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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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SENYAWA KIMIA STEROL DARI KULTUR JARINGAN KELADI TIKUS (Typhonium divaricatum Decne) Lilik Sulastri; Partomuan Simanjuntak
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i2.264

Abstract

Keladi tikus (Typhonium divaricatum Decne) is one of Aracaceae family which a plant that’s very popular in Indonesian society because it contains anti-cancer substances. Nowadays, keladi tikus plants have been cultivated in tissue culture widely. The simplicia used in this study was keladi tikus from tissue culture which was separated into the upper part (leaves and petioles) and the bottom (tubers) dried in the sun. Dry simplicia was extracted with methanol at a temperature of 60-70 oC and the methanol extract was partitioned with ethylacetate then with n-BuOH solvents, and all extracts were tested for cytotoxic tests using the Brine Shrimp Lethality test (BSLT) method. The active fraction of ethylacetate extract, which is the tuber parts was carried out by column chromatography (SiO2; i). n-hexane: ethylacetate = 10: 1 ~ 1: 1; ethylacetate; MeOH; ii). n-hexane-ethylacetate = 5: 1) give one pure isolate. The results of identification based on Infrared (IR) spectra, and gas chromatography-mass spectra (GC-MS) are b-sitosterol which LC50 is 76.2 ppm
KONSENTRASI HAMBAT MINIMUM (KHM) KADAR EKSTRAK ETANOL BATANG BAJAKAH TAMPALA (Spatholobus littoralis Hassk) TERHADAP BAKTERI ESCHERICHIA COLI MELALUI METODE SUMURAN Mochammad Maulidie Alfiannor Saputera; Tio Widia Astuti Marpaung; Noverda Ayuchecaria
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i2.267

Abstract

Empirically, one of the plants that are widely used by the Dayak tribe as a medicine is the bajakah tampala (Spatholobus littoralis Hassk.) This plant is claimed to be able to treat several diseases such as abdominal pain, diarrhea and dysentery. But until now studies on the antibacterial activity of bajakah tampala have never been done. This study studied the antibacterial activity of bajakah ethanol extract against the growth of Escherichia coli bacteria and minimum inhibitory value (MIC). This type of research is experimental research. The stem bajakah Tampala looks like it wastaken from the inland forest in Garung Village, Jabiren District, Pulang Pisau Regency, Central Kalimantan. The sample of this study was 70% ethanol extract of bajakah tampala stems obtained by maceration. Extract payment of antibacterial activity using a concentration of 3.12%; 6.25%; 12.5%; 25% and 50%. The positive control used is ampicillin 0.01 mg/ml and negative control using distilled water. Tests are carried out by the well method. The tested data were analyzed statistically by the One-Way ANOVA test method. The results of the study showed that the ethanol extract bajakah tampala could inhibit the growth of E. coli bacteria. The biggest inhibition of E. coli bacteria at a concentration of 50% with an average inhibition diameter of 20.32 mm. included in the category of very strong. The minimum inhibitory concentration of extract batang bajakah tampala is 6.25%
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL KULIT PISANG KEPOK MENTAH SECARA IN VITRO Novia Ariani; Rakhmadhan Niah
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i2.270

Abstract

The incidence of infections in the gastrointestinal tract is increasing every year. Some bacteria that often cause infections in the gastrointestinal tract are Salmonella typhi, which is a bacterium that causes typhoid fever, and Shigella dysenteriae which is a bacterium that causes dysentery. Handling of infection can only be done by using antibiotics. Improper use of antibiotics can lead to resistance, so it is necessary to look for alternative treatments that come from nature to overcome resistance levels. One of them is raw Kepok banana peel (Musa paradisiaca formatypica) which has secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, where these compounds have many antibacterial activities unknown to the public. This research was an experimental research. The extraction method was using the maceration method with 96% ethanol solvent. Antibacterial activity test for Salmonella typhi and Shigella dysenteriae was using diffusion method therefore the wells were divided into 7 treatment groups, namely extract concentration 0.3125%; 0.625%; 1.25%; 2.5%; 5.0%; positive control (Chloramphenicol dose 30 mg / ml for Salmonella typhi, Ciprofloxacin dose 100 mg / ml for Shigella dysenteriae), and negative control (ethanol 96%). The diameter of the inhibitory zone formed was then measured using a caliper. From the results of the research that has been done, it was found that the ethanol extract of raw Kepok banana peel (Musa paradisiaca forma typica) had inhibitory effect on the growth of Salmonella typhi and Shigella dysenteriae bacteria with the highest inhibition zone diameter of 11.36 mm and the lowest 6.45 mm for Salmonella typhi, and the highest inhibition zone for Shigella dysenteriae was 17.99 mm and the lowest was 15.13 mm. The minimum concentration of banana skin ethanol extract which had inhibitory power was 0.3125%.
FORMULASI DAN UJI EFEKTIVITAS MOUTHWASH KOMBINASI DAUN BINAHONG DAN DAUN KEMANGI Isnaeni Usman; Ismail Ismail; Jane Stefany Rambung; Ermi Reski Hijriah AR
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.271

