandeng, Serbuk Effervescent, Kalsium
Korelasi Kadar Fenol dan Flavonoid terhadap Indeks Aktivitas Antioksidan Ekstrak Batang Vernonia amygdalina: Correlation of Phenol and Flavonoid Content with Antioxidant Activity Index of Vernonia amygdalina Stem Extracts Mardhatillah Awwaliah; Mukhriani Mukhriani; Nur Asma; Muhammad Ikhlas Arsul
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1959

Abstract

Bitter leaf (in Africa) is the most widely cultivated species of the genus Vernonia which is the most prominent in the family Asteraceae that has been studied in Africa. African leaves have been widely used for traditional medicine and/or treating various human diseases. This study aimed to determine the bioactive compounds that correlate to the antioxidant activity of V. amygdalina stem. Extraction of V. amygdalina stem was carried out by reflux method. Determination of total phenol and flavonoid content was done spectroscopically. Antioxidant activity was measured based on antioxidant activity index (AAI) using DPPH and CUPRAC methods. Correlation coefficient between bioactive compounds and antioxidant activity using Pearson's correlation method. The results showed the antioxidant activity index of V. amygdalina stem showed strong to very strong activity. The ethyl acetate extract showed the highest total phenol and flavonoid levels. The phenol and flavonoid content of V. amygdalina stem extract showed a strong and significant correlation to the antioxidant activity index with a positive r value Kata Kunci:         AAI, DPPH, CUPRAC, pearson’s correlation   Abstrak Daun afrika merupakan spesies yang paling banyak dibudidayakan dari genus Vernonia yang paling menonjol dalam famili Asteraceae yang telah dipelajari di Afrika. Daun afrika telah banyak digunakan untuk pengobatan tradisional dan/atau mengobati berbagai penyakit pada manusia. Tujuan dari penelitian ini adalah untuk mengetahui senyawa bioaktif yang berkorelasi terhadap aktivitas antioksidan dari batang V. amygdalina. Ekstraksi batang V. amygdalina dilakukan dengan metode refluks. Penentuan kadar  fenol dan flavonoid total dilakukan secara spektroskopi. Aktivitas antioksidan diukur berdasarkan indeks aktivitas antioksidan (AAI) dengan metode DPPH dan CUPRAC. Koefisien korelasi antara senyawa bioaktif dan aktivitas antioksidan menggunakan metode korelasi pearson’s. Hasil penelitian menunjukkan indeks aktivitas antioksidan batang V. amygdalina menunjukkan aktivitas yang kuat hingga sangat kuat. Kadar fenol dan flavonoid total tertinggi ditunjukkan pada ekstrak etil asetat. Kadar fenol dan flavonoid ekstrak batang V. amygdalina menunjukkan korelasi kuat dan signifikan terhadap indeks aktivitas antioksidan dengan nilai r positif. Kata Kunci:         AAI, DPPH, CUPRAC, korelasi pearson’s
Aktivitas Obat Golongan SGLT-2i dan GLP-1RA serta SGLT-2i dan DPP-4i dengan atau tanpa Metfomin pada Tikus Diabetes tipe 2 dengan Model Kerusakan Sel Beta Pankreas dan Resistensi Insulin: Comparing Drug Classes SGLT-2i and GLP-1 as well as SGLT-2i and DPP-4i with or without Metfomin in Type 2 Diabetic Rats with Pancreatic Beta Cell Damage and Insulin Resistance Neng Fisheri Kurniati; Desi Sukaeningsih; Zahra Hasna Fadhilah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1964

