cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rusdiati Helmidanora
Contact Email
ejournal.akfarsam@gmail.com
Phone
+6285246812793
Journal Mail Official
ejournal.akfarsam@gmail.com
Editorial Address
Jl. Brig. Jend. Abdul Wahab Sjahranie No.226, Air Hitam, Samarinda, Kalimantan Timur, Indonesia
Location
Kota samarinda,
Kalimantan timur
INDONESIA
Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
 26   27   28   29   30 
AKTIVITAS PENURUNAN KADAR GLUKOSA DARAH TIKUS PADA EKSTRAK DAUN LIDAH MERTUA (Sansevieria trifasciata Prain) Rifda Naufa Lina; Hasty Martha Wijaya; Utatik
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.664

Abstract

Sansevieria trifasciata is one of the plants used as medicine, especially the leaves are used by the community as a lowering blood glucose. Flavonoid compounds contained in Sansevieria trifasciata’s leaves have antioxidant properties that protect pancreatic cells from free radicals. The purpose of this study was to determine the activity of the ethanol extract of Sansevieria trifasciata’s leaves in reducing blood glucose levels in rats. This research was conducted using the pre and post-test method with randomized control group design, using 5 treatment groups: negative control (CMC Na), positive control (Glibenclamide 0.09 mg/200 gBW) and 3 treatment groups with doses: 100, 150 and 200 mg/kgBB. All groups were induced with alloxan 150 mg/kgBW i.p for 3 consecutive days, then given treatment for 15 days. Data were analyzed statistically by ANOVA test with p <0.05 then followed by LSD test. The test results in this study showed that there was no significant difference between the positive controls at doses of 150 and 200 mg/kgBW with p>0.05. The highest activity was achieved by a dose of 200 mg/kgBW because it reduced blood glucose levels to the highest, namely 32.6 mg/dl on the 15th day.
OPTIMASI GEL EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi Linn) SEBAGAI ANTIBAKTERI Staphylococcus aureus Dwi Saryanti; Iwan Setiawan; Pingki Retnosari
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.666

Abstract

Belimbing wuluh leaves (DBW) are a plant that has antibacterial properties with active flavonoid compounds. The leaf extract with a concentration of 10% has a strong inhibitory ability against Staphylococcus aureus (SA) bacteria. Gel preparations have several advantages, including having water content with cooling, soothing, moisturizing properties, easy to use, easy to penetrate the skin, and provide a healing effect. The aim of this research was to determine the optimal comparison of CMC-Na and Carbopol 940 bases in starfruit leaf extract gel preparations using the Simplex lattice design (SLD) method and to evaluate the antibacterial activity on SA bacteria. DBW extraction uses a maceration extraction method using 96% ethanol. The optimal DBW extract gel formula was determined using the Simplex Lattice Design (SLD) method using Design Expert 11. Verification of the optimal DBW extract gel formula using one sample T-test. The antibacterial test on SA used the well method and the results were analyzed using One Way Anova. The optimal formula obtained was tested for stability using freeze thaw cycling and acceptability tested. The optimal concentration of CMC-Na and Carbopol 940 produced by the SLD method is CMC-Na of 35% (0.7 g) and Carbopol 940 of 65% (1.3 g) with a total base weight of 2g. The results of the antibacterial test showed that the gel preparation could inhibit SA bacteria with an inhibition zone of 14.43 ± 0.707 mm. The results of the optimal formula verification test obtained a p value of >0.05, so the data obtained was not significantly different and it can be said that the formula for the SLD method results was valid including pH, viscosity, spreadability, adhesion power. The optimal gel formula obtained shows that the preparation is stable in storage and can be accepted by respondents.
PERBANDINGAN KADAR DAN UJI MUTU FISIK INJEKSI DEXAMETHASONE SODIUM PHOSPHATE SEBELUM DAN SESUDAH MASA KADALUARSA SECARA SPEKTROFOTOMETRI UV-VIS Ruddat Ilaina Rahmah; Nur Anggreini Dwi Sasangka; Dian Marlina
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.668

