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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : 23388404     EISSN : 26572311     DOI : https://doi.org/10.33508/jfst
Core Subject :
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year in March and October, containing research articles, review and short communication in the pharmacy science field, including medicinal chemistry, analytical chemistry, biological pharmacy, pharmaceutical sciences, and clinical pharmacy researches; the practice of pharmacy in industry, clinic and community, such as pharmacies, distributors and pharmacy education.
Arjuna Subject : -
Articles 172 Documents
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Optimasi Sediaan Pelembab Ekstrak Kering Kulit Buah Manggis (Garcinia mangostana L.) dengan Kombinasi Asam Stearat dan Trietanolamin sebagai Emulgator Chomariyah, Nur; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 1 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2008

Abstract

Mangosteen is a plant which has a high antioxidant activity. The mangosteen pericarp contains antioxidant compound alpha mangosteen. Beside as an antioxidant, alpha-mangosteen has the potential as skin moisturizer, which gives protection for dry skin condition. The purpose of this research was to know the influence a combination stearic acid and trietanolamin on the physical characteristics and effectiveness. As the results of this researchs optimum formula was obtained using factorial design expert. The formula divided into 4 groups, formula A 10% of stearic acid and 0.1% trietanolamine, formula B was 16% of staric acid and 0.1% trietanolamine, formula C 10% of stearic acid and 0.5% trietanolamine and formula D 16% of stearic acid and 0.5% trietanolamine. Effectiveness and physical quality results were analyzed using one way anova and post hoc tukey with the level of confidence 95%. The results showed that stearic acid as an emulsifying agent have significant effect on the decrease of spreadibility, effectiveness and an increase in pH, viscosity, stickiness and ease for removal. Triethanolamin as an emulsifying agent had significant effect on them decrease of spreadibility, effectiveness and an increase in pH, viscosity, stickiness, and ease for removal. Interaction of both agents had signifficant effect to increase pH, viscosity, and effectiveness and a decrease in spreadibility, stickiness, and ease to removal of moisturizing cream containing the extract mangosteen pericarp. Optimum formula of moisturizing cream dry extract of mangosteen pericarp was obtained, a combination of 14.02% stearic acid and 0.41% trietanolamine as an anionic emulsifying agents.
Analisis Efektivitas Pengikat Fosfat Tablet Kalsium Karbonat yang Dikunyah Dibandingkan yang Ditelan Utuh pada Pasien Penyakit Ginjal Kronis Dengan atau Tanpa Gangguan Saluran Cerna Prawesti, Galuh Nawang; Yogiantoro, R. Moh.; Widodo, Gunawan; Purnamayanti, Anita
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 1 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2009

Abstract

Chronic Kidney Disease (CKD) patient with Mineral and Bone Disorder complication have to chew calcium carbonate tablet as a phosphate binder, but infact, patient swallow it in a whole. Gastrointestinal (GI) disorders can affect the efficacy of medicine. This study aims to analyze the effectiveness comparation of chewed and whole swallowed calcium carbonate tablet in CKD patients with or without gastrointestinal disorders. This prospective quasi experimental study with non-inferiority design was conducted on May 28th to August 22nd 2012, with 22 sample (stage 3-5 CKD), 14 men, 8 women, divided into 4 groups (1st: patients with GI disorder and whole swallowed calcium carbonate, 2nd: with GI disorders and chewed tablet, 3rd: without GI disorders and whole swallowed tablet, 4th group: without GI disorders and chewed tablet, all tablet are used with meal). Before and after the 6th week research period, calcium and phosphate blood levels measurements had been taken, adherence had been measured every two weeks using the Morisky questionnaire and pill count. The results showed that there was no significant difference in the increased of calcium levels, except for group 1 compared to group 3 (p = 0.027), the decreased phosphate levels (p = 0.724; 0.089; 0.089; 0.414; 0.569; 1.000) and the value of the product calcium-phosphate (p = 1.000; 0.308; 0.186; 0.414; 0.425; 0.728). The conclusion is that the way to use the medicine and the states of gastrointestinal disorders did not significantly influence the effectiveness of calcium carbonate tablet.
Analisis Vitamin B6 (Piridoksin) pada Sediaan Tablet Multivitamin Neurotropik Menggunakan Spektrofotometri UV-Vis Maritha, Vevi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 1 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2010