Abstract

Type 2 DM occurs in approximately 90-95% of total DM cases, antihyperglycemic agents such as GLP-1RA, SGLT2i, DPP-4i, and metformin have been shown to have glycemic control benefits of the four groups which have been confirmed as single administration. in type 2 DM patients, but not yet. neither explains which drug combination has the strongest effect on lowering blood glucose levels. In this study, the effect of both with and without metformin on the blood glucose profile was examined. Animals were induced with lipomed 20% MCT/LCT 20 ml/kg BW for 14 days then continued with a double dose of 35 mg/kg BW streptozotocin. Animals were treated according to the group, negative control and positive control were given 0.5% Na-CMC, empagliflozin (1 mg/kg BW), liraglutide (0.062 mg/kg BW); linagliptin (0.5 mg/kgBW); metformin (87.8 mg/kgBW); combination 1 (0.062 mg/kgBW liraglutide and 1 mg/kgBW empagliflozin); combination 2 (0.5 mg/kgBW linagliptin and 1 mg/kgBW empagliflozin); combination 3 (liraglutide 0.062 mg/kg, empagliflozin 1 mg/kg and metformin 87.8 mg/kg); combination 4 (linagliptin 0.5 mg/kg, empagliflozin 1 mg/kg and metformin 87.8 mg/kg for 30 days. The blood glucose control profile was determined by measuring GDP, administering SGLT-2i, GLP-1RA, DPP-4i, and metformin either alone or in combination can reduce the value of GDP every week. The value of GDP in the SGLT-2i (Empagliflozin) and combination group 1 (Empagliflozin + Liraglutide) can reduce GDP significantly. In improving insulin sensitivity all groups except metformin can significantly increase KITT values. Keywords: Diabetic, empagliflozin, liraglutide, linagliptin, metformin Abstrak DM tipe 2 terjadi pada sekitar 90-95% dari total kasus DM, agen antihiperglikemik seperti GLP-1RA, SGLT2i, DPP-4i dan metformin terbukti memiliki manfaat kontrol glikemik dari keempat golongan tersebut telah terkonfirmasi pemberian tunggalnya pada pasien DM tipe 2, namun belum ada yang menjelaskan kombinasi obat mana yang memiliki efek paling kuat dalam menurunkan kadar glukosa darah. Pada penelitian ini diteliti efek kombinasi keduanya dengan atau tanpa metformin terhadap profil glukosa darah. Hewan diinduksi dengan lipomed 20% MCT/LCT 20 ml/kgBB selama 14 hari kemudian dilanjutkan streptozotocin dosis ganda 35 mg/kg BB. Hewan diberikan perlakuan sesuai kelompok, kontrol negatif dan kontrol positif diberi Na-CMC 0,5%, empagliflozin (1 mg/kgBB), liraglutide (0,062 mg/kg BB); linagliptin (0,5 mg/kgBB); metformin ( 87,8 mg/kgBB); kombinasi 1 (liraglutide 0,062 mg/kgBB dan empagliflozin 1 mg/kgBB); kombinasi 2 (linagliptin 0,5 mg/kgBB dan empagliflozin 1 mg/kgBB); kombinasi 3 (liraglutide 0,062 mg/kgBB, empagliflozin 1 mg/kgBB dan metformin 87,8 mg/kgBB); kombinasi 4 (linagliptin 0,5 mg/kgBB, empagliflozin 1 mg/kgBB dan metformin 87,8 mg/kgBB selama 30 hari. Profil kendali glukosa darah ditentukan melalui pengukuran GDP, pemberian obat golongan SGLT-2i, GLP-1RA, DPP-4i, dan metformin baik tunggal ataupun kombinasinya dapat menurunkan nilai GDP di setiap minggunya. Nilai GDP pada kelompok SGLT-2i (Empagliflozin) dan kombinasi 1 (Empagliflozin+Liraglutide) dapat menurunkan GDP secara signifikan. Pada perbaikan sensitivitas insulin semua kelompok kecuali metformin dapat meningkatkan nilai KITT secara signifikan. Kata Kunci: Diabetes, empagliflozin, liraglutide, linagliptin, metformin
Hubungan Kepatuhan Pengobatan TB-RO terhadap Outcome Terapi Pasien Tuberkulosis di Rumah Sakit Muhammadiyah Lamongan: Correlation between Tuberculosis Drugs Resistence Treatment Compliance and Outcome of Tuberculosis Therapy Patients at Muhammadiyah Lamongan Hospital Fauza Nisfu Laili; Devi Ristian Octavia; Muhtaromah Muhtaromah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1968

