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Skrining Fitokimia Ekstrak Etanol 96% Bunga Telang (Clitoria ternatea L.) Dan Uji Kemampuan Sebagai Antibakteri Niken Hataningtyas; Anjas, Anjas Wilapangga; Sri Royani
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Indonesia secara geografis memiliki letak yang strategis untuk ditumbuhi tanaman herbal seperti bunga telang. Bunga telang dengan nama ilmiah Clitoria ternatea L. tergolong ke dalam keluarga Fabaceae yang merupakan salah satu jenis tanaman yang hidup dengan baik di Indonesia. Bunga telang merupakan salah satu tanaman yang telah lama digunakan dalam pengobatan dan telah terbukti memiliki aktivitas sebagai antibakteri. Salah satu metabolit sekunder yang berperan sebagai antibakteri yaitu flavonoid. Oleh karena itu dilakukan penelitian terkait bunga telang sebagai antibakteri. Berdasarkan hasil skrining fitokimia ekstrak etanol 96% bunga telang yang telah dilakukan, diketahui bahwa bunga telang positif mengandung alkaloid, flavonoid, saponin dan tanin. Ekstrak bunga telang diperoleh dengan metode maserasi dengan menggunakan pelarut etanol 96%. Pada proses maserasi yang telah dilakukan diperoleh hasil rendemen sebesar 22,5%. Pada pengujian antibakteri menunjukkan bahwa ekstrak etanol 96% bunga telang dapat menghambat bakteri Strapylococcus aureus. Pengujian antibakteri dilakukan menggunakan metode difusi cakram, dimana cakram kosong direndam pada ekstrak etanol 96% bunga telang dengan berbagai konsentrasi. Ekstrak etanol 96% bunga telang untuk pengujian antibakteri dibuat dengan konsentrasi 50 ppm dan 100 ppm. Sedangkan kontrol positif yang digunakan yaitu antibiotik chloramphenicol. Pada penelitian ini ekstrak etanol 96% bunga telang dengan konsentrasi 50 ppm memiliki daya hambat terhadap bakteri Straphylococcus aureus sebesar 1,04 mm dan pada konsentrasi 100 ppm memiliki daya hambat sebesar 1,72 mm. Dengan demikian ekstrak etanol 96% bunga telang konsentrasi 100 ppm memiliki daya hambat terhadap bakteri Strapylococcus aureus lebih besar dibandingkan konsentrasi 50 ppm.

Green Synthesis Nanopartikel Perak (NPAg) Menggunakan Ekstrak Etanol 96% Daun Kelor (Moringa oleifera) Sebagai Antibakteri Viderika Haini Nurfadia; Anjas, Anjas Wilapangga; Sri Royani
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Indonesia has various types of plants that can be used as medicine, one of which is moringa leaves (moringa oleifera). To utilize Indonesia's natural wealth, a method was developed in a drug delivery system that uses the principle of nanoparticles by utilizing medicinal plants as reductants. This study aims to prove that moringa leaf extract functions as a bioreductor and the synthesized silver nanoparticles have antibacterial potential. The nanoparticle synthesis method used in this study is the green synthesis method. Moringa leaves (Moringa oleifera) were extracted using the maceration method, then the 100 ppm concentration extract was used to synthesize silver nitrate (AgNO3). The silver nanoparticle solution was characterized using UV-Vis spectrophotometry and tested for antibacterial activity. An extract yield of 40.85% was obtained. The synthesis process of silver nanoparticles solution is brownish yellow in 6.56 seconds, has a wavelength of 400 nm with an absorbance value of 0.966. Antibacterial activity is indicated by the formation of a clear zone around the disc paper, silver nanoparticles showed an inhibition zone of 1.44 cm on petri dish 1 and 1.25 cm on petri dish 2. Based on the research that has been done, flavonoids in Moringa leaves are able to act as bioreductors in the synthesis of silver nanoparticles. In addition, the silver nanoparticles obtained have potential as antibacterial agents.

