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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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HUBUNGAN DERAJAT TROMBOSITOPENIA DENGAN MALARIA BERAT PADA PASIEN MALARIA DI RUMAH SAKIT KANUJOSO DJATIWIBOWO BALIKPAPAN Loly R.D Siagian; Mona Zubaidah; Riski Ayu Rimadani
Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i2.196

Abstract

Malaria is one of the health problems in Indonesia. Kanujoso Hospital Djatiwibowo Balikpapan is a referral hospital for Balikpapan, Penajam Paser Utara and Paser. Kabupaten Penajam Paser Utara is the district with the highest incidence of malaria in East Kalimantan. In malaria there is a change of hematology one of them is thrombocytopenia. Several studies have suggested the involvement of thrombocytopenia with severe malaria events. The aim of this reasearch was to know the relations of degree of thrombocytopenia with severe malaria in malaria patients treated at Kanudjoso Djatiwibowo Hospital Balikpapan period 2013-2017. This research was conducted by using analytic observational research method with cross sectional design. The sample was taken from the patient's medical record at Kanujoso Djatiwibowo Hospital Medical Record Installation for 2013-2017 period with the sample of 81 patients. The data were analyzed by using Fisher test. The results of this research showed that distribution malaria patients based on degree of thrombocytopenia were moderate, severe and mild respectively 41,98%; 40,79% and 17,28%. Severe malaria found in 13.58% patients. We found correlation between degree of thrombocytopenia with severe malaria with Fisfer test ((p=0,043). Our study found correlation between degree of thrombocytopenia with severe malaria in malaria patientspatients at Kanudjoso Djatiwibowo Hospital Balikpapan
DRPs (DRUG RELATED PROBLEMS) PADA PENDERITA DIABETES MELLITUS DENGAN KOMPLIKASI GAGAL GINJAL DI RUMAH SAKIT UMUM DAERAH ‘X’ DI SAMARINDA PERIODE OKTOBER-DESEMBER 2016 Rusdiati Helmidanora; Muhammad Reza; Yullia Sukawaty
Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i2.197

Abstract

Drug Related Problems (DRPs) is an unexpected event from the patient's experience because drug therapy can interfere with the success of healing. Patients with chronic disease for a long time have a chance of developing DRP. One chronic disease is diabetes mellitus which is a metabolic disorder due to lack of insulin production produced by the pancreas gland. Diabetic nephropathy is a microvascular complication that often occurs in type 1 and type 2 diabetes, due to high blood sugar levels that can cause kidney structure to change and impaired function. The aim of this study was to determine DRP in patients with diabetes with kidney failure. Research conducted was non-experimental research with data collection retrospectively. The data were analyzed by using standard reference books, Drug Information Handbooks. Based on the results of the study found DRPs in patients with DM with kidney failure in the inpatient installation of RSUD 'X' Samarinda in the period October-December 2016 who needed drugs but did not receive it (24%), received drugs without appropriate indications (11%), received wrong drugs (3%), dose was too low (0%), dose was too high (5%), the patient has ADR (13%), and compliance (0%).
SITOTOKSISITAS EKSTRAK ETANOL 70% KULIT JENGKOL (ARCHIDENDRON JIRINGA (JACK). I.C. NIELSEN) TERHADAP PENGHAMBATAN SEL KANKER PAYUDARA MCF-7 DAN KANKER SERVIKS HELA: Cytotoxicity Extract Ethanol 70% of Jengkol Skin (Archidendron jiringa (Jack). I.C. Nielsen) Against the Inhibition of Breast Cancer Cell MCF-7 and Cervical Cancer HeLa Harry Noviardi; Antonius Padua Ratu; Diah Ajeng Tri R
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.201

