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Waras Nurcholis
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Tropical Biopharmaca Research Center (TropBRC) IPB University CRC Building, 2nd Floor, STP Area IPB Taman Kencana Campus Taman Kencana St. No. 3, Bogor West Java, Indonesia 16128
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 212 Documents
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Bioactive Compounds, Pharmacological Activities, Toxicity Profiles, and Prospects for New Drug Discovery from Rhodomyrtus tomentosa (Karamunting) Jajang Japar Sodik; Entris Sutrisno; Taufik Muhammad Fakih
Jurnal Jamu Indonesia Vol. 11 No. 5 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i5.450

Abstract

Rhodomyrtus tomentosa (Karamunting) is an evergreen shrub of the Myrtaceae family traditionally used in South and Southeast Asia for treating diarrhea, dysentery, gynecological disorders, and wounds. Recent studies have identified diverse metabolites, especially triterpenoids, flavonoids, phenolics, and meroterpenoids, with rhodomyrtone as a key antibacterial compound. A review of 128 studies (2014–2024) shows that extracts and isolated compounds of Rhodomyrtus tomentosa exhibit strong antioxidant, antimicrobial, anti-inflammatory, and anticancer activities. Major bioactive compounds include rhodomyrtone, myricetin, gallic acid, ellagic acid, and piceatannol. Acute toxicity tests indicate safety up to 3,000 mg/kg BW, though nanoformulations may increase toxicity. Novel mechanisms, such as membrane protein trapping and antibiofilm effects, suggest potential against multidrug-resistant pathogens. Despite gaps in long-term toxicity and clinical data, Rhodomyrtus tomentosa holds promise as a source of new therapeutic agents. Keywords: Rhodomyrtus tomentosa; Karamunting; Bioactive compounds; Pharmacological activities; Antimicrobial.
Effect of Morinda citrifolia L. Ethanolic Leaf Extract on PancreaticHistopathology in Streptozotocin-Induced Diabetic Rats Yunlis S. Kenta; Niluh Puspita Dewi; Indah Kurnia Utami; Nur Ramadhani; Nani Astria Polontalo
Jurnal Jamu Indonesia Vol. 11 No. 5 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i5.467

Abstract

Morinda citrifolia L. (noni) is used in Indonesian jamu for diabetes, but evidence for its leaf is limited. This study evaluated its ethanolic leaf extract (MCLE) on pancreatic histopathology in streptozotocin (STZ)-induced diabetic rats. Thirty male rats were randomised into six groups (n = 5): normal and negative controls, glibenclamide (0.45 mg/kg BW), and MCLE at 250, 500 or 750 mg/kg BW orally for 28 days after confirmed diabetes (STZ 40 mg/kg BW). Haematoxylin–eosin-stained pancreata were graded on a 0–3 damage scale. Screening detected alkaloids, flavonoids, saponins, tannins and steroids. Pancreatic damage differed markedly among the groups (p < 0.001). Only the highest dose, 750 mg/kg BW, gave significantly less damage than the untreated diabetic control, reaching a condition indistinguishable from both healthy animals and glibenclamide. The 250 and 500 mg/kg BW doses did not differ from the untreated diabetic control. MCLE is therefore pancreatoprotective at 750 mg/kg BW only.
Potential Active Compounds from Cashew (Anacardium occidentale L.) Leaves against SARS-CoV-2 RNA-Dependent RNA Polymerase: An In Silico Study Willy Wijayanti; Nancy D Yuliana; Endang Prangdimurti; Setyanto Tri Wahyudi
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.476

Abstract

Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has driven the search for effective antiviral candidates. SARS-CoV-2 RNA replication is catalyzed by RNA-dependent RNA polymerase (RdRp), making this enzyme a potential target for antiviral drug development. Cashew (Anacardium occidentale L.) leaves are traditionally consumed in Southeast Asia, and several of their polyphenolic compounds have been reported to inhibit RNA-dependent RNA polymerases of other RNA viruses. This study aimed to identify potential SARS-CoV-2 RdRp inhibitors through molecular docking and molecular dynamics simulations and to evaluate their drug-likeness and predicted bioactivity. Five polyphenolic compounds formed stable interactions with RdRp, as indicated by RMSD, RMSF, interaction energy, and radius of gyration analyses. These compounds warrant further in vitro and in vivo evaluation as candidate SARS-CoV-2 RdRp inhibitors.
Supply Chain Network Optimization for Local Baccaurea Fruits from West Sulawesi as Herbal Medicine Raw Materials Heri Irawan; Fityan Shobar Setyawan; Syarif Hidayat; Aswan Munang
Jurnal Jamu Indonesia Vol. 11 No. 5 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i5.484

