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Fakultas Farmasi UMI, Kampus II UMI, Jl. Urip Sumoharjo No.225, Panaikang, Panakkukang, Kota, Makassar,, Panaikang, Kec. Panakkukang, Macassar, Sulawesi Selatan 90231
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MPSJ
Published by Universitas Muslim Indonesia
ISSN : -     EISSN : 29870887     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Makassar Pharmaceutical Science Journal merupakan salah satu jurnal yang dikelola oleh Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Maret 2023. Makassar Pharmaceutical Science Journal merupakan jurnal ilmiah yang terbit secara on-line dan menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang farmasi sains.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 100 Documents
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Antibacterial Activity Test of Tembelekan Leaf Ethanol Extract (Lantana camara L) Against Bacteria Causing Gastrointestinal Tract Infections Hajar, Siti; Fitriana, Fitriana; Asmaliani, Ira
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.51

Abstract

Tembelekan leaves have been shown to be efficacious as antioxidants, anticancer, antibiotics, antibacterial, which are known to contain alkaloids, saponins, flavonoids, and tannins. The purpose of this study was to determine the antibacterial activity of the ethanol extract of tembelekan leaves (Lantana camara L) against bacteria that cause digestive tract infections. The method used in this research is agar diffusion. Antibacterial screening test with concentrations of 0.1%, 0.5% and 1% against test bacteria E.Coli, S.Dysenteriae, V.Cholerae, S.Typhi. After that, MIC, KBM, and antibacterial activity testing were carried out. The results of the screening test gave activity at a concentration of 1% against the four test bacteria. The MIC test value obtained a concentration of 0.5% on E. Coli bacteria and V. cholerae bacteria, a concentration of 0.25% on S. Dysentriae bacteria and S. typhi bacteria. KBM value of 1% concentration on E. coli and V. Cholerae bacteria, 0.5% concentration on S. Dysentriae and S.typhi bacteria. The results of the antibacterial activity test of the ethanol extract of tembelekan leaves against the test bacteria obtained the largest diameter of the inhibition zone at a concentration of 20%. Based on the research, the ethanol extract of tembelekan leaves has antibacterial activity.
ANALISIS PENGELOLAAN OBAT DI PUSKESMAS WAARA KABUPATEN MUNA SULAWESI TENGGARA Khofifah, Dien Noor
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 4 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i4.65

Abstract

Drug management is a series in health development which involves several aspects, namely needs planning, demand, acceptance, storage, distribution, control, recording and reporting, as well as monitoring and evaluation. The purpose of this study was to determine drug management at the Waara Health Center, Muna Regency, Southeast Sulawesi and its compliance with regulations in force in Indonesia. This research is descriptive in nature, collecting data through observation, document review and interviews with the person in charge of the pharmacy. The results of the study showed that: drug management was in accordance with pharmaceutical service standards at the puskesmas with a percentage value of 100% conformity based on applicable regulations, while in the planning aspect the need to obtain a percentage result of 88.8%, on the storage aspect of the percentage results obtained, namely 91.66% and on the recording and reporting of the percentage results obtained, namely 93.33%. This indicates that drug management at the Waara health center still does not meet drug management standards in accordance with the Regulation of the Minister of Health no.74 of 2016 and the Ministry of Health of 2019.
Profil Pengkajian Resep Racikan Pediatri Pasien Rawat Jalan di Rumah Sakit Umum Daerah Labuang Baji Periode Bulan Juni-Desember 2022 Annisyah, Nur; Ririn, Ririn; Azizah, Rizqi Nur
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.68

Abstract

Prescription screening is one of the pharmaceutical services used to minimize the occurrence of errors in drug prescribing. The purpose of this study was to review the prescription of pediatric concoctions for outpatients in June-December 2022 at Labuang Baji Hospital based on Permenkes No. 72 of 2016 concerning Pharmaceutical Service Standards in Hospitals. non-experimental descriptive research with data collection was carried out retrospectively. The population in this study was 217 prescription sheets. The results showed the percentage of completeness of administrative aspects, namely patient name 98%, patient age 41%, gender 0%, body weight 25%, height 1%, doctor's name 91%, address and doctor's signature and license number 100%, prescription date 93%, prescription origin unit 95%. The suitability of the pharmaceutical aspects, namely the name of the drug, dosage form, amount of drug, rules and methods of use 100%, dosage strength 0%, no incompatibility, 35% hygroscopic & 65% photolysis. The suitability of clinical aspects, namely the accuracy of the indication and the accuracy of the time of use of 100%, there were no drugs that were duplicated, for the accuracy of the dose there were 9% overdose and 5% underdose. From the results of this study it can be concluded that the prescription at Labuang Baji Hospital has not fully met the suitability of the prescription based on Permenkes RI No. 72 of 2016 concerning Pharmaceutical Service Standards in Hospitals.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Benalu Batu (Begonia medicinalis) Terhadap Bakteri Uji Penyebab Infeksi Saluran Pencernaan pratiwi, dita; Fitriana, Fitriana; Amirah, Sitti
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.70

