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Fakultas Farmasi UMI, Kampus II UMI, Jl. Urip Sumoharjo No.225, Panaikang, Panakkukang, Kota, Makassar,, Panaikang, Kec. Panakkukang, Macassar, Sulawesi Selatan 90231
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MPSJ
Published by Universitas Muslim Indonesia
ISSN : -     EISSN : 29870887     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Makassar Pharmaceutical Science Journal merupakan salah satu jurnal yang dikelola oleh Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Maret 2023. Makassar Pharmaceutical Science Journal merupakan jurnal ilmiah yang terbit secara on-line dan menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang farmasi sains.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 100 Documents
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Analisis aktivitas perlindungan sinar UV ekstrak etanol daun kakao (Theobroma cacao L.) berdasarkan nilai Sun Protection Factor. Rustam, Julis Tina; Maryam, St.; Suhaenah, Asriani
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 2 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i2.243

Abstract

UV rays have a bad impact on the skin, but they can be minimized by using ingredients that are UV protective. Sunscreen can be obtained from natural ingredients, one of which is Cocoa Leaves (Theobroma cacao L.) which contains flavonoid and phenolic compounds. The aim of this research was to determine the UV protection activity of ethanol extract of cocoa leaves (Theobroma cacao L.) originating from the Malino, Jeneponto and Wajo areas based on the Sun Protection Factor value. Measurement of the Sun Protection Factor (SPF) value using the UV-Vis Spectrometry method was measured at wavelengths of 290, 295, 300, 305, 310, 315 and 320 nm. The results showed that the ethanol extract of cocoa leaves (Theobroma cacao L.) had UV protection activity for the Malino area at a concentration of 0.01% of 3.25 (minimum protection), a concentration of 0.03% of 10.34 (maximum protection). , 0.05% concentration of 17.10 (ultra protection). For the Jeneponto area, the 0.01% concentration is 3.88 (minimum protection), the 0.03% concentration is 12.3 (maximum protection), the 0.05% concentration is 20.18 (ultra protection) and the Wajo area has a value at a concentration of 0.01% it is 3.38 (minimum protection), a concentration of 0.03% is 10.77 (maximum protection), a concentration of 0.05% is 17.05 (ultra protection). Ethanol extract of cocoa leaves (Theobroma cacao L.) originating from Jeneponto has the greatest UV protection activity with a value of 20.18 with ultra protection ability.
ANALISIS KADAR SENYAWA FLAVONOID DARI EKSTRAK ETANOL DAUN KAKAO (Theobroma cacao L.) DENGAN PERBANDINGAN DAERAH TEMPAT TUMBUH Mahmud, Nurul Faiza; Maryam, St; Suhaenah, Asriani
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 2 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i2.246

Abstract

Cocoa leaves (Theobroma cacao L.) contain active compounds that have many health benefits. Flavonoids are one of the active compounds contained therein that can prevent the formation of free radicals and reduce tissue damage due to inflammation. This study aims to determine the flavonoid content of ethanol extract of cacao leaves (Theobroma cacao L.) based on the comparison of growing regions using the UV-Vis spectophotometric method. Samples were taken from three regions namely Jeneponto, Wajo and Malino. This research method begins with the preparation of samples by maceration with 96% ethanol solvent, then qualitative analysis is carried out by Thin Layer Chromatography (KLT) method and quantitative analysis is carried out measuring quercetin standards and determining flavonoid levels with a UV-Vis spectrophotometer at a maximum wavelength of 430 nm. The results showed that the ethanol extract of cocoa leaves (Theobroma cacao L.) positively contained flavonoids and had flavonoid levels in the Jeneponto, Wajo, Malino regions of 45.812 mgQE/g extract; 41.556 mgQE/g extract, and; 38.343 mgQE/g extract, respectively. Where the ethanol extract of cocoa leaves (Theobroma cacao L.) from the Jeneponto region has higher flavonoid levels than the other two regions.
AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL RIMPANG KUNYIT (Curcuma domestica Val.) SECARA IN VITRO RAHMAN, ANDI AMALIA RAMADHANI; Maryam, St.; Razak, Rais
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 2 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i2.247

Abstract

Kunyit merupakan salah satu tanaman rempah-rempah yang memiliki berbagai aktivitas farmakologis. Rimpang kunyit (Curcuma domestica Val.) mengandung kurkumin dan minyak atsiri yang bermanfaat sebagai antioksidan, antiinflamasi, dan antibakteri. Tujuan penelitian ini yaitu untuk mengetahui potensi rimpang kunyit sebagai antiinflamasi secara in vitro menggunakan metode penghambatan denaturasi protein. Penggunaan metode ini karena salah satu penyebab inflamasi adalah terjadinya denaturasi protein pada jaringan sel tubuh. Hasil uji berupa persentase inhibisi dengan nilai 38,38% pada konsentrasi 10 ppm hingga 46,51% pada konsentrasi 50 ppm. Persentase inhibisi >20% menunjukkan bahwa ekstrak dapat menghambat denaturasi protein. Perhitungan IC50 menunjukkan nilai sebesar 46,87 μg/mL. Sehingga dapat disimpulkan bahwa ekstrak etanol 96% rimpang kunyit memiliki potensi sebagai antiinflamasi.
Penentuan Kadar Fenolik, Tanin, Flavonoid, dan Saponin Ekstrak Etanol Daun Kenikir (Cosmos caudatus Kunth.) Abidin, Zainal; Aminah, Aminah; Razak, Rais; Eka Putri, Andi Yuyun; M, Murti Nurhidayah; A, Aridha
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 2 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i2.249

