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Prasetyadi Mawardi
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Indonesian Basic and Experimental Health Sciences
Published by RSUD Dr. Moewardi
ISSN : -     EISSN : 30255929     DOI : 10.11594/ibehs
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Indonesian Basic and Experimental Health Sciences Journal (IBEHS) is a health journal published by RSUD Dr. Moewardi Surakarta, Central Java, Indonesia as a contribution to RSUD Dr. Moewardi for the development and progress of health science which is marked by various innovations and creativity of health workers, both in the Dr. Moewardi or other health workers who are always concerned about education, research, and community service in the health sector.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 25 Documents
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The Relationship Between Measurements Of Medial Tibial Plateau Depth And Femoral Notch (Notch Witdh & Shape) On Genu Mri And The Severity Of The Isolated Anterior Cruciate Ligament Tear Cross Sectional Study At Tertiary Refferal Hospital Dr. Moewardi General Hospital & Prof. Soeharso Orthopedic Hospita Irawan, Amelia Tjandra; Adhie, Anistyaning Wahyu; Anindyarani, Yutrisa Sasti; Lillah, Yudhi
Indonesian Basic and Experimental Health Sciences Vol. 12 No. 2 (2024): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol12iss2pp63-72

Abstract

Background: The knee is a complex joint, composed of ligament components, one of which is the Anterior cruciate ligament which functions as a knee stabilizer. ACL injury is the most common ligament injury in the knee joint. Anatomical factors are one of the factors that predict the severity of an ACL tear. Medial Tibial Plateau Depth and Femoral Notch are one of the influencing factors. Genu MRI examination plays an important role in assessing these factors regarding the severity of an Isolated ACL tear. Objective: To determine the relationship between measurements of Medial Tibial Plateau Depth and Femoral Notch (Notch Witdh & Shape) on MRI genu with the severity of Isolated Anterior Cruciate Ligament Tear at Dr. Moewardi Hospital Surakarta and Prof. Soeharso Orthopedic Hospital Surakarta Method: Quantitative analytical research with a cross-sectional design was conducted from May to June 2023. The research sample was patients who underwent a Knee MRI examination with clinical Isolated ACL Tear in the period 1 January 2021 to 30 June 2023. Patients were assessed for the severity of the ACL tear and measurements of the Medial Tibial Plateau Depth and Notch Width and the shape of the Femoral Notch Os Femur Results: Medial tibial plateau depth on MRI Genu was positively correlated with the severity of isolated ACL tear (p value <0.001 and r correlation value of 0.943). Femoral Notch Shape, especially the A shape, has a relationship with the severity of isolated ACL tear (p value = 0.036 (p < 0.05) and r value = 0.274). Meanwhile, the relationship between femoral notch width on MRI Genu and the degree of isolated ACL tear is not significant because the p value obtained is 0.484 (p>0.05) Conclusion: Medial Tibial Plateau Depth and Femoral Notch Shape on MRI Genu have a relationship with the Severity of Isolated Anterior Cruciate Ligament Tear, whereas Femoral Notch Witdh has no relationship
Effect Of Vitamin C On Tnf-Alpha Expression In Recurrent Tonsillitis At Rsud Dr. Moewardi Kandhi, Putu Wijaya
Indonesian Basic and Experimental Health Sciences Vol. 12 No. 2 (2024): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol12iss2pp59-62

Abstract

Background: The immunopathogenesis of tonsillitis is thought to be due to the involvement of various proinflammatory cytokines including tumor necrosis factor α (TNF-α). Considering the role of TNF-α in the immunopathogenesis of tonsillitis, various interventions have been carried out both surgically and with drugs. Vitamin C, which is one of the important micronutrients in the body, has a role as an antioxidant and immunomodulator so that its administration is thought to be able to overcome the increase in TNF-α during the disease process. This study aims to determine the effect of vitamin C administration on TNF-α levels in patients with recurrent tonsillitis at Dr. Moewardi Hospital. Methods: This study is an experimental quantitative study using Randomized Controlled Trials research design with non-blinding. Samples in the study were divided into two treatment groups, namely treatment with oral vitamin C and placebo 50mg/kg body weight/day which then measured serum TNF-α levels. Results: The average TNF-α level in the Vitamin C group was smaller at 110.72 pg/mL compared to the control group which amounted to 148.96 pg/mL. The results of the independent t-test of TNF-α levels in both groups obtained a significant value <0.05, which was 0.037. This means that there is a significant difference in TNF-α levels between the two treatment groups. Conclusions: Vitamin C administration before tonsillectomy in patients with recurrent tonsillitis can significantly reduce TNF-α levels compared to the control group. This opens the possibility of routine use of vitamin C in recurrent tonsillitis patients to get better treatment results.
Correlation between Nasal Patency and Chronic Rhinosinusitis based on Peak Nasal Inspiratory Flow and Sino-Nasal Outcome Test-22 Hendradewi, Sarwastuti
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 1 (2024): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss1pp7-10