Aktivitas Analgesik Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) pada Mencit Putih Jantan (Mus musculus) Lusi Indriani; Tri Nova Lovena; Nursyafni; Nawwar Irfan; Alfahtiah Zurlina
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Analgesics are substances that reduce or eliminate pain without causing loss of consciousness. Traditional medicines are considered safer than synthetic drugs. One plant with potential as an analgesic is the red shoot plant (Syzygium myrtifolium Walp). This plant contains flavonoids, anthocyanins, phenolics, and triterpenoids. This study aimed to determine the analgesic activity of ethanol extract of red shoot leaves (EPM) in male white mice. The analgesic effect was obtained through the writhing test using 1% glacial acetic acid induction. Twenty male white mice were divided into 5 treatment groups, including negative control (0.5% Na CMC), treatment 1 (EPM 3.7 mg/kgBW), treatment 2 (EPM 7.4 mg/kgBW), and treatment 3 (EPM 14.8 mg/kgBW), and positive control (mefenamic acid 500 mg/70 kgBW). All mice were given treatment according to their respective groups. After 30 minutes, all mice were induced with 1% glacial acetic acid at a dose of 10 ml/kgBW intraperitoneally. Then, the number of writhes was observed every 5 minutes for 60 minutes. The average number of writhes data was analyzed using ANOVA and Tukey HSD tests. The results showed that treatment groups 2 (7.40 mg/kgBW) and 3 (14.80 mg/kgBW) showed analgesic activity in male white mice induced by 1% acetic acid. The best dose was 14.80 mg/kgBW with writhing protection of 34.74% and analgesic efficacy of 45.59% compared to mefenamic acid.

Pengujian Konsentrasi Hambat Minimum Ekstrak Daun Mangrove (Avicennia alba Blume) Terhadap Shigella sonnei Nursyafni; Rahmawati, Ayu; Nurbaiti; Irfan, Nawwar; Nabilla, Alivia
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Infectious diseases are a public health problem for both developed and developing countries. The cause of an infectious disease such as in Shigella sonnei bacteria which occurs in dysentery is characterized by feces mixed with blood and mucus usually accompanied by fever. One solution to overcome dysentery is by utilizing plants that can be processed into medicine. One of them is mangrove (Avicennia alba Blume) which contains phytochemical compounds as antibacterial activity. This study is an experimental study that aims to determine the minimum inhibitory concentration (MIC) of mangrove leaf ethanol extract (Avicennia alba Blume) against Shigella sonnei bacteria. The minimum inhibitory concentration (MIC) value of the extract was determined using the liquid dilution method and continued with solid dilution, with concentrations of 11%, 12%, 13%, 14%, and 15%. Observations were made to see whether bacterial growth in the media. The test results showed that mangrove leaf ethanol extract (Avicennia alba Blume) had a minimum inhibitory concentration at a concentration of 15% in inhibiting the growth of Shigella sonnei bacteria with clear around the media.

Tingkat Pengetahuan Dan Perilaku Swamedikasi Penggunaan Obat Bebas Pada Masyarakat Di Kecamatan Simpang Kanan Kabupaten Rokan Hilir Ayu Rahmawati; Nursyafni; Novtafia Endri; Muhammad Arif; Nawwar Irfan; Wulandari, Tri Ayu; Fitratul Wahyuni
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Self-medication is an act of self-medication carried out by the community to maintain health or manage disease based on personal diagnosis, using drugs repeatedly. This study aims to analyze the relationship between knowledge level and self-medication behavior using over-the-counter drugs in the community in Simpang Kanan District, Rokan Hilir Regency. The research was conducted observational with a cross-sectional approach, using quota sampling technique and questionnaires as instruments. The results showed that out of 90 respondents, 77.8% had good knowledge, 21.1% had sufficient knowledge, and 1.1% had poor knowledge. In terms of behavior, 81.1% had good behavior, while 18.9% had moderate behavior in self-medication. Analysis using the Chi-Square test resulted in a p-value of 0.002 (p<0.05), indicating a significant relationship between the level of knowledge and behavior of self-medication using over-the-counter drugs in the community in Simpang Kanan District, Rokan Hilir Regency.