Abstract

Abstract Non-compliance with treatment will result in a high rate of failure in the outcome of therapy and result in the occurrence of Acid-resistant Bacilli that are resistant to standard treatment, causing unacceptable therapeutic outcomes to be achieved. This study was conducted with the aim of knowing the relationship between TB-RO treatment adherence to the therapeutic outcomes of tuberculosis patients at Muhammadiyah Lamongan Hospital. The research design uses a cross-sectional method. The population in this study were all RO-TB patients at Muhammadiyah Lamongan Hospital who came for treatment and were registered as patients at Muhammadiyah Lamongan Hospital, with a sample size of 30 patients. The sample selection was carried out using the Consecutive Sampling method. Data selection was carried out using the MARS-5 questionnaire and medical records. The data in this study were analyzed using the Chi-square test to determine the relationship between TB-pulmonary medication adherence to the therapeutic outcomes of tuberculosis patients at Muhammadiyah Lamongan Hospital. The results showed that the number of patients who had high medication adherence was 86.7% with a cured category of 83.3%. There is a significant relationship between TB-RO treatment adherence to the outcome of tuberculosis therapy in Muhammadiyah Lamongan Hospital with a p value <0.05 on the results of the Fisher's Exact Test. The higher the level of adherence, the higher the success rate of the therapeutic outcome obtained, but the lower the level of adherence, the lower the success rate of the TB-RO patient therapy. Kewords:             Treatment Adherence, Therapy Outcome, Drug Resistant Tuberculosis   Abstrak Ketidakpatuhan terhadap pengobatan akan mengakibatkan tingginya angka kegagalan pada outcome terapi dan mengakibatkan terjadinya Basil Tahan Asam yang resisten terhadap pengobatan standar sehingga menyebabkan outcome terapi yang diterima tidak tercapai. Penelitian ini dilakukan dengan tujuan untuk mengetahui hubungan antara kepatuhan pengobatan TB-RO terhadap outcome terapi pasien Tuberkulosis di Rumah Sakit Muhammadiyah Lamongan. Desain penelitian menggunakan metode cross-sectional. Populasi dalam penelitian ini adalah seluruh pasien TB-RO di Rumah sakit Muhammaadiyah Lamongan yang datang berobat dan sudah terdaftar sebagai pasien di RS Muhammadiyah Lamongan, dengan jumlah sampel 30 pasien pemilihan sampel dilakukan dengan metode Consecutive Sampling. Pemilihan data dilakukan menggunakan kuesioner MARS-5 dan Rekam Medis. Data pada penelitian ini dianalisis dengan uji Chi-square untuk mengetahui hubungan antara kepatuhan pengobatan TB-Paru terhadap Outcome terapi pasien Tuberkulosis di Rumah Sakit Muhammadiyah Lamongan. Hasil penelitian menunjukkan bahwa jumlah pasien yang memiliki kepatuhan pengobatan tinggi sebesar 86,7% dengan kategori sembuh sebesar 83,3%. Terdapat hubungan yang signifikan antara kepatuhan pengobatan TB-RO terhadap Outcome terapi pasien tuberkulosis di Rumah Sakit Muhammadiyah Lamongan dengan nilai p <0,05 pada hasil Uji Fisher’s Exact. Semakin tinggi tingkat kepatuhan akan semakin tinggi angka keberhasilan Outcome terapi yang didapatkan, namun semakin rendah tingkat kepatuhan akan semakin rendah angka keberhasilan Outcome terapi pasien TB-RO. Kata Kunci:         Kepatuhan Pengobatan, Outcome Terapi, TB-RO
Kajian Interaksi Obat Antihipertensi pada Pasien Gagal Jantung Kongestif di Ruang ICCU RSUD dr. Soedarso Pontianak: Antihypertensive Drug Interaction Study in Congestive Heart Failure Patients in the ICCU Room of RSUD dr. Soedarso Pontianak Mulatsih, Elisabeth indah; Rizkifani, Shoma; Nurbaeti, Siti Nani
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.1970