Abstract

Benalu batu (Begonia medicinalis) mengandung senyawa sekunder seperti polifenol, saponin, flavonoid, dan tannin yang mempunyai aktivitas sebagai antimikroba. Penelitian ini bertujuan untuk mengetahui aktivitas antimikroba dari ekstrak etanol daun benalu batu terhadap bakteri penyebab infeksi saluran pencernaan. Hasil penelitian yang diperoleh pada uji skrining terhadap bakteri uji Escherichia coli, Salmonella typhi, Shigella dysenteriae, dan Vibrio chloreae memberikan aktivitas pada konsentrasi 6% untuk bakteri E. Coli, S. dysentriae V. Cholerae. Pengujian dilanjutkan dengan penentuan nilai KHM menggunakan metode dilusi cair dan KBM menggunakan metode dilusi padat. Hasil uji KHM yang diperoleh pada konsentrasi 18% terhadap bakteri uji. Hasil uji KBM yang diperoleh yaitu 18% untuk bakteri E. Coli, 12% untuk bakteri S.Dysentriae, dan 6% untuk bakteri V. Cholerae. Selanjutnya dilakukan pengujian aktivitas antimikroba menggunakan metode difusi agar dengan seri konsentrasi yaitu 18%, 24%, dan 30%. Hasil uji aktivitas antibakteri ekstrak etanol daun benalu batu diperoleh diameter zona hambatan terbesar pada konsentrasi 30%. Hasil uji statistik data diameter zona hambatan menunjukkan adanya perbedaan kemampuan penghambatan pertumbuhan bakteri antara konsentrasi 18% dan 24% serta 18% dan 30%, kemudian antara konsentrasi 24% dan 30% memiliki kemampuan yang sama dalam menghambat pertumbuhan bakteri. Berdasarkan penelitian, ekstrak etanol daun benalu batu memiliki potensi sebagai antibakteri.
UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL BIJI ALPUKAT (Persea americana Mill.) SECARA IN VITRO DENGAN MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Zulhijja .S, Faradiba; Abidin, Zainal; Wati, Aulia
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.75

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia, which is caused by insulin resistance and dysfunction of insulin secretion. Avocado is used as a traditional medicine to treat various diseases, one of which is the seed of the avocado which contains alkaloids, polyphenols, tannins, flavonoids, triterpenoids, quinones, saponins, monoterpenes and sesquiterpenes and can lower blood glucose levels. The aim of this study was to determine the antidiabetic potential of ethanol extract of avocado seeds (Persea americana Mill.) in vitro using the Nelson Somogyi method. The test began with preparing a series of sample ethanol extract concentrations with concentrations of 40, 50 and 60 ppm using a UV-Vis spectrophotometer measured at a wavelength of 745 nm. The results of testing the anti-diabetic activity by the test samples were able to show the effectiveness of reducing glucose levels in vitro by showing the EC50 value in the ethanol extract sample was 59.1018 μg/mL. From the results of the study it can be concluded that the ethanol extract of avocado seeds (Persea americana Mill) has activity in reducing glucose levels.
UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT DAUN KARET KEBO (Ficus elastica) DENGAN MENGGUNAKAN METODE FRAP Hasyim, Amita; Suhaenah, Asriani; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.76

Abstract

Free radicals are atoms, molecules or compounds that can stand alone, having one or more unpaired electrons in their outermost orbitals. Antioxidants are molecules that are able to deactivate or stabilize free radicals. The kebo rubber leaf plant is known to have benefits as an antioxidant because it contains ingredients such as glycosides, flavonoids, phenolic acids, alkaloids, steroids, saponins, coumarins, tannins, and triterpenoids. The aim of this research was to test the antioxidant activity of the ethyl acetate fraction of kebo rubber leaves (Ficus elatica) using the FRAP (Ferric Reducing Antioxidant Power) method. The rubber kebo leaf extraction method uses the maceration method with 96% ethanol solvent. The ethanol extract was fractionated using the liquid-liquid partition method to obtain the ethyl acetate fraction. the sample fraction was added with several FRAP reagents and then measured using a UV-Vis spectrophotometer at a maximum wavelength of 712 nm with quercetin as a comparison. The results showed that the ethyl acetate fraction of kebo rubber leaves for antioxidant activity was 26.692 mgQE/g fraction.
antioxidant capacity of ethanol extract of garlic (Allium sativum) in vitro Amirna, Nina
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 4 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i4.77

