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Journal of Microbiology, Biotechnology and Conservation
Published by Universitas Mataram
ISSN : -     EISSN : 3090708X     DOI : https://doi.org/10.29303/jmbc.v1i2
Core Subject : Science, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Immunology & microbiology
The journal prioritizes papers in the following areas: Basic and Applied Microbiology Biotechnology and its applications in various aspects of life Bioinformatics Microbiome Molecular Biology and Genetics Conservation of Biota and Environment All organisms related to microbial communities, including fungi, plants, animals, humans, and viruses In line with the multidisciplinary nature of microbiology, biotechnology, and conservation.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 31 Documents
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Analisis Bioinformatika GenblaCTX-M Pengkode β-Laktamase Spektrum Luas pada Klebsiella pneumoniae Menggunakan Data GenBank NCBI Dwi Sakila Ulfa; Gusti Ayu Niscari Dewi; Ira Firati Fionita; Faturrahman; Sarkono
Journal of Microbiology, Biotechnology and Conservation Vol. 2 No. 1 (2026): Journal of Microbiology, Biotechnology and Conservation (jMBC)
Publisher : Master’s Program in Biology, Faculty of Mathematics and Natural Sciences, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/6805v662

Abstract

Klebsiella pneumoniae is a short rod-shaped Gram-negative bacterium capable of fermenting lactose and various other carbohydrates, producing acid and gas. The blaCTX-M gene is one of the major genes responsible for β-lactam resistance in K. pneumoniae. This study aimed to analyze the genetic variation and phylogenetic relationships of the blaCTX-M gene in K. pneumoniae using nucleotide sequence data retrieved from the NCBI GenBank database. A total of 19 sequences representing isolates from different countries were aligned to identify nucleotide variations. The alignment results revealed genetic variation among the isolates, with most forming a closely related cluster indicating high sequence similarity. Eighteen isolates showed identical characteristics with minor variations, while one isolate, NG_048898, exhibited the highest number of nucleotide variations. A total of 168 nucleotide variations were identified, predominantly nonsynonymous substitutions, distributed throughout the nucleotide sequence. Phylogenetic analysis using the Neighbor-Joining method with the Kimura 2-parameter model supported the alignment results, showing a distinct branch for isolate NG_048898, suggesting a different evolutionary origin. These findings highlight the genetic diversity of the blaCTX-M gene in K. pneumoniae isolates and provide important insights into the distribution of β-lactamase genes, which are essential for understanding antibiotic resistance patterns.

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