Abstract

Treatment therapy that uses various types of drugs is known as polypharmacy. Patients with congestive heart failure are at risk of experiencing interactions between drugs that can have beneficial or detrimental effects on patients. This study aims to describe the number of interaction events in patients with congestive heart failure who are treated in the ICCU room at RSUD dr. Soedarso for the period from January to December 2021. Retrospective data collection and purposive sampling technique. 130 data met the inclusion criteria. Data were analyzed using Microsoft Excel, chi square test, Stockley's Drug Interaction E-book edition 8, the Drug Interaction Checker application, accessed through Medscape.com and drugs.com. The results showed that the potential for drug interactions of 130 patients on the use of antihypertensive drugs had 634 interactions, 458 pharmacodynamic interactions (72.23%), 35 pharmacokinetic interactions (5.52%), and 141 unknown interactions. (22.23%), The chi square test showed a p-value <0.001. This study concludes the percentage of drug interactions that occur in GJK patients in the ICCU room at RSUD dr. Soedarso in pharmacodynamics.   Keywords:          Antihypertensive, Pharmacodynamics, Congestive Heart Failure, Interaction   Abstrak Terapi pengobatan yang menggunakan berbagai jenis obat dikenal dengan nama polifarmasi. Penderita gagal jantung kongestif memiliki risiko mengalami interaksi antar obat yang dapat memberikan efek menguntungkan atau merugikan bagi pasien. Penelitian ini bertujuan untuk menggambarkan jumlah kejadian interaksi pada pasien gagal jantung kongestif yang dirawat di ruang ICCU RSUD dr. Soedarso periode Januari hingga Desember 2021. Pengambilan data secara retrospektif dan teknik purposive sampling. Data yang memenuhi kriteria inklusi sebanyak 130. Data melalui  analisis dengan menggunakan Microsoft Excel, uji chi squareE-book Stockley’s Drug Interaction edisi 8, aplikasi Drug Interaction Checker yang dapat diakses melalui Medscape.com dan drugs.com. Hasil penelitian menunjukkan potensi interaksi obat dari 130 pasien pada penggunaan obat  antihipertensi memiliki total kejadian sebanyak 634 interaksi, dan interaksi farmakodinamik sebanyak 458 kejadian (72,23%), farmakokinetik sebanyak 35 kejadian (5,52%), dan tidak diketahui sebanyak 141 kejadian (22,23%), uji chi square memberikan hasil p-value <0,001. Kesimpulan dari penelitian ini adalah persentase interaksi obat yang banyak terjadi pada pasien GJK di ruang ICCU RSUD dr. Soedarso secara farmakodinamik.   Kata Kunci:         Antihipertensi, Farmakodinamik, Gagal Jantung Kongestif, Interaksi
Variasi Waktu dan Suhu Penyimpanan Ekstrak Daun Andong Merah Cordyline fruticosa (L.) A. Cheval tehadap Kadar Total Antosianin: Variations in Storage Time and Temperature of Cordyline fruticosa (L.) A. Cheval Red Andong Leaf Extract on Total Anthocyanin Contents Utami, Yuri Pratiwi; Sarwati, Dewi
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.1971

