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Fakultas Farmasi UMI, Kampus II UMI, Jl. Urip Sumoharjo No.225, Panaikang, Panakkukang, Kota, Makassar,, Panaikang, Kec. Panakkukang, Macassar, Sulawesi Selatan 90231
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MPSJ
Published by Universitas Muslim Indonesia
ISSN : -     EISSN : 29870887     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Makassar Pharmaceutical Science Journal merupakan salah satu jurnal yang dikelola oleh Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Maret 2023. Makassar Pharmaceutical Science Journal merupakan jurnal ilmiah yang terbit secara on-line dan menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang farmasi sains.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 100 Documents
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PENGARUH MINYAK ATSIRI KULIT BUAH JERUK NIPIS (Citrus aurantiifolia (Christm.) Swingle ) TERHADAP LARVA Aedes aegypti Tonang, Maswa Ruslan; Hasnaeni, Hasnaeni; Handayani, Virsa
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 1 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i1.3

Abstract

Lime peel (Citrus aurantiifolia (Christm.) Swingle) belongs to the Rutceae family. It contains essential oil, limonene and limonoid, with the potential as a larvicides. The research aimed to determine the effect of essential oil of lime peel against Aedes aegypti larvae. The method used was steam distillation to obtain the essential oil. The activity test was conducted by determining LC50 at the concentration of 250 ppm, 500 ppm, and 1000 ppm. Each concentration was tested for 10 Aedes aegypti mosquito larvae. The result showed that the essential oil of lime peel had the effect against Aedes aegypti larvae with the LC50 value of 151.356 µg/mL
STUDI KOMPARASI AKTIVITAS ANTIRADIKAL BEBAS ANTARA EKSTRAK METANOL DAUN DAN KULIT KAYU TUMBUHAN KEDONDONG PAGAR (Lannea coromandelica (Houtt.) Merr) DENGAN METODE PEREDAMAN SENYAWA 1,1-DIPHENYL -2-PICRYLHYDRAZIL (DPPH) Alwi, Asma; Najib, Ahmad; Waris, Risda
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 1 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i1.16

Abstract

Lannea coromandelica (Houtt.) Merr is one of the plants that hast he potential to have free antiradical activity. The research aimed to compare the free antiradical activity of methanol extract of the bark and leaves of Lannea coromandelica (Houtt.) Merr using the free radical reduction method 1.1 diphenhyl-2-picrylhydrazil (DPPH). The bark nd the leaves extract of the tree were obtained by maceration using methanol. The methanol extract preliminary tests were conducted by TLC using n-hexane: ethyl acetate (9 : 1) and ( 7: 3). The positive results for free antiradical aoctivity marked with purple to yellow spots after DPPH spraying was obtained. The thick bark and leaves extract were then quantitatively tested for free antiradical activity to obtain lC50 values using spectrophotometry at the maximum wavelength of 516 nm. The results of data analysis showed that methanol extract of its bark and leaves had lC50 of 20.778 µg / mL and 19.819 µg / mL, with ascorbic acid as a comparison having an lC50 value of 6.816 µg / mL. So it can be concluded that the methanol extract of the leaves of"Lannea coromandelica (Houtt) Merr has stronger anti-radical activity than its bark.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN KOPASANDA (Chromolaena odorata L.)TERHADAP KEMAMPUAN EPITELISASI PADA TIKUS (Rattus norvegicus) YANG DIINDUKSI LUKA BAKAR Sukmawati, Sukmawati; Auliawati, Auliawati; Syasmar, Andi Mustagfira
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 1 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i1.17

Abstract

Burns are injuries that are quite common. Severe types show a relatively high morbidity and degree of disability and the costs required for treatment are also high. Epithelialization is a tissue repair process with the growth of epithelium on the peeled surface. The research aimed to determine the effect and effective concentration of the ethanol extract of siam weed leaves (Chromolaena odorata L.) on the epithelialization effect of burn-induced rats. The research used 15 rats divided into 5 treatment groups, namely negative group (Sodium CMC), positive group (Lanakeloid®), ethanol extract of siam weed leaves group with concentrations of 10%, 20% and 40%. The induction of burns used a heat plate at a temperature of 100°C for 2 seconds on the back of the rats. The therapy was given twice a day for 28 days. The measurement of wound area was done on days -1, -3, -7, -9, -11, -14, -17, -21, -24, and -28. The data were statistically done using One Way Anova followed by further test of LSD (Least Significant Difference). The results showed that the positive control group was not significantly different from the extract given group with the concentrations of 10% and 20%, therefore, it can be concluded that the ethanol extract of siam weed leaves had an effect in accelerating the wound healing process in burn-induced rats with an effective concentration of 20%.
KESESUAIAN PENGKAJIAN RESEP RACIKAN PEDIATRI DI RSUD SIWA Aztriana, Aztriana; Mumtihanah, Andi; Kadir, Melly Amanda
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 1 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i1.18