Abstract

Dental caries and bad breath are oral health problems that are complaints by teenagers and children caused by Streptococcus mutans which is normal flora bacteria in the oral cavity but in large numbers, these bacteria can trigger the formation of dental plaque. This study aims to compare the antibacterial effectiveness of a single extract and extracts combination formulated in mouthwash. Basil and madeira-vine leaves are known to have antibacterial activity against several bacteria, one of them is Streptococcus mutans. Simplicia of madeira-vine and basil leaves were extracted by maceration using 70% ethanol and phytochemical screening tests has done on the extracts produced. Mouthwash formulation is performed using the bottle method and antibacterial activity test and its effectiveness are carried out using the agar diffusion method. Phytochemical screening result shows that basil leaves extract contains alkaloid and flavonoid, while madeira-vine leaves extract contains alkaloid and phenolic compounds. A single extract at a concentration of 7% had the most optimal inhibition of Streptococcus mutans while in the combination of extracts, the most optimal concentration ratio was shown at an extracts combination of madeira-vine : basil leaves 70:30. Mouthwash preparations are formulated in several formulas namely F1, F2, F3. Tests carried out before and after storage were expedited showing that F3 (a combination formula of madeira vine leaves extract : basil leaves 70:30) is the most stable and effective formula in inhibiting Streptococcus mutans.
PEMBUATAN VIRGIN COCONUT OIL (VCO) DENGAN METODE PENGASAMAN SEBAGAI KRIM TABIR SURYA BERBAHAN AKTIF TiO2 Agung Giri Samudra; Nurfijrin Ramadhani; Fathnur Sani K; Ulfa Febriyani
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.274

Abstract

Palm trees is one plantation commodities important in development sub the plantation sector, among others to meet the needs of domestic, and as a commodity export foreign exchange producing countries. Cream sunscreen is made with an emulsion phase (VCO, lanolin, stearic acid and cetyl alcohol) and aqueous phase (triethanolamine, glycerin, aquadest). TiO2 was added with various concentrations of F0 (0%), F1 (5%), F2 (10%), and F3 (15%). The research vco oil colorless and odorless typical fresh coconut. Produce the centrifugation does not happen the separation between the oil and the water pH value the range of 6.87-7.63; viscosity and range of cp 12400-21600; SPF value at F0 (0.189); F1 (2.857); F2 (4.252); F3 (6.154). Of the value of the two of them have met the standards according to the SPF concentration F2 and F3.
UJI EFEKTIVITAS ANTIBAKTERI ESKTRAK ETIL ASETAT BAWANG DAYAK (Eleutherine palmifolia Merr) TERHADAP STAPHYLOCOCCUS AUREUS DENGAN METODE SUMURAN Fitriyanti Fitriyanti; Abdurrazaq Abdurrazaq; Muhammad Nazarudin
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i2.278

Abstract

Dayak onion (Eleutherine palmifolia Merr.) is a multifunctional medicinal plant for various diseases, one of which is an antibacterial. Dayak Onions (E. palmifolia Merr.) contains an alkaloid, flavonoid, triterpenoid, and saponin compound which has antibacterial properties. This study aims to determine the effect of the ethyl acetate extract of Dayak Onion tubers inhibits the growth of Staphylococcus aureus bacteria. Dayak onion tuber was extracted using ethyl acetate solvent by the maceration method until thick extract was obtained. The concentration extract used were 30 mg/ml;15 mg/ml;7,5 mg/ml;3,75 mg/ml; 1,875 mg/ml; and 0,9375 mg/ml tested for antibacterial effectivity against Staphylococcus aureus using Mueller Hinton Agar (MHA) with the wells method. The result showed that the ethyl acetate of Dayak onion with MEC (Minimum effective concentration) 3,75 mg/ml obtained inhibition zone of 10,367 mm while at the highest concentration of 30 mg/ml had the best antibacterial effectiveness. The effective concentration of ethyl acetate onion of Dayak tuber which is 30 mg/ml obtained inhibition zone of 18,404 mm even in the moderate category.
FORMULASI EKTSTRAK POLIHERBAL KOMBINASI EKSTRAK TULANG CEKER AYAM TERHADAP BAKTERI STAPILOCOCUS AUREUS Joko Santoso; Heru Nurcahyo
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i2.279