Abstract

Species of the genus Baccaurea (Phyllanthaceae) have reported medicinal properties and potential as herbal medicine raw materials, but an established supply chain is lacking. This study developed a preliminary supply chain network for Baccaurea fruits in West Sulawesi by identifying supply from 25 villages, selecting a distribution center (DC), and optimizing vehicle routes. Supply data were obtained through field surveys in September 2024, while demand was estimated using proxy data from comparable herbal raw materials. Mixed Integer Linear Programming identified Polewali Mandar Regency as the optimal DC location, with a total monthly supply chain cost of IDR 24,459,750. The Savings Matrix method generated four vehicle routes, and the Nearest Neighbor algorithm produced the shortest cumulative travel distance of 1,821.7 km. The proposed model provides a preliminary logistics framework, although further validation of supply variability, demand, postharvest quality, processing feasibility, and regulatory requirements is needed before industrial implementation. 
Ethnobotany of Medicinal Trees Used by the Dayak Meratus Community in Tumingki, Hulu Sungai Selatan, Indonesia Bayu Hari Mukti; Muhammad Rajuli; Budi Prayitno
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.515

Abstract

This study identified medicinal tree species used by the Dayak Meratus community in Tumingki, documented their traditional applications, and quantified their ethnobotanical importance. Data were collected through field observations, vegetation sampling in ten 20 × 20 m plots, and structured interviews with eight informants selected through snowball sampling. Use Report (UR), Use Value (UV), Frequency of Citation (FC), and Relative Frequency of Citation (RFC) were calculated. Sixteen tree species were recorded, eight of which (50%) were used medicinally. Bark was the most frequently used plant part (60%). Langsat had the highest UR (16) and UV (2.00), while langsat, keminting, jambu air, and durian were cited by all informants (FC = 8; RFC = 1.00). These findings document culturally important medicinal trees and provide a baseline for conserving local ethnomedicinal knowledge and guiding future pharmacological research.
LC-HRMS Metabolite Profiling, Antioxidant, and α-Glucosidase Inhibitory Activities of Averrhoa bilimbi L. Fruit Extracts by Maceration and Ultrasound-Assisted Extraction Lilik Sulastri; Siti Nurul Habibah; Ema Hermawati; Rikkit Rikkit
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.535

Abstract

Bilimbi fruit (Averrhoa bilimbi L.) contains bioactive compounds with antioxidant and α-glucosidase inhibitory potential. This study compared 70% ethanolic extracts prepared by maceration and ultrasound-assisted extraction (UAE) in terms of yield, total phenolic content (TPC), total flavonoid content (TFC), DPPH radical-scavenging activity, α-glucosidase inhibition, and LC-HRMS metabolite profiles. Maceration produced a higher yield than UAE (16.23% vs. 11.16%), whereas TPC and TFC were comparable. UAE showed lower DPPH IC₅₀ (37.06 ± 0.27 vs. 51.59 ± 0.21 µg/mL) and α-glucosidase IC₅₀ (23.94 vs. 33.45 µg/mL) than maceration. LC-HRMS yielded 24 tentative or probable metabolite annotations, of which seven were selected for focused interpretation. Because each extraction method was performed once and analytical measurements were technical replicates, between-method differences are descriptive. LC-HRMS findings were qualitative and do not establish quantitative enrichment or compound-specific causality.
Network Pharmacology and Molecular Docking Analysis of Zingiberaceae Bioactive Compounds as Candidate Adjuncts for Hypertension Therapy Asarini Asarini; Gemini Alam; Hermanus Ehe Hurit
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.541