Abstract

Cordyline fruticosa. (L.) A. Cheval plant is one of the traditional medicines which has been proven to have benefits including as a medicinal ingredient. This plant contains several chemical compounds including saponins, tannins, flavonoids, polyphenols and steroids. The aim of the research This was to determine the effect of temperature and storage time of red andong leaf extract on anthocyanin levels. Red andong leaves were extracted by maceration using 70% ethanol. The results showed total anthocyanin levels at temperatures of -20°C, 4°C, 25°C and 37°C for 7 days and 14 days. For the first week it was 7.81 mg/L, 8.41 mg/L, 7.29 mg/L, 6.19 mg/L and the 2nd week was 5.99 mg /L, 7.14 mg/L, 3.03 mg/L, 2.37 mg/L. Based on the research results, it was concluded that increasing temperature and storage time damaged the color of anthocyanins. The highest anthocyanin levels after storage were at 4°C of 8.41 mg/l in week 1 and 7.14 mg/L in week 2.   Keywords:          Cordyline fruticosa ( L.) A. Cheval, anthocyanin, Temperature and storage time   Abstrak Tumbuhan andong merah (Cordyline fruticosa. (L.) A. Cheval merupakan salah satu obat tradisional yang terbukti memiliki  manfaat diantaranya sebagai bahan obat. Tanaman ini mengandung beberapa senyawa kimia antara lain saponin, tanin, flavonoid, polifenol, dan steroid. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh suhu dan waktu penyimpanan ekstrak daun andong merah terhadap kadar antosianin. Daun andong merah diekstraksi dengan maserasi menggunakan etanol 70%. Hasil penelitian menunjukkan kadar antosianin total pada suhu -20°C, 4°C, 25°C dan 37°C selama 7 hari dan 14 hari. Untuk minggu pertama adalah 7,81 mg/L, 8,41 mg/L, 7,29 mg/L, 6,19 mg/L dan minggu ke-2 adalah 5,99 mg/L, 7,14 mg/L, 3,03 mg/L, 2,37 mg/L. Berdasarkan hasil penelitian disimpulkan bahwa peningkatan suhu dan lama penyimpanan merusak warna antosianin. Kadar antosianin tertinggi setelah penyimpanan berada pada suhu 4°C sebesar 8,41 mg/l pada minggu ke-1 dan 7,14 mg/L pada minggu ke-2.   Kata Kunci:         Andong merah, antosianin, lama dan waktu penyimpanan
Manajemen Terapi Bakterial Meningitis Akut pada Pasien Anak (Fokus Terapi Antibiotik dan Kortikosteroid): Management of AcuteBacterial Meningitis Therapy in Pediatric Patients (Focus on Antibioticand Corticosteroid Therapy) Pandu Laksono; Pande Made Ayu Aprianti; Patricia Valery Rahaded; Hidayati Adi Putri; Rizqiyanti Ramadhani; Jainuri Erik Pratama; Antonius Adji Prayitno Setiadi; Marisca Evalina Gondokesumo
Jurnal Sains dan Kesehatan Vol. 5 No. 6 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i6.1974

Abstract

Acute bacterial meningitis is an inflammatory condition of the brain that develops rapidly due to bacterial infection in the lining of the brain (meninges) or in the subarachnoid space (fluid-filled space between the meninges). Common clinical manifestations include headache, fever, convulsions, and nuchal rigidity with diagnosis based on cerebrospinal fluid analysis. Management of cases of acute bacterial meningitis, especially in pediatric patients, focuses on selecting antibiotics and corticosteroids as the key treatment, followed by other supportive therapies such as antifever and anticonvulsants. There is a case of a 1-year-old child with a diagnosis of bacterial meningitis, this case report aims to examine the selection, dosage, method of administration, and monitoring of the effectiveness of antibiotics and corticosteroids as therapy in this case. The patient received treatment at RSUD Dr. Soetomo for 4 days by receiving ceftriaxone and dexamethasone injections per kg of body weight. In this case, observation was carried out in the form of observing the patient's clinical condition every day until the patient experienced an improvement in seizures and fever from the 2nd day of treatment. On the 4th day, the patient was allowed to go home and continue oral therapy for outpatient treatment. In conclusion, patients with acute bacterial meningitis need to be given antibiotics which must be started as soon as possible, aimed at eradicating bacteria that infect the lining of the brain, while corticosteroid injections are aimed at reducing the inflammatory response that occurs in the brain so as not to worsen the prognosis of the disease in my condition. Keywords:          bacterial meningitis, ceftriaxone, dexamethasone   Abstrak Meningitis bakterial akut adalah kondisi peradangan otak yang berkembang dengan cepat akibat infeksi bakteri pada selaput otak (meningen) atau pada ruang subarachnoid (ruang berisi cairan di antara meningen). Manifestasi klinis yang umum meliputi sakit kepala, demam, kejang dan kakukuduk dengan penegakan diagnosis berdasarkan analisis cairan serebrospinal. Penatalaksanaan kasus bakterial meningitis akut, khususnya pada pasien anak-anak difokuskan pada pemilihan antibiotik dan kortikostreroid sebagai kunci pengobatan, diikuti dengan terapi suportif lain seperti antidemam dan antikonvulsi. Terdapat kasus anak berusia 1 tahun dengan diagnosa bakterial meningitis, laporan kasus  ini  bertujuan  untuk mengkaji pemilihan, dosis, cara pemberian serta monitoring efektivitas antibiotik dan kortikosteroid sebagai terapi pada kasus ini. Pasien mendapatkan perawatan di RSUD Dr. Soetomo selama 4 hari dengan mendapatkan injeksi ceftriaxone dan deksametason per kg berat badan. Pada kasus ini dilakukan pengamatan berupa observasi kondisi klinis pasien setiap harinya hingga pasien mengalami perbaikan kejang dan demam sejak hari ke-2 perawatan. Pada hari ke-4, pasien diperbolehkan pulang dengan melanjutkan terapi per oral untuk menjalani rawat jalan. Kesimpulannya, pasien dengan meningitis bakterial akut perlu pemberian antibiotik yang harus dimulai sesegera mungkin yang ditujukan untuk eradikasi bakteri penginfeksi selaput otak sedangkan pemberian injeksi kortikosteroid ditujukan untuk menurunkan respon inflamasi yang terjadi di otak agar tidak memperparah prognosis penyakit pada kondisi akut Kata Kunci:         bakterial meningitis, ceftriaxone, deksametason
Toxicity of Anti-Inflammatory Substances in Hemigraphis Alternata Leaves: In Silico Study Using ProTox-II Yeni Yeni; Rizky Arcinthya Rachmania
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1975