Abstract

INTRODUCTION Chronic Rhinosinusitis (CRS) is a chronic inflammatory condition of the sinuses and nasal mucosa that affects quality of life. This study aims to analyze the correlation between Peak Nasal Inspiratory Flow (PNIF) and Sino-Nasal Outcome Test-22 (SNOT-22) in assessing nasal patency in CRS patients. METHODS This study used a cross-sectional design with CRS patient subjects who underwent PNIF examination and were interviewed using SNOT-22. Statistical analysis involved normality test, log transformation, and Mann Whitney test for non-normally distributed data. RESULTS Results showed that there was a significant correlation between increased PNIF scores and decreased SNOT-22 scores (p=0.021), indicating improved nasal patency and decreased CRS symptoms. The data showed a significant difference between the groups with normal and low PNIF in terms of SNOT-22 scores. In normal PNIF there were 6 people with Mild SNOT-22 and 1 person with M-S SNOT-22. In low PNIF there were 2 people with Mild SNOT-22 and 44 people with M-S SNOT-22. CONCLUSION PNIF and SNOT-22 are effective as measurement tools to assess nasal patency in CRS patients. The correlation between these two tools shows that increased nasal patency is associated with decreased CRS symptoms.
Dermoscopy Of Onychomycosis: A Literature Review Primisawitri, Pratiwi Prasetya; Mulianto, Nurrachmat
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 1 (2024): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss1pp23-33

Abstract

Background: Onychomycosis is a fungal infection of the nails. Onychomycosis is caused by dermatophytes, non-dermatophyte molds, and non-dermatophyte fungi. Dermoscopy examination has gradually been used as a modern diagnostic method to assess non-invasive nail abnormalities that are easy and inexpensive to visualize abnormal microscopic features of the nail. However, it is still uncommon for medical personnel to diagnose onychomycosis using dermoscopy. Purpose: To provide information on the benefits of the nail dermoscopy technique that can diagnose onychomycosis and describe observable dermoscopic findings. Results: Dermoscopy findings on onychomycosis showed a diverse picture depending on the type. Distal and lateral subungual onychomycosis shows the proximal margin of the onycholytic area with spikes leading to proximal folds and longitudinal striae. White superficial onychomycosis shows large, brittle, irregularly spreading white-yellow patches on the nail's surface. Proximal subungual onychomycosis has one or more transverse white bands on the inner nail plate, while total dystrophic onychomycosis shows longitudinal striae and spikes and irregular distal terminations. Conclusion: Nail dermoscopy improves quality and simplifies examination to establish the diagnosis of onychomycosis because it can guide clinicians in conducting screening, choosing the best time for mycological sampling, and making therapeutic decisions.
Testosterone Levels And Dna Fragmentation Index In Male Undergoing Intrauterine Insemination After Vitamin D3 Supplementation Wijayanti, Agung Sari; Budihastuti, Uki Retno; Melinawati, Eriana; Laqif, Abdurahman; Fahsan, Fatmiyanti
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 1 (2024): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss1pp16-22

