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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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PENGARUH METODE MASERASI DAN SOXHLETASI TERHADAP KADAR FLAVONOID EKSTRAK ETANOL DAUN KEMANGI (Ocimum basilicum L) Agung Budi Prasetyo; Maria Fatmadewi Imawati; Angga Rahabistara Sumadji
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 2 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i2.641

Abstract

Basil leaf (Ocimum basilicum L) is one of the plants which can be used as medicine, it can be used as an anti-microbial and an anti-free radical. Flavonoids were one of the chemical compounds in basil leaves (Ocimum basilicum L). This study aimed to compare the flavonoid total content level based on extraction method variance. The extraction methods were maceration and soxhletation. Flavonoid level was measured with Spectrophotometer UV-Vis and quercetin standard. Data results were analyzed with Mann-Whitney statistical test. The results showed that the flavonoid total content level from soxhletation was 9,3106% and from maceration was 6,2756%. The statistical test result showed that the significant value <0,05 which means there was a significant difference between the flavonoid total content level from maceration and soxhletation methods.
PENGEMBANGAN DAN VALIDASI KUESIONER UNTUK MENGUKUR PENGETAHUAN PENGGUNAAN ANTIBIOTIK PADA MASYARAKAT KOTA WILAYAH KEPULAUAN BANGKA BELITUNG Lana Sari; Mirnawati Zalili Sailan
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.642

Abstract

Diseases caused by bacteria are treated with antibiotics. Antibiotics can be a threat globally, especially related to high resistance rates. Research has found that 40-62% of antibiotics are abused for diseases that do not require antibiotics for treatment. The results of research conducted by WHO from 12 countries, one of which is Indonesia, as many as 53-62% stops using antibiotics if they feel they have recovered. This study aims to develop and validate a questionnaire used to measure knowledge of antibiotic use in the people of Pangkalpinang City, Archipelago Region. The study was conducted in Pangkalpinang City from May to June 2022. This study involved 10 pharmacists as a panel of experts and 30 residents of Pangkalpinang City. The sampling technique was cluster sampling and tested the validity and reliability of the questionnaire. The results of the content validity test obtained the value of the content validity index (I-CVI) of each statement item. The content validity test was carried out in two rounds and the I-CVI value was 0.94 so that it could be concluded that the questionnaire was valid with 42 statement items. After that, it was continued with validity and reliability tests involving 30 people in Pangkalpinang City. The results of this validity test obtained 39 valid statements, and for the reliability test, the KR 20 value was 0.8. Questionnaires can be used to measure the level of knowledge of the use of antibiotics in cities and communities on the island.
GAMBARAN TINGKAT PENGETAHUAN DAN PERILAKU MASYARAKAT TERHADAP SWAMEDIKASI PENYAKIT GASTRITIS DI DESA GAGAAN KABUPATEN BLORA Paulina Maya Octasari; Febyana Dewi Shinta
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 2 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i2.643

Abstract

Self-medication is an effort to treat the common health problems or symptoms without medical supervision. Although it has good intentions, self-medication also has the potential to be harm if it is not supported by adequate knowledge. The purpose of this study was to determine the level of community knowledge and attitude towards self-medication of gastritis in Gagaan Village, Blora Regency. This cross-sectional study was undertaken in Gagaan, Blora, Central Java, Indonesia. The study population consisted of people who had done self-medication about gastritis. The respondents were briefed about the nature of the study and the way to answer the pre-validated questionnaire. The type of questionnaire was closed ended questions for knowledge level assessment and likert scale questions for attitude level assessment. The data was analysed and were espressed as percentage. The questionnaire was administered to 113 respondents who had self-medicated for gastritis. Out of the 113 respondents, 64 (56,6%) were female and 49 (43,4%) were male; their mean age in years + SD was 33,15. + 13,94; 75 (66,4%) were worker; and 48 (42,5%) were undergraduate. Of the respondents, 92,9% had a high level of knowledge and 76,1% had a good attitude in the self-medication of gastritis. More than 70% (72,1%) respondents had a high knowledge level and good attitude. Knowledge of appropriate self-medication was high and attitude towards self-medication was good.
UJI EFEKTIVITAS EKSTRAK CIPLUKAN (PHYSALLIS ANGULATA) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS JANTAN GALUR WISTAR Liska Marlinda Sari; Haty Latifah Priatni; Azmi Darotulmutmainnah
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.644

