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Nawwar Irfan
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Evaluasi Penggunaan Obat Anti Hipertensi Pada Pasien Stroke Iskemik Di Rsud Arifin Achmad Tahun 2022 Nawwar Irfan; Nursyafni; Ayu Rahmawati; Mestika, Diani
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Antihypertensive drugs are one of the drugs most commonly given to ischemic stroke patients. Ischemic stroke is a stroke resulting from thrombosis or embolism that occurs in the cerebral blood vessels and causes obstruction of cerebral blood flow to the cerebral blood vessels. The use of drugs is rational if the patient receives treatment according to his clinical needs. The aim of this study was to determine the appropriate use of antihypertensive drugs in ischemic stroke patients based on the right indication, selection of the right drug, right dose and determine the relationship between sociodemographics and the results of antihypertensive treatment in ischemic stroke patients at Arifin Achmad Regional Hospital. The method used in this research is a descriptive observational method using retrospective data which was carried out by recording medical record data of patients with a final diagnosis of ischemic stroke accompanied by hypertension with a sample size of 80 patients. people (52.5%), 45-64 years old 44 people (55%), working patients 53 people (66.3%), and the most widely used drug class was amlodipine as many as 67 people (56.8%). In the results of the chi-square test with a significance value of p value = 0.05 for the relationship between age and gender on risk factors, the age value was p = 0.004, while the gender value was p = 0.014. It was concluded that the evaluation of the use of antihypertensive drugs at Arifin Achmad Hospital was 100% correct and showed that age and risk factors were related, and gender and risk factors were related. Keywords: Hypertension, ischemic stroke, evaluation of drug use
Evaluasi Penggunaan Obat Antihipertensi Pada Pasien Hipertensi Primer Rawat Jalan Lanjut Usia Periode Januari 2022 – Juli 2023 Di RSUD Arifin Achmad Provinsi Riau Nawwar Irfan; Ayu Rahmawati; Nurbaiti; Aulia Fitri, Windy
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Hypertension is a condition where the increase in systolic blood is above the normal limit, which is more than 140 mmHg and diastolic blood pressure is more than 90 mmHg. The purpose of this study was to determine the sociodemographic relationship to the treatment outcomes of hypertensive patients and to examine patterns of antihypertensive drug use at Arifin Achmad Hospital, Riau Province. The method used in this study was an observational descriptive method using retrospective data which was carried out by recording medical record data and the research subjects used in this study were outpatients with a diagnosis of hypertension with a total sample of 90 elderly patients. The results of this study showed that the most data on patient characteristics, namely female sex, amounted to 66 people (73.3%) and the most widely used drug class, namely amlodipine, was 76 patients (62.3%). On the results of the chi-square test with a significance value of p value = 0.05 for the relationship between age and gender for risk factors, the age value was p = 0.123 while gender had a p value = 0.000. It was concluded that the evaluation of antihypertensive drugs was 100% correct and showed that age and risk factors had no relationship, while gender had a relationship with risk factors.
Potensi Aktivitas Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) sebagai Antihiperurisemia pada Mencit Putih (Mus musculus) Lusi Indriani; Ayu Rahmawati; Nursyafni; Nawwar Irfan; Novita Sari
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Hyperuricemia is a condition where uric acid production increases or the kidneys cannot remove uric acid from the body so that uric acid levels in the blood exceed 7.0 mg/dL in men and 6.0 mg/dL in women. One of the secondary metabolites that have the potential to act as anti-hyperuricemia is flavonoids. Red shoots contain flavonoids, alkaloids, terpenoids, chalcones, and tannins. This study aimed to determine the anti-hyperuricemia activity of ethanol extract of red shoots (Syzygium myrtifolium Walp.) in white mice. This study used 16 male white mice which were randomly divided into 4 treatment groups. Group 1 was negative control (Na-CMC 0.5%), group 2 was positive control (allopurinol 300 mg/KgBW), group 3 was dose 1 (pucuk merah ethanol extract 10 mg/kgBW), and group 4 was dose 2 (pucuk merah ethanol extract 15 mg/KgBW). Before giving treatment, mice were first induced with KBrO3 at a dose of 148 mg/KgBW intraperitoneally and initial uric acid levels were measured. Then each group was given oral treatment. Uric acid levels were measured at 30, 60, and 90 minutes. The results showed that the pucuk merah ethanol extract 15 mg/KgBW (dose 2) had an anti-hyperuricemia activity of 62.42% compared to allopurinol 65.80%.
