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All Journal Jurnal Riset Multidisiplin Edukasi Journal Of Pharmacy Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah
Nawwar Irfan
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Religion Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Medicine & Pharmacology Public Health Social Sciences Other

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Evaluasi Penggunaan Obat Anti Hipertensi Pada Pasien Stroke Iskemik Di Rsud Arifin Achmad Tahun 2022 Nawwar Irfan; Nursyafni; Ayu Rahmawati; Mestika, Diani
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Antihypertensive drugs are one of the drugs most commonly given to ischemic stroke patients. Ischemic stroke is a stroke resulting from thrombosis or embolism that occurs in the cerebral blood vessels and causes obstruction of cerebral blood flow to the cerebral blood vessels. The use of drugs is rational if the patient receives treatment according to his clinical needs. The aim of this study was to determine the appropriate use of antihypertensive drugs in ischemic stroke patients based on the right indication, selection of the right drug, right dose and determine the relationship between sociodemographics and the results of antihypertensive treatment in ischemic stroke patients at Arifin Achmad Regional Hospital. The method used in this research is a descriptive observational method using retrospective data which was carried out by recording medical record data of patients with a final diagnosis of ischemic stroke accompanied by hypertension with a sample size of 80 patients. people (52.5%), 45-64 years old 44 people (55%), working patients 53 people (66.3%), and the most widely used drug class was amlodipine as many as 67 people (56.8%). In the results of the chi-square test with a significance value of p value = 0.05 for the relationship between age and gender on risk factors, the age value was p = 0.004, while the gender value was p = 0.014. It was concluded that the evaluation of the use of antihypertensive drugs at Arifin Achmad Hospital was 100% correct and showed that age and risk factors were related, and gender and risk factors were related. Keywords: Hypertension, ischemic stroke, evaluation of drug use
Evaluasi Penggunaan Obat Antihipertensi Pada Pasien Hipertensi Primer Rawat Jalan Lanjut Usia Periode Januari 2022 – Juli 2023 Di RSUD Arifin Achmad Provinsi Riau Nawwar Irfan; Ayu Rahmawati; Nurbaiti; Aulia Fitri, Windy
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Hypertension is a condition where the increase in systolic blood is above the normal limit, which is more than 140 mmHg and diastolic blood pressure is more than 90 mmHg. The purpose of this study was to determine the sociodemographic relationship to the treatment outcomes of hypertensive patients and to examine patterns of antihypertensive drug use at Arifin Achmad Hospital, Riau Province. The method used in this study was an observational descriptive method using retrospective data which was carried out by recording medical record data and the research subjects used in this study were outpatients with a diagnosis of hypertension with a total sample of 90 elderly patients. The results of this study showed that the most data on patient characteristics, namely female sex, amounted to 66 people (73.3%) and the most widely used drug class, namely amlodipine, was 76 patients (62.3%). On the results of the chi-square test with a significance value of p value = 0.05 for the relationship between age and gender for risk factors, the age value was p = 0.123 while gender had a p value = 0.000. It was concluded that the evaluation of antihypertensive drugs was 100% correct and showed that age and risk factors had no relationship, while gender had a relationship with risk factors.
Potensi Aktivitas Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) sebagai Antihiperurisemia pada Mencit Putih (Mus musculus) Lusi Indriani; Ayu Rahmawati; Nursyafni; Nawwar Irfan; Novita Sari
