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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : 10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan menerima naskah karya asli (Artikel Penelitian, Artikel Review, dan Studi Kasus), baik eksperimental maupun teoretis, dalam bidang-bidang berikut: Sains dan Kesehatan (Kedokteran, Farmasi, Kesehatan Masyarakat, Keperawatan, Kebidanan, Gizi, dan lain-lain). Tujuan penerbitan Jurnal Sains dan Kesehatan adalah untuk menyediakan informasi ilmiah tentang perkembangan ilmu dan teknologi di bidang Ilmu Pengetahuan dan Kesehatan.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 750 Documents
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Hubungan Tingkat Pengetahuan dengan Sikap terhadap Penggunaan Antibiotik Amoxicillin di Kampung X, Kabupaten Purwakarta: The Relationship Between Knowledge Level and Attitude to Using Amoxicillin Antibiotics in X Village, Purwakarta Yulika, Herma; Marselina, Marselina
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.1992

Abstract

Antibiotics are drugs that are used to deal with bacterial infections or are bacteriostatic, which prevents the occurrence of bacteria. Amoxicillin is the most well-known antibiotic used by people without a doctor’s prescription. The aim of this study is to analyze the relationship between the level of knowledge and the attitude towards the use of antibiotics Amoxicillin. This research is a quantitative study with cross-sectional approach carried out on 58 respondents in Kampung X  Purwakarta. Questionnaire that has been tested for validity and reliability, SPSS univariat and bivariat analysis chi-square test square. The result of this study is obtained a value (p = 0,000) which means there is a meaningful relationship between the level of knowledge and attitude towards the use of antibiotics Amoxicillin. Respondents whose level of knowledge is less good and have a less good attitude are at risk of using an antibiotic Amoxicillin that does not comply with the rules of use. A good level of knowledge can reduce the adverse impact on the use of antibiotic Amoxicillin that does not comply with the rules of use. Keywords:          Education, Age,  Pharmacy   Abstrak Antibiotik merupakan obat yang digunakan untuk mengatasi infeksi bakteri atau bersifat bakteriostatik yaitu menghambat terjadinya perkembangbiakan bakteri. Antibiotik Amoxicillin merupakan antibiotik yang paling banyak dikenal sekaligus dipergunakan oleh masyarakat tanpa resep dokter. Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara tingkat pengetahuan dengan sikap terhadap penggunaan antibiotik Amoxicillin. Menggunakan penelitian kuantitatif yang dilakukan pada 58 responden di Kampung X Kabupaten Purwakarta. Menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya, Diuji  menggunakan SPSS analisis univariat dan bivariat serta uji chi-square kuadrat. Dari penelitian ini didapatkan hasil  dengan nilai (p = 0,000) yang artinya terdapat hubungan bermakna antara tingkat pengetahuan dengan sikap terhadap penggunaan antibiotik Amoxicillin. Responden yang tingkat pengetahuannya kurang baik dan memiliki sikap yang kurang baik berisiko menggunakan antibiotik Amoxicillin yang tidak sesuai dengan aturan pakai. Tingkat pengetahuan yang baik dapat mengurangi dampak negatif penggunaan antibiotik Amoxicillin yang tidak sesuai aturan pakai. Kata Kunci:         Pendidikan, Usia, Apotek
Formulasi dan Uji Aktivitas Antibakteri Sediaan Obat Kumur Fraksi Air Kulit Durian (Durio zibethinus Murray) terhadap Bakteri Streptococcus mutans: Formulation and Test of Antibacterial Activity of Durian (Durio zibethinus Murray) Mouthwash Faction on Streptococcus mutans Marwah S, Marwah S; Nadjamuddin, Mirfaidah; Salemuddin, Muh. Reski; Safaruddin, Safaruddin; Asjur, Asti Vebriyanti
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.1998