Abstract

Nutrition is one of the factors that contribute to male infertility. Vitamin D3 are known to affect spermatozoa and usually served in fertility supplementation in doses of 400 and 1000 IU. Low levels of vitamin D3 have been linked to decreased sperm quality and quantity. This research would like to know the effect of Vitamin D3 to the DNA Fragmentation Index (DFI) and Testosterone blood level in men undergoing intrauterine insemination (IUI). This was an analytical observational study with two groups and a pretest-posttest design. Seventeen men aged 20 to 45 who were undergoing the IUI program and did not have diabetes or hypertension are participate in this study. Sperm DFI was determined by using an ELISA method with a DNA Kit. Blood testosterone levels in ng/mL units was measure using ELISA. IBM-SPSS version 22 was used to perform univariate and bivariate analysis on the collected data. The blood level of Vitamin D3 was significantly increased after the intervention of six week Vitamin D3. Meanwhile, this study shows there are no differences in the level of blood testosterone before and after treatment. The DFI was significantly increased in the 400 IU groups.
Diagnostic Reference Levels for Radiology Examination Using General Purpose X Ray Radiography Hapsari Purbarani, Alviana; Mariyatun; Asih Widiani, Tri; Umaimah, Umi
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 2 (2025): APRIL
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss2pp48-51

Abstract

The local DRL for Dr. Moewardi Hospital is used as a control of patient radiation safety and to measure the quality of radiological examinations conducted at the Radiology Installation of Dr. Moewardi Hospital. The study conducted an assessment on a conventional examination with a General Radiography X-ray plane. The research methodology used was a quantitative approach by using a sample of 30 patients in each examination. X-ray machine data collection was conducted by looking for the Entrance Surface Air Kerma (ESAK) equation, then inputting the patients' data of kV, mAs, FSD, and BSF into the ESAK equation to obtain Entrance Surface Dose (ESD) value of each patient. From ESD data, DRLs were made for each examination using the 3rd quartile data. The results of the study indicated that the local DRL of Dr. Moewardi Hospital was lower than the National DRL of BAPETEN
Effect of the Period of Glucocorticoid Administration on Bone Quality in Patients with Autoimmune Inflammatory Rheumatism Disease (AIIRD) Werdiningsih, Yulyani; Sunarso, indrayana; Nurudhin, Arief
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 2 (2025): APRIL
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss2pp52-58

Abstract

Introduction Inflammatory autoimmune rheumatic disease (AIIRD) such as rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome often requires long-term glucocorticoid therapy. Despite its effectiveness, glucocorticoids are recognized to cause decreased bone quality and increase the risk of osteoporosis. This study aims to evaluate the effect of the period of glucocorticoid administration on bone quality parameters in AIIRD patients. Methods This study was an observational analytical study with a cross-sectional design. A total of 28 female patients with AIIRD were divided into two groups based on the period of glucocorticoid administration: less than 24 months and more than 24 months. The parameters to be measured included bone mineral density (BMD), Collagen Type I C-Telopeptide (CTX), Vitamin D3 levels, and Calcium Ions. Data analysis was conducted using the Mann-Whitney test and the unpaired t-test with a significance level of p<0.05. Results There was no statistically significant difference between the two groups on all measured parameters. The mean BMD in the group of less than 24 months was 0.9471 kg/m², while in the group of more than 24 months it was 0.8920 kg/m² (p>0.05). The mean CTX also did not differ significantly between the two groups (0.2474 vs. 0.2508 ng/mL; p>0.05). Vitamin D3 and Calcium Ion levels showed similar results in the absence of significant differences (Vitamin D3: 15,596 vs. 16,255 ng/mL; Calcium Ion: 1,075 vs. 1,040 mmol/L; p>0.05). Conclusions The period of glucocorticoid administration does not show a significant effect on bone quality in AIIRD patients in this study. Nonetheless, regular monitoring and an individualized approach are still necessary to prevent bone complications in patients receiving long-term glucocorticoid therapy.
The Effect Of Prescription Service Flow Optimization On Medication Waiting Time At Pharmaceutical Supplies Distribution Unit Of Regular Outpatient Dr. Moewardi Hospital Gilchrist, Rafael Ega; Fildzah Ghassani, Yumma; Pratiwi, Retno; Ihsan Udin, Muhammad
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 2 (2025): APRIL
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss2pp59-64