Abstract

Corticosteroids are drugs that contain synthetic steroid hormones. Dexamethasone sodium phosphate injection is a sterile preparation where a sterile preparation when opened will be exposed to air and microorganism in the surrounding environment, so that drug levels and potency will decrease. The use of steroid injection includes the use that is often used in hospitals and makes stock increase, this increase in preparations which often makes expired preparations will increase and become a problem in every hospital. This study aimed to determine the effect of storage at room temperature and refrigerator temperature on the level and physical quality of dexamethasone sodium phosphate injection before and after expiration. This study used dexamethasone sodium phosphate injection before and after expiration. The raw material for dexamethasone sodium phosphate is listed on the COA, 2022. The injection was stored at room temperature (<300C) and refrigerator temperature (2-80C) within 14 days, then organoleptic observation, pH test, and assay were carried out using UV-VIS Spectrophotometry. Quantitative analysis was carried out by comparing the levels of dexamethasone injection before and after the expiration date based on the linear regression chart and the paired sample t-test. The results obtained show that storage at room temperature and refrigerator temperature does not affect organoleptic observations, pH at the levels of dexamethasone sodium phosphate injection before and after expiration. Testing of dexamethasone sodium phosphate injection levels before and after expiration at room temperature storage (<300C) did not have a significant difference, while dexamethasone sodium phosphate injection levels before and after expiration at refrigerator temperature storage (2-80C) had a significant difference.
AKTIVITAS ANTIBAKTERI SABUN PADAT EKSTRAK KULIT BUAH NANAS (Ananas comosus L.) PADA Escherichia coli Elly Purwati; Sih Wahyuni Raharjeng
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.670

Abstract

Pineapple skin is available in abundance, as much as 50-70% of pineapple fruit. However, this fruit peel is simply thrown away as waste, whereas pineapple peel contains many bioactive compounds such as flavonoids, carotenoids, alkaloids, saponins, and vitamin C. These compounds have various properties, one of which functions as an antibacterial. The purpose of this study was to determine the antibacterial activity of solid soap extract from pineapple peel (Ananas comosus L) with a concentration of 1% and 3% on Escherochia coli. The research method was experimental, making solid soap from pineapple peel extract 1% (F1) and 3% (F2). The extraction method was carried out using 70% ethanol solvent maceration and the bacterial inhibition test using disk diffusion. Chloramphenicol as a positive control. In conclusion, solid soap of pineapple peel extract (Ananas comosus L.) concentration of 3% is more effective than 1% in inhibiting Escherichia coli bacteria with an average inhibition zone of 20.5 mm, SPSS One Way Anova data states a value of 0.016 <0.05 which indicates there is a significant difference.
ISOLASI DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA METABOLIT SEKUNDER DARI EKSTRAK METANOL DAUN MARPUYAN (Rhodamnia cinerea Jack.) Musyirna Rahmah Nst; Dwi Andreyas; Rahma Dona; Emrizal; Emma Susanti; Ihsan Ikhtiarudin; Rahayu Utami
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.671

Abstract

A study on isolation and antibacterial activity of secondary metabolites from the methanol extract of Marpuyan (Rhodamnia cinerea Jack.) Leaves on Escherichia coli has been carried out. Isolation was carried out by column chromatography methods. Whereas the antibacterial activity test was carried out using agar diffusion method. The results of the isolation produced 17.9 mg of RC-F13 isolate compound in the form of light yellow crystals, with a melting point of 170-172oC and soluble in methanol. The results of identification of RC- F13 isolate compounds through testing with AlCl3 reagents, positive including the flavonoid group, were strengthened by the results of the UV spectrum and FT-IR spectrum. Based on the results of the UV spectrum, it was seen that the RC- F13 isolate compound showed λ max 353.60, 257.00 and 209.20 nm. The FT-IR spectrum shows the presence of several functional groups such as OH, C aliphatic C-H, C = O carbonyl, C = C aromatic and C-O. testing the antibacterial activity of methanol extract with a concentration of 20%; 10%; 1%; 0.1% and 0.01%, fraction 13 at 1% concentration; 0.1% and 0.01% and RC- F13 isolate compound concentration of 0.1%, against Escherichia coli bacteria did not show any antibacterial activity which was marked by the absence of clear areas around the disc.
PERBANDINGAN KANDUNGAN FLAVONOID EKSTRAK ETANOL DAUN DAN BUAH CEPOKA (SOLANUM TORVUM SWARTZ) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Fatdhilah Febyari; Bida Cincin Kirana; Angga Rahabistara Sumadji
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.672