Abstract

The water fraction of durian peel (Durio zibethinus Murray) contains compounds chemical flavonoids, saponins, tannins and alkaloids which have antibacterial effects against Streptococcus mutans bacteria. The aim of the study was to determine the water fraction of durian (Durio zibethinus Murray) can be formulated into a mouthwash and has activity as an antibacterial in inhibiting the growth of Sterptococcus mutans bacteria. Experimental research method with maceration extraction using 96% ethanol solvent, then a mouthwash formulation was made with concentrations of FI (1%), FII (5%), and FIII (10%), and tasted for antibacterial activity with the Paperdisk method. The results showed that water fraction durian skin mouthwash  (Durio zhibetinus Murray) on organoleptic testing, pH, and stable viscosity before and after cycling test. Mouthwash water fraction of durian skin (Durio zibethinus Murray) has antibacterial activity FI 8.5 mm, FII 11.9 mm and FIII 15.4 mm against Streptococcus mutans. The mouthwash of the water fraction of durian skin (Durio zhibetinus Murray) is stable physically and chemically and has the best antibacterial activity inhibiting growth of Streptococcus mutans bacteria in FII (5%) and FIII (10%) with strong inhibition zone category.   Keywords:          Water fraction of durian peel, mouthwash, antibacterial, Streptococcus mutans   Abstrak Fraksi air kulit durian (Durio zibethinus Murray) memiliki kandungan senyawa kimia flavonoid, saponin, tanin dan alkaloid yang memiliki efek antibakteri terhadap bakteri Streptococcus mutans. Tujuan penelitian untuk mengetahui fraksi air kulit durian (Durio zibethinus Murray) dapat diformulasi menjadi sediaan obat kumur serta memiliki aktivitas antibakteri terbaik dalam menghambat pertumbuhan bakteri Streptococcus mutans. Metode penelitian secara eksperimental dengan ekstraksi secara maserasi menggunakan pelarut etanol 96%, lalu dibuat formulasi sediaan obat kumur dengan konsentrasi FI (1%), FII (5%), dan FIII (10%), dan uji aktivitas antibakteri dengan metode Papperdisk.  Hasil penelitian menunjukkan bahwa obat kumur fraksi air kulit durian (Durio zhibetinus Murray) pada pengujian organoleptik, pH, dan viskositas stabil sebelum dan setelah Cycling test. Obat kumur fraksi air kulit durian (Durio zibethinus Murray) memiliki aktivitas antibakteri FI 8,5 mm, FII 11,9 mm, dan FIII 15,4 mm terhadap bakteri Streptococcus mutans. Obat kumur fraksi air kulit durian (Durio zhibetinus Murray) stabil secara fisika dan kimia serta memiliki aktivitas antibakteri terbaik menghambat pertumbuhan bakteri Streptococcus mutans yaitu pada FII (5%) dan FIII (10%) dengan kategori zona hambat kuat.   Kata Kunci:         Fraksi air kulit durian, obat kumur, antibakteri, Streptococcus mutans
Formulasi Gel dari Niosom Elastik Span 80 Ekstrak Etanol Rimpang Etlingera alba dengan Variasi Karbopol sebagai Gelling Agent: Formulation Gel of Span 80 Elastic Niosome of Etlingera alba’s Rhizomes Ethanolic Extract with Carbopol Variations as Gelling Agent Astrid Indalifiany; Suryani Suryani; Vica Aspadiah; Rifa’atul Mahmudah; Rezki Annisa
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2000