Abstract

After receiving a prescription, it is the responsibility of a pharmacist to examine the prescription's administrative, pharmacological, and clinical components for completeness, suitability, and accuracy. This study aimed to examine the administrative, pharmacological, and clinical completeness of pediatric prescriptions at RSUD of Siwa pertinent to Minister of Health Regulation No. 72 of 2016 concerning Pharmaceutical Service Standards in Hospitals. This research was conducted at RSUD of Siwa Hospital using descriptive quantitative methodology. During the period of October to December 2021, 104 pediatric prescription sheets were collected retrospectively using the approach of purposive sampling, and 51 prescription sheets matched the inclusion criteria and data processing was then performed based on the completeness of administrative aspect, the suitability of pharmaceutical aspect and the clinical aspect. The results obtained on administrative aspect were as comprehensive as 67.91%, pharmacological aspects as comprehensive as 80%, clinical aspect of the drug interaction component as complete as 45%, and dosage accuracy as complete as 31,38%.
Studi Variasi Pelarut Terhadap Efek Antioksidan Pada Ekstrak Daun Bidara ( Ziziphus Jujube Mill ) Menggunakan Metode Peredaman Radikal Bebas 1,1-Difenil-2-Pikrilhidrazil (DPPH) Yusman, Dayandi; Risda, Waris; Ahmad, Najib
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 1 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i1.29

Abstract

Study On a Solvent Variation againtst the Antioxidant Effect on Red Date leaf Extract (Ziziphus Jujuba mill). by free Radical Scavanging 1,1-dipheyil-2-picrilhidrazil (DPPH). (Supervised by Ahmad Najib and Risda Waris) The research aimed to determine the differences of the antioxidant activities by three types of the extract variantions (Ziziphus Jujuba mill.) against DPPH (free radicals). Red date leaf extract was extracted by sequence maceration method by N-Hexane, ethyle acetal, and ethanol. The extract obtained was analyzed its antioxidant activity againts DPPH free radicals. The tests were conducted in 5 series concentration (20, 40, 60, 80 and 100) ppm using methanol. The activity on the free radicals, the absorbances were measured by a spectrophotometer at the maimum wavelength of 515 nm and calculated IC50 value. The results showed that n-hexane, ethyl acetate, and ethanol extract on the red date leaves had the activities with IC50 value with the very weak intensity as antioxidants ( >200 ppm)
Evaluasi Pengelolaan Sediaan Farmasi, Alat Kesehatan, dan Bahan Medis Habis Pakai di Apotek Chrysto Kabupaten Banggai Wanti, Ris; Nurlina, Nurlina; Aztriana, Aztriana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 4 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i4.31

Abstract

The implementation of pharmaceutical services in pharmacies must guarantee the availability of pharmaceutical preparations, medical devices and consumable medical materials that are safe, of good quality, useful and affordable. Therefore, pharmacists must understand and be aware of the possibility of errors in the management of pharmaceutical preparations, medical devices and consumable medical materials in pharmacies. This study aims to describe and evaluate the management of pharmaceutical preparations, medical devices, and medical consumables at the Chrysto Pharmacy, Banggai Regency. This research is a descriptive study with a qualitative approach using interviews, observation, and document review. The results of the study indicate that there are still several activities that have not been carried out, especially in planning activities that are still not optimal which results in frequent drug stock vacancies. In accordance with the standard regulations in Indonesia, namely the Regulation of the Minister of Health of the Republic of Indonesia Number 73 of 2016 and the 2019 Technical Guidelines for Pharmaceutical Service Standards in Pharmacies, the management of pharmaceutical preparations, medical devices and consumable medical materials at the Chrysto Pharmacy, Banggai Regency is in the good category with a percentage value of 66%.
ANALISIS KANDUNGAN SENYAWA FENOLIK DAN TANIN PADA ISOLA FUNGI ENDOFIT (IFEBK20) BUNGA KERSEN (Muntingia calabura L) DENGAN METODE SPEKTROFOTOMETRI UV-VIS p, irmawan jamal; Maryam, St.; Suhaenah, Asriani
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.33

Abstract

Bunga Kersen (Muntingia calabura L.) mengandung fungi endofit yang mampu menghasilkan metabolit sekunder yang sama dengan sel inangnya, dimana metabolit sekunder ini dari isolat fungi endofit IFEBK20 seperti senyawa fenol dan tanin yang merupakan kelompok senyawa fenolik terbesar. Pada penelitian ini bertujuan untuk mengetahui berapa kadar senyawa fenolik dan tanin yang dihasilkan dari isolat fungi endofit bunga kersen (Muntingia calabura L.) secara kuantitatif menggunakan metode spektrofotometri UV-Vis. Dari hasil penelitian menunjukkan bahwa ekstrak isolat IFEBK20 bunga kersen (Muntingia calabura L.) mengandung senyawa fenol dan tanin. Secara kuantitatif ekstrak isolat IFEBK20 bunga kersen (Muntingia calabura L.) diukur pada panjang gelombang maksimum 739,901 nm untuk fenol dengan baku pembanding asam galat, dan diukur pada panjang gelombang maksimum 738,578 nm untuk tanin dengan baku pembanding asam tanat. Hasil penelitian menunjukkan bahwa kadar rata-rata ekstrak isolate IFEBK20 bunga kersen (Muntingia calabura L.) mengandung senyawa fenol sebesar 21,447 mgGAE/g ekstrak atau 2,144 % b/b GAE, dan senyawa tanin sebesar 31,584 mgTAE/g ekstrak atau 3,158 %
Formulasi serum ekstrak daun kemangi (Ocimum basilicum L.) sebagai antioksidan khusnia, Khusnia; Mumtihanah, A.; Zulkarnain, Iskandar
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.39

