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Journal Of Pharmacy
Published by Universitas Muhammadiyah Riau
ISSN : -     EISSN : 30898587     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Journal Scope : 1. Pharmacology and Toxicology 2. Pharmacokinetics 3. Community and Clinical Pharmacy 4. Pharmaceutical Chemistry 5. Pharmaceutical Biology 6. Pharmaceutics 7. Pharmaceutical Technology 8. Biopharmaceutics 9. Pharmaceutical Microbiology and Biotechnology 10. Alternative medicines
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 29 Documents
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Rasionalitas Antibiotik Pasien Bronkitis Akut Anak Dengan Metode Gyssens Di RSIA Zainab Kota Pekanbaru Endri, Novtafia; Rahmawati, Ayu; Rahmawati, Noveri; Nesya, Nabilla Fadhia
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

According to WHO, as many as 13 million children in the world die every year and most of these deaths are in developing countries, where ISPA is one of the main causes of death by killing as many as 4 million children each year. Bronchitis ranks 6th out of 10 causes of death. However, Indonesia still has no reports on exact figures regarding this disease. This study aims to determine the accuracy of the use of antibiotics in pediatric patients with acute bronchitis based on the Gyssens method at RSIA Zainab Pekanbaru City. This type of research was non-experimental with data collection using a purposive sampling technique retrospectively. The results of the study based on a qualitative evaluation of the use of antibiotics in pediatric acute bronchitis patients at RSIA Zainab Pekanbaru City using the Gyssens method showed the quality of rational use of antibiotics found that 64 patients were declared rational ( category 0) and 5 patients were declared irrational. If possible further research regarding the rationality of using antibiotics in pediatric acute bronchitis patients at RSIA Zainab Pekanbaru City can be carried out using the DDD method or with a prospective approach so that monitoring of the patient's condition progress can be carried out from day to day.
Evaluasi Penggunaan Obat Anti Hipertensi Pada Pasien Stroke Iskemik Di Rsud Arifin Achmad Tahun 2022 Nawwar Irfan; Nursyafni; Ayu Rahmawati; Mestika, Diani
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Antihypertensive drugs are one of the drugs most commonly given to ischemic stroke patients. Ischemic stroke is a stroke resulting from thrombosis or embolism that occurs in the cerebral blood vessels and causes obstruction of cerebral blood flow to the cerebral blood vessels. The use of drugs is rational if the patient receives treatment according to his clinical needs. The aim of this study was to determine the appropriate use of antihypertensive drugs in ischemic stroke patients based on the right indication, selection of the right drug, right dose and determine the relationship between sociodemographics and the results of antihypertensive treatment in ischemic stroke patients at Arifin Achmad Regional Hospital. The method used in this research is a descriptive observational method using retrospective data which was carried out by recording medical record data of patients with a final diagnosis of ischemic stroke accompanied by hypertension with a sample size of 80 patients. people (52.5%), 45-64 years old 44 people (55%), working patients 53 people (66.3%), and the most widely used drug class was amlodipine as many as 67 people (56.8%). In the results of the chi-square test with a significance value of p value = 0.05 for the relationship between age and gender on risk factors, the age value was p = 0.004, while the gender value was p = 0.014. It was concluded that the evaluation of the use of antihypertensive drugs at Arifin Achmad Hospital was 100% correct and showed that age and risk factors were related, and gender and risk factors were related. Keywords: Hypertension, ischemic stroke, evaluation of drug use
Analisis Manajemen Pengelolaan Obat di Gudang Farmasi Rumah Sakit X Maulidi Arkan, Ulfa; Marian Tonis; Abdul Zaky
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Drug management is one of the most important parts of hospital management in the provision of health services as a whole, because inefficiency and inefficiency in management will have a negative impact on the hospital both from a medical, social and economic perspective. Based on the results of the document review, there are expired drugs in the Pharmacy Installation in 2021 where there are 4,454 expired drugs in the Pharmaceutical Warehouse, the Emergency Room and Inpatient Pharmacy Depots have 1,173 Expired Drugs and the Outpatient Pharmacy Depot has 2,180 expired drugs. Expired drugs in 2022 where there are 37,959 expired drugs in the Pharmaceutical Warehouse, , ER and Inpatient Pharmacy Depots have 6,582 expired drugs and Outpatient Pharmacy Depots have 31,852 expired drugs. The purpose of this study is to determine the Management of Drug Management in the Pharmacy Warehouse of the X Hospital. This study uses a type of qualitative research with a descriptive observation approach, with a total of 4 informants. This research was conducted using in-depth interviews, observation and document review methods. The results of the study found that drug planning uses the consumption method which is carried out every two months, the determination of the types of drugs in the procurement is adjusted to the National Formulary and is constrained by distributor receivables, the receiving process sometimes the goods that arrive do not match the invoice, and the storage is not up to standard, there is no Special room for expired drugs. It is recommended that the planning process use a combination of consumption and epidemiology methods so that empty drugs and over stock do not occur, the need for a special place for storing expired drugs, and expanding storage warehouses so that there is no more cardboard buildup.
