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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : 10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan menerima naskah karya asli (Artikel Penelitian, Artikel Review, dan Studi Kasus), baik eksperimental maupun teoretis, dalam bidang-bidang berikut: Sains dan Kesehatan (Kedokteran, Farmasi, Kesehatan Masyarakat, Keperawatan, Kebidanan, Gizi, dan lain-lain). Tujuan penerbitan Jurnal Sains dan Kesehatan adalah untuk menyediakan informasi ilmiah tentang perkembangan ilmu dan teknologi di bidang Ilmu Pengetahuan dan Kesehatan.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 750 Documents
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Posisi Tidur Lateral 30 Derajat Terhadap Kualitas Tidur Lansia Pasca Stroke: Lateral Sleeping Position 30 Degrees on Sleep Quality of Elderly Post Stroke Priastana, I Ketut Andika; Agustini, Ni Rai Sintya
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2031

Abstract

Post-stroke conditions will affect the quality of sleep of the elderly. Sleep disturbance is one of the health problems often faced by the elderly. This condition requires serious attention. Poor elderly sleep quality is caused by increased sleep potential, reduced sleep efficiency, and early awakening due to the aging process. This study aims to analyze the effect of 30-degree lateral positioning on the quality of sleep of the elderly post-stroke. Methods: The design in this study uses a Pre-Experiment design with a One Group Pre-Test Post-Test Design approach. This research will be conducted in 2023 in Ekasari Village, Jembrana Regency, Bali. The number of samples that met the criteria was 84 respondents. Data analysis in this study used the Wilcoxon Signed Rank Test. Results: The results of the Wilcoxon Sign Rank Test showed a Z value of -7,211 with a p-value of 0.000 (<0.05) which means that H0 is rejected, this means that there is an effect of 30-degree lateral sleeping position on the quality of sleep of the elderly after stroke. This study found that there is an effect of 30-degree lateral sleeping position on the quality of sleep of post-stroke elderly. Post-stroke elderly tend to experience improved sleep quality when sleeping in a 30-degree lateral position. This position can be applied to the elderly who experience poor sleep quality so that the elderly can improve their sleep quality.   Keywords:          post-stroke elderly; sleep quality; sleep position; lateral 30 degrees   Kondisi pasca stroke akan memberikan pengaruh pada kualitas tidur lansia. Gangguan tidur merupakan salah satu masalah kesehatan yang sering dihadapi bagi lansia. Kondisi ini membutuhkan perhatian yang serius. Buruknya kualitas tidur lansia disebabkan oleh meningkatnya potensi tidur, berkurangnya efisiensi tidur dan terbangun lebih awal karena proses penuaan. Penelitian ini bertujuan untuk menganalisis pengaruh pengaturan posisi lateral 30 derajat terhadap kualitas tidur lansia pasca stroke. Metode: Desain dalam Penelitian ini menggunakan desain Pre-Experiment dengan pendekatan One Group Pre-Test Post-Test Design. Penelitian ini akan dilaksanakan pada tahun 2023 di Desa Ekasari, Kabupaten Jembrana, Bali. Jumlah sampel yang memenuhi kriteria sebanyak 84 responden. Analisis data dalam penelitian ini menggunakan Wilcoxon Signed Rank Test. Hasil: Hasil Wilcoxon Sign Rank Test menunjukkan nilai Z sebesar -7.211 dengan p-value sebesar 0.000 (<0.05) yang berarti H0 ditolak, hal ini bermakna bahwa ada pengaruh posisi tidur lateral 30 derajat terhadap kualitas tidur lansia pasca stroke. Penelitian ini menemukan bahwa adanya pengaruh posisi tidur lateral 30 derajat terhadap kualitas tidur lansia pasca stroke. Lansia pasca stroke cenderung mengalami peningkatan kualitas tidur ketika tidur dengan posisi lateral 30 derajat. Posisi ini dapat diterapkan pada lansia yang mengalami kualitas tidur yang buruk sehingga lansia dapat meningkatkan kualitas tidurnya.   Kata Kunci:         lansia pasca stroke; kualitas tidur; posisi tidur; lateral 30 derajat
Optimasi Waktu Perendaman dan Waktu Ekstraksi Pembuatan Gelatin dari Sisik Ikan Nila Hitam (Oreocharomis niloticus) sebagai Gelling Agent: Optimization of Soaking Time and Extraction Time for Making Gelatin from Black Tilapia (Oreocharomis niloticus) Fish Scales as a Gelling Agent Rini Ambarwati; Septia Andini; Siti Salwah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2032