Abstract

Hypertension remains a major cardiovascular risk factor, and plant-derived compounds may provide leads for adjunctive therapeutic development. This study evaluated bioactive compounds from six Zingiberaceae species using ADMET screening, network pharmacology, and molecular docking. Thirty-two compounds were screened with DeepPK using predicted human oral bioavailability (≥20%) and selected toxicity endpoints. Six compounds met the screening criteria: zingerone, isoborneol, terpinyl acetate, 1,8-cineole, linalool, and α-terpineol. SwissTargetPrediction, GeneCards, STRING, and Cytoscape analyses identified TNF as the highest-ranked hub by both degree and bottleneck metrics. Three independent native-ligand redocking runs against human TNF-α (PDB ID: 6OP0) yielded RMSD values below 2 Å. Pentoxifylline showed a Rerank Score of -43.846, whereas zingerone had the most favorable score among the selected plant compounds (-36.2546) and was predicted non-toxic for the screened endpoints. These computational findings prioritize zingerone for further experimental validation as a potential antihypertensive adjunct candidate.
Antidiabetic Activity of Pulutan (Urena lobata L.) and Temu Blenyeh (Curcuma purpurascens Blume) Leaf Extracts in Alloxan-Induced Mice Oktariani Pramiastuti; Nabiilah Febrianti Sausan; Endang Istriningsih
Jurnal Jamu Indonesia Vol. 11 No. 5 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i5.442

Abstract

Diabetes mellitus is a disorder of blood glucose regulation caused by impaired insulin secretion. This study aimed to determine the antidiabetic activity of a combination of pulutan leaf extract (Urena lobata L.) and temu blenyeh leaf extract (Curcuma purpurascens Blume) in reducing blood glucose levels. Twenty‑five male white mice were divided into five groups. Diabetes was induced with 120mg/kgBW alloxan, and blood glucose was measured three days later. The groups received metformin 65mg/kgBW, (positive control), distilled water (negative control), or a combination of pulutan (300mg/kgBW) and temu blenyeh (400mg/kgBW) leaf extracts at ratios of 25%:75%, 50%:50%, and 75%:25%. Blood glucose levels were measured on days 1, 3, 5, and 7. All three combinations reduced blood glucose relative to the negative control and did not differ from metformin on day 7; the greatest reduction, 69.85 ± 3.51%, was obtained with pulutan and temu blenyeh leaf extracts at 25%:75%.
Effect of Premna serratifolia Leaf Ethanol Extract on Pancreatic Histopathology in Hypercholesterolemic Diabetic Rats Wayan Wirawan; Niluh Puspita Dewi; Yasinta Rakanita; Matra Novalia Palipadang; Magfirah; Nuraisya; Ni Ketut Marlina
Jurnal Jamu Indonesia Vol. 11 No. 5 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i5.466

Abstract

This study evaluated the protective effect of Premna serratifolia leaf ethanol extract on pancreatic histopathology in hypercholesterolemic diabetic rats. Thirty male rats (n = 5/group) were assigned to normal, negative, and positive (metformin) controls and extract-treated groups (200, 300, and 400 mg/kg BW). Phytochemical screening detected alkaloids, flavonoids, saponins, and tannins in the extract. Pancreatic damage scores differed significantly among groups (Kruskal–Wallis H(5) = 20.13, p = 0.001, ε² = 0.63). After correcting for multiple comparisons, damage scores at 300 and 400 mg/kg were significantly lower than the negative control, while 200 mg/kg was not. No extract dose differed significantly from the positive control or from each other, so a clear dose-response pattern was not established; 300 mg/kg gave the numerically lowest mean damage score. These findings indicate that P. serratifolia leaf ethanol extract has a protective, though only partly dose-related, effect against pancreatic damage in hypercholesterolemic diabetic rats.
α-Glucosidase Inhibitory Activity and Total Flavonoid Content of Green and Purple Kale (Brassica oleracea L.) Leaf Extracts Wempi Budiana; Dewi Kurnia; Ina Rodinah
Jurnal Jamu Indonesia Vol. 11 No. 5 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i5.469

Abstract

Type 2 diabetes mellitus is managed in part by delaying carbohydrate digestion through α-glucosidase inhibition. Kale (Brassica oleracea L.) is rich in flavonoids, but green and purple kale have not been compared under identical extraction conditions. Leaves of both varieties were extracted sequentially by reflux with n-hexane, ethyl acetate, and 96% ethanol. α-Glucosidase inhibition was assayed in vitro with p-nitrophenyl-α-D-glucopyranoside, and total flavonoid content by the aluminum chloride method. IC50 values, in that solvent order, were 82.70, 59.87, and 77.32 µg/mL for green kale and 78.35, 52.25, and 76.80 µg/mL for purple kale, against 74.63 µg/mL for acarbose. Flavonoid content followed the same pattern: 24.61–32.71 mg QE/g extract in green kale and 26.02–35.97 mg QE/g extract in purple kale. The ethyl acetate extract of purple kale was the most active and the most flavonoid-rich, indicating that semi-polar constituents drive α-glucosidase inhibition by kale leaves.

Page 21 of 22 | Total Record : 212

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