Formulation And Physical Stability Of Hair Tonic Ethanol Extract Of Katuk Leaves (Sauropus Androgynous (L.) Merr) Arif, Muhammad; Nurbaiti; Rahmawati, Ayu; Oriendhini, Salsa
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Katuk leaves (Sauropus androgynus (L.) Merr) contain provitamin A and vitamin E, flavonoid, and ascorbic acid, which help hair growth. This study aims to determine the stability level of hair tonic preparations of ethanol extract from katuk leaves. The method used in this study is the cycling test method. This study made a hair tonic formulation with 2.5% ethanol extract of katuk leaves with a variation of 96% ethanol concentration of 35 ml and 10 ml. The stability parameters tested include organoleptic, pH, viscosity, specific gravity, and homogeneity. The pH test results range from 4.4 to 5.3; this pH value follows the Indonesian National Standard (SNI). The viscosity test ranged from 0.59-0.69; this pH value complies with the Indonesian National Standard (SNI). The specific gravity test results ranged from 1.02-1.04, and this particular gravity value was not the theory of specific gravity of hair tonic less than 1. The homogeneity test results showed that the hair tonic experienced precipitation and was not homogeneous. Furthermore, the hedonic test showed that the panellists preferred the negative control preparation, then the hair tonic preparation of katuk leaf ethanol extract with 96% ethanol variation of 60 ml and finally, the hair tonic preparation of katuk leaf ethanol extract with 96% ethanol variation of 35 ml.
Evaluasi Penggunaan Obat Dispepsia Pada Pasien Rawat Jalan Periode Juni-November 2022 Di RSUD Rokan Hulu Nursyafni; Tri Nova Lovena; Ulfha, Ulfha Ikhwani
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Dyspepsia is a feeling of discomfort originating from the upper abdomen. The purpose of this study was to evaluate the accuracy of drug use in patients with dyspepsia and the relationship between sociodemographic characteristics, especially age and sex, and risk factors at Rokan Hulu Hospital for the period June–November 2022. This study used a non-experimental descriptive method. Samples were taken from as many as 110 patients. The results showed that the most common patient characteristics were female sex by 66.4% (73 people), the elderly-late age group of 56 years by 30.9% (34 people), patients who did not work by 66.4% (73 people), the drug that was widely used was lansopazole by 48.7% (95 prescriptions), and the class of drug that was widely used was the proton pump inhibitor group by 48.7% (95 prescriptions). On the results of the chi-square test with a significance value of p = 0.05 for the relationship between age, gender, and risk factors, the age value is p = 0.025, while gender is p = 0.000. It was concluded that at Rokan Hulu Hospital, the evaluation of dyspepsia drugs was 100% correct and showed that there was a relationship between age, gender, and risk factors for work. Further research is expected to take observation locations in two or more places as a comparison for more varied results.
