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Jurnal Bioteknologi & Biosains Indonesia
Published by Badan Riset dan Inovasi Nasional
ISSN : 24422606     EISSN : 2548611X     DOI : https://doi.org/10.55981/jbbi
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
JBBI is published twice annually and provide scientific publication medium for researchers, engineers, practitioners, academicians, and observers in the field related to biotechnology and bioscience. This journal accepts original research papers, review articles, case studies, and short communications. The articles published are peer-reviewed by no less than two referees, and cover various biotechnology subjects related to the field of agriculture, industry, health, environment, bioinformatics, as well as life sciences in general. JBBI terbit dua kali setahun dan menyediakan media penerbitan ilmiah bagi para peneliti, insinyur, praktisi, akademisi, dan pemerhati di bidang yang terkait dengan bioteknologi dan biosains. Jurnal ini menerima naskah asli hasil penelitian, naskah ulasan, studi kasus, dan komunikasi singkat. Naskah yang diterbitkan adalah peer-review oleh tidak kurang dari dua orang penelaah, dan mencakup berbagai cabang bioteknologi yang terkait dengan bidang pertanian, industri, kesehatan, lingkungan, bioinformatika, serta ilmu kehidupan pada umumnya.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 179 Documents
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FACTOR INFLUENCING HEALTHY EATING PATTERNS AND NUTRITIONAL STATUS OF CHILDREN AGED 3-7 YEARS: LAWRENCE GREEN THEORY APPROACH Widia Shofa Ilmiah; Rifzul Maulina; Anik Sri Purwanti
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.15186

Abstract

Background: Nutrition issues among children in Indonesia remain a significant challenge, with the prevalence of stunting in children under five reaching 24.4% in 2021. Objective: This study aim to analyse the dominant factors affecting healthy eating patterns and nutritional status in children aged 3-7 years: Lawrence Green's theory approach. Material and Methods: Used observational study with a cross-sectional approach, the sample consisted of 44 children. Data collection was carried out using weight scales, microtoises, observation sheets, and food recall questionnaires. Results: Showed that the knowledge level was quite good (52.3%); family support was quite good (56.8%); children's eating patterns were mostly healthy (65.9%); children's nutritional status scored between ≥-2SD and ≤+2SD (65.9%). Heteroscedasticity scatter plot shows a certain pattern, normal PP Plots closely approach the line. Conclusion: That the most dominant factor affecting children's nutritional status is the parents' knowledge level about nutrition and children's eating patterns.
EFFECTS OF SOYBEAN JUICE (Glycine max L.) ON SPERMATOZOA FERTILITY AND TESTICULAR WEIGHT IN RATS (Rattus norvegicus L.) Wa Ode Harlis; Isdayanti Isdayanti; Nurhayu Malik; Takdir Saili; Resman Resman
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.15251

Abstract

Soybeans (Glycine max L.) contain isoflavone compounds which can disrupt hormonal balance through negative feedback on the hypothalamic-pituitary-gonadal axis causing inhibition of Leydig cell activity and Sertoli cell function. The aim of this research was to determine the effect of giving soybean juice on spermatozoa fertility and testicular weight in rats (Rattus norvegicus L.). This type of experimental research was structured based on a Completely Randomized Design (CRD) pattern consisting of 4 treatments and 6 replications, namely K (control/drinking water), P1 (7.1 g/kgBW/day), P2 (14.2 g/kgBW/day) and P3 (21.3 g/kgBW/day). Soybean extract was given for 49 days, and on the 50th day the rats were sacrificed and dissected to observe variables in the form of testicular weight and spermatozoa fertility (morphology, pH and viscosity). Data were analyzed using ANOVA and further BNT test α=0.05. The results showed that administration of soybean extract caused a decrease in the percentage of testicular weight and spermatozoa fertility. Testicular weight is K=0.98 g. P1=1.08 g, P2=0.77g and P3=0.62 g. The percentage of abnormal spermatozoa morphology increased, namely K = 17.8%, P1 = 37.0%, P2 = 47.7%, P3 = 56.0%. The acidity of sperm pH increases, namely K= 7.50, P1=6.17, P2=5.67, and P3=5.83. Sperm-matozoa viscosity decreased, namely K=1.57, P1=1.58, P2= 0.76 and P3=0.77. The results of the study concluded that soybean juice caused a decrease in testicular weight and spermatozoa fertility in mice.
ANALYSIS OF THE PHYTOCHEMICAL POTENTIAL OF Moringa oleifera LEAF TEA FORMULATION AND NATURAL SPICES AS AN ALTERNATIVE TO STUNTING PREVENTION Angga Dwi Prasetyo; Moh. Taufik; Bertina Seviana Putri; A'ida Fajrin Najwa
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.15307