Abstract

Ciplukan chemical compounds containing flavonoids. Flavonoid act as antioxidants. The ability of flavonoids as antioxidants can reduce oxidative stress and reduce ROS (Reactive Oxygen Species). This can lead to a protective effect on beta cells of the pancreas and increases insulin sensitivity. This study aims to determine the effectiveness and on how many levels extract ciplukan (Physallis angulata) which has effectivenes on reducing blood glucose in male rats induced by alloxan. This test uses an experimental method. Statistical data processing using one-way ANOVA and t-tes. This test is performed on 18 rats were divided into 6 group negative control which was given distilled water solution, positive control group treated with a solution of metformin, the normal group was not given any treatment, and the 3 group was given the extract solution ciplukan with a dose 3mg, 6mg, dan 9mg. The results showed the existence of differences in each extract treatment provision ciplukan. Of the 3 variants dose ciplukan extract the most effective in lowering blood glucose levels in male rats that 3mg dose, but by doing so the effect can not be equated with the positive control.
PENGARUH PENGETAHUAN DAN SIKAP TERHADAP PERILAKU PENGGUNAAN ANTIBIOTIK TANPA RESEP DOKTER Rahmayanti Fitriah; Eka Karlina; Depy Oktapian Akbar; Fitri Handayani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.653

Abstract

Antibiotics are drugs that are often prescribed, sold, and used throughout the world so that people still think that by using antibiotics all diseases can be cured. Many antibiotics are available without a prescription and cause someone to use antibiotics unwisely. The high use of antibiotics that are not appropriate in society causes antibiotic resistance. The purpose of this study was to determine the effect of knowledge and attitudes on the behavior of using antibiotics without a doctor's prescription in Ilung Pasar Lama Village, Batang Alai Utara District, Hulu Sungai Tengah Regency, South Kalimantan, Indonesia. This research is descriptive-analytic with a cross-sectional survey research design, sampling with a probability sampling technique. Data collection was carried out on 93 respondents using a questionnaire that had been tested for validity and reliability. The data analysis used was univariate and bivariate analysis with the chi-square test. The results showed that respondents had less knowledge of 55.9%, respondents who had less attitude of 63.4% and respondents who had less behavior of 38.7%. The results of the chi-square statistical test showed that there was no effect between knowledge on the behavior of using antibiotics without a doctor's prescription with a value of 0.118 (Sig. > 0.05) but there was an effect of attitudes towards the behavior of using antibiotics without a doctor's prescription with a value of 0.000 (Sig. <0, 05).
GAMBARAN RASIONALITAS PENGGUNAAN OBAT DIARE PADA BALITA PENDERITA DIARE AKUT Muhammad Akib Yuswar; Sofia Futria Wulandari; Nera Umilia Purwanti
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.656

Abstract

Diarrhea is the highest causes of death for children under five years of age in Indonesia 2019. Dehydration is one of the main causes of death in diarrhea. This study aims to find out the rationality for the use of diarrhea drugs in toddlers with acute diarrhea based on the degree of dehydration at the Sultan Syarif Mohamad Alkadrie Hospital Pontianak in 2020. The method used in this study is descriptive observational with a cross-sectional design. Data collection was carried out retrospectively, the sample was determined by purposive sampling method through searching medical record data. The results showed that the percentage rationality of using diarrhea drugs for acute watery diarrhea without dehydration based on the criteria for the right indication of (100%), the right patient of (100%), the right drug selection of (100%), the right dose of (78.57%), and the right duration of treatment of (100%); the percentage rationality of using diarrhea drugs for acute watery diarrhea with mild/moderate dehydration based on the criteria for the right indication of (100%), the right patient of (100%), the right drug selection of (62,40%), the right dose of (47.93%) and the right duration of treatment of (76.86 %) and the percentage rationality of using diarrhea drugs for acute watery diarrhea with severe dehydration based on the criteria for the right indication of (100%), right patient of (100%), the right drug selection of (90%), the right dose of (65%) and the right duration of treatment of (90%). The overall conclusion of this study is that the use of diarrhea drugs in toddlers is rational, but it needs to be considered again for drug dosing, especially in acute liquid diarrhea with mild/moderate dehydration because it has the smallest percentage of 47.93%.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MARKISA KUNING (Passiflora edulis var. flavicarpa degener) PADA BAKTERI Escherchia coli Panji Ratih Suci; Latiful Fauziyah; Pramudita Putra Dwi Ramadhan
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.658

Abstract

Diarrhea is a condition in which the body loses most of its fluids and electrolytes caused by defecating three or more times a day with a thick, fluid consistency. The purpose of this study was to determine the antibacterial activity of the ethanolic extract of passion fruit (Passiflora edulis var. flavicarpa Degener) to inhibit the growth of Escherichia coli bacteria. The extraction method used maceration with 70% ethanol solvent and then continued with the antibacterial activity test at a concentration of 10%, 20%, and 30% using the disk diffusion method with 3x replication. The results of the antibacterial activity test were analyzed by the method of one-way ANOVA followed by a post hoc test (Tukey). The results of data analysis showed that the ethanolic extract of yellow passion fruit leaves had activity to inhibit the growth of Escherichia coli bacteria with the average diameter of the inhibition zone at a concentration of 10% (3.85 mm), at a concentration of 20% (6.61 mm), at a concentration of 30% (11.69 mm), and in the data analysis test, a value (sig 0.05) was obtained, which means that there are differences in the antibacterial activity of each concentration and positive control.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL 50% BIJI PINANG (Areca catechu) DENGAN METODE DPPH (2,2-diphenyl-1-picryhydrazyl) Humaryanto; Fathnur Sani K; Yuliawati Yuliawati; Ave Olivia Rahman; Muhaimin Muhaimin
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.659