Abstract

Garlic is one type of plant that is familiar in everyday life and has a very important function for human life. The purpose of this study was to determine the antioxidant capacity of the ethanol extract of garlic (allium sativum). This type of research was a laboratory experiment using the spectrophotometer method based on the calculation of the IC550 value of the extract at the value of y = 0.9983x + 16.763 (r = 9983) ; and IC550 value of 107.493 µg/mL. The results of this study illustrate that the ethanol extract of garlic has an antioxidant effect against DPPH free radicals.
Gambaran Pengetahuan Masyarakat Terhadap Penggunaan Analgesik OTC (Over The Counter) Di Kecamatan Wawonii Timur Kabupaten Konawe Kepulauan Provinsi Sulawesi Tenggara Yuliana, Dewi
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 4 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i4.79

Abstract

Analgesics are substances or drugs that can be used to reduce pain without losing consciousness. This drug is the most widely used type of drug in self-medication in society. This study aims to describe the knowledge of the people of East Wawonii District, Konawe Islands Regency, Southeast Sulawesi Province. This research was conducted by giving questionnaires to respondents, namely the people in East Wawonii District, Konawe Islands Regency, which then collected data and analyzed it descriptively. The sampling method used was purposive sampling and the number of samples was calculated using the slovin formula. The results showed that people in East Wawonii District, Konawe Islands Regency, Southeast Sulawesi Province already had knowledge that was included in the fairly good category regarding the use of OTC (Over The Counter) analgesics with a percentage of 73%.
AKTIVITAS INHIBISI ENZIM ALFA-GLUKOSIDASE DARI EKSTRAK BUNGA KERSEN (Muntingia calabura L.) SECARA IN VITRO Azzahra, Resqinah; Maryam, St.; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.80

Abstract

The cherry tree is one of the plants that has great potential to be utilized because it contains several beneficial bioactive compounds, one of which is flavonoids.. The purpose of this research is to determine the alpha-glucosidase enzyme inhibition activity of an ethanol extract of cherry blossoms (Muntingia calabura L.) in vitro using a microplate reader instrument. The research method begins with preparing the sample by maceration using 96% ethanol as a solvent, followed by testing the inhibition of alpha-glucosidase enzyme activity using p-nitrophenyl- α-D-glucopyranoside (PNPG) substrate and acarbose as a comparison. The potential of a compound to inhibit enzyme activity can be determined by calculating the IC50. The results showed that the ethanol extract of cherry blossoms (Muntingia calabura L.) has an IC50 value of 135.53 µg/mL, higher than the IC50 value of acarbose at 41.17 µg/mL.
AKTIVITAS ANTIBAKTERI FRAKSINASI EKSTRAK DAUN ASAM JAWA (Tamarindus indica L.) (Tamarindus indica L.) TERHADAP BAKTERI Salmonella thyphi DAN Escherichia coli DENGAN METODE KLT-BIOAUTOGRAFI Rusli, Rusli; Faradila, Aulia; Kosman, Rachmat
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.87

Abstract

Tropical infectious diseases are often caused by viruses, bacteria, fungi or even parasites. Indonesian people use medical plants to treats diseases. One of them is tamarind leaves which have the ability as an antibacterial. The purpose of this study was to determine the antibacterial activity of the fractionated extract of tamarind leaves (Tamarindus indica L.) against Salmonella thyphi and Escherichia coli. Tamarind leaf simplicial was extracted using the maceration method and evaporated with a rotary evaporator to obtain thick extract. Then fractionated using n-hexane and ethyl acetate and evaporated again with a rotary evaporator. After that, ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) was used for antibacterial screening test with a concentration of 0,1% and 0,5%. Then, the TLC-Bioautography test was carried out and followed by the identification of chemical components. The results of the screening test of the ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) showed antibacterial activity against Salmonella thyphi and Escherichia coli. TLC-Bioautography test result showed that it was active on Salmonella thyphi and Escherichia coli with an Rf value of 0,81. Then the results of the identification of the chemical component of the ethyl acetate fraction of tamarind leaves (Tamarindus indica L.) were positive for alkaloid and taninns. Based on this study, tamarind leaves have the potential as an antibacterial.

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