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Fakultas Farmasi UMI, Kampus II UMI, Jl. Urip Sumoharjo No.225, Panaikang, Panakkukang, Kota, Makassar,, Panaikang, Kec. Panakkukang, Macassar, Sulawesi Selatan 90231
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MPSJ
Published by Universitas Muslim Indonesia
ISSN : -     EISSN : 29870887     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Makassar Pharmaceutical Science Journal merupakan salah satu jurnal yang dikelola oleh Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Maret 2023. Makassar Pharmaceutical Science Journal merupakan jurnal ilmiah yang terbit secara on-line dan menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang farmasi sains.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 100 Documents
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Uji Aktivitas Ekstrak Etanol Daun Kenikir (Cosmos caudatus Kunth.) Dengan Metode DPPH Abidin, Zainal; Aminah, Aminah; Sari, Nurmala
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 3 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i3.297

Abstract

Kenikir (Cosmos caudatus Kunth.) is a traditional vegetable that can be eaten raw or cooked as a vegetable. This plant is also used for food flavoring and traditional medicine. In addition, several nutritional and medical studies show that Kenikir is rich in bioactive compounds such as flavonoids, phenols, carbohydrates, minerals, proteins and vitamins, which can increase its nutritional value. This study aims to determine the antioxidant activity of ethanol extract of kenikir leaves (Cosmos caudatus Kunth) using the DPPH method. The results showed that the ethanol extract of kenikir leaves (C. caudatus Kunth) had high antioxidant activity. Antioxidants are substances that can delay, slow down and prevent oxidation. Antioxidants are very beneficial for health and play an important role in maintaining the quality of food products. The antioxidant activity is in the very strong category (<50 ppm), namely 25,212 ppm. The macerated extract showed the highest antioxidant activity because it contained many secondary metabolites such as flavonoids and phenolics.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN KENIKIR (Cosmos caudatus Kunth) DENGAN METODE FERRIC REDUCING ANTIOXIDANT POWER Abidin, Zainal; Salsabila Ihsan, Nur Rifdah; Aminah, Aminah
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 4 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i4.298

Abstract

Antioxidants are defined as inhibitors that work with the oxidation process, even at relatively small concentrations. Antioxidants are substances that can delay, slow down and prevent the oxidation process. Kenikir leaves contain flavonoid compounds, polyphenols, saponins, tannins, alkaloids and essential oils and also contain bioactive compounds such as ascorbic acid, quercetin, chlorogenic acid and polyphenolic compounds which function as antioxidants. The aim of this research was to determine the antioxidant activity test of the ethanol extract of Kenikir leaves using the FRAP (Ferric Reducing Antioxidant Power) method. The Kenikir leaf extraction method uses the maceration method with 96% ethanol solvent to obtain Kenikir leaf ethanol extract. The ethanol extract of Kenikir leaves was reacted with several FRAP reagents and then measured using a UV-Vis spectrophotometer at a maximum wavelength of 720 nm. Quercetin as a comparison with the quercetin test results obtained a linearity equation of y = 0.0117x + 0.4212 with a correlation coefficient value of r = 0.9986. The results showed that the ethanol extract of Kenikir leaves had an antioxidant activity of 12.7464 mgQE/g extract.
POTENSI AKTIVITAS ANTIBAKTERI FUNGI ENDOFIT DAUN PARANG ROMANG (Boehmeria virgata) (G.Forst.) Guill TERHADAP BAKTERI UJI MICROCOCCUS LUTEUS DAN BACILLUS SUBTILIS SECARA KLT-BIOAUTOGRAFI FITRIANI, SITTI ANNISA; Kosman, Rachmat; Rusli, Rusli
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 4 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i4.299

Abstract

Parang romang (Boehmeria virgata (G.Forst) Guill) is a plant used to treat various infectious diseases, one of which is the digestive tract. Antibacterials are compounds that can inhibit or kill bacteria that cause infection. Endophytic fungi produce bioactive compounds in the form of antioxidants, anticancer, antiviral, antifungal and so on. This research uses the TLC-Bioatography method. The research started with the isolation of endophytic fungi and antagonist tests, which obtained active isolates against the test bacteria Micrococcus luteus and Bacillus subtilis, namely IFBV-6. Then this isolate was fermented and continued with testing using the TLC-Bioautography method. The resulting fermentate was dissolved in chloroform:methanol (5:1) solvent. Test results from TLC-Bioautography of IFBV-6 fermentate showed Rf values ​​of 0.9, 0.81 and 0.58. In the case of Micrococcus luteus and bacillus subtilis bacteria, good Rf values ​​from TLC show that there is quite good separation, ranging from 0.2-0.8, indicating clear antibacterial activity. In this test, each fermentation code has the same Rf value and number of spots. The results of identifying the chemical components of endophytic fungal isolates from parang romang leaves of Boehmeria virgata (G.Forst) Guill) gave positive results using alkaloid and saponin spotting.
Antioxidant Activity ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT OF RED BAJAKAH KALALAWIT ROOTS (Uncaria gambir Roxb) USING THE FRAP METHOD Aris, Arru'nnisa Ika Nur Ilmi; Baits, Muzakkir; Suhaenah, Asriani
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 4 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i4.302