Abstract

Vitamin B6 analysis in neurotrophic multivitamin tablet preparations requires a simple, fast and cheap method. UV-Vis spectrophotometer is having these criteria. Vitamin B6 analysis using UV Vis spectrophotometry is very quick so that the substance degradation can be inhibited and the results obtained will be accurate. Selection of single maximum wavelength for vitamin B6 will be able to separate with other components of vitamins B1 and B6 although all three are soluble in water. The optimal condition of vitamin B6 analysis in neurotropic multivitamin samples was using UV-Vis spectrophotometry at 325 nm wavelength. The solvent used is water. The calibration result curve in series of 60 ppm, 70 ppm, 80 ppm, 90 ppm, 100 ppm, 110 ppm, 120 ppm and 130 ppm have r value of 0, 9965. Determination of vitamin B6 levels using three brands of neurotrophic multivitamin samples performed. The measured theoretical level was 100 ppm, whereas the recovery of neurotropic multivitamin A samples were 98.24 ppm, 95 ppm and 95.78 ppm respectively with SD 1.69. The theoretical content of vitamin B6 in the neurotrophic multivitamin sample of B brand was 100 ppm, whereas the recovery was 99 ppm, 102 ppm and 98 ppm with SD 1.15. Determination of vitamin B6 concentration in the neurotropic multivitamin brand C the measured theoretical level was 100 ppm, while the recovery was 102 ppm, 101 ppm and 99 ppm with SD value of 1.53. The recovery of vitamin B6 level determination has been in accordance with AOAC requirements, ie for 100% ppm% analytical calculation 90-107%. The primary SD values of the three neurotrophic multivitamin samples of less than 2 indicate that vitamin B6 levels are acceptable. The results of this study indicate that vitamin B6 in a neurotrophic multivitamin sample can be analyzed using UV-VIS spectrophotometry at a wavelength of 325 nm using a water solvent.
Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Semangka (Citrullus lanatus) Ekayanti, Ni Luh Putu Serly; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 1 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2011

Abstract

Watermelon is a tropical fruit which rich of carbohydrates such as sucrose, glucose and fructose that can moisturized the skin. Carotenoids such as lycopene in watermelons can acts as an antioxidant which protected skin from free radicals. Moisturizer are preparations used to improve dry skin. These preparations may decrease the Trans Epidermal Water Loss (TEWL) by forming a thin layer of fat on the surface of the skin as a barrier and restore skin softness. Watermelon extracts in this study are formulated into moisturizing cream. This study aims to determine the effect of the increasing concentration of the watermelon extract against its physical quality, effectiveness, safety, acceptability and cream stability. The watermelon extract obtained using is fresh fruit juice thickened with waterbath thermostat temperature ≤ 800C. Watermelon extract concentration used was 10% (Formula 1), 20% (Formula 2) and 30% (Formula 30. Evaluation of the cream includes the physical quality test; effectiveness test which; safety test; acceptability test and stability test. The results of this study showed the increasing concentrations of watermelon extract affect the results of the evaluation of moisturizing cream were organoleptic, pH, viscosity, dispersive power, adhesion, water washing power, effectiveness, and aseptability. Preparations which have the best quality are formula 3 containing extract 30%.
Formulasi Sediaan Gel Rektal Ketoprofen dengan Peningkat Kelarutan Tween 80 Imami, Sulfia; Hendriati, Lucia; Widodo, Teguh
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 1 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2012