Abstract

Free radicals contain at least one or more free electrons, so they are reactive and unstable. Several diseases experience increased oxidative stress due to the stability of free radicals, which has the potential to damage the integrity of DNA, proteins, and lipids. The body's ability to accumulate free radicals can be stopped with natural antioxidants. One plant with antioxidant potential is Etlingera alba. Utilization of potential is carried out through the preparation of elastic niosomes from the ethanol extract of E. alba rhizomes using Span 80 so that it can facilitate this natural material transdermally. Gel preparations with carbopol as a gelling agent can be used in the application of E. alba ethanol extract elastic niosomes to the skin. The aim of this research was to make an elastic niosome gel with optimal concentrations of Span 80 and carbopol. Elastic niosomes were characterized through morphology, particle size, and polydispersity index. The results of the characterization of elastic niosomes showed that FD (Span 80 15%) produced the best elastic niosomes with an average vesicle size of 10.43 nm, polydispersity index of 0.282, and spherical shape. Elastic niosome gel preparations were evaluated through organoleptic, pH, viscosity, spreadability, and physical stability using cycling tests. The evaluation results showed that F1 gel (carbopol 0.5%) produced the best physical properties of the gel with organoleptic viscosity, characteristic odor and white, pH 6, viscosity 2,433 cps, and spreadability 6.6 cm and was physically stable through method testing. cycling-test. Keywords:          Niosome, Etlingera, Span 80, Carbopol, Nanoparticle   Abstrak Radikal bebas mengandung setidaknya satu/lebih elektron bebas, sehingga reaktif dan tidak stabil. Beberapa penyakit mengalami peningkatan stres oksidatif akibat tercapainya stabilitas radikal bebas sehingga berpotensi merusak integritas DNA, protein, dan lipid. Kemampuan tubuh dalam mengakumulasi radikal bebas dapat dihentikan dengan antioksidan alami. Salah satu tumbuhan dengan potensi antioksidan adalah Etlingera alba. Pemanfaatan potensi dilakukan melalui preparasi niosom elastik ekstrak etanol rimpang E.alba menggunakan Span 80 sehingga dapat memfasilitasi bahan alam tersebut secara transdermal. Sediaan gel dengan karbopol sebagai gelling agent dapat digunakan dalam aplikasi niosom elastik ekstrak etanol E. alba pada kulit. Tujuan dari penelitian ini adalah untuk membuat gel niosom elastik dengan konsentrasi Span 80 dan karbopol yang optimal. Niosom elastik dikarakterisasi melalui morfologi, ukuran partikel dan indeks polidispersitas. Hasil karakterisasi niosom elastik diperoleh bahwa FD (Span 80 15%) menghasilkan niosom elastik terbaik dengan rata-rata ukuran vesikel 10,43 nm, indeks-polidispersitas 0,282, dan bentuk sferis. Sediaan gel niosom elastik dievaluasi melalui organoleptik, pH, viskositas, daya-sebar dan stabilitas fisik dengan cycling test. Hasil evaluasi diperoleh bahwa gel F1 (karbopol 0,5%) menghasilkan sifat fisik gel terbaik dengan organoleptik kental, bau khas, dan putih, pH 6, viskositas 2.433cps, dan daya-sebar 6,6 cm serta stabil secara fisik melalui pengujian metode cycling-test. Kata Kunci:         Niosom, Etlingera, Span 80, Karbopol, Nanopartikel
Karakteristik Selulosa Mikrokristal dan Proses Delignifikasi pada Isolasinya dari Berbagai Sumber Limbah Alami: Characteristics of Microcrystalline Cellulose and Delignification Process on Its Isolation from Various Natural Waste Sources Alatas, Fikri; Permana, Setia
Jurnal Sains dan Kesehatan Vol. 6 No. 5 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i5.2005

Abstract

The use of microcrystalline cellulose in the pharmaceutical field is generally used as an excipient in tablet dosage forms. Microcrystalline cellulose is produced from the process of isolating alpha cellulose from various natural wastes through several stages of the process. One of the stages of the isolation process is the separation of lignin from cellulose or known as the delignification process which is the most difficult process stage. This literature review aims to determine the characteristics of microcrystalline cellulose and its isolation process from various natural wastes. This review article was written based on 38 national and international journal articles published in the last 10 years (2013-2023) after being screened based on inclusion and exclusion criteria. Microcrystalline cellulose can be analyzed using the Fourier transform infrared (FTIR) method, powder X-ray diffraction (PXRD), scanning electron microscope (SEM), and differential scanning calorimetry (DSC) and the results of the analysis can show identity, purity, crystallinity index, and morphology. Most alkali treatments in the delignification process use sodium hydroxide and/or sodium sulfite followed by a bleaching process with sodium chlorite or hydroxy peroxide depending on the part of the plant. The delignification process for soft plant parts, such as leaves and fruit skin, generally uses sodium hydroxide and sodium chlorite solutions, while for harder plant parts, for example stems, sodium hydroxide and sodium sulfite are usually used. Keywords:          microcrystalline cellulose, cellulose sources, characteristics, delignification   Abstrak Pemanfaatan selulosa mikrokristal dalam bidang farmasi umumnya digunakan sebagai eksipien dalam bentuk sediaan tablet. Selulosa mikrokristal dihasilkan dari proses isolasi selulosa alfa berbagai limbah alami melalui beberapa tahapan proses. Salah satu tahap proses isolasi adalah pemisahan lignin dari selulosa atau delignifikasi yang merupakan tahapan proses yang paling sulit. Kajian literatur ini bertujuan untuk mengetahui karakteristik khas selulosa mikrokristal dan proses delignifikasi dari berbagai limbah alami. Artikel review ini ditulis bersumber dari 38 artikel jurnal nasional dan internasional yang terbit pada 10 tahun terakhir (2013-2023) setelah dilakukan penapisan berdasarkan kriteria inklusi dan eksklusi. Selulosa mikrokristal dapat dianalisis dengan metode Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), scanning electron microscope (SEM), dan differential scanning calorimetry (DSC) dan hasil analisis tersebut bisa menunjukkan identitas, kemurnian, indeks kristalinitas, dan morfologinya. Sebagian besar perlakuan alkali pada proses delignifikasi menggunakan natrium hidroksida dan atau natrium sulfit yang dilanjutkan dengan proses pemutihan dengan natrium klorit atau hidroksi peroksida yang bergantung pada bagian tanamannya. Proses delignifikasi di bagian tanaman yang lunak, seperti daun dan kulit buah umumnya menggunakan larutan natrium hidroksida dan natrium klorit, sementara untuk bagian tanaman yang lebih keras, seperti batang menggunakan natrium hidroksida dan natrium sulfit. Kata Kunci:         selulosa mikrokristal, sumber selulosa, karakteristik, isolasi, delignifikasi
Analysis of Sodium Benzoate Content in Sauces Circulating in Segiri Market Samarinda City by UV-Vis Spectrophotometric Method Jenly Adinata; Nurillahi Febria Leswana; Maria Elvina Tresia Butar-Butar
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2008