Abstract

The kenikir plant is a tropical plant originating from Latin America that can easily grow in various places. The use of kenikir leaves (Cosmos caudatus Kunth.) as a medicinal plant has been widely used. People usually use kenikir leaves as traditional medicine. Kenikir leaves are extracted by maceration method using 96% ethanol solvent after which a liquid extract is obtained and then evaporated using a rotavapor so that a thick extract is obtained. This study aims to analyze the levels of phenolic compounds, tannins, flavonoids, and saponins contained in kenikir leaves (Cosmos caudatus Kunth.). Determination of levels using UV-Vis spectrophotometric method. The ethanol extract of kenikir leaves (Cosmos caudatus Kunth.) contains phenolic compounds, tannins, flavonoids, and saponins with the levels of each phenolic compound, tannins, flavonoids, and saponins respectively as follows: 43.592 mgGAE/g, 40.639 mgEAT/g, 36.319, and 142.527 mgSE/g.
UJI AKTIVITAS ANTIOKSIDAN DARI TEH DAUN TANAMAN KAKAO (Theobroma cacao L.) BERDASARKAN TEMPAT TUMBUH DENGAN METODE PEREDAMAN RADIKAL BEBAS DPPH Syam, Nurizzah Aulia; Maryam, St.; Baits, Muzakkir
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 2 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i2.267

Abstract

Tanaman kakao merupakan salah satu tanaman yang digunakan oleh masyarakat sebagai obat tradisional. Daun tanaman kakao mengandung metabolit sekunder yaitu flavonoid,saponin dan tanin serta mengandung senyawa fenolat, yang juga memiliki peran sebagai antioksidan. Tujuan dari penelitian ini untuk mengetahui aktivitas antioksidan dan menganalisa IC50 dari teh daun tanaman kakao (Theobroma cacao L.) dengan menggunakan metode DPPH (2,2-difenil-1-pikrilhidrazil). Sampel yang digunakan berasal dari tiga daerah yaitu Jeneponto, Wajo, dan Malino. Berdasarkan hasil penelitian, menunjukkan bahwa sediaan teh daun kakao (Theobroma cacao L.) memiliki aktivitas sebagai antioksidan. Nilai IC50 sediaan teh daun kakao (Theobroma cacao L.) Jeneponto sebesar 187,946 µg/mL, Wajo 309,629 µg/mL, dan Malino sebesar 314,055 µg/mL dengan kategori klasifikasi sangat lemah. Sediaan teh daerah Jeneponto memiliki aktivitas antioksidan yang lebih baik dari dua daerah lainnya. Kata kunci: Antioksidan, DPPH (2,2-difenil-1-pikrilhidrazil), Theobroma cacao L., Kuarsetin.
UJI AKTIVITAS ANTIOKSIDAN PADA EKSTRAK ETANOL DAUN KAKAO (Theobroma cacao L.) DENGAN PERBANDINGAN BERDASARKAN TEMPAT TUMBUH DENGAN METODE PEREDAMAN RADIKAL BEBAS DPPH Salahuddin, Muthia Amaliah; Maryam, St.; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 2 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i2.268

Abstract

Kakao (Theobroma cacao L.) merupakan salah satu tanaman yang mengandung senyawa metabolit sekunder yaitu flavonoid, saponin dan tanin. Secara empiris daun kakao digunakan sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol daun kakao (Theobroma cacao L.) dengan perbandingan berdasarkan tempat tumbuh menggunakan metode peredaman radikal bebas DPPH (2,2-Difenil-1-Pikrilhidrazil) dengan parameter nilai IC50. Berdasarkan hasil yang diperoleh, hasil uji kualitatif menunjukkan adanya metabolit sekunder yang terkandung dalam esktrak etanol daun kakao seperti alkaloid, fenolik, flavonoid, saponin, dan tanin serta diperoleh nilai IC50 ekstrak etanol daun kakao daerah Jeneponto sebesar 24,658 µg/mL kategori sangat kuat, daerah Malino 59,742 µg/mL kategori kuat, serta Wajo 56,898 µg /mL kategori kuat dengan perbandingan baku pembanding yaitu kuersetin dengan nilai IC50 sebesar 1,882 µg/mL kategori sangat kuat. keyword: Theobroma cacao L., antioksidan, IC50;
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL AKAR BAJAKAH TAMPALA (Spatholobus Littoralis Hassk) MENGGUNAKAN METODE PEREDAMAN RADIKAL BEBAS DPPH Sari, Wina Astri; Tahir, Masdiana; Baits, Muzakkir
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 3 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i3.271