Abstract

Ketoprofen is a non steroidal anti-inflammatory drugs,often used as a post operative analgesic for the patient which is oral drug delivery, so ketoprofen should be formulated in rectal gel dosage forms that their therapeutic effect can be achieved quickly and has a low solubility. Tween 80 is a surfactant that is used to improve the solubility of ketoprofen. The purposes of this study were to determine the effect of Tween 80 on the release of ketoprofen and the physical quality of rectal gel. Evaluation of physical quality of the preparation includes organoleptic test, homogeneity test, spreadability test, viscosity test and pH test. The release of ketoprofen determined by Franz diffusion cell using whatman membrane 0.45μm and a solution of pH 7.4 phosphate buffer as receptor media. The amount of ketoprofen pass in through the membrane was determined by UV-VIS spectrophotometer. The results showed that the release profile of ketoprofen was affected by the concentration of Tween 80, the greater the concentration of Tween 80 the greater the value of flux release. Tween 80 at the concentration 1%, 2.5%, 5%, 7.5% to produce release flux values of 111.660; 155.465; 449.648; 644.853μg/cm2/hour1/2. Statistical analysis by Anova of difference release flux values of each formula were significantly different (p
Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Pepaya (Carica Papaya L.) Ningsih, Kadek Sri Utami; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 1 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2013

Abstract

Sucrose in papaya fruit was used as a moisturizer because it has worked as humectants, which reduce water evaporation on the surface of the skin. The purpose of this research was to determine the effect of the increasing concentrations of water extract of papaya fruit to evaluate its physical quality, effectiveness, safety, acceptability, and stability of the moisturizing cream water extract of papaya (Carica papaya L.). In this study, it used 3 formulas containing the extract of papaya fruit at concentration of 10% (formula 1), 20% (formula 2), 30% (formula 3), also blank containing base only, and base without extract and without moisturizing agent. The physical quality tests include organoleptic, pH, viscosity test, emulsion type test, dispersive power test, homogeneity, water washed power and adhesion test. The effectiveness of mouisturizer effect on the skin was tested with in vitro method: Sorption Desorption Test. Savety testing include irritation test and acceptability test. The data was analyzed using oneway ANOVA then continued with post hoc Tukey. The results showed that the increasing concentrations of the extract provides significant effect on efectivity, wherein the greater the concentration of water extract of papaya fruit (Carica papaya L.) were added, then the higher the ability to moisturize the skin and produce of moisturizer cream with pH test 6.04, viscosity 159710 cps, dispersive power 3.63 cm, water washed power 13.48 ml, adhesion 6005 second, and moisturizer cream stable during storage. The best formula is the formula 3 with a concentration extract of 30%.
Formulasi Sediaan Eyeshadow Ekstrak Air Buah Syzygium cumini dalam Bentuk Compact Powder Dwiwulandari, Fransisca Yunita; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 1 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i1.2048

Abstract

Coloring substance are needed in eyeshadow. It is used to give colors, shadows, and glittery effect on eyes. The trend in beauty world nowadays is using a natural dye because of safety issues. Antocyanine, which is contained in “juwet” fruit (Syzygium cumini), is one of the potential natural dyes. The aim of this research is to know the effect of Syzygium cumini in different concentration (20%, 25% dan 30%) on the physical quality and ffectiveness of the eyeshadow. The extract of Syzygium cumini fruit was formulated into compact powder eyeshadow. This type of preparation is the dominant dosage form used because it has good adhesiveness to the skin. The extract was obtained by extracting the juice and evaporated it using thermostatic water bath in the temperature of 40-60°C. The result showed that the increase in extract concentration significantly affected the physical quality test results (organoleptic, pH, particle size, friability and hardness), but did not affect the color dispersion and effectiveness. Based on the evaluation, formula II (extract of Syzyium cumini 25 %) was chosen as the best formula.
Studi Penggunaan Natrium Valproat Kurang Dari Tiga Bulan Terhadap Magnesium Serum Dan Jumlah Kejang Pasien Epilepsi Di RSUD Dr. Soetomo Latuasan, Ivana Rahayu; Sugianto, Paulus; Kasih, Elisabeth; Octavia, Evi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 1 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i1.2049