Abstract

Hemigraphis alternata is empirically used to treat wounds. Hemigraphis alternata leaves ethyl acetate extract can assist in resolving the inflammatory process by inhibiting enzymes that play a role in the inflammatory cycle. Twenty-two substances found in the leaves of Hemigraphis alternata were predicted to have an anti-inflammatory effect by inhibiting cyclooxygenase-1 (COX-1) or 5-lipoxygenase (5-LOX) as an enzyme target. In-silico toxicology was carried out to acquire new anti-inflammatory drugs with low toxicity from 22 compounds. ProTox-II was utilized to measure the level of toxicity of these drugs at many endpoints. In this study, five compounds have LD50 > 5000 mg/kg body weight, toxicity class 5-6, and inactive for cytotoxicity, carcinogenicity, hepatotoxicity, mutagenicity and immunotoxicity parameters. They are 2-methyleneoctanenitrile, nerolidol, 2,7-dioxa-tricyclo[4.4.0.0(3,8)]deca-4,9-diene, 9,9-dimethoxybicyclo[3.3.1]nonane-2,4-dione, and phytol. Keywords:          in silico, toxicity, Hemigraphis alternata, anti-inflammatory, ProTox-II
An Evaluation of the Antidiabetic and Antimicrobial Activity of an Ethanolic Extract from Rhizophora mucronata Leaf Usman Usman; Pintaka Kusumaningtyas; Sukemi Sukemi; Erwin Erwin
Jurnal Sains dan Kesehatan Vol. 5 No. 4 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i4.1978

Abstract

The aim of this research was to determine the antidiabetic and antimicrobial properties of ethanolic extract of Rhizophora mucronata leaves, as well as the phytochemical elements contained in the leaf extract. Extracts from R. mucronata leaf samples were obtained by maceration in ethanol-based solvents. The ethanolic extract of R. mucronata leaves is known to have an antidiabetic effect on mice, evidenced by its ability to reduce blood glucose levels. Giving ethanol extract at a dose of 600 mg/kg BW gives the greatest antidiabetic effect. The antibacterial activity of the extract against the tested bacteria and fungi was also limited due to the presence of contaminants in the ethanolic extract. The analysis of secondary metabolites using LC-MS revealed that the ethanolic extract of R. mucronata leaves contained 25 different secondary metabolite compounds. Furthermore research to purify and identify the compounds in the ethanolic extract of R. mucronata is required to develop this resource as an antimicrobial and antidiabetic drug based on natural materials.
Studi Penggunaan Obat Golongan Statin pada Pasien Penyakit Jantung Koroner di Ruang ICCU RSUD dr. Soedarso Pontianak: Study of Drug Use Classification Statins in Heart Disease Patients Coronary in the ICCU Room RSUD dr. Soedarso Pontianak Dhenaya Pradina; Shoma Rizkifani; Siti Nani Nurbaeti
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1979