Abstract

Stunting prevention efforts require a locally focused, nutrient-rich, and easily accessible approach. This study aims to analyze the phytochemical potential of moringa tea (Moringa oleifera) and various natural spices such as ginger, turmeric, lemongrass, and galangal as natural alternatives in stunting prevention. The research will be carried out from June to December 2024. The methods used include qualitative phytochemical tests to identify active compounds such as flavonoids, tannins, saponins, alkaloids, and terpenoids/steroids; the formulation of moringa leaf tea and natural spices; and a literature review and meta-analysis of the role of these bioactives in supporting the nutritional status and immune system of children. The results of the analysis showed that moringa tea and spices contain a variety of bioactive compounds with antioxidant, anti-inflammatory, and immunostimulant properties that have the potential to support optimal growth of children. Based on the results of meta-analysis and literature studies, it can be concluded that the phytochemical content of Moringa leaf tea has the potential to prevent stunting in mothers and children. Further research is needed to test the effectiveness of the formula and optimal dosage in clinical applications.
HYDROLYTIC ENZYME SYSTEMS OF Trichoderma spp.: FERMENTATION STRATEGIES, STRAIN ENGINEERING, AND SUSTAINABLE LIGNOCELLULOSIC VALORIZATION Sri Helianty; Yuana Nurulita; Panca Setia Utama; Titania Tjandrawati Nugroho
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.15450

Abstract

Hydrolytic enzymes produced by Trichoderma spp. play a central role in lignocellulosic biomass conversion due to their high secretion capacity and catalytic versatility. This review provides a critical and integrated analyzes of enzyme systems, fermentation strategies, and bioprocess engineering approaches governing enzyme production and biomass valorization. A structured literature review was conducted using peer-reviewed publication 2019 to 2025. The analysis highlights synergistic interactions among cellulases, hemicellulases, and oxidative enzymes in overcoming biomass recalcitrance. Key process parameters—including aeration, moisture content, temperature regulation, and bioreactor design—are identified as a primary deteminants of productivity and efficiency. Solid-state fermentation is recognized as an efficient strategy for valorizing agricultural residues such as rice straw, although challenges in heat and mass transfer and scale-up remain. Advances in strain engineering, regulatory pathway optimization, and enzyme cocktail design improve hydrolytic performance, but trade-offs between productivity, stability, and process robustness persist. Integration within circular biorefinery frameworks is essential for scalable and sustainable biomass conversion.
MAPPING HUMAN RESOURCE INDICATORS IN HOSPITAL RESEARCH : A BIBLIOMETRIC PERSPECTIVE Solichati Fatonah; Qurratul Aini
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.15474

Abstract

Human resource indicators are important determinants of hospital service quality because workforce management directly affects patient care and organizational performance. However, the literature on hospital human resource management remains fragmented, particularly regarding its relationship with service quality and performance outcomes. This study aimed to map the research landscape on human resource indicators in hospitals from a bibliometric perspective. A bibliometric analysis was conducted using the Scopus database for articles published between 2015 and 2025. Of 3,995 records initially identified, 1,985 articles met the eligibility criteria and were included in the final analysis. Bibliometric mapping was performed using VOSviewer. The results showed a clear increase in publication output over time, especially in 2024–2025, indicating growing scholarly interest in hospital human resource indicators. The keyword health care quality had the highest total link strength, showing that the literature is strongly oriented toward quality assessment, organizational performance, and service improvement. Overall, the findings demonstrate that research on hospital human resource indicators is closely linked to hospital quality, management, and patient safety, while several workforce-related themes remain underexplored.
EFFECTIVENESS OF Bacillus spp. IN CONTROLLING Fusarium sp. AND ITS EFFECT ON GROWTH AND PHYTOCHEMICAL OF SHALLOT (Allium ascalonicum L.) Yuningsih Yuningsih; Yenny Wuryandari; Arika Purnawati
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.15844