Abstract

Jengkol (Archidendron jiringa (Jack).I.C. Nielsen) skin for this belongs to the organic wastes that do not provide economic value. Compounds of natural ingredients on the Jengkol Skin among others, alkaloids, flavonoids, tannins, saponins, and triterpenoids. Some of the molecular structures of the compound are thought to potentially in inhibiting the growth of cancer cells. This research aimed to determine the cytotoxicity effect of 70% ethanol extract of Jengkol Skin as anticancer. Jengkol Skin was macerated in ethanol 70% then extract was concentrated with a rotary vacuum evaporator and water bath. Cytotoxicity test was carried out using cells MCF-7 (breast cancer) and HeLa cells (cervical cancer) based upon the method of MTT assay. The parameter was the value measured inhibition concentration (IC50). Extracts of the Jengkol Skin showed activity against cytotoxicity MCF-7 cells with IC50 values of 51.76 μg/mL and for the IC50 value of HeLa cells 39.618 μg/mL. IC50 values of the cell were less than 100 μg/mL, indicated categories of potential cytotoxicity. The Jengkol Skin extract could be used as anticancer agents.
UJI ANTI INFLAMASI EKTRAK KOMBINASI TERIPANG PASIR (HOLOTHURIA SCABRA) DAN DAUN KERSEN (MUNTINGIA CALABURA L.) PADA TIKUS (RATTUS NORVEGICUS) Asril Burhan; Marwati Marwati; Besse Hardianti; Waode Ratnasari Hasan
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.204

Abstract

Teripang pasir (Holothuria scabra) dan daun kersen (Muntingia calabura L.) digunakan sebagai obat tradisional yang memiliki aktivitas antiinflamasi. Penelitian ini bertujuan untuk mengetahui aktivitas antiinflamasi dari kombinasi ekstrak etanol teripang pasir dan daun kersen terhadap penurunan udem pada kaki tikus yang telah diinduksi dengan karagenan 1%. Tikus kemudian dibagi menjadi 5 kelompok dan masing-masing kelompok terdiri dari 3 ekor tikus. Kelompok 1 sebagai kontrol positif, kelompok 2 sebagai kontrol negatif, kelompok 3 sebagai kombinasi ekstrak 1:1 (200 mg/kgBB:200 mg/kgBB), kelompok 4 sebagai kombinasi ekstrak 1:2 (200 mg/kgBB:400 mg/kgBB), kelompok 5 sebagai kombinasi ekstrak 2:1 (400 mg/kgBB:200 mg/kgBB), dan masing-masing kelompok diberikan secara peroral. Pada EK 2:1 memiliki efek antiinflamasi yang sama dengan kontrol positif dengan %DAI, yaitu 4,84%. Sedangkan pada EK 1:2 dengan %DAI 4,24% dan EK 1:1 dengan %DAI 1,81%.
PENGARUH BRIEF COUNSELING FARMASIS TERHADAP AKTIVITAS FISIK DAN HASIL TERAPI PASIEN HIPERTENSI RAWAT JALAN DI POLIKLINIK PENYAKIT DALAM RSUD ULIN BANJARMASIN Saftia Aryzki; Noverda Ayuchecaria; Anna Khumaira Sari
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.206

Abstract

According to Riskesdas (2013) the prevalence of hypertension in South Kalimantan Province is 30.4%, this means around 1,145,536 people. Risk factors are occupation of less physical activity 26.1% and residents> 10 years consuming less vegetables and fruits. The government invites the entire community to carry out a movement of healthy living people by doing physical activities, consuming vegetables and fruits and checking health regularly. The purpose of this study was to determine the effect of Brief Counseling of Pharmacists on Physical Activity and Therapeutic Results of Hypertensive Patients Outpatient in the Internal Medicine Polyclinic of Ulin Hospital, Banjarmasin.The quasi-experimental study used a prospective two-group pretest and posttest design. Patients were grouped randomly into two groups, namely the group that received the intervention in the form of a pharmacist / researcher briefing and group without intervention (control) followed for one month. Sampling using co-executive sampling method that meets the inclusion and exclusion criteria. The study was conducted at the internal medicine clinic at Ulin Banjarmasin Public Hospital in the period January-March 2018. The instrument used is International Physical Activity Questionnaire (IPAQ).The results of physical activity data analysis in the control group with the Wilcoxon Test which showed data had a significant difference (p <0.05), while in the treatment group with the Wilcoxon Test which showed data did not have a significant difference (p> 0.05). Analysis of blood pressure data in the control group with the Wilcoxon Test which showed data had a significant difference (p <0.05), while in the treatment group with the Wilcoxon Test which showed data had a significant difference (p <0.05).
PEMBUATAN DAN UJI SIFAT FISIK GEL ANTINYERI KOMBINASI MINYAK ATSIRI BUNGA CENGKEH ( Syzygium aromaticum(L.) Merr.&Perry ) DAN SEREH (Cymbopogon nardus L. Rendle): PEMBUATAN DAN UJI SIFAT FISIK GEL ANTINYERI KOMBINASI MINYAK ATSIRI BUNGA CENGKEH ( Syzygium aromaticum(L.) Merr.&Perry ) DAN SEREH (Cymbopogon nardus L. Rendle) Purgiyanti Purgiyanti; Inur Tivani
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.210