Abstract

Sodium benzoate is one of the permitted preservatives, if the amount is still below the maximum limit. This study was conducted to identify sodium benzoate levels in sauces circulating in Segiri Market, Samarinda. According to BPOM RI regulation No.36 of 2013, the maximum amount of sodium benzoate used in sauce is 1000 mg/kg. In this study, a qualitative analysis of sodium benzoate was carried out using the FeCl3 reagent, where 10 sauce samples taken from the Segiri market in Samarinda City were positive of containing sodium benzoate, forming a salmon-colored or brownish-red precipitate. Quantitative analysis was performed using a UV-Vis spectrophotometer where sodium benzoate was measured at a maximum wavelength of 226 nm. The verification parameters tested in this study are accuracy test and precision test. Based on the verification parameters, the average % recovery was 94.505% which is still in the range of 80-110%, and %RSD of 0.0642% which is less than 2%. Based on quantitative analysis, sample A content was 2,084.8 mg/kg, sample B was 1,895.1 mg/kg, sample C was 2,547.4 mg/kg, sample D was 1,700.7 mg/kg, sample E was 1,466 mg/kg, sample F was 7. 100.1 mg/kg, sample G by 1,388.1 mg/kg, sample H by 1,587.6 mg/kg, sample I by 1,647.1 mg/kg, sample J by 3,172.9 mg/kg, the sodium benzoate content in the sauce samples above the maximum amount as determined by the  BPOM regulation No. 36 of 2013. Keywords:          Sodium benzoate, Preservative, Sauce, UV-Vis Spectrophotometry
Inhibitor Enzim Papain-Like Protease (Plpro) SARS CoV-2 dan Mediator Inflamasi TNF-? dan IFN-? pada Bawang Putih (Allium Sativum L): Inhibitors of Papain-Like Protease (Plpro) Enzyme SARS CoV-2 and Inflammatory Mediators TNF-? and IFN-? in Garlic (Allium Sativum L) Romadhona, Pipit; Anwar, La Ode Muhammad; Hashim, Salma Hilmy Rusydi
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2010