Abstract

Flavonoid content in basil leaves can be used as an antioxidant. Serum is a preparation that is formulated from high concentrations of active substances so that the effect is absorbed more quickly by the skin. The purpose of this study was to formulate basil leaf extract serum as an antioxidant using an experimental method. Evaluation test and antioxidant test using basil leaf extract concentrations of 0.06%, 0.30%, 0.6%. Evaluation of serum preparations was carried out with parameters namely organoleptic test, homogeneity test, pH test, spreadability test, Viscosity test, stability test, and antioxidant test with the DPPH method. The results showed that after stability testing for 6 cycles the serum formula did not change color, homogeneous conditions, the average formula pH was F1 (4.659 ± 0.007), F2 (4.826 ± 0.002), F3 (4.981 ± 0.001), the viscosity of the preparation F1 ( 2356 ± 40.412 cps), F2 (2285 ± 5 cps), F3 (2176 ± 1.572 cps), the average spread of the preparation was 5.2-6.3 cm. it was concluded that the serum formula gave good results and fulfilled the parameter requirements for evaluating the physical quality of the preparation. The antioxidant test results of the serum basil leaf extract formula had IC50 values in F1 (94.605 µg/mL), F2 (74.900 µg/mL), F3 (54.695 µg/mL) the three formulas were categorized into strong antioxidants.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kayu Jawa (Lannea coromandelica (Houtt.) Merr.) Terhadap Bakteri Penyebab Infeksi Kulit Dengan Metode Difusi Agar Kayla, Aulia Putri; Fitriana, Fitriana; Nuryanti, Siska
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.40

Abstract

The purpose of this study was to determine the antibacterial activity of ethanol extract of Java wood leaves (Lannea coromandelica (Houtt.) Merr.) against bacteria that cause skin infections. The research method begins with an extraction process using the maceration method with 96% ethanol solvent and evaporated using a rotavapor. Java wood leaf ethanol extract was screened with a concentration of 0.1%; 0,5%; and 1% against bacteria Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Propionibacterium acnes. MIC and MBC tests were carried out and antibacterial activity tests were continued using the agar diffusion method with a concentration variation of 0.8%; 1,6%; 3,2%; 6,4%; and 12.8%. Screening test results of Staphylococcus aureus bacteria at 0.5% and Propionibacterium acnes bacteria at 0.1%. MIC value against Staphylococcus aureus bacteria at 0.2% and Propionibacterium acnes bacteria at 0.05%. While the MBC value against Staphylococcus aureus bacteria at 0.8% and Propionibacterium acnes bacteria at 1.6%. The results of testing the antibacterial activity of ethanol extract of Java wood leaves against Staphylococcus aureus and Propionibacterium acnes bacteria had the largest inhibitory zone diameter at a concentration of 12.8% of 11.32 mm and 12.83 mm respectively. Based on the results of research, ethanol extract of Java wood leaves has potential as an antibacterial.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kayu Jawa (Lannea coromandelica (Houtt.) Merr.) Terhadap Bakteri Penyebab Infeksi Saluran Pencernaan Dengan Metode Difusi Agar Rabbana, Rahmawati; Kosman, Rachmat; Nuryanti, Siska
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.41

Abstract

The purpose of this research was to determine the antibacterial activity of the ethanol extract of Javanwood leaves Lannea coromandelica (Houtt.) Merr.) against bacteria that cause digestive tract infections. The research method begins with the extraction process using the maceration method with 96% ethanol solvent and evaporated using a rotary evaporator. Java wood leaf ethanol extract was subjected to screening tests with a concentration of 0.1%; 0.5%; and 1% against the test bacteria Eschericia coli, Salmonella typhi, Shigella dysenteriae and Vibrio cholerae. MIC and MBC tests were carried out and continued with antibacterial activity tests using the agar diffusion method with variations in concentrations of 0.5%; 1%; 2%; 4%; 8%; and 16%. The results of the screening test for Escherichia coli and Shigella dysenteriae bacteria at 0.5%. MIC values for Escherichia coli bacteria at 0.125% and Shigella dysenteriae bacteria at 2%. While the MBC value for Escherichia coli bacteria is at 0.5% and Shigella dysenteriae bacteria at 2%. The results of testing the antibacterial activity of the ethanol extract of Javanwood leaves against Escherichia coli and Shigella dysenteriae bacteria had the largest diameter of the inhibition zone at a concentration of 16%, respectively 17.10 mm; and 13.56 mm which is included in the criteria of having strong inhibition. Based on the results of the ethanol extract of Javanwood leaves, it has potential as an antibacterial.

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