Evaluasi Penggunaan Obat Antituberkulosis (OAT) Pada Pasien Tuberkulosis (TB) Di RSUD Arifin Achmad Provinsi Riau Periode Januari – Oktober 2022 Nursyafni; Nurbaiti; Nur Anisa
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

A study has been conducted regarding the evaluation of the use of antituberculosis drugs (OAT) in pulmonary tuberculosis (TB) patients at Arifin Achmad Hospital in Riau Province during the period January–October 2022. This study aims to determine patterns of use of anti-tuberculosis drugs (OAT), evaluate errors in the use of anti-tuberculosis drugs based on The 2016 National Tuberculosis Control Guidelines from the Indonesian Ministry of Health, and test the relationship between treatment outcomes and gender, age, and length of treatment. This research is descriptive in nature, with data collection conducted retrospectively. The results of the study showed that 94.3% of the patients at the hospital were given KDT-type OAT (fixed-dose combination), while for recovery, it reached 71.7%. Based on compliance with the 2016 National TB Control Guidelines standards for indications, dosage, and drug selection, it is 100% balanced. Analysis of the relationship between several factors on treatment outcomes concluded that the factors Gender (p = 0.014; p 0.05) and Age (p = 0.183) both had no significant relationship to patient treatment outcomes. While the length of treatment (p = 0.000; p 0.05) had a significant relationship to patient treatment outcomes.
Evaluasi Penggunaan Obat Antihipertensi Primer Pasien Lanjut Usia Periode Januari – Juni 2022 Di Puskesmas Minas Ayu Rahmawati; Dewi Gulyla Hari; nisa, Annisa Nurul Maharani
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Hipertensi adalah keadaan seseorang yang mengalami peningkatan tekanan darah di atas normal, yaitu tekanan darah sistolik ≥ 140 mmHg dan atau tekanan darah diastolik ≥ 90 mmHg. Tujuan penelitian ini adalah untuk mengetahui ketepatan penggunaan obat antihipertensi primer dan hubungan Sosiodemografi terhadap hasil pengobatan pasien di Puskesmas Minas periode januari – juni tahun 2022. Metode yang digunakan adalah metode deskriptif dengan rancangan non ekperimental. Data penelitian diperoleh dari berkas catatan medik yang dikumpulkan dengan teknik pengumpulan secara purposive sampling dengan jumlah sampel sebanyak 110 pasien yang berusia lanjut. Pada hasil penelitian ini menunjukkan data karakteristik pasien yang paling banyak yaitu jenis kelamin perempuan sebesar 69 orang (62,7%), kelompok usia 45-59 tahun 53 orang (48,2%), pasien yang tidak bekerja 81 orang (73,6), dan golongan obat yang banyak digunakan yaitu amblodipin sebesar 107 pasien (97,2%). Pada hasil uji chi-square dengan nilai kemaknaan p value = 0,05 terhadap hubungan umur dan jenis kelamin terhadap faktor resiko didapatkan nilai umur adalah p = 0,873 sedangkan jenis kelamin memiliki nilai p = 0,000. Disimpulkan bahwa evaluasi penggunaan obat antihipertensi di Puskesmas Minas sudah 100% tepat dan menunjukkan bahwa umur dengan faktor resiko tidak memeliki hubungan, sedangkan jenis kelamin dengan faktor resiko memeliki hubungan. Untuk penelitian lebih lanjut diharapkan dapat melakukan observasi terhadap 2 tempat atau lebih sebagai pembanding untuk hasil yang lebih bervariatif.