Abstract

Cepoka (Solanum torvum Swartz.) included in the herbaceous plants it can be cultivated as a traditional medicinal material. The parts most used as traditional medicine are the leaves and fruits. Cepoka leaves contain alkaloid compounds, flavonoids, quinone, polyphenols, saponins, steroids, monoterpenoids. While in the fruit chemical content is alkaloid compounds, saponins, anthraquinone, tannins, flavonoids and glycosides. The purpose of this study is compared flavonoid levels in leaves and fruit cepoka. The extraction method uses maceration method with 96% ethanol solvent. Flavonoid level was measured with Spectrophotometer UV-Vis and quercetin standard.. The results of this study show that the content of flavonoids in the leaves cepoka amounted to 14.6346% W / W while the fruit contains cepoka flavonoids 0.9768% W / W.
PENGARUH TEMPAT PENYIMPANAN DI APOTEK TERHADAP KADAR VITAMIN C DALAM SEDIAAN TABLET Yohana Mitta Puspitasari; Erlien Dwi Cahyani; Leo Eladisa Ganjari
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.673

Abstract

Vitamin C is an unstable in storage. The stability of vitamin C is influenced by many factors such as temperature, pH, sunlight and the presence of heavy metals such as iron and copper. The purpose of this study was to determine differences in vitamin C levels in tablets based on storage areas with different lighting conditions at a pharmacy in Madiun. In this study, samples of vitamin C tablets were stored on the front shelf facing the entrance of the pharmacy which was exposed to indirect sunlight, the upper shelf which was exposed to the light, and the lower shelf which was protected from the light and sunlight, and. Storage was carried out for one month. Determination of vitamin C levels in tablet was determined using Spectrophotometry UV-Vis method, then the results were statistically analyzed using One Way Anova. The results showed that the levels of vitamin C in the tablets on the front shelf, upper shelf, and lower shelf were 95,56%, 97,67%, and 98,95% respectively. The results exhibit the lowest level of vitamin C was found on front storage, nonetheless there was no significantly difference levels from all storage location.
AKTIVITAS ANTIBAKTERI DARI SEDIAAN GEL EKSTRAK TERPURIFIKASI KELOPAK ROSELLA TERHADAP BAKTERI Escherichia coli Fita Sari; Ida Kristianingsih; Tri Puji Lestari; Fathul Hidayatul; Yuyun Wulandari
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.674

Abstract

Natural materials had various types of primary and secondary metabolite compounds that were useful for treating a disease. Plant materials that contain high levels of secondary metabolites could be developed into raw materials for traditional medicines. An example of the development of natural medicine which was in high demand is making traditional medicinal raw materials which have antibacterial properties. These could add to the type of therapy for a disease with smaller side effects. The aim of this study was to determine the activity of the purified extract gel preparation of rosella petals as an antibacterial. The extract was obtained from the maceration method which was then followed by purification. The antibacterial activity test in this study used the well diffusion method. Detection of metabolites by Thin Layer Chromatography (TLC) includes the stationary phase of silica GF254 and the mobile phase Toluene: Acetic acid: Formic acid (6:6:1). The concentration of purified extract of rosella petals for the formulation was 5, 15 and 25%. Data analysis was carried out with the One Way Anova test with a 95% confidence level. The results of the research that the purified extract gel preparation of rosella petals has the potential to inhibit the growth of Escherichia coli bacteria in the sensitive category at a concentration of 25%. The results of a positive phytochemical screening for flavonoid compounds were indicated by the formation of a red-orange color in the test and identification using TLC produced an Rf of 0.85 which has similarities with previous studies. The conclusion of this study was that the ETKR gel preparation with a concentration of 25% was sensitive as an antibacterial
PENETAPAN KADAR TOTAL FENOLIK-FLAVONOID EKSTRAK ETANOL 70% KULIT BATANG TANDUI (Mangifera rufocostata Kosterm.) Eka Fitri Susiani; Revita Saputri; Allisa Fanadia; Liana Fitriani Hasymi
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.676