Abstract

The development of traditional plants as herbal medicines continues to be increased, especially in local use. Aloe vera (Aloe vera), bay leaf (Eugenia polyantha) and Turmeric Rhizome (Curcuma domestica Val) have compounds that function as antibacterial. Chicken claw bones play a role in accelerating the growth of skin cells, but it also has the potential as an antibacterial. This combination is expected to increase the work of medicinal ingredients in killing bacteria. The work method begins with the selection of herbal ingredients, dry sorting, wet sorting and slicing. Drying the sample using an oven at a temperature of 40 which is then pollinated and sieved with 100 mesh. Before macerated with 70% ethanol solvent 1:10 ratio, the sample was tested microscopically. The extract was made of three formulas and tested for antibacterial activity in Stapilococus aureus bacteria using the well method. The antibacterial activity in formula 1 was 7.1mm, Formula 2 was 8.7mm and formula 3 was 10.2mm. Experiments were also carried out on extracts without collagen extracts with better inhibitory results compared to polyherbal extract combinations of collagen extracts. This research proves that polyherbal extract from chicken claw collagen extract has the ability of antibacterial activity. Formula 3 has the best inhibition compared to formulas 1 and 2.
FORMULASI DAN UJI KARAKTERISTIK FISIK SEDIAAN PATCH EKSTRAK ETANOL DAUN KUMIS KUCING (Orthosiphon stamineus) Arfiani Arifin; Muhammad Iqbal
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i2.280

Abstract

Various forms of medicine can provide options for using drugs to the public such as patch. The research purpose was to determine variation concentration of Polyvinylpirolidone (PVP) and Ethyl cellulose (EC) as polymer patch which obtain the best physical characteristics of the Orthosiphon stamineus leaves ethanol extract patch. The ethanol extract of Orthosiphon stamineus leaves was obtained through maceration method using 70% ethanol solvent. The extract was formulated in the form of patch using the solvent casting method. The result showed that the best physical characteristics patch formulation was the F3 formula (250 mg of EC and 25 mg of PVP) with organoleptic test (a brownish green color, square shape and characteristic odor), patch humidity ( 3,64%), the average weight uniformity test (0.567 gram ± 0.01) and the patch thickness test (0.375 mm ± 0.02).
EFEKTIFITAS EKSTRAK ETANOL DAUN RUMPUT MALAYSIA (Chromolaena odorata L) PADA LUKA DIABETES MENCIT JANTAN (Mus muscullus) Setya Enti Rikomah; Fiske Rani Firdita
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.282

Abstract

Diabetic wounds are a form of diabetic complications that results in wounds experiencing deeper tissue damage and a longer healing process due to the condition of hyperglycemia. One of the plants known to the community as a wound medicine is the Malaysian grass plant (Chromolaena odorata L). The purpose of this study was to determine whether the ethanol extract of Malaysian grass leaves can accelerate the wound healing process in diabetes mice.The research process using the induction of alloxan monohydrate and the wound observed in this study was a cut. Diabetes mice were injured along 1.5 cm on the back of the scalpel and then divided into 5 treatment groups namely not treated (KN), ointment Betadine® (KP), ethanol extract of Malaysian grass leaves at a dose of 5 mg (P1), 10 mg ( P2) and 15 mg (P3). Basting is done twice a day for 14 days.One Way Anova analysis results 0.033> 0.05 which shows that there are significant differences between each treatment group. In the study it was found that treatment group 3 with a dose of 15 mg better accelerated wound healing and followed by positive control and treatment group 1.
OPTIMASI KARBOPOL DAN HPMC DALAM FORMULASI GEL ANTIJERAWAT NANOPARTIKEL EKSTRAK DAUN SIRIH (Piper betle Linn) Dwi Saryanti; Dian Nugraheni; Nisa Sindi Astuti; Natasya Intania Pertiwi
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i2.293

Abstract

Gel is a semisolid preparation that is clear, translucent containing active ingredients, can provide a cool effect on the skin and good spread of the skin. The use of gelling agent in gel formulations greatly affects the physical properties of the resulting gel preparations. HPMC is a gel forming material that is neutral and can form a clear gel and can maintain the viscosity of the resulting gel, while carbopol are easily dispersed in water and produce preparations with sufficient viscosity. The research conducted aims to determine the comparison of carbopol and HPMC in the optimal gel formula of betel leaf extract nanoparticles with Simplex Lattice Design method. The response used was pH, viscosity, spreadability, adhesion and antibacterial activity against Staphylococcus aureus. The results obtained by carbopol concentration of 80.9% and HPMC 19.1% was the optimal gel formula of betel leaf extract nanoparticle. Based on the verification, an insignificant difference was obtained between the predictions of the software and the results of the tests performed. This shows that the method used was valid or can be trusted.

Page 15 of 33 | Total Record : 326

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