Abstract

Shallot (Allium ascalonicum L.) is a key horticultural crop in Indonesia, but its productivity is constrained by moler disease caused by Fusarium sp. Chemical fungicides have limited effectiveness and raise environmental concerns, necessitating eco-friendly alternatives such as Bacillus spp. This study aimed to evaluate the potential of Bacillus spp. in suppressing moler disease and promoting shallot growth and resistance. A factorial Completely Randomized Design (CRD) was employed under in vitro and in vivo conditions, with two factors: Fusarium sp. inoculation (with and without) and Bacillus spp. treatments (control, Bcz 14, and Bcz 20). Results demonstrated that Bacillus spp., particularly isolate Bcz 20, significantly reduced disease intensity by up to 73.91% and delayed symptom development. Moreover, Bacillus spp. enhanced plant growth and induced the accumulation of flavonoids and saponins. These findings indicate that Bacillus spp. function as effective biological control agents and plant growth promoting rhizobacteria (PGPR), offering a sustainable strategy to improve shallot productivity while reducing reliance on chemical fungicides.
THE EFFECT OF COMBINED PROPOLIS EXTRACT AND VITAMIN E SUPPLEMENTATION ON IL-10 AND CRP Fauziah Rezkiyati Sufath; Joko Wahyu Wibowo; Hadi Sarosa
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.15848

Abstract

A high-fat diet induces oxidative stress and systemic inflammation, characterized by decreased the effects of propolis extract and vitamin E on IL-10 and CRP levels in male Wistar rats induced by a high-fat Interleukin-10 (IL-10) and increased C-Reactive Protein (CRP). This study aimed to evaluate diet. An experimental post-test only control group design was used, involving 30 rats divided into five groups: healthy control, high-fat diet control, vitamin E, propolis extract, and combination treatment. Interventions were administered for 14 days. Serum IL-10 and CRP levels were measured using ELISA and analysed using one-way ANOVA. The results showed that propolis extract and vitamin E significantly increased IL-10 levels (p < 0.05), indicating an improved anti-inflammatory response. However, CRP levels did not show significant differences among groups (p > 0.05). In conclusion, both treatments enhanced anti-inflammatory activity through IL-10 modulation but did not significantly affect CRP levels.
FORMULATION AND CHARACTERIZATION OF NANOEMULGEL OF SAPPAN WOOD EXTRACT (Caesalpinia sappan L.) WITH CMC-Na VARIATION AS GELLING AGENT Fikria Marfuatin Nur; Joice Halima Moto; Novamei Indriani
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.14368

Abstract

Sappan wood (Caesalpinia sappan L.) contains brazilin, a major bioactive compound with antioxidant, anti-inflammatory, and antibacterial activities. However, its poor water solubility and low chemical stability limit its therapeutic potential, requiring an improved delivery system such as nanoemulgel to enhance penetration, stability, and topical efficacy. Previous research formulated nanoemulgel using 3–5% CMC-Na but did not include particle size analysis or flavonoid content determination, leaving gaps in stability and active compound retention. This study addresses these limitations by developing nanoemulgel with 2%, 3%, and 4% CMC-Na. The extract was obtained by maceration using 96% ethanol, followed by TLC identification and flavonoid quantification via UV–Vis spectrophotometry. Formulations were evaluated for organoleptic properties, pH, viscosity, spreadability, adhesiveness, homogeneity, particle size, physical stability, and final flavonoid content. The 3% CMC-Na formulation demonstrated the most balanced characteristics, nano-sized particles, and good overall stability.
THERMOHALOPHILIC BACTERIA PRODUCING THERMOSTABLE LIPASE FROM WAWOLESEA HOT SPRING, SOUTHEAST SULAWESI Sapto Raharjo; Muzuni; Ardiansyah; Rahman Hakim; Muh. Musafir; Tien; L.O.M. Iman Sulaeman
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.14975

Abstract

This study aimed to isolate and characterize thermohalophilic bacteria producing lipase and to purify thermostable lipase from the Wawolesea hot spring in Southeast Sulawesi. A total of 24 isolates were obtained, all of which demonstrated lipase-producing capability. Three selected isolates (BT2.M3, CT2.M4, and DT1.M2) were identified as Gram-negative bacilli and showed lipase activities ranging from 0.17 to 21 U/mL, with the highest activity recorded for BT2.M3 at 50°C and pH 6. Purification through ammonium sulfate fractionation yielded the highest activity in the 60–80% saturation fraction (43 U/mL) at pH 6–7 and 50–60°C. Protein analysis showed the highest concentration in the 80% dialysis fraction (0.954 mg/mL). These findings highlight the potential of Wawolesea thermohalophilic bacteria as a valuable source of thermostable lipase for biotechnological applications.

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