Abstract

Epilepsy is a brain disorder characterized by a tendency to cause continuous epilepsy attacks with neurobiological, cognitive, psychological and social consequences. The appearance of temporary signs or symptoms is caused by abnormal and excessive neuron activity in the brain. Sodium valproate can be used as epilepsy therapy because it is effective in inhibiting seizures, partial seizures, and tonic-clonic seizures. The mechanism of action of sodium valproate in the treatment of epilepsy is to increase the inactivation of Na + channels, thereby reducing the nerve's ability to transmit electric charges. Magnesium is a potential modulator of seizure activity because of its ability to inhibit excitation through N-methyl D-aspartate receptors. The aim of this study was to determine serum magnesium levels with sodium valproate treatment and the number of seizures as well as to identify drug-related problems in epilepsy patients who were less than three months old. The research was conducted in the Electroencephalography Room of the Regional Hospital Dr. Soetomo Surabaya by using observational methods in the form of prospective studies using data collection sheets and questionnaires. Samples were taken from July 1 to September 30, 2017. Based on laboratory results, the average magnesium content of patients with seizures was 2.22 mg / dL while non-seizure patients were 2.08 mg / dL. The conclusion of this study is that the use of sodium valproate does not affect magnesium levels in epilepsy patients and epilepsy patients who get sodium valproate therapy have a lower risk of seizures than those who do not get sodium valproate medication.
Uji Potensi Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) Terhadap Peningkatan Ketebalan Jaringan Granulasi dan Waktu Penyembuhan Luka Bakar Tikus Betriksia, Dea; Hamid, Iwan Syahrial; Hermanu, Liliek Suyatmiatun
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 1 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i1.2050

Abstract

Burns are skin damage caused by high-temperature which contact to the skin. Second-degree burns are the most common accident at home. The process of wound healing can be accelerated using traditional medicines, one of which is Binahong (Anredera cordifolia (Ten.) Steenis). Binahong contains saponins, flavonoids, alkaloids, tannins, and steroids which have been shown to accelerate the wound healing process in previous experiments. The purpose of this study was to analyze the potential of binahong leaf extract to increase granulation tissue thickness and reduce healing time of burns. This study uses an experimental method. Wistar rats were used in this study, which were divided into 4 groups, namely K (-), K (+), and treatment groups namely the concentration of binahong leaf extract 20% (P1) and 40% (P2). Burns are made using an iron plate that has been heated to 95° C and pasted for 30 seconds on the lower back of the mouse to cause second-degree burns. The binahong leaf extract used in this study was made in the form of an ointment and given twice a day for 7 days. Increased granulation tissue thickness and wound healing time were observed on day 3 and day 7. The results showed an increase in granulation tissue thickness and shorter healing time in the experimental group given binahong leaf extract with a concentration of 40% (P2) compared to the experimental group that was given binahong leaf extract with a concentration of 20% (P1).
Studi Penggunaan Asam Traneksamat pada Penderita Tuberkulosis dengan Hemoptisis di Instalasi Rawat Jalan Rumah Sakit Umum Haji Surabaya Yuni, Santi Eka; Hasmono, Didik; Kasih, Elisabeth; Ayumuyas, Nur Palestin
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 1 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i1.2051

Abstract

Tuberculosis is one of the world's health problems, especially in developing countries with coughing in the form of blood (hemoptysis) as a sign of this disease. Tranexamic acid can be used as one of the treatments for hemoptysis. Tranexamic acid is a synthesis derivative of aminolenic acid which provides antifibrinolytic effects through reversible blocking of lysine binding sites on plasminogen molecules and inhibits plasmin. This study aims to analyze the pattern of use of tranexamic acid in tuberculosis patients with hemoptysis including dosage, frequency and duration of use in the Outpatient Installation of Surabaya Haji General Hospital. The study was conducted observationally with a retrospective method on medical records of patients diagnosed with tuberculosis with hemoptysis and received treatment for tranexamic acid, then analyzed descriptively. Sampling was done by purposive sampling, from January 1, 2016 to December 31, 2017. From the results of the study, the use of tranexamic acid single dose (3x500mg) as many as 2 patients (67%), 500 mg intravenously as many as 1 patient (33%) and combination with Vitamin K as many as 3 patients. The highest duration of use was 3 days in 11 patients (56%). The use of tranexamic acid in hemoptysis patients related to dose, frequency and duration of use is in accordance with the existing literature.

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