Aktivitas Analgesik Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) pada Mencit Putih Jantan (Mus musculus) Lusi Indriani; Tri Nova Lovena; Nursyafni; Nawwar Irfan; Alfahtiah Zurlina
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Analgesics are substances that reduce or eliminate pain without causing loss of consciousness. Traditional medicines are considered safer than synthetic drugs. One plant with potential as an analgesic is the red shoot plant (Syzygium myrtifolium Walp). This plant contains flavonoids, anthocyanins, phenolics, and triterpenoids. This study aimed to determine the analgesic activity of ethanol extract of red shoot leaves (EPM) in male white mice. The analgesic effect was obtained through the writhing test using 1% glacial acetic acid induction. Twenty male white mice were divided into 5 treatment groups, including negative control (0.5% Na CMC), treatment 1 (EPM 3.7 mg/kgBW), treatment 2 (EPM 7.4 mg/kgBW), and treatment 3 (EPM 14.8 mg/kgBW), and positive control (mefenamic acid 500 mg/70 kgBW). All mice were given treatment according to their respective groups. After 30 minutes, all mice were induced with 1% glacial acetic acid at a dose of 10 ml/kgBW intraperitoneally. Then, the number of writhes was observed every 5 minutes for 60 minutes. The average number of writhes data was analyzed using ANOVA and Tukey HSD tests. The results showed that treatment groups 2 (7.40 mg/kgBW) and 3 (14.80 mg/kgBW) showed analgesic activity in male white mice induced by 1% acetic acid. The best dose was 14.80 mg/kgBW with writhing protection of 34.74% and analgesic efficacy of 45.59% compared to mefenamic acid.
Tingkat Pengetahuan Dan Perilaku Swamedikasi Penggunaan Obat Bebas Pada Masyarakat Di Kecamatan Simpang Kanan Kabupaten Rokan Hilir Ayu Rahmawati; Nursyafni; Novtafia Endri; Muhammad Arif; Nawwar Irfan; Wulandari, Tri Ayu; Fitratul Wahyuni
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Self-medication is an act of self-medication carried out by the community to maintain health or manage disease based on personal diagnosis, using drugs repeatedly. This study aims to analyze the relationship between knowledge level and self-medication behavior using over-the-counter drugs in the community in Simpang Kanan District, Rokan Hilir Regency. The research was conducted observational with a cross-sectional approach, using quota sampling technique and questionnaires as instruments. The results showed that out of 90 respondents, 77.8% had good knowledge, 21.1% had sufficient knowledge, and 1.1% had poor knowledge. In terms of behavior, 81.1% had good behavior, while 18.9% had moderate behavior in self-medication. Analysis using the Chi-Square test resulted in a p-value of 0.002 (p<0.05), indicating a significant relationship between the level of knowledge and behavior of self-medication using over-the-counter drugs in the community in Simpang Kanan District, Rokan Hilir Regency.
Analisis Potensi Interaksi Obat Pada Pasien Diabetes Melitus Tipe II Dengan Kompetensi Hipertensi Di RS Kota Pekanbaru Rahmawati, Ayu; Lubis, Nursyafni; Nawwar Irfan; Muhammad Arif; Putri Afriani
The Journal Of Pharmacy Vol. 3 No. 1 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Patients with type 2 Diabetes Mellitus accompanied by hypertension commonly receive multiple medications, increasing the risk of polypharmacy and potential drug interactions. This study aimed to analyze the relationship between the number of drugs used and the occurrence of potential drug interactions among patients with type 2 Diabetes Mellitus and hypertension at Hospital Ini Pekanbaru City. This study employed a non-experimental observational design with retrospective data collection. Samples were selected using purposive sampling, and data were analyzed using IBM SPSS Statistics version 27. A total of 98 medical records met the inclusion criteria. The results showed that 57 patients experienced potential drug interactions, with a total of 67 interaction events. All identified interactions were classified as moderate in severity (100%). Based on the interaction mechanisms, pharmacodynamic interactions were predominant, accounting for 64 events (95.52%), while pharmacokinetic interactions accounted for 3 events (4.48%). Statistical analysis demonstrated a significant association between the number of drugs prescribed and the occurrence of potential drug interactions (p = 0.001). Close monitoring of potential drug interactions is essential to ensure the effectiveness and safety of therapy, particularly in patients undergoing polypharmacy.