Abstract

Almost about 3/4 of the total weight of tilapia is waste, so the use of tilapia scale waste as gelatin has not been widely done. This study was designed to determine the effect of soaking and optimum extraction time on gelatin quality and determine the optimum conditions of soaking time and extraction time with Central Composite Design (CCD) design and optimum conditions determined by Response Composite Design (RSM). The conditions to be designed are to use 2 independent variables with variations in soaking time (12 hours, 24 hours, and 36 hours) and variations in extraction time (1 hour, 2 hours, and 3 hours) and the response to be seen is yield (%), viscosity (cP), and pH. The results of the study obtained the optimum condition of soaking time of 27,082 hours and extraction time of 2,989 hours, with a yield of 3.4356%, viscosity of 2.3933 cP and pH 3.8107, with the results of organoleptic evaluation parameters (brownish clear, coarse powder texture, typical tilapia aroma), yield (3.4356%.), pH (3.8107), water content (7.66%), ash content (0.18%), gelatin identification (positive biuret, millon and xantoprotein), viscosity (2.3933 cP),  protein content (90.91%) and gel strength 5.417 (Bloom). Keywords:          Gelatin, Ossein, Black tilipia scales   Abstrak Hampir sekitar ¾ dari berat total ikan nila merupakan limbahnya, sehingga pemanfaatan limbah sisik ikan nila sebagai gelatin belum banyak dilakukan. Penelitian ini dirancang untuk mengetahui adanya pengaruh perendaman dan waktu ekstraksi optimum terhadap mutu gelatin dan mengetahu kondisi optimum waktu perendaman dan waktu ekstraksi dengan rancangan Central Composite Design (CCD) dan kondisi optimum ditentukan dengan Respon Composite Design (RSM). Kondisi yang akan dirancang adalah dengan menggunakan 2 variabel indipenden dengan variasi waktu perendaman (12 jam, 24 jam, dan 36 jam) dan variasi waktu ekstraksi (1 jam, 2 jam, dan 3 jam) dan respon yang akan dilihat yaitu rendemen (%), viskositas (cP), dan pH. Hasil penelitian didapatkan kondisi optimum waktu perendaman 27.082 jam dan waktu ekstraksi 2.989 jam, dengan rendemen 3.4356%, viskositas 2.3933 cP dan pH 3.8107, dengan hasil parameter evalusi organoleptik (berwarna bening kecoklatan, bertektur serbuk kasar, beraroma khas ikan nila), rendemen (3.4356%.), pH (3.8107), kadar air (7.66%), kadar abu (0.18%), identifikasi gelatin (positif biuret, millon dan xantoprotein), viskositas (2.3933 cP), kadar protein (90.91%) dan kekuatan gel 5.417  (Bloom). Kata Kunci:         Gelatin, ossein, Sisik Nila Hitam
Jamur Endofitik BJS-3 Asosiasi Sambiloto (Andrographis paniculata): Skiring Fitokimia dan Aktivitas Antioksidan: Endophytic Fungal BJS-3 Associated Sambiloto (Andrographis paniculata): Screening Phytochemistry and Antioxidant Activity Riga Riga; Mauline Adia Silvani; Wandi Oktria; Edi Nasra; Desy Kurniawati; Dewi Meliati Agustini
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2034