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Hyperuricemia is a condition where uric acid production increases or the kidneys cannot remove uric acid from the body so that uric acid levels in the blood exceed 7.0 mg/dL in men and 6.0 mg/dL in women. One of the secondary metabolites that have the potential to act as anti-hyperuricemia is flavonoids. Red shoots contain flavonoids, alkaloids, terpenoids, chalcones, and tannins. This study aimed to determine the anti-hyperuricemia activity of ethanol extract of red shoots (Syzygium myrtifolium Walp.) in white mice. This study used 16 male white mice which were randomly divided into 4 treatment groups. Group 1 was negative control (Na-CMC 0.5%), group 2 was positive control (allopurinol 300 mg/KgBW), group 3 was dose 1 (pucuk merah ethanol extract 10 mg/kgBW), and group 4 was dose 2 (pucuk merah ethanol extract 15 mg/KgBW). Before giving treatment, mice were first induced with KBrO3 at a dose of 148 mg/KgBW intraperitoneally and initial uric acid levels were measured. Then each group was given oral treatment. Uric acid levels were measured at 30, 60, and 90 minutes. The results showed that the pucuk merah ethanol extract 15 mg/KgBW (dose 2) had an anti-hyperuricemia activity of 62.42% compared to allopurinol 65.80%.
Aktivitas Analgesik Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) pada Mencit Putih Jantan (Mus musculus) Lusi Indriani; Tri Nova Lovena; Nursyafni; Nawwar Irfan; Alfahtiah Zurlina
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Analgesics are substances that reduce or eliminate pain without causing loss of consciousness. Traditional medicines are considered safer than synthetic drugs. One plant with potential as an analgesic is the red shoot plant (Syzygium myrtifolium Walp). This plant contains flavonoids, anthocyanins, phenolics, and triterpenoids. This study aimed to determine the analgesic activity of ethanol extract of red shoot leaves (EPM) in male white mice. The analgesic effect was obtained through the writhing test using 1% glacial acetic acid induction. Twenty male white mice were divided into 5 treatment groups, including negative control (0.5% Na CMC), treatment 1 (EPM 3.7 mg/kgBW), treatment 2 (EPM 7.4 mg/kgBW), and treatment 3 (EPM 14.8 mg/kgBW), and positive control (mefenamic acid 500 mg/70 kgBW). All mice were given treatment according to their respective groups. After 30 minutes, all mice were induced with 1% glacial acetic acid at a dose of 10 ml/kgBW intraperitoneally. Then, the number of writhes was observed every 5 minutes for 60 minutes. The average number of writhes data was analyzed using ANOVA and Tukey HSD tests. The results showed that treatment groups 2 (7.40 mg/kgBW) and 3 (14.80 mg/kgBW) showed analgesic activity in male white mice induced by 1% acetic acid. The best dose was 14.80 mg/kgBW with writhing protection of 34.74% and analgesic efficacy of 45.59% compared to mefenamic acid.
Tingkat Pengetahuan Dan Perilaku Swamedikasi Penggunaan Obat Bebas Pada Masyarakat Di Kecamatan Simpang Kanan Kabupaten Rokan Hilir Ayu Rahmawati; Nursyafni; Novtafia Endri; Muhammad Arif; Nawwar Irfan; Wulandari, Tri Ayu; Fitratul Wahyuni
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Self-medication is an act of self-medication carried out by the community to maintain health or manage disease based on personal diagnosis, using drugs repeatedly. This study aims to analyze the relationship between knowledge level and self-medication behavior using over-the-counter drugs in the community in Simpang Kanan District, Rokan Hilir Regency. The research was conducted observational with a cross-sectional approach, using quota sampling technique and questionnaires as instruments. The results showed that out of 90 respondents, 77.8% had good knowledge, 21.1% had sufficient knowledge, and 1.1% had poor knowledge. In terms of behavior, 81.1% had good behavior, while 18.9% had moderate behavior in self-medication. Analysis using the Chi-Square test resulted in a p-value of 0.002 (p<0.05), indicating a significant relationship between the level of knowledge and behavior of self-medication using over-the-counter drugs in the community in Simpang Kanan District, Rokan Hilir Regency.
LITERATUR REVIEW: FITOTERAPI UNTUK MENINGKATKAN SISTEM IMUN Nawwar Irfan; Citra Aulia Restu; Jesika Sinaga; Syukron Jauhary; Yunita Lumban Raja
Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah Vol. 2 No. 1 (2026): Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah (Januari 2026)
Publisher : PT. Saha Kreasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64788/ar-rasyid.v2i1.290