Abstract

Coronary Heart Disease (CHD) is a cardiovascular disease that occurs due to narrowing of the coronary arteries from atherosclerosis process. High levels of lipids in the blood can be the one of the key factor that can increase the risk of cardiovascular disease, one of which is CHD. So this problem is used as the main target in CHD treatment. One of the drugs used in the treatment of CHD is the statin group. This study aims to examine the pattern of statins use in CHD patients in the ICCU RSUD dr. Soedarso Pontianak. Data collection was done retrospectively based on the medical records of CHD patients in 2021. This study is an observational cross-sectional descriptive study. Data was collected using a total sampling technique, and a sample of 45 patients who met the inclusion criteria were obtained. The results showed that the most widely used statin class of drugs in CHD patients in the ICCU was Atorvastatin (95.55%) compared to Simvastatin (4.44%) with the dose used was Atorvastatin 20 mg (66.66%), Atorvastatin 40 mg (28.88%), and Simvastatin 20 mg (4.4%). The frequency of using Atorvastatin and Simvastatin in the ICCU is once a day orally. The conclusion of this study is based on medical record data of CHD patients in the ICCU room at RSUD dr. Soedarso Pontianak, the most widely used statin class drug is Atorvastatin with an average dose of 20 mg of Atorvastatin at a frequency of administration once a day orally. Keywords:          Coronary Heart Disease, Statin Class, Atorvastatin, Simvastatin   Abstrak Penyakit Jantung Koroner (PJK) adalah salah satu penyakit kardiovaskular yang terjadi karena penyempitan pada arteri koroner yang berasal dari proses aterosklerosis. Tingginya kadar lipid dalam darah menjadi aspek kunci yang dapat memberikan risiko penyakit kardiovaskular salah satunya pada PJK. Sehingga masalah ini digunakan sebagai target utama pada pengobatan PJK. Salah satu obat yang digunakan pada pengobatan PJK adalah golongan statin. Penelitian ini bertujuan untuk melihat bagaimana pola golongan statin digunakan oleh pasien PJK di ICCU RSUD Dr. Soedarso Pontianak. Pengumpulan data dilakukan secara retrospektif menurut rekam medis pasien PJK tahun 2021. Penelitian ini merupakan penelitian observasional dengan rancangan studi cross-sectional dengan sifat deskriptif. Teknik total sampling ini digunakan dalam  proses pengumpulan data, dan diperoleh 45 sampel pasien yang masuk pada kriteria inklusi. Hasil penelitian memperlihatkan bahwa penggunaan obat golongan statin yang digunakan pada pasien PJK di ICCU adalah Atorvastatin (95,55%) dan Simvastatin (4,44%) dengan dosis yang digunakan adalah Atorvastatin 20 mg (66,66%), Atorvastatin 40 mg (28,88%), dan Simvastatin 20 mg (4,4%). Frekuensi penggunaan Atorvastatin dan Simvastatin di ICCU adalah 1 kali sehari secara per oral. Kesimpulan pada penelitian ini adalah berdasarkan data rekam medis pasien PJK di ruang ICCU RSUD dr. Soedarso Pontianak, obat golongan statin yang paling banyak dikonsumsi adalah Atorvastatin dengan rata-rata penggunaan dosis Atorvastatin 20 mg pada frekuensi pemberian 1 kali sehari secara per oral. Kata Kunci:         Atorvastatin, Golongan Statin, Penyakit Jantung Koroner, Simvastatin

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