Abstract

Sambiloto (Andrographis paniculata) is a member of the Acanthaceae family reported to synthesis various bioactive compounds and has biological activities. One of the activities is antioxidant. An alternative source of searching for antioxidant compounds from Sambiloto is its endophytic fungi. The research aims to examine the content of secondary metabolites and determine the antioxidant activity of the BJS-3 endophytic fungus associated with Sambiloto seeds. The steps of the research were inoculation, optimization, fermentation, as well as extraction using ethyl acetate to obtain crude extract (EtOAc). Crude extract of fungal BJS-3 was evaluated for their phytochemical screening and antioxidant activity. The results of the phytochemical test on the endophytic fungus BJS-3 showed positive for terpenoids and phenolic compounds. Furthermore, antioxidant actitvity of extract of fungal BJS-3 was categorized as strong antioxidant properties (IC50 = 67.58 ppm). Keywords:          Antioxidant, Andrographis paniculata, endophytic fungi   Abstrak Sambiloto (Andrographis paniculata) adalah salah satu anggota keluarga Acanthaceae yang mampu mensintesis beragam senyawa bioaktif dan memiliki aktivitas biologis. Salah satu aktivitas tersebut adalah antioksidan. Sumber alternatif pencarian metabolit sekunder dengan aktivitas antioksidan dari sambiloto adalah dengan memanfaatkan jamur endofitik. Penelitian ini bertujuan untuk menguji kandungan metabolit sekunder dan menentukan sifat antioksidan (IC50) dari jamur BJS-3 yang berasosiasi dengan biji sambiloto. Tahapan riset ini meliputi inokulasi, optimasi, fermentasi, dan ekstraksi dengan pelarut etil asetat dan diperoleh ekstrak etil asetat (EtOAc). Ekstrak EtOAc jamur BJS-3 tersebut dianalisis kandungan metabolit sekunder dan sifat antioksidannya. Hasil uji fitokimia pada jamur endofitik BJS-3 menunjukkan positif bahwa ekstrak tersebut mengandung terpenoid dan senyawa fenolik. Sementara itu, uji aktivitas antioksidan mengindikasikan bahwa ekstrak jamur BJS-3 berpotensi sebagai agen antioksidan yang tergolong kuat (IC50 = 67,58 ppm). Kata Kunci:         Antioksidan, Andrographis paniculata, jamur endofitik
Uji Skrining Fitokimia dan Aktivitas Tabir Surya Ekstrak Etanol Daun Bangkal (Nauclea subdita (Korth.) Steud.): Phytochemical Screening Test and Sunscreen Activity of Bangkal Leaf Ethanol Extract (Nauclea subdita (Korth.) Steud.) Fadlilaturrahmah Fadlilaturrahmah; Rahmat Ramadhani; Normaidah Normaidah; Audya Rahmah; Adinda Dwina Hadiastuti; Amalia Khairunnisa
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2036

Abstract

Bangkal (Nauclea subdita (Korth.) Steud.) is a type of plant originating from South Kalimantan that contains antioxidants so it can protect the skin from sun radiation. This study aims to identify secondary metabolites and sunscreen activity based on the Sun Protecting Factor (SPF) value of the ethanol extract of N. subdita leaves. Identification of secondary metabolite compounds was carried out using a tube test. Testing of sunscreen activity was carried out by determining the SPF value in vitro using a UV-Vis spectrophotometer instrument. The results of phytochemical screening tests on the ethanol extract of N. subdita leaves contain alkaloids, flavonoids, phenolics, saponins, steroids, and tannins. The results of testing the activity of sunscreen from the ethanol extract of N. subdita leaves which had the highest SPF value was at a concentration of 250 ppm with an SPF value of 11.369 which was categorized as maximum protection. Keywords:          Nauclea subdita (Korth.) Steud, Identification, Sunscreen   Abstrak Bangkal (Nauclea subdita (Korth.) Steud.) merupakan salah satu jenis tumbuhan yang berasal dari Kalimantan Selatan yang memiliki kandungan antioksidan sehingga mampu melindungi kulit dari adanya radiasi sinar matahari. Penelitian ini bertujuan untuk menentukan kandungan fitokimia dan aktivitas tabir surya berdasarkan nilai Sun Protecting Factor (SPF) pada ekstrak etanol daun N. subdita. Kandungan fitokimia dilakukan dengan menggunakan uji tabung dan pengujian terhadap aktivitas tabir surya dilakukan secara in vitro dengan menentukan nilai SPF menggunakan instrumen spektrofotometer uv-vis. Hasil pengujian skrining fitokimia pada ekstrak etanol daun N. subdita mengandung alkaloid, flavonoid, fenolik, saponin, steroid, dan tannin sedangkan hasil pengujian aktivitas sebagai tabir surya dari ekstrak etanol daun N. subdita yang memiliki nilai SPF paling tinggi adalah pada konsentrasi 250 ppm dengan nilai SPF sebesar 11,369 yang dikategorikan memiliki proteksi maksimal. Kata Kunci:         Nauclea subdita (Korth.) Steud, Identifikasi, Tabir surya
Uji In Vitro Ekstrak n-Heksana Rimpang Curcuma mangga Val. terhadap Ekspresi VEGF pada sel 4T1: In Vitro Test of Curcuma mangga Val. Rhizome’s n-Hexane Extract in VEGF Expression on 4T1 Cells Nurul Mukhlisa; Sitti Hadijah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2037