Abstract

Clove and lemongrass are agricultural commodities that have high economic value. One of the natural compounds produced from both and is usually obtained by distillation is essential oil. The use of clove oil and citronella oil that has often been used by the public is as an analgetics. The purpose of this study was to make an analgetics gel from a combination of essential oils of clove and citronella oil with variations in the concentration of CMC-Na as a gelling agent and to determine the gel that wasmost preferred by respondents. This research is an experimental research, the method of document collection uses qualitative and quantitative data from laboratory experiments. The resulting gel is then tested for physical properties of the preparation which includes organoleptic test, homogeneity, pH, clarity, dispersion , protection power, and adhesion. Test of preference for 10 respondents to determine the most preferred gel. The results showed that the gel combination of clove and citronella oil with 2% CMC-Na concentration was the best formula seen from the physical test and preference test.
IDENTIFIKASI METABOLIT SEKUNDER DAN POTENSI ANTIDIARE EKSTRAK DAUN CINCAU (Stephania capitata (Blume) Spreng) Ika Ayu Mentari; Indah Hairunisa; Arsyik Ibrahim; Aditya Fridayanti
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.211

Abstract

Indonesia biodiversity has the second highest number of indigenous medical plants after the amazon rain forest, meanwhile Indonesian people usually used plants as a medicine source and some medicine plants have been developed as modern drugs. One of medicine plant in Indonesia that usually used as a refreshment was grass jelly (Stephania capitata (Blume) Spreng). This plant frequently found in Sumatra, Borneo and Java island and the leaf of grass jelly has been reported as a medicine against stomach complaint (diarrhea) and fevers. This research was designed to investigate the secondary metabolites and the efficacy of leaf extract of grass jelly as anti diarrhea. The leaves extraction was done by using maceration with ethanol solvent at room temperature. Meyer reagent, dagendroff reagent, methanol, magnesium band, hydrochloric acid, iron (III) chloride, anhydrous acetic acid, sulfuric acid, chloroform were used for identification of secondary metabolites from grass jelly leaves. For potency anti diarrhea, animals were divided into six group: diarrhea group, treatment group with loperamid HCl and treatment group of leaf extract of grass jelly. The results showed that the leaf extract of grass jelly contain saponin, phenol, sterol and triterpen and the treatment with leaf extract of grass jelly significantly decreasing time duration of diarrhea.
TOTAL KANDUNGAN FLAVONOID DAN PEMBUATAN FORMULASI SALEP EKSTRAK ETANOL KULIT UBI JALAR UNGU (Ipomea Batatas L.) ASAL KOTA PALU SULAWESI TENGAH TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS Viani Anggi; Dewi Sufiani
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.212