Abstract

Tandui (Mangifera rufocostata Kosterm.) is a species of the genus Mangifera which is known to contain phenolic and flavonoid compounds and is one of the plants used as an alternative medicine by the people of South Kalimantan. The purpose of this study was to determine the total phenolic and flavonoid content of 70% ethanol extract of tandui bark. Qualitative analysis using phenolic and flavonoid phytochemical screening with 3% FeCl3, Mg-HCl reagents and Thin Layer Chromatography (TLC) with spot appearance 10% FeCl3 for phenolic and 5% AlCl3 for flavonoid compounds. Quantitative analysis using UV-Vis spectrophotometry, determination of total phenolic content using Folin-Ciocalteu reagent with gallic acid standard solution, while determination of total flavonoid content using AlCl3 reagent with quercetin standard solution. The results of identification of phenolic and flavonoid compounds by phytochemical screening and TLC showed that 70% ethanol extract of tandui bark contained phenolic and flavonoid. The results of the determination of the total phenolic content using UV-Vis spectrophotometry were 471.3126 mgGAE/g or 47.1312%, while the total flavonoid content was 872.075 mgQE/g extract or 87.2075%. Based on these results, it can be concluded that 70% ethanol extract of tandui bark contains secondary metabolites in the form of phenolics and flavonoids which have potential as medicine.
POTENSI ANTIBAKTERI GEL EKSTRAK ETANOL DAUN PARE (Momordica charantia L) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923 Afrida Tri Ningsih; Novena Yety Lindawati; Aulia Nur Rahmawati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.677

Abstract

Bacteria The main causes of skin infections among them caused by staphylococcus aureus bacteria, each infected network usually appears typical signs such as inflammation and abscess formation. Pare leaves (Momordica Charantia L.) can be used as antibacterial because they contain flavonoids, alkaloids, saponins, and tannins. This study aims to obtain a gel preparation of the pare leaf ethanol extract that has antibacterial activity against Staphylococcus aureus. Dietary leaf extract pare is done by Maceration method using 70% ethanol solvent. Deads are made with a concentration of 15%, 20% and 25%. The quality control test of the gel preparations include tests for homogeneity, organoleptic, dispersibility, adhesion, pH, viscosity and irritation then continued with antibacterial activity tests. The results showed that formula 3 (concentration 25%) met the requirements of the physical properties test including organoleptic test of green color, brownish concentrated, transparent, distinctive aroma, thick texture, homogeneous, has a pH of 5.8±0.0, viscosity 3100±0.0 cps, spreadability 5.3 ±0.27 cm, adhesion 1.22±0.02 seconds, and does not irritate the skin and has the greatest antibacterial activity. The antibacterial activity test showed that the diameter of the inhibition zones obtained in the ethanol extract gel preparations of pare leaves at concentrations of 15%, 20% and 25% were 16.58±0.33 mm, 17.87±0.78 mm, and 22.20±0.78 mm, respectively.

Page 28 of 33 | Total Record : 326

 26   27   28   29   30 

Filter by Year

2015 2025


Reset
Filter By Issues
All Issue Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 2 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 10 No. 1 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 2 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung Vol. 4 No. 1 (2018): Jurnal Ilmiah Manuntung Vol 4 No 1 (2018): Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung Vol 2 No 1 (2016): Jurnal Ilmiah Manuntung Vol 1 No 2 (2015): Jurnal Ilmiah Manuntung Vol 1 No 1 (2015): Jurnal Ilmiah Manuntung More Issue