Abstract

Breast cancer is the most fatal disease to women in the world. Breast cancer prevalence teands to increase every year. Total 25,208 cases in which 20% is Triple Negative Breast Cancer (TNBC). VEGF crucial angiogenic marker in stimulating endothelial cell proliferation and regulation vascular permeability which are important roles in breast cancer growth; invasion and metastasis. Curcuma mangga Val. rhizomes empirically are used as an herbal anti-breast cancer. N-hexane extract of Curcuma mangga Val. have antibreast cancer potency to T47D and MCF-7 cells. Therefore, it is necessary to conduct a study that examine the anti TNBC breast cancer of n-hexane extract of Curcuma mangga Val. In this study was carried out on n-hexane extract of Curcuma mangga Val. againts 4T1 cells using MTT Assay and immunocytochemical test for inhibition of angiogenic VEGF protein expression. The result of cytotoxicity test showed that n-hexane extract of Curcuma mangga Val. is cytotoxic to 4T1 cells with IC50 63,37 ?M; while the IC50 alpelisib (positive control) was 32,96 ?M. Immunocytochemical test showed that there was no significant difference between n-hexane extract of Curcuma mangga Val. and alpelisib in inhibiting VEGF expression. So it can be concluded that n-hexane extract of Curcuma mangga Val. has anticancer potential for TNBC through inhibiting the VEGF protein expression. Keywords:          TNBC, Curcuma.mangga Val.; VEGF, 4T1   Abstrak Kanker payudara merupakan salah satu penyakit penyebab kematian utama pada wanita di dunia. Prevalensi kanker payudara cenderung meningkat setiap tahunnya. Jumlah kasus di Indonesia mencapai 25.208 kasus dimana 20% merupakan Triple Negative Breast Cancer (TNBC). VEGF merupakan marker angiogenesis yang krusial dalam menstimulasi proliferasi sel endotel dan mengatur permeabilitas pembuluh darah yang memiliki peran penting dalam pertumbuhan, invasi, dan metastasis kanker payudara. Rimpang Curcuma.mangga Val. secara empirik digunakan masyarakat sebagai agen antikanker payudara. Ekstrak n-heksana Curcuma mangga Val. memiliki aktivitas sitotoksik terhadap sel T47D dan MCF-7. Namun, belum ada penelitian yang menunjukkan bahwa ekstrak n-heksana Curcuma mangga Val. mempunyai aktivitas sitotoksik pada sel kanker payudara TNBC. Pada penelitian ini dilakukan uji sitotoksisitas ekstrak n-heksana Curcuma mangga Val. terhadap sel 4T1 secara MTT Assay dan pengujian imunositokimia penghambatan angiogenesis ekpresi protein VEGF. Hasil pengujian sitotoksisitas menunjukkan bahwa ekstrak n-heksana Curcuma mangga Val. bersifat sitotoksik terhadap sel 4T1 dengan nilai IC50 63,37 ?M; sedangkan nilai IC50 alpelisib (kontrol sel) sebesar 32,96 ?M. Uji imunositokimia menunjukkan bahwa tidak ada perbedaan signifikan antara ekstrak n-heksana rimpang Curcuma mangga Val. dan alpelisib dalam penghambatan ekspresi VEGF. Sehingga disimpulkan bahwa ekstrak n-heksana rimpang Curcuma mangga Val. memiliki potensi antikanker TNBC melalui penghambatan protein VEGF. Kata Kunci:         TNBC, Curcuma mangga Val.; VEGF, 4T1
Penentuan Kandungan Fenolik Total Kombinasi Ekstrak Etanol Daun Jeruk Purut (Citrus hystrix) Dan Daun Kelor (Moringa oleifera L.) : Determination of Total Phenolic Content in Combination Ethanol Extracts of Kaffir Lime Leaves (Citrus hystrix) and Moringa Leaves (Moringa oleifera L.) Fadilah Qonitah; Reni Ariastuti; Jihan Aulia Kusumasari
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2046