Abstract

Introduction Medication waiting time is one of the minimum pharmaceutical service standards in hospitals, which, if not achieved, can lead to patient dissatisfaction. Based on a field observation, several things hinder prescription services at the Pharmaceutical Supplies Distribution Unit of the regular outpatient of Dr. Moewardi Hospital. Optimization is carried out to reduce medication waiting times for drug services. Objective: To analyse the effect of optimization to medication waiting time at Pharmaceutical Supplies Distribution Unit of regular outpatient in Dr. Moewardi General Hospital   Method The research method was conducted by comparing the average medication waiting time before and after optimization. Before a comparative test, a normality test was carried out with Kolmogorov – Smirnov. A T-test would be conducted if the data were distributed normally, if the data were not distributed normally, the Mann-Whitney test would be performed. Results The results showed a decrease in the waiting time for compounded medicines, both the time from the doctor ordering the prescriptions to the pharmacy validating the prescriptions (p=0.044), and the time from the pharmacy receiving the prescriptions until the medicines were ready (p=0.000). There was a decrease in the average waiting time for non-compounded medicines, the waiting time from the pharmacy receiving the prescriptions until the medicines were prepared, which was originally 45.54 minutes to 36.9 minutes after the service optimization was conducted. However, the decrease in time was not significantly different, both for the time from the doctor ordering the prescriptions to the pharmacy validating the prescriptions (p=0.386), and the time from the pharmacy receiving the prescriptions until the medicines were ready (p=0.305). Conclusion There is an effect of optimizing the flow of prescription services on waiting time of the compounded medicines at the UDPF of Regular Outpatient of Dr. Moewardi Hospital.
Profile of Sexually Transmitted Diseases and The Influence of COVID-19 Pandemic on Sexual Transmitted Infection Testing in Dr. Moewardi General Hospital Ellistasari, Endra Yustin; Mawardi, Prasetyadi; Primisawitri, Pratiwi Prasetya; Octarica , Stella Gracia
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 2 (2025): APRIL
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss2pp34-40

Abstract

Introduction Sexually transmitted infections (STIs) are diseases resulting from bacteria, viruses, or parasites transmitted during vaginal, anal, or oral sexual intercourse. The COVID-19 pandemic markedly influenced STI statistics, leading to potential underreporting of cases and heightened transmission rates. Objective : To analyse the profile of sexually transmitted infections and the influence of COVID-19 on STI assessments at the Dermatology and Venereology (DV) Outpatient Clinic of Dr. Moewardi General Hospital. Method A retrospective study using secondary data derived from medical records and registration logs at DV Outpatient Clinic of Dr. Moewardi General Hospital, spanning from January 2018 to December 2022.   Results 284 new STI cases were documented in the before pandemic lockdown period, however during the pandemic lockdown, there was a significant decline of 149 new cases. After the pandemic lockdown, there was 200 additional cases of STIs. Up to 90 patients with STIs were co-infected with HIV. The predominant instance of STIs was condyloma acuminata., and there was a strong correlation between gender and the incidence of STIs (p=0.000; p<0.05) Conclusion There was a sharp decline in STI cases during the COVID-19 pandemic and a surge in STI cases after the COVID-19 pandemic, predominantly featuring instances of condyloma acuminata and syphilis.
Simultaneous Acute Cardio-Cerebral Infarction: A Rare Case Report Experience in Type C Hospital in Indonesia Andriani, Nurlita Asri; Mangkoesoebroto, Arjatya Pramadita; Chairina Yuliandita, Rizkia; Pramudyo, Bayu Hendro
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 2 (2025): APRIL
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss2pp41-47

Abstract

Background: The simultaneous occurrence of ST-elevation myocardial infarction (STEMI) and acute ischemic stroke (AIS) was described as Cardio-Cerebral Infarction. Consequently, we aimed to provide an overview of the available treatment option for patients in type c hospital in order to guide the similar cases. Case Description: A 50-year-old man came to the emergency room complaining of chest pain for two hours before. The patient had a history of hypertension and an active smoker. The patient had a left hemiparesis. The patient's electrocardiogram showed ST segment elevation in leads V3 and V4. A non-contrast head CT-scan showed infarct in the right occipital region. Echocardiogram showed regional wall motion abnormality. The patient was admitted to the hospital, administered DAPT, statin, anticoagulant and discharged after relief of symptoms. Intravenous alteplase followed by primary PCI is the gold standard therapy. However, due to limitation, anticoagulants were chosen and showed clinical improvements. Conclusion: In summary, the goal for treat CCI is to achieve more efficacy therapy while minimising the risk of bleeding. Despite the limitations, patient outcome was good.

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