Implementasi Minuman Fungsional Berbasis Jahe, Kayu Manis, Kelor, dan Ketumbar untuk Pengendalian Gula Darah Rialita Lifiani; Nurul Adzkia Ghearizky; Tri Nova Lovena; noveri rahmawati; Nawwar Irfan; Nurbaiti
Jurnal Pengabdian Magister Pendidikan IPA Vol 9 No 2 (2026): April-Juni 2026
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v9i2.15208

Abstract

Prevalensi penyakit diabetes melitus terus mengalami peningkatan dan menuntut pendekatan promotif dan preventif berbasis potensi lokal. Salah satu upaya yang dapat dilakukan adalah melalui edukasi pemanfaatan tanaman herbal lokal kepada masyarakat dalam kegiatan pengabdian kepada masyarakat. Kegiatan ini bertujuan meningkatkan pengetahuan dan keterampilan masyarakat dalam memanfaatkan tanaman herbal lokal sebagai minuman fungsional pendukung pengendalian kadar gula darah. Herbal yang digunakan meliputi jahe (Zingiber officinale), kayu manis (Cinnamomum burmannii), daun kelor (Moringa oleifera), dan ketumbar (Coriandrum sativum). Metode pelaksanaan berupa penyuluhan edukatif dan demonstrasi pembuatan minuman fungsional wedang herbal. Hasil menunjukkan semangat peserta yang tinggi, pemahaman dan kemampuan dalam membuat kembali minuman fungsional wedang herbal. Secara ilmiah, keempat tanaman ini mengandung senyawa bioaktif seperti flavonoid, polifenol, gingerol, cinnamaldehyde, dan isothiocyanate yang berpotensi meningkatkan sensitivitas insulin dan membantu menurunkan kadar glukosa darah. Pemanfaatan herbal lokal ini dapat menjadi strategi pemberdayaan masyarakat dalam mendukung pengendalian faktor risiko diabetes secara mandiri dan berkelanjutan.
Efektivitas Antibakteri Ekstrak Etanol Kulit Jeruk Manis (Citrus sinensis (L).) Terhadap Pertumbuhan Bakteri Penyebab Jerawat Staphylococcus epidermidis Fitratul wahyuni; Dhea Frediriva Anuar; Nawwar Irfan; Efilia Meirita; Reza Laila Najmi; Najmi Hilaliyati; Izza Aulia Rizqika Nasution
The Journal Of Pharmacy Vol. 3 No. 2 (2026): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Acne (Acne vulgaris) is a skin condition frequently caused by the bacterium Staphylococcus epidermidis. Sweet orange peel (Citrus sinensis (L.)) is an agricultural waste product with potential as a natural antibacterial agent due to its content of various secondary metabolites. This study aimed to determine the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and antibacterial activity of the ethanolic extract of sweet orange peel against the growth of Staphylococcus epidermidis. The study employed the maceration method using 70% ethanol as the solvent. Standardization was conducted through specific and non-specific parameter tests. The MIC was determined using the broth dilution method with a UV-Vis spectrophotometer at concentrations of 6%, 7%, 8%, and 9%, while the MBC was determined using the subculture method on Nutrient Agar medium. Antibacterial activity was assessed using the disc diffusion method at concentrations of 10%, 20%, and 30%. The results showed that the crude drug material (simplicia) and the extract tested positive for alkaloids, flavonoids, saponins, tannins, and terpenoids. Values ​​for loss on drying and total ash content met quality requirements (<10%). Both MIC and MBC values ​​were observed at a concentration of 9%. The average inhibition zone diameters at concentrations of 10%, 20%, and 30% were 10.01 mm, 13.96 mm, and 18.06 mm, respectively, indicating strong inhibitory activity. It is concluded that the ethanolic extract of sweet orange peel (Citrus sinensis (L.)) possesses strong antibacterial activity against Staphylococcus epidermidis and has the potential to be developed as a natural agent for acne treatment.