Abstract

Kaffir lime leaves and moringa leaves are known to contain phenolic compounds that can have potential as antioxidants. The purpose of this study was to determine the total phenolic content of the combination of ethanol extracts of kaffir lime leaves and moringa leaves. Preparation of extracts was done by maceration method using 95% ethanol. Determination of total phenolic content by colorimetric method using Folin-Ciocalteu reagent and gallic acid as standard. The results showed that the largest total phenolic content in the combination of J:K extract (1:0) was 3.58 ± 0.09 %EAG while the smallest phenolic content in the combination of J:K extract (0:1) was 1.32 ± 0.08 %EAG.
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Nipah (Nypa fruticans Wurmb.) dan Pembuatan Formulasi Basis Krim: Antioxidant Activity Test of Ethanol of Nipah Leaf (Nypa fruticans Wurmb.) and Cream Base Formulation Ahmad Rezky; Sabanniah Indjar Gama; Angga Cipta Narsa
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2048

Abstract

Nipah leaves (Nypa fruticans Wurmb.) is a palm plant that grows in tidal areas close to the edge of the sea which is suspected to contain secondary metabolites as antioxidants and rich in vitamins A and C. This study aims to determine the antioxidant activity of nipa leaf extract and obtain the best formula from the basic cream with varying concentrations of stearic acid and TEA. The research method used was phytochemical screening, specific and non-specific parameter tests of the extract including organoleptic, water content, pH, ash content, acid insoluble ash content, specific gravity, antioxidant activity test of nipa palm leaf ethanol extract using the DPPH method, formulation and base evaluation. cream includes organoleptic, pH, emulsion type, spreadability, and viscosity. The results obtained from the ethanol extract of nipah leaves contain secondary metabolites in the form of phenols, tannins and steroids. The results of extract specific and non-specific parameters obtained for all parameter values have occupy the applicable standards. The antioxidant activity of the ethanol extract of nipah leaves obtained the IC50 of 2,379 ppm which shows very strong antioxidant activity. The results of the evaluation of the cream base formulation found that the cream bases F1, F2, F3 occupy the cream evaluation requirements. Keywords: Nypa fruticans Wurmb., antioxidant, cream Base Abstrak Daun nipah (Nypa fruticans Wurmb.) merupakan tanaman palem yang tumbuh di daerah pasang surut yang dekat dengan tepi laut yang diduga memiliki kandungan metabolit sekunder sebagai antioksidan dan kaya akan vitamin A dan C. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari ekstrak daun nipah dan mendapatkan formula terbaik dari basis krim dengan memvariasikan konsentrasi asam stearat dan TEA. Metode penelitian yang dilakukan yaitu skrining fitokimia, uji parameter spesifik dan non-spesifik ekstrak meliputi organoleptis, kadar air, pH, kadar abu, kadar abu tidak larut asam bobot jenis, uji aktivtias antioksidan ekstrak etanol daun nipah dengan metode DPPH, formulasi serta evaluasi basis krim yang meliputi organoleptis, pH, tipe emulsi, daya sebar, dan viskositas. Hasil yang didapatkan ekstrak etanol daun nipah mengandung metabolit sekunder berupa fenol, tanin, dan steroid. Hasil parameter spesifik dan non-spesifik ekstrak diperoleh semua nilai parameter telah memenuhi standar yang berlaku. Aktivitas antioksidan ekstrak etanol daun nipah didapatkan nilai IC50 sebesar 2.379 ppm yang menunjukkan aktivitas antioksidan sangat kuat. Hasil evaluasi formulasi basis krim didapatkan basis krim F1, F2, F3 memenuhi persyaratan evaluasi krim. Kata Kunci: Nypa fruticans Wurmb., antioksidan, basis krim
Analisis Karakteristik dan Profil Pengobatan Pasien Demam Berdarah Dengue Anak di Instalasi Rawat Inap Rumah Sakit Samarinda Medika Citra Tahun 2020-2021: Analysis of Characteristics and Medication Profile of Dengue Hemorrhagic Fever Patients in Children at the Inpatient Installation of Samarinda Medika Citra Hospital in 2020-2021 Jessyca Azzahra; Angga Cipta Narsa; Novianty Indjar Gama
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2049