Evaluasi Penggunaan Obat Antihipertensi Pada Pasien Hipertensi Primer Rawat Jalan Lanjut Usia Periode Januari 2022 – Juli 2023 Di RSUD Arifin Achmad Provinsi Riau Nawwar Irfan; Ayu Rahmawati; Nurbaiti; Aulia Fitri, Windy
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Hypertension is a condition where the increase in systolic blood is above the normal limit, which is more than 140 mmHg and diastolic blood pressure is more than 90 mmHg. The purpose of this study was to determine the sociodemographic relationship to the treatment outcomes of hypertensive patients and to examine patterns of antihypertensive drug use at Arifin Achmad Hospital, Riau Province. The method used in this study was an observational descriptive method using retrospective data which was carried out by recording medical record data and the research subjects used in this study were outpatients with a diagnosis of hypertension with a total sample of 90 elderly patients. The results of this study showed that the most data on patient characteristics, namely female sex, amounted to 66 people (73.3%) and the most widely used drug class, namely amlodipine, was 76 patients (62.3%). On the results of the chi-square test with a significance value of p value = 0.05 for the relationship between age and gender for risk factors, the age value was p = 0.123 while gender had a p value = 0.000. It was concluded that the evaluation of antihypertensive drugs was 100% correct and showed that age and risk factors had no relationship, while gender had a relationship with risk factors.
Potensi Aktivitas Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) sebagai Antihiperurisemia pada Mencit Putih (Mus musculus) Lusi Indriani; Ayu Rahmawati; Nursyafni; Nawwar Irfan; Novita Sari
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Hyperuricemia is a condition where uric acid production increases or the kidneys cannot remove uric acid from the body so that uric acid levels in the blood exceed 7.0 mg/dL in men and 6.0 mg/dL in women. One of the secondary metabolites that have the potential to act as anti-hyperuricemia is flavonoids. Red shoots contain flavonoids, alkaloids, terpenoids, chalcones, and tannins. This study aimed to determine the anti-hyperuricemia activity of ethanol extract of red shoots (Syzygium myrtifolium Walp.) in white mice. This study used 16 male white mice which were randomly divided into 4 treatment groups. Group 1 was negative control (Na-CMC 0.5%), group 2 was positive control (allopurinol 300 mg/KgBW), group 3 was dose 1 (pucuk merah ethanol extract 10 mg/kgBW), and group 4 was dose 2 (pucuk merah ethanol extract 15 mg/KgBW). Before giving treatment, mice were first induced with KBrO3 at a dose of 148 mg/KgBW intraperitoneally and initial uric acid levels were measured. Then each group was given oral treatment. Uric acid levels were measured at 30, 60, and 90 minutes. The results showed that the pucuk merah ethanol extract 15 mg/KgBW (dose 2) had an anti-hyperuricemia activity of 62.42% compared to allopurinol 65.80%.
Skrining Fitokimia dan Uji Antibakteri Ekstrak Daun Jambu Kristal (Psidium guajava cv. Kristal L.) Nicolas Yonathan; Anjas, Anjas Wilapangga; Sri Royani
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

The crystal guava plant or (Psidium guajava cv. Kristal L) grows abundantly in tropical regions, especially in Kemangkon, Purbalingga, Indonesia. This plant is known for its health benefits, one of which is as an antibacterial agent due to its secondary metabolite content. This research is an experimental study that examines the secondary metabolites and antibacterial properties of crystal guava leaf extract from Kemangkon, Purbalingga. The method used is maceration extraction with 96% ethanol solvent, phytochemical screening including saponins, tannins, flavonoids, and alkaloids, and antibacterial testing using the disc diffusion method with concentrated extracts at 50 ppm and 150 ppm tested against Staphylococcus aureus, with chloramphenicol as a positive control. Phytochemical results show that crystal guava leaves contain alkaloids, flavonoids, saponins, and tannins. Antibacterial tests prove that ethanol extract of crystal guava leaves effectively inhibits bacteria, especially at concentrations of 50 ppm and 150 ppm. At 50 ppm, the inhibition zone within 24 hours reaches 1.3 cm and expands to 1.5 cm after 48 hours. At 150 ppm, the inhibition zone reaches 1.7 cm within 24 hours and remains the same after 48 hours.

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