LITERATUR REVIEW: FITOTERAPI UNTUK AROMATERAPI DAN PENYAKIT DEPRESI Nawwar Irfan; Syafitri; Nur Atika; Juliana Dara; Auliya Rabbani
Jurnal Riset Multidisiplin Edukasi Vol. 3 No. 1 (2026): Jurnal Riset Multidisiplin Edukasi (Januari 2026)
Publisher : PT. Hasba Edukasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71282/jurmie.v3i1.1587

Abstract

Depression is one of the most common psychological disorders and can significantly affect an individual’s quality of life. In addition to conventional pharmacological therapy, aromatherapy using plant-derived essential oils has been widely applied as a complementary treatment to reduce depressive symptoms. This study aimed to review the potential of aromatherapy-based phytotherapy in the management of depression through a literature review. Articles were collected from Google Scholar and PubMed using the keywords aromatherapy, depression, and essential oils. A total of 20 relevant articles were selected based on inclusion and exclusion criteria, and 10 main journals were analyzed. The results indicate that several essential oils, including bergamot, gardenia, jasmine, lavender, ylang-ylang, peppermint, cinnamon, lemon, pandan, as well as Plumeria alba and Michelia alba, exhibit antidepressant, anxiolytic, anti-stress, and relaxing effects. Overall, aromatherapy using essential oils has potential as a safe and easily applicable complementary therapy to help reduce depressive symptoms. Further studies with stronger experimental designs are required to support its clinical application.
Antipiretic Activity Test of Papaya Leaf Ethanol Extract (Carica Papaya L.) on Male White Mice (Mus Musculus) Rialita Lifiani; Nurdina Putri; Nurul Adzkia Ghearizky; Nawwar Irfan; Muhammad Ridho Bahar
The Journal Of Pharmacy Vol. 3 No. 2 (2026): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Fever is a condition characterized by an increase in body temperature above normal levels due to infection or inflammatory processes. The use of synthetic antipyretic drugs may cause adverse effects, necessitating alternative treatments derived from natural sources. Papaya leaves (Carica papaya L.) contain secondary metabolites that are suspected to have antipyretic activity. This study aimed to determine the antipyretic activity of papaya leaf ethanol extract and the most effective dose in male white mice (Mus musculus). This experimental study used a Randomized Block Design (RBD) involving 25 male white mice divided into five groups: negative control receiving 1% Na-CMC, positive control receiving ibuprofen 52 mg/kgBW, and treatment groups receiving papaya leaf ethanol extract at doses of 100, 200, and 400 mg/kgBW. Fever was induced subcutaneously using a 40% bread yeast suspension. Data were analyzed using One-Way ANOVA followed by Tukey's Post Hoc test. The results showed that the extract contained alkaloids, flavonoids, tannins, and saponins and was able to reduce body temperature at all tested doses. The 400 mg/kgBW dose showed the best antipyretic activity and was not significantly different from ibuprofen. In conclusion, papaya leaf ethanol extract has antipyretic activity, with 400 mg/kgBW being the most effective dose.
Co-Authors Alfahtiah Zurlina Astuti Damayanti Aulia Fitri, Windy Auliya Rabbani Ayu Rahmawati AYU RAHMAWATI Citra Aulia Restu Dhea Frediriva Anuar Fitratul Wahyuni Jesika Sinaga Juliana Dara Lubis, Nursyafni Lusi Indriani Meirita, Efilia Mestika, Diani Muhammad Arif Muhammad Arif Muhammad Ridho Bahar Najmi Hilaliyati Nasution, Izza Aulia Rizqika Noveri Rahmawati Novita Sari Novtafia Endri Nur Atika Nurbaiti Nurdina Putri Nursyafni Nurul Adzkia Ghearizky Putri Afriani Reza laila Najmi Rialita Lifiani Sapna Ariani Syafitri Syukron Jauhary Tirta Naila Tri Nova Lovena Wulandari, Tri Ayu Yucuely Benedika N Yunita Lumban Raja