Abstract

COVID-19 is an infectious disease caused by the SARS CoV-2 virus. Garlic (Allium sativum L) contains compounds that are responsible for immunomodulatory effects and have antiviral activity. This study aims to find out more about the compounds contained in garlic that have the potential for COVID-19 treatment. The research method is in silico. Macromolecules targeting papain-like protease enzyme tethering with code 6B18 and TNF-? mediators with code 1TNF and IFN-? with code 4Z5R. The results of research on 34 compounds in garlic obtained compounds that can inhibit the enzyme PLpro, namely the hyperin compound at -8.7 kcal/mol, compounds that can inhibit TNF-? mediators, namely phytol compounds at -8.0 kcal/mol, and compounds that can inhibit INF-a mediators, namely ergosterol compounds at -8.2 kcal/mol. Keywords:          COVID-19, PLpro, garlic, inflammation, TNF-a, IFN-a, in silico   Abstrak COVID-19 adalah penyakit menular yang disebabkan oleh virus SARS CoV-2. Bawang putih (Allium sativum L) mengandung senyawa yang bertanggung jawab atas efek imunomodulator dan memiliki aktivitas antivirus. Penelitian ini bertujuan untuk mengetahui lebih lanjut senyawa yang terkandung didalam bawang putih yang berpotensi sebagai pengobatan COVID-19. Metode penelitian secara in silico. Makromolekul target penambatan enzim papain-like protease dengan kode 6B18, dan untuk mediator TNF-? dengan kode 1TNF dan IFN-? dengan kode 4Z5R. Hasil penelitian dari 34 senyawa pada bawang putih diperoleh senyawa yang dapat menghambat enzim PLpro yaitu senyawa hyperin sebesar -8.7 kcal/mol, senyawa yang dapat menghambat mediator TNF-? yaitu senyawa phytol sebesar -8.0 kcal/mol dan yang dapat menghambat mediator INF-a yaitu senyawa ergosterol sebesar -8.2 kcal/mol. Kata Kunci:         COVID-19, PLpro, bawang putih, inflamasi, TNF-?, IFN-?, in silico
Analisis Interaksi ?-Amilase Bacillus licheniformis (BLA) dan Mutannya (MTBLA) dengan Maltoheptaosa pada Suhu Tinggi menggunakan Metode In Silico: Interaction Analysis of ?-Amylase Bacillus licheniformis (BLA) and its Mutant (MTBLA) with Maltoheptaose at High Temperature using In Silico Method Annisyaban Fatiha Azzahra; Regaputra Satria Janitra; Wahyu Widayat; Farhan Azhwin Maulana; Safri Ishmayana; Muhammad Yusuf
Jurnal Sains dan Kesehatan Vol. 5 No. 6 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i6.2013

Abstract

?-Amylase is an enzyme that hydrolyzes starch into oligosaccharides used in the food and health industry sector. Hydrolysis products such as maltopentose can be a high-nutrition source for patients with kidney failure and calorie deficit. Therefore, increasing the thermostability of enzymes needs to be done to meet industrial criteria. In this study, we studied the effect of the Bacillus licheniformis ?-amylase (BLA) mutation on its activity at 298 and 373 K in silico through enzyme-substrate interaction analysis. Maltoheptaose was used as a model substrate. At 373 K, the Asn190Phe mutation plays a direct role in forming interactions with the substrate while the Gln264Ser mutation does not play a direct role. At 298 K the Asn265Tyr mutation plays a direct role in the enzyme-substrate interaction. In this study, we found a relationship between enzyme-substrate interaction and activity, the most determining factor being the interaction with the catalytic residue. At 298 K, the total interaction of the mutant BLA (MTBLA)-maltoheptaose was slightly stronger than that of BLA-maltoheptaose. However, the interaction of maltoheptaose with catalytic residues in BLA is stronger than in MTBLA. This is in agreement with the previous experiment at 298 K. A similar pattern is found at 373 K. Thereby, MTBLA activity at 373 K is also not more improved than BLA. Keywords:          ?-Amylase, activity, thermostability, Bacillus licheniformis, In silico   Abstrak ?-Amilase merupakan enzim yang menghidrolisis pati menjadi oligosakarida yang digunakan di sektor industri makanan dan kesehatan. Produk hidrolisis seperti maltopentosa dapat menjadi sumber makanan tinggi nutrisi untuk pasien gagal ginjal dan defisit kalori. Oleh sebab itu, peningkatan termostabilitas enzim perlu dilakukan untuk memenuhi kriteria industri. Pada penelitian ini kami mempelajari pengaruh mutasi ?-amilase Bacillus licheniformis (BLA) terhadap aktivitasnya pada suhu 298 dan 373 K secara in silico melalui analisis interaksi enzim-substrat. Maltoheptaosa digunakan sebagai model substrat. Pada suhu 373 K, mutasi Asn190Phe berperan langsung membentuk interaksi dengan substrat sedangkan mutasi Gln264Ser tidak berperan langsung. Pada suhu 298 K mutasi Asn265Tyr berperan langsung terhadap interaksi enzim-substrat. Pada penelitian ini, kami menemukan hubungan antara interaksi enzim-substrat terhadap aktivitas, faktor yang paling menentukan adalah interaksinya dengan residu katalitik. Pada suhu 298 K, total interaksi mutan BLA (MTBLA)-maltoheptaosa sedikit lebih kuat dibandingkan BLA-maltoheptaosa. Namun, interaksi maltoheptaosa dengan residu katalitik pada BLA lebih kuat daripada MTBLA. Hal ini bersesuaian dengan eksperimen sebelumnya pada suhu 298 K. Pola yang mirip terlihat pada 373 K, sehingga aktivitas MTBLA pada suhu 373 K juga tidak lebih baik daripada BLA. Kata Kunci:         ?-Amilase, aktivitas, termostabilitas, Bacillus licheniformis, In silico
Potensi Fraksi Ekstrak Herba Krokot (Portulaca grandiflora) Varietas Bunga Magenta dalam Menyembuhkan Luka: The Magenta Flower Variety Purslane Herbs (Portulaca grandiflora) Extract Fraction Potency in Wound Healing Budiawan, Antonius; Puradewa, Levi; Kirana, Bida Cincin
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2025