Abstract

Bajakah tampala (Spatholobus littoralis Hassk.) is a plant that lives on vines in tropical areas. This plant comes from Sebuku Village, North Kalimantan. The Bajakah Tampala plant contains saponins, flavonoids and tannins. The roots of the Bajakah Tampala plant are thought to have strong antioxidant activity which is able to reduce the activity of free radicals. The aim of this research is to analyze the antioxidant activity of Bajakah Tampala roots using the DPPH reduction method using a UV Vis spectrophotometer which is based on calculating the IC50 value. The results of this study indicate that the ethanol extract of Bajakah Tampala roots has antioxidant activity against DPPH free radicals with an IC50 value of 9.206 µg/mL. which is included in the group of very strong antioxidants.
FORMULASI LOTION ANTIOKSIDAN EKSTRAK KULIT PISANG KEPOK (Musa balbsiana colla) MENGGUNAKAN EMULGATOR TWEEN 80 DAN SPAN 80 Olii, Audia Triani; Musyid, Mumtihanah; Nurfitriani, Besse
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 3 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i3.272

Abstract

Kepok banana peels contain flavonoid compounds which can be used as antioxidants. Lotion is a type of cosmetic in the emollient (softener) category which has a higher air content. Its functions include maintaining skin moisture, cleaning, preventing moisture loss or retaining active ingredients on the skin. The use of an appropriate combination of emulsifiers between Tween 80 and Span 80 in lotion preparations can form an optimal oil-in-water type emulsion. The aim of this research is to optimize the formulation of kepok banana peel extract lotion (Musa balbisiana colla) with Tween 80 and Span 80 as emulsifiers. The research results showed that the lotion formula was optimized to produce a formula using Tween 80 : Span 80 of 9% : 1%, which had a pH value of 6.4467, viscosity of 12860 cPs, adhesive power of 5.66 seconds, spreadability of 6.4 cm/ seconds, and the antioxidant activity test was 79.9249. Meanwhile, the results of stability testing of the optimum lotion formula showed good stability in homogeneity, pH, spreadability and adhesion tests. However, the viscosity test was unstable.
Review Artikel : PEMANFAATAN KULIT PISANG RAJA (Musa paradisiaca L.) DALAM FORMULASI SEDIAAN KOSMETIK Olii, Audia Triani; Mursyid, Mumtihanah; Shinta, Fitriyah Maya
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 3 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i3.273

Abstract

Plantain peel contains flavonoid compounds that can be used as sunscreen. The purpose of this research is to optimize the preparation of plantain peel extract lotion (Musa paradisiaca L.). The use of Tween 80 and Span 80 in lotion preparations can form a stable in-water oil-type emulsion. The lotion formula is optimized then produces the optimal formula obtained on the use of Tween 80 (6.9%) and Span 80 (3.1%). The optimal formula has a pH of 5.78; viscosity of 20613.33 cPs; adhesion of 4.6 seconds; a spread of 6.23 cm/sec; and determination of an SPF value of 17.262. The optimal formula of the optimization method has insignificant differences. The stability test results of the optimum lotion formula show a stable formula result.
FORMULASI LOTION TABIR SURYA EKSTRAK KULIT PISANG Goroho (Musa acuminafe sp) MENGGUNAKAN KONSENTRASI TWEEN 80 DAN SPAN 80 Olii, Audia Triani; Mursyid, Mumtihanah; Mokodompit, Sukma Meilinda
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 3 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i3.275

Abstract

Flavanoids are compounds that have activity as sunscreen. This compound is contained in banana peels and can be used as sunscreen ingredients. The purpose of this research is to optimize the preparation of goroho banana peel extract lotion (Musa acuminafe sp). The use of certain combinations of Tween 80 and Span 80 in lotion preparations has been reported to be able to form an optimal in-water oil-type emulsion. Formula optimization with various variations of Tween 80 and Span 80 concentrations using Design expert version 10 of the Simplex Lattice Design model with pH parameters, viscosity, adhesion, spreadability and SPF determination. The optimal lotion formula was obtained at the use of Tween 80 4.5% and Span 80 5.5%. The optimal formula has a pH of 5.46, a viscosity of 33226.66 dPas, a adhesion of 6.01 seconds, a spread of 6.25 cm/s, and an SPF test and has good asceptability to respondents. The optimal formula of software prediction results with research results shows insignificant differences. This shows that the Simplex Lattice Design method can be used to predict the physical properties parameters of goroho banana peel extract lotion preparations.

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