Abstract

Akar bajakah kalalawit merah (Uncaria gambir Roxb) merupakan salah satu tanaman yang dikenal memiliki kandungan alkaloid, fenol, dan triterpenoid yang digunakan untuk mengobati kanker, tumor, luka, penuaan dini, diabetes, dan antioksidan. Antioksidan adalah suatu senyawa yang memiliki struktur molekul yang dapat memberikan elektron untuk molekul radikal bebas yang tidak stabil tanpa terganggu sama sekali sehingga dapat memutuskan reaksi berantai radikal bebas. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan ekstrak etanol akar bajakah kalalawit merah (Uncaria gambir Roxb) menggunakan metode FRAP, berdasarkan kemampuan sampel mereduksi ion Fe3+ menjadi Fe2+. Hasil pengujian kualitatif menunjukkan bahwa akar bajakah kalalawit merah (Uncaria gambir Roxb) mengandung senyawa alkaloid, flavonoid, fenolik,dan tannin. Hasil pengujian kuantitatif diperoleh nilai rata-rata aktivitas antioksidan ekstrak etanol akar bajakah kalalawit merah (Uncaria gambir Roxb) yaitu sebesar 193,403 mg QE/g ekstrak.
Analysis of Tannin Analisis Senyawa Tanin pada Rimpang Kunyit (Curcuma longa L.) Kering dan Segar secara Spektrofotometri UV – Vis Noviandhita, Nikita
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 4 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i4.303

Abstract

Turmeric is a biopharmaceutical plant originating from the Zingiberaceae family, widely distributed in Southeast Asia and Africa. The rhizome of Turmeric (Curcuma longa L.) is the most commonly used part in various applications such as traditional medicine, textile dyes, food, spices, and cosmetics. This study aims to determine the tannin content in turmeric rhizomes (Curcuma longa L.), both in dry and fresh conditions, extracted with 96% ethanol solvent, and measured using UV-Vis spectrophotometry. The results showed that the extracts of both dry and fresh turmeric rhizomes (Curcuma longa L.) contain tannin compounds. Quantitatively, the extracts were measured at a maximum wavelength of 706 nm with gallic acid as a standard, yielding the regression equation y = 0.0898x – 0.037, an r-value of 0.9955, and the average tannin content of dry turmeric rhizome extract being 29.005 mg GAE/g extract and fresh turmeric rhizome extract being 57.046 mg GAE/g extract. This study indicates that fresh turmeric rhizome extract contains higher tannin levels than dry turmeric rhizome extract.
ANALISIS KANDUNGAN FORMALIN PADA IKAN KERING DI PASAR TANJONGE SENGKANG KABUPATEN WAJO Abidin, Zainal; Putri, Anggi Dwi; Razak, Rais
Makassar Pharmaceutical Science Journal (MPSJ) Vol 3 No 1 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v3i1.301

Abstract

Formalin (formaldehyde) is one of the chemical compounds banned by BPOM as a preservative in food additives. This study aims to determine the content of formalin (formaldehyde) in dried fish circulating in the Tanjonge Sengkang market, Wajo Regency. The sampling method used was purposive side and the test method used was qualitative analysis method using KMnO4 reagent, Tollens, Nash, Fehling A and Fehling B and Chromic Acid. The test results using the KMnO4, Tollens, Nash, Fehling A and Fehling B reagents and Chromatophytic Acid of the nine dried fish samples did not contain formalin.
Uji Aktivitas Antioksidan Minyak Nilam (Pogostemon cablin Benth.) Dengan Metode FRAP Niza, Nabila Ikhwanun; Ahmad, Aktsar Roskiana; Widiastuti, Harti
Makassar Pharmaceutical Science Journal (MPSJ) Vol 3 No 1 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v3i1.319

Abstract

ABSTRACT Patchouli oil (Pogostemon cablin Benth.) is an essential oil derived from the leaves of the patchouli plant. This oil is recognized for its primary component, patchouli alcohol, an antioxidant. The antioxidant properties of patchouli oil effectively inhibit free radical oxidation through the exchange of hydrogen atoms, forming more stable compounds. This study seeks to evaluate the antioxidant potential of patchouli oil through the FRAP method, utilizing a UV-Vis spectrophotometer for measurement at a wavelength of 692 nm. The findings indicate a regression equation of y = 0.0258x + 0.0256, with correlation coefficient of r = 0.9981 and an antioxidant activity measured at 1.7831 mgQE/g extract. Keywords: Antioxidant; Patchouli oil (Pogostemon cablin Benth.); FRAP method; UV-Vis spectrophotometer ABSTRAK Minyak nilam (Pogostemon cablin Benth.) merupakan minyak atsiri yang diperoleh dari daun tanaman nilam. Minyak ini dikenal memiliki kandungan utama patchouli alcohol, yang berfungsi sebagai antioksidan. Aktivitas antioksidan minyak nilam dapat menghambat oksidasi radikal bebas dengan cara menyumbangkan atom hidrogen, sehingga menghasilkan senyawa yang lebih stabil. Penelitian ini bertujuan untuk mengetahui potensi minyak nilam sebagai antioksidan menggunakan metode FRAP, kemudian diukur menggunakan spektrofotmeter UV-Vis pada panjang gelombang 692 nm. Dari penelitian ini diperoleh persamaan regresi y = 0,0258x + 0,0256, r = 0,9981 dan aktivitas antioksidan sebesar 1,7831 mgQE/g ekstrak. Kata kunci: Antioksidan; Minyak nilam (Pogostemon cablin Benth.); Metode FRAP; Spektrofotometer UV-Vis
PENGUJIAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BUNGA KERSEN (Muntingia calabura L.) MENGGUNAKAN METODE FRAP Kaisupy, Siti Sumayya; Maryam, St; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 3 No 1 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v3i1.324