Abstract

The immune system serves as the primary defense mechanism against pathogenic agents and plays an essential role in maintaining physiological homeostasis. Impairment of immune function may increase susceptibility to infections and adversely affect overall health. Phytotherapy, which involves the use of medicinal plants as therapeutic agents, has been increasingly explored as a natural immunomodulatory approach due to its favorable safety profile and abundant availability in Indonesia. This article aims to evaluate the potential of phytotherapy in enhancing immune function based on existing scientific evidence. A literature review was conducted involving 20 national and international scientific articles retrieved from PubMed, Scopus, ScienceDirect, Google Scholar, and Garuda databases. The reviewed articles included in vitro, in vivo, in silico, clinical studies, and community-based research addressing the immunomodulatory effects of medicinal plants. The findings indicate that 18 medicinal plant species have been reported to exhibit immunomodulatory activity, with the most extensively studied plants being Phyllanthus niruri, Zingiber officinale, Curcuma longa, Curcuma xanthorrhiza, and Nigella sativa. The immunomodulatory effects are mediated through enhanced macrophage phagocytic activity, stimulation of lymphocyte proliferation, activation of natural killer cells, and regulation of cytokine production, including IL-2, IL-6, IL-12, IFN-γ, and TNF-α. These biological activities are associated with the presence of bioactive compounds such as flavonoids, alkaloids, polysaccharides, terpenoids, and phenolic compounds. In conclusion, phytotherapy demonstrates considerable potential as a natural immunomodulator; however, further standardization of raw materials, formulation processes, and well-designed clinical trials are required to support its development into evidence-based phytopharmaceuticals.
LITERATURE REVIEW: FITOTERAPI UNTUK PENGOBATAN GANGGUAN SISTEM PERNAFASAN Nawwar Irfan; Yucuely Benedika N; Astuti Damayanti; Sapna Ariani; Tirta Naila
Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah Vol. 2 No. 1 (2026): Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah (Januari 2026)
Publisher : PT. Saha Kreasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64788/ar-rasyid.v2i1.296

Abstract

Respiratory system disorders are a common condition and their prevalence continues to increase, especially in developing countries. The use of traditional medicinal plants is widely utilized as an alternative therapy because it is considered safe, easily accessible, and highly effective. The purpose of writing this article is to present a pharmacological study of medicinal plants that have the potential to be used as phytotherapy for respiratory system disorders. The method used in this study is a literature review of relevant scientific articles. The study results indicate that active compounds such as flavonoids, phenolics, terpenoids, and alkaloids possess anti-inflammatory, bronchodilator, immunomodulatory, antioxidant, and antiviral activities that play a role in improving respiratory tract function and reducing the symptoms of respiratory disorders. Medicinal plants have great potential as a complementary therapy for respiratory system disorders, although further research is needed to clinically confirm their effectiveness and safety.
LITERATUR REVIEW: FITOTERAPI UNTUK AROMATERAPI DAN PENYAKIT DEPRESI Nawwar Irfan; Syafitri; Nur Atika; Juliana Dara; Auliya Rabbani
Jurnal Riset Multidisiplin Edukasi Vol. 3 No. 1 (2026): Jurnal Riset Multidisiplin Edukasi (Januari 2026) In Press
Publisher : PT. Hasba Edukasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71282/jurmie.v3i1.1587

Abstract

Depression is one of the most common psychological disorders and can significantly affect an individual’s quality of life. In addition to conventional pharmacological therapy, aromatherapy using plant-derived essential oils has been widely applied as a complementary treatment to reduce depressive symptoms. This study aimed to review the potential of aromatherapy-based phytotherapy in the management of depression through a literature review. Articles were collected from Google Scholar and PubMed using the keywords aromatherapy, depression, and essential oils. A total of 20 relevant articles were selected based on inclusion and exclusion criteria, and 10 main journals were analyzed. The results indicate that several essential oils, including bergamot, gardenia, jasmine, lavender, ylang-ylang, peppermint, cinnamon, lemon, pandan, as well as Plumeria alba and Michelia alba, exhibit antidepressant, anxiolytic, anti-stress, and relaxing effects. Overall, aromatherapy using essential oils has potential as a safe and easily applicable complementary therapy to help reduce depressive symptoms. Further studies with stronger experimental designs are required to support its clinical application.
Co-Authors Alfahtiah Zurlina Astuti Damayanti Aulia Fitri, Windy Auliya Rabbani Ayu Rahmawati Citra Aulia Restu Fitratul Wahyuni Jesika Sinaga Juliana Dara Lusi Indriani Mestika, Diani Muhammad Arif Novita Sari Novtafia Endri Nur Atika Nurbaiti Nursyafni Sapna Ariani Syafitri Syukron Jauhary Tirta Naila Tri Nova Lovena Wulandari, Tri Ayu Yucuely Benedika N Yunita Lumban Raja