Abstract

Purslane rose-like flower variety (Portulaca grandiflora) is a popular decorative plant in society. Purslane utilization for health in Indonesia is still limited. Rose-like magenta flower variety purslane (P. grandiflora) is already known for its wound healing activity. This wound healing activity may occur from its secondary metabolites such as flavonoids, saponins, tannins, and terpenoids. Flavonoids extracted in a suitable solvent have the potency to increase the purslane wound healing activity. This research aimed to determine the magenta flower variety purslane herbs extract fraction potency in wound healing. This experimental research was conducted using wound-induced rabbits. The wounds were divided into negative and positive control groups, water, ethyl acetate, and n-hexane treatment groups. The wounds treated with aqua destilata re-epithelization was 12.33 ± 0.94 days, meanwhile, the wounds treated with betadine solution, water, ethyl acetate, and n-hexane fraction were 9.33 ± 0.47, 9.33 ± 0.47, 9.67 ± 0.47, dan 10.00 ± 0.00 days respectively. The water, ethyl acetate, and n-hexane fraction of magenta flower variety purslane herbs (P. grandiflora) have potency in wound healing. The water fraction showed the fastest re-epithelization pace compared to ethyl acetate and n-hexane fraction.   Keywords:          fraction, purslane, Portulaca grandiflora, magenta, wound healing   Abstrak Krokot varietas berbunga seperti mawar (Portulaca grandiflora) merupakan tanaman hias yang cukup populer di masyarakat. Di Indonesia pemanfaatan krokot untuk kesehatan masih sangat terbatas. Krokot mawar (P. grandiflora) varietas bunga magenta diketahui memiliki aktivitas penyembuhan luka. Aktivitas penyembuhan luka tersebut kemungkinan diperoleh karena kandungan metabolit sekunder seperti flavonoid, saponin, tanin, dan terpenoid. Flavonoid yang tertarik dalam pelarut yang sesuai tersebut berpotensi meningkatkan kemampuan krokot dalam menyembuhkan luka. Penelitian ini bertujuan mengetahui potensi dari fraksi ekstrak herba krokot (P. grandiflora) varietas bunga magenta dalam menyembuhkan luka. Penelitian eksperimental ini dilakukan menggunakan kelinci yang diinduksi luka pada bagian punggung. Luka dibagi menjadi kelompok kontrol negatif dan positif serta kelompok perlakuan fraksi air, etil asetat, dan n-heksana. Kelompok luka yang diberi aqua destilata menunjukkan re-epitelisasi 12.33 ± 0.94 hari, sedangkan kelompok luka yang diberi betadine solution, fraksi air, etil asetat, dan n-heksana berturut-turut 9.33 ± 0.47, 9.33 ± 0.47, 9.67 ± 0.47, dan 10.00 ± 0.00 hari. Fraksi air, etil asetat, dan n-heksana herba krokot (P. grandiflora) memiliki potensi menyembuhkan luka dengan mempercepat laju re-epitelisasi. Fraksi air menunjukkan laju re-epitelisasi yang paling baik dibandingkan fraksi etil asetat dan n-heksana.   Kata Kunci:         fraksi, krokot, Portulaca grandiflora, magenta, penyembuhan luka
Front Cover, Editorial Information, Table of Content, Author Guideline, Back Cover Journal Editor
Jurnal Sains dan Kesehatan Vol. 5 No. 4 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i4.2026