Abstract

Kersen Flower (Muntingia calabura L.) contains several chemical compounds, including flavonoids, tannins, triterpene, saponins and polyphenols that play a role in antioxidant activity. This study aims to determine the antioxidant activity and determine the antioxidant activity value of ethanol extract Muntingia Flower (Muntingia calabura L.) using FRAP (Ferry Reducing Antioxidant Power) method. Extraction was done using maceration method and measurement was done using UV-Vis spectrophotometry method at wavelength of 715 nm. The comparator used was quercetin. The results showed that the concentration of antioxidant activity Muntingia Flower using FRAP method was 684.209 mgQE/g which showed high activity.
GAMBARAN MAKROSKOPIK LIMPA TIKUS (Rattus norvegicus) PADA PEMBERIAAN EKSTRAK ETANOL DAUN GINSENG (Talinum paniculatum (Jacq.) Gaertn) YANG DIINDUKSI OVALBUMIN Multazania, Multazania; sahab, Fitria; Muarsih, Ahmad Juniardhy; Ashar, Muhammad Affan; Emelda, Andi; Putra, Bayu; Santi, Irma
Makassar Pharmaceutical Science Journal (MPSJ) Vol 3 No 1 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v3i1.331

Abstract

Fameflower Leaves (Talinum paniculatum (Jacq) Gaertn) are medicinal plants that communities have traditionally used due to their active compounds, such as saponins, flavonoids, tannins, triterpenes, sterols, and polyphenols found in both the leaves and roots. This study aimed to determine the dose of ethanol extract of fameflower leaves affecting the histology of the spleen in male rats (Rattus norvegicus) following ovalbumin antigen stimulation, as well as to observe changes in the spleen tissue structure after the extract treatment. The study used 20 Wistar rats divided into four groups. The rats were first adapted for 2 weeks and then fasted for 8 hours before the treatment—a group I served as the standard control. Group II was induced with ovalbumin antigen. Groups III and IV were induced with the antigen, and the ethanol extract of fameflower leaves was administered at doses of 0.4g/kgBW and 0.8g/kgBW, respectively. The extract was administered orally for 7 days to the test animals. On day 8, the test animals were sacrificed, and their spleens were harvested for histological preparation using the Hematoxylin-Eosin staining method. Microscopic observation showed no histological damage in the spleen, such as inflammation, degeneration, congestion, hemorrhage, or necrosis. Therefore, it can be concluded that the ethanol extract of Bugis Ginseng leaves did not affect the spleen of rats at doses of 0.4g/kgBW and 0.8g/kgBW
STUDI ETNOFARMASI TUMBUHAN OBAT SEBAGAI ANTIHIPERTENSI DI DESA PATTALLASSANG, KECAMATAN PATTALLASSANG KABUPATEN GOWA Fadhilah, Putri Nur; Malik, Abd.; Hasnaeni, Hasnaeni
Makassar Pharmaceutical Science Journal (MPSJ) Vol 3 No 1 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v3i1.332

Abstract

Hypertension remains a prevalent global health concern and leading cause of mortality worldwide. In Pattallassang Village, traditional medicine utilizing medicinal plants persists as a common therapeutic approach for hypertension management. This study aimed to systematically identify, document and evaluate the ethnomedicinal knowledge of local communities regarding antihypertensive plants. Employing a descriptive observational design, data were collected through structured interviews and questionnaires administered to 100 respondents. The investigation identified 31 plant species utilized as antihypertensive agents, with the most prevalent being Allium sativum (garlic), Cucumis sativus (cucumber), Annona muricata (soursop leaves), Apium graveolens (celery), and Syzygium polyanthum (bay leaf). The leaves were boiled and the decoction was consumed as herbal infusions. Quantitative analysis using Use Value (UV) indices revealed Allium sativum as the most utilized species (UV=0.41), followed by Cucumis sativus (0.26), Apium graveolens (0.16), and Annona muricata (0.15). These findings demonstrate the preservation of significant ethnobotanical knowledge within the community regarding plant-based hypertension treatment. The study highlights the need for: (1) conservation efforts to protect this traditional knowledge, and (2) further pharmacological research to validate the therapeutic efficacy of these plants. Keywords: Ethnopharmaceutical; medicinal plants; Hypertension; Traditional Medicine; Pattallassang Village

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