Uji Aktivitas Antioksidan Ekstrak Etanol 70% Daun Pandan Wangi (Pandanus amaryllifolius Roxb) Dengan Metode DPPH Muhammad Arif; Ayu Rahmawati; Noveri Rahmawati; Nursyafni; Indah, Indah Kurniawati
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Antioxidants and free radicals are topics that are increasingly discussed in the field of health and lifestyle. Free radicals, which result from oxidative stress, are known to play a role in the development of many serious diseases, such as cancer, cardiovascular disorders and premature aging. Antioxidants are able to neutralize free radicals, thus having the potential to prevent or reduce the impact of these diseases. This study aims to evaluate the antioxidant activity of ethanol extract of pandan wangi leaves (Pandanus amaryllifolius Roxb) using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method and determine the IC50 value as an indicator of effectiveness. Experimental methods were used to analyze antioxidant activity, with DPPH assays performed using a UV-Vis spectrophotometer. The results showed that the ethanol extract of pandan leaves had an IC50 value of 180.21 µg/mL, which was slightly lower than vitamin C as a positive control with an IC50 value of 136.03 µg/mL. Nevertheless, the antioxidant activity of pandan leaf extract is still in the moderate category, indicating its potential as a source of natural antioxidants. This study also emphasizes the importance of technical factors, such as temperature, incubation duration, and solvent quality, in influencing the test results. This study opens up opportunities for further development in the optimization of extraction and utilization of pandan wangi leaves as a natural ingredient to fight oxidative stress.

Penetapan Kadar Flavonoid Total Ekstrak Etanol 96% Daun Gaharu (Aquilaria malaccensis Lam) dengan Spektrofotometer UV-Vis Indriani, Lusi; Dewi Gulyla Hari; Arabella Natasya; Nurdina Putri
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Gaharu leaves (Aquilaria malaccensis Lam) are a type of plant commonly used as a raw material for pharmaceuticals, cosmetics, and perfumes due to its secondary metabolic compounds such as flavonoids, alkaloids, terpenoids, steroids, and quinones. This study aims to determine the total flavonoid content of 96% ethanol extract of gaharu leaves using UV-Vis spectrophotometry. Gaharu leaves were extracted using the Microwave-Assisted Extraction (MAE) method with 96% ethanol as the solvent. The resulting extract was then qualitatively tested and the flavonoid content was measured using UV-Vis spectrophotometry with quercetin as the standard. The results of the determination of the total flavonoid content of the 96% ethanol extract of gaharu leaves were 2.539 ± 0.005% equivalent to quercetin.

Hubungan Tingkat Pengetahuan, Sikap Siswa SMAN Se- Kota Pekanbaru Terhadap Praktik Penggunaan Obat Analgetik Yang Dijual Bebas Di Pasaran Ayu Rahmawati; Nursyafni; Nurhasanah; Efilia Meirita
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Analgesics are drugs that are often used to relieve pain without affecting a person's consciousness. This study aims to determine the relationship between the level of knowledge, attitudes of SMAN students in Pekanbaru City towards the practice of using analgesic drugs sold over the counter on the market. This study uses a descriptive survey method with a sampling technique, namely the simple random sampling technique using a questionnaire instrument. Where there were 367 respondents involved in this study, dominated by 204 females and 163 male respondents. The age range is 15-18 years, the majority of whom are 16 years old. Data analysis using bivariate using chi square test and multivariate using F test. The results showed that the level ofknowledge was sufficient 251 respondents (68.4%), positive attitude 311 (84.7%) and lack of practice as many as 276 (75.2%). In bivariate analysis there was a significant relationship between knowledge of the practice of using analgesic drugs with (p value = 0.000 <0.05). There was no significant relationship between attitudes towards the practice of using analgesic drugs with (p value = 0.0716 > 0.05). This study emphasizes the importance of education about the use of analgesic drugs among high school students to prevent drug abuse