Abstract

Purple sweet potato rind has content of flavonoid and inhibitory activity against Staphylococcus aureus bacteria. This study aims to determine the content of flavonoid and difference between variations in the concentration of purple sweet potato rind ointment as inhibitory capacity to produce the physical quality of ointment that is in accordance with Indonesian Pharmacopoeia requirements and to know the difference in activity of inhibition of purple sweet potato rind ointment between variations in concentration on Staphylococcus aureus. The research method used has total flavonoid equivalent quercetin by spectrophotometry uv-vis and to inhibitory activity was used the paper disk method, namely by applying Staphylococcus aureus bacteria culture using sterile cotton sticks and then placed paper discs which had been soaked for 15 minutes with purple sweet potato rind extract ointment. Purple sweet potato rind extract was obtained by maceration using 96% ethanol solvent until the ethanol extract of purple sweet potato rind was obtained. It was then formulated into ointment dosage forms with variations in concentrations of 20%, 25%, 30%. The results showed has total flavonoid equivalent quercetin of purple sweet potato rind is 8,36% and the variation of the concentration of purple sweet potato rind ointment influential in producing the physical quality of the ointment, the ointment the concentration of 30% produced a distinctive aroma and brighter colors from concentrations of 20% and 25%. The inhibitory activity of purple sweet potato rind extract ointment showed a significant value of < 0,05 (p=0,000) at a concentration of 30% having a strong inhibitory activity against the Staphylococcus aureus bacteria.
SKRINING THALASEMIA-BETA MINOR PADA MAHASISWA FAKULTAS KEDOKTERAN Fransiska Anggreni Sihotang; Loly Rotua Dharmanita Siagian; Novia Fransiska Ngo; Lily Pertiwi Kalalo
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.214

Abstract

Thalassemia is a group of congenital hemoglobinopathy characterized by deficiency or absence of one (or more) of the globin chains that constitute hemoglobin. Thalassemia major is inherited through autosomal recessive pattern by marriage between carriers of the thalassemia gene known as thalassemia minor. Beta-thalassemia is the most common type of thalassemia. It is estimated that 10% of Indonesia's population carries the beta-thalassemia gene. However, there has been no routine screening for thalassemia gene carriers. Several recognized methods of thalassemia screening are available. One of them is screening of prospective brides using several hematology parameters such as Mentzer index and red blood cells fragility; both are relatively straightforward and inexpensive compared to hemoglobin analysis or genetic testing. This study aimed to determine the frequency of beta-thalassemia minor suspects among students in the Medical Faculty of Mulawarman University. This study was a descriptive quantitative study with cross sectional approach that involved 160 participants. Participant's blood sample was collected for complete blood count and one tube osmotic fragility test (OTOFT). Mentzer index is calculated by dividing MCV values ​​with erythrocyte count. Participants were determined as beta-thalassemia minor suspects if they met following criterias: (1) MCV < 80 fL; (2) Mentzer index < 13; and (3) positive OTOFT result. This study demonstrated that 1.25% (n=2) of 160 participants were beta-thalassemia minor suspect. Further examination of hemoglobin electrophoresis or genetic testing is needed to further confirm this finding.
ANALISIS EFEKTIVITAS BIAYA KEMOTERAPI PADA PASIEN KANKER PAYUDARA DI RSPAD GATOT SOEBROTO JAKARTA Lili Musnelina; Jenny Pontoan; Clara Jesica Martin
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.216

Abstract

Breast cancer is a disease of malignant neoplasm which is an abnormal growth of tissue that is different from the surrounding tissue. Various used of chemotherapy in the process of achieving management in cancer that causes the use of benefits and costs. This study aims to determine a more effective therapy in breast cancer patients at RSPAD Gatot Soebroto in 2017. This study was non experimental with comparative study into two group chemotherapy is single group (chemotherapy bondronat) and combination group (chemotherapy doxorubicin-paclitaxel). This study use secondary data from medical records patients on retrospectively. The results showed a decrease in the scale of single chemotherapy (Bondronat) was 82,61% with an average direct medical cost of IDR 9,3 million where as in combination chemotherapy (Doxorubicin-Paclitaxel) 95,65% with an average direct medical cost of IDR 7,6 million. The ACER value in single chemotherapy was IDR 11,3 million and combination chemotherapy was IDR 7,9 million. The ICER value in the two treatment groups was IDR 13,5 million. The conclusion is the combination of chemotherapy of Doxorubicin-Paclitaxel is the most cost-effective than Bondronate single chemotherapy.

Page 13 of 33 | Total Record : 326

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