Abstract

Dengue hemorrhagic fever (DHF) is an acute viral infectious disease caused by the dengue virus. In general, DHF treatment is supportive and symptomatic. Supportive treatment is administering replacement fluids for the body, such as intravenous fluids. As symptomatic therapy, paracetamol can be given as an antipyretic. This study aimed to determine the characteristics and treatment profile of pediatric patients diagnosed with DHF at the inpatient installation of Samarinda Medika Citra Hospital in 2020-2021. The research method used is observational research which will then be described descriptively. Based on the results of the characteristics of most patients, namely in male patients (62.4%) with school-age patients (6-18 years) (80%), the degree of severity experienced by DHF pediatric patients is degree 1 of (78, 4%) with an average length of stay of 4 days (28.8%) the average weight of pediatric patients with DHF is 20-
Efektivitas Pemberian Kombinasi Teh Daun Mint (Mentha piperita) dan Madu terhadap Intensitas Nyeri Haid (Dismenore): Effectiveness Giving a Combination of Mint Leaf Tea (Mentha piperita) and Honey Against Menstrual Pain Intensity (Dysmenorrhea) Nafara Aghnia Anfusufi; Adam M. Ramadhan; Vita Olivia Siregar
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2050

Abstract

Dysmenorrhea or menstrual pain is still a major problem for most women. There are many ways to deal with menstrual pain or dysmenorrhea, one of which is by consuming herbal drinks. Mint leaves contain menthol compounds which can reduce contractions in the myometrium so that the pain of dysmenorrhea that is felt can be reduced. Flavonoids contained in honey can reduce pain by inhibiting the formation of prostaglandins through inhibition of the cyclooxygenase enzyme. So that the combination of the two can work synergistically in reducing the intensity of dysmenorrhea pain. This study aims to determine the effectiveness of giving mint leaf tea (Mentha piperita) and honey to reduce the intensity of menstrual pain (dysmenorrhea). The research method used was quasy experimental with purposive sampling and obtained 50 respondents divided into 2 groups. The results obtained in the two groups of respondents after giving the combination of mint leaf tea and honey for 2 days were a decrease between the pretest and posttest with a significance value of 0.000 (p
Kajian Potensi Interaksi Obat pada Pasien Infeksi Saluran Kemih di RSUD Inche Abdoel Moeis Samarinda Periode Tahun 2021: Study of Potential Drug Interactions in Urinary Tract Infection Patients at Inche Abdoel Moeis Hospital Samarinda for the 2021 Period Nia Audina; Juniza Firdha Suparningtyas; Herman Herman
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2051

Abstract

Urinary Tract Infection (UTI) patients generally have co-morbidities, which allows many drugs to be prescribed. The increasing combination of drugs used can lead to an increased risk of drug interactions, which potentially affect the success of patient treatment therapy. This study aims to determine the potential for drug interactions that occur in the treatment of inpatient UTI patients at Inche Abdoel Moeis Samarinda Hospital for the 2021 period. This research is a retrospective descriptive study using a purposive sampling technique and the mechanism of drug interactions and the severity of the interaction are analyzed using Drug Interaction Checker on the drug.com website and the Medscape app. The results of the study of 45 medical records of UTI patients who met the inclusion requirements showed that there were 14 potential drug interactions found with potential pharmacokinetic and pharmacodynamic mechanisms, and there were results of the severity of drug interactions consisting of minor, moderate, and major. Keywords: Urinary tract infection; Drug interactions; Inpatient Abstrak Pasien Infeksi Saluran Kemih (ISK) umumnya memiliki penyakit penyerta sehingga memungkinkan banyak obat yang diresepkan. Meningkatnya kombinasi obat yang digunakan dapat menyebabkan peningkatan risiko terjadinya interaksi obat, yang secara potensial mempengaruhi keberhasilan terapi pengobatan pasien. Penelitian ini bertujuan untuk mengetahui potensi interaksi obat yang terjadi pada terapi pengobatan pasien ISK rawat inap di Rumah Sakit Inche Abdoel Moeis Samarinda periode tahun 2021. Penelitian ini merupakan penelitian deskriptif secara retrospektif dengan teknik purposive sampling serta mekanisme interaksi obat dan tingkat keparahan interaksi dianalisis menggunakan Drug Interaction Checker pada situs drug.com dan aplikasi Medscape. Dari hasil penelitian 45 rekam medik pasien ISK yang telah memenuhi syarat inklusi menunjukan bahwa terdapat potensi interaksi obat yang ditemukan sebanyak 14 kejadian dengan mekanisme potensi interaksi secara farmakokinetik dan farmakodinamik, serta terdapat hasil tingkat keparahan interaksi obat yang terdiri dari minor, moderate, dan mayor. Kata Kunci: Infeksi saluran kemih; Interaksi obat; Rawat inap

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