Abstract

Areca nut is a plant that contains secondary chemical metabolites of flavonoids, alkaloids, tannins, terpenoids, and steroids. Where content has activity as an antioxidant. The aim of this study were to determine the antioxidant activity of 50% ethanol extract of areca nut against DPPH free redicals based on the IC50 value. Extraction method using 50% ethanol with maceration method. The antioxidant activity test was made with 5 concentration series, namely 10 ppm, 50 ppm, 100 ppm, 150 ppm, and 200 ppm. The extract was tested for free radical scavenging against DPPH (2,2-diphenyl-1-picrylhydrazyl) with a wavelength of 517 nm using a UV-Vis spectrophotometer. The comparator used is Vitamin C. The results showed that the 50% ethanol extract of areca nut has a very strong category of antioxidant activity with an IC50 value of 27,565 ppm, while a positive control of Vitamin C has an IC50 value of 28,546 ppm. The conclusion obtained from the above results is that 50% ethanol extract has very strong antioxidant activity.
EFEKTIVITAS EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi L.) SECARA TOPIKAL TERHADAP PENYEMBUHAN LUKA PADA KELINCI (Oryctolagus cuniculus) Richa Dwi Novita Sari; Antonius Budiawan; Angga Rahabistara Sumadji
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.660

Abstract

Wound healing is a repair process of damaged skin tissue caused by injury. The bilimbi (Averrhoa bilimbi L.) plant is widely known to have potential in wound healing and the plant part that is commonly used is the leaves. The purpose of this study was to determine the wound healing effects of bilimbi leaf extract (Averrhoa bilimbi L.) on rabbits (Oryctolagus cuniculus) topically. The wound healing test was conducted using the New Zealand strain rabbit test animal. The rabbit’s back skin was induced with 8 mm diameter wound and the induced wounds were grouped into 5 groups. The groups included a negative control group that was given with aqua dest solution; the positive control group was given with betadine solution; treatment groups were given with 3%; 6%; and 12% bilimbi leaves extract. The wounds that were treated with betadine solution and bilimbi leaves extract 3% healed on day 13th. The wounds that were treated with bilimbi leaves extract 6 and 12% were healed on day 12nd. The different results showed by the wounds that were treated with aqua destilata which were healed on day 14th. The results showed that bilimbi leaf extract was topically effective in wound healing on rabbit test animals. The most effective concentration of bilimbi leaves extract in wound healing was 6% and 12%.
PENGEMBANGAN SEDIAAN TABLET ESTROGENIK DARI EKSTRAK RUMPUT KEBAR (Biophytum petersianum) MENGGUNAKAN VARIASI KONSENTRASI PENGIKAT PVP K-30 Wilda Nurhikmah; Erni Rustiani; Dania Triska Puspita
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.661

Abstract

Kebar grass (Biophytum petersianum Klotzsch) contains steroid, saponins, flavonoids, alkaloids, and triterpenoids. The use of Kebar grass extract can increase the development of follicles because it contains saponins which are the basic ingredients for the synthesis of steroid hormones and can improve the performance of reproductive system. This study aims to determine the quality the tablets made from Kebar grass extract with varying concentrations of PVP K-30 binder. Tablets were made in 3 formulas with varying concentrations of PVP K-30 as a binder, namely 2% (F1), 3% (F2), and 4% (F3). Methods of making tablets by wet granulation. Tablet quality testing includes organoleptic, weight uniformity, thickness, diameter, hardness, friability, and disintegration time. The flavonoid quercetin was used as a marker for tablet analysis. The results showed that the tablets were round in shape, white-gray in color, had a slightly bitter taste and had a characteristic aromatic odor. The average value of tablet weight uniformity is 290.06 – 306.45 mg (KV <5%), tablet diameter is 0.91 -0.92 cm, thickness is 0.41 – 0.48 cm, hardness is 4.06 – 7.95 kp, friability 0.17 – 0.21% and tablet disintegration time < 15 minutes. The results of the statistical analysis showed that the differences in the concentration of PVP K-30 did not affect the hardness and friability of the tablets (p> 0.05). The level of the flavonoid quercetin in the tablet is 0.17 – 0.21%. The conclusion that Kebar grass extract tablets can be made using PVP K-30 at a concentration of 2-4% as a binder and the quality of the tablets is not significantly different.

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