Abstract

Formulasi dan Uji Aktivitas Sediaan Plester Hidrogel Ekstak Etanol Daun Randu (Ceiba pentandra (L.) Gaertn) sebagai Antipiretik: Formulation and Activity Test of Ethanol Extract Hydrogel Fever Patch Randu (Ceiba pentandra (L.) Gaertn) Leaf as Antipyretic Ratih Purwasih; Srie Rezeki Nur Endah; Ali Nofriyaldi
Jurnal Sains dan Kesehatan Vol. 5 No. 6 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i6.2030

Abstract

Antipyretics are drugs that work by suppressing body temperature in a state of fever. Randu leaf (Ceiba pentandra (L.) Gaertn) is one of the plants that has activity as an antipyretic and can be formulated in the form of fever-reducing hydrogel patch transdermal preparations. This study aims to determine the physical properties of hydrogel patch drug of ethanol extract of randu leaves and to determine the antipyretic activity of hydrogel plaster preparations of ethanol extract of randu leaves against male white rat test animals (Rattus norvegicus) induced with 5% peptone. The method used is experimental method. The extract was formulated into a hydrogel plaster preparation with a dose variation of 150 mg (FI), 300 mg (FII), and 600 mg (FIII). Evaluation tests were carried out on preparations such as organoleptic, pH, weight uniformity, folding resistance, preparation thickness, and moisture absorption. The results showed that the ethanol extract of randu leaf can be formulated into a hydrogel plaster dosage form that meets the physical evaluation requirements. The antipyretic activity test of randu leaf ethanol extract has a percent (%) of antipyretic activity in FI (150 mg) of 1.91%, in FII (300 mg) of 2.93% and FIII (600 mg) with a percent (%) of 3.25%. This study can be concluded that the preparation of hydrogel plaster ethanol extract of randu leaves has met the requirements of a good evaluation and has the best antipyretic activity in formula III (600mg) with a percent (%) antipyretic activity of 3.25%. Keywords:          Antipyretic, Randu leaf, Fever, Hydrogel patch, Transdermal drug   Abstrak Antipiretik merupakan obat yang bekerja dengan cara menekan suhu tubuh pada keadaan demam. Daun randu (Ceiba pentandra (L.) Gaertn) ialah salah satu tanaman yang memiliki aktivitas sebagai antipiretik dan berpotensi diformulasikan dalam bentuk sediaan transdermal plester hidrogel penurun demam. Penelitian ini bertujuan untuk mengetahui sifat fisik sediaan plester hidrogel ekstrak etanol daun randu dan mengetahui aktivitas antipiretik sediaan plester hidrogel ekstrak etanol daun randu terhadap hewan uji tikus putih jantan (Rattus norvegicus) yang diinduksi dengan pepton 5%. Metode yang digunakan yaitu metode eksperimental. Ekstrak diformulasikan menjadi sediaan plester hidrogel dengan variasi dosis 150 mg (FI), 300 mg (FII), dan 600 mg (FIII). Dilakukan pengujian evaluasi sediaan seperti organoleptik, pH, keseragaman bobot, ketahanan lipat, ketebalan sediaan, dan daya serap kelembaban. Hasil penelitian menunjukan ekstrak etanol daun randu dapat diformulasikan dalam bentuk sediaan plester hidrogel yang memenuhi persyaratan fisik evaluasi. Uji aktivitas antipiretik ekstrak etanol daun randu memiliki persen (%) aktivitas antipiretik pada FI (150 mg) sebesar 1,91%,  pada FII (300 mg) sebesar 2,93% dan FIII (600 mg) dengan persen (%) sebesar 3,25%. Penelitian ini dapat disimpulkan bahwa sediaan plester hidrogel ekstrak etanol daun randu telah memenuhi persyaratan evaluasi yang baik dan memiliki aktivitas antipiretik terbaik pada formula III (600mg) dengan persen (%) aktivitas antipiretik 3,25%. Kata Kunci:         Antipiretik, Daun randu, Demam, Plester hidrogel, Sediaan transdermal

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