Evaluasi Tingkat Pengetahuan dan Perilaku Terhadap Penggunaan dan Resistensi Antibiotik Di Kalangan Mahasiswa Farmasi Universitas Muhammadiyah Riau Nursyafni; Ayu Rahmawati; Shakynna Suandha
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Antibiotik adalah obat yang digunakan untuk mencegah dan mengobati infeksi bakteri, yang merupakan salah satu jenis obat yang paling umum dan banyak digunakan di masyarakat. Penelitian ini bertujuan untuk mengidentifikasi distribusi karakteristik responden dan hubungan antara ingkat pengetahuan serta perilaku terhadap penggunaan antibiotik di kalangan mahasiswa farmasi Universitas Muhammadiyah Riau. Sampel penelitian terdiri dari 86 orang yang didominasi oleh perempuan (87,2%), sementara laki-laki hanya berjumlah 12,8%. Rentang usia responden berkisar antara 18 hingga 22 tahun, dengan mayoritas berada pada usia 19 dan 21 tahun, yang bersama-sama mencakup 59,3% dari total sampel. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki tingkat pengetahuan yang baik mengenai penggunaan antibiotik, dengan 94,2% responden berada dalam kategori ini. Selain itu, perilaku penggunaan antibiotik di kalangan responden juga tergolong baik, dengan 100% responden menunjukkan perilaku yang positif. Analisis statistik lebih lanjut mengungkapkan adanya hubungan yang signifikan antara tingkat pengetahuan dan perilaku penggunaan antibiotik, dengan nilai p sebesar 0,000 (p<0,05). Hasil ini menunjukkan bahwa tingkat pengetahuan yang lebih tinggi berkorelasi positif dengan perilaku yang lebih baik dalam penggunaan antibiotik. Temuan ini menggarisbawahi pentingnya pendidikan yang memadai dalam meningkatkan pengetahuan tentang penggunaan antibiotik yang tepat, yang pada gilirannya dapat mempengaruhi perilaku penggunaan yang lebih bertanggung jawab di kalangan mahasiswa.

Studi Cross-Sectional Tentang Pengetahuan, Sikap, dan Praktik Terhadap Penggunaan Obat OTC Di Kalangan Mahasiswa Farmasi Universitas Muhammadiyah Riau Nursyafni; Nurbaiti; Reza laila Najmi; Rahmi Amini; Izza Aulia Risqika Nasution; Lilian Rahma Dayani; Najmi Hilaliyati
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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OTC (Over the Counter) drugs are a class of over-the-counter and limited over-the-counter drugs, which can be purchased without a prescription from a doctor, are safe, and effective when used according to the instructions on the drug packaging label. This study is a cross-sectional study that aims to evaluate the knowledge, attitudes, and practices towards the use of OTC drugs among Pharmacy students of the University of Muhammadiyah Riau. The study sample consisted of 86 respondents, consisting of 86% female and 14% male, with the majority aged 19-21 years. Data were collected using a validated questionnaire and analyzed using the Spearman correlation test to determine the relationship between knowledge, attitudes, and practices. The results showed that 62.8% of respondents had sufficient knowledge about OTC drugs, 64% had moderate attitudes, and 79.1% showed positive practices in the use of OTC drugs. Correlation analysis showed a significant positive relationship between knowledge and attitude (correlation coefficient: 0.362; p=0.001), knowledge and practice (correlation coefficient: 0.751; p=0.000), and attitude and practice (correlation coefficient: 0.553; p=0.000). These findings indicate that increasing knowledge about OTC drugs can contribute to more positive attitudes and better practices in their use. This study provides important insights for educational institutions in designing more effective educational programs to improve pharmacy students' knowledge, attitudes, and practices towards OTC drugs. Increased knowledge is expected to not only shape more positive attitudes, but also encourage safer and more responsible drug use practices

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admin JFMU

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Kampus Utama UMRI, Jl. Tuanku Tambusai Kota Pekanbaru Kode Pos 28294 Provinsi Riau

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Kota pekanbaru,

Riau

INDONESIA

Abstract

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name admin JFMU

Contact Email jfmu@umri.ac.id

Phone -

Journal Mail Official jfmu@umri.ac.id

Editorial Address Kampus Utama UMRI, Jl. Tuanku Tambusai Kota Pekanbaru Kode Pos 28294 Provinsi Riau

Location Kota pekanbaru, Riau INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
admin JFMU

Contact Email
jfmu@umri.ac.id

Phone
-

Journal Mail Official
jfmu@umri.ac.id

Editorial Address
Kampus Utama UMRI, Jl. Tuanku Tambusai Kota Pekanbaru Kode Pos 28294 Provinsi Riau

Location
Kota pekanbaru,

Riau

INDONESIA