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Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 782 Documents
 1   2   3   4   5 
Relationship of TTF-1 and EGFR on Lung Adenocarcinoma at Dr. Saiful Anwar General Hospital Malang lumban gaol, andy; Pratiwi, Suryanti Dwi; Putra, Ngakan Putu; Norahmawati, Eviana; Rasyid, Harun Al
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.01.9

Abstract

There is a correlation between mutation of Epidermal Growth Factor Receptor (EGFR) and lung adenocarcinoma. Unfortunately, examination for EGFR mutation is difficult because surgery must be conducted to obtain the best specimen. Thyroid Transcription Factor-1 (TTF-1) is a marker for lung adenocarcinoma. This observational study took place at Dr. Saiful Anwar Hospital from stored biological materials from 2013-2018. Samples were lung adenocarcinoma patients that undergo EGFR examination. Data then analyzed using Fischer's Exact Test to determine the relationship between EGFR and TTF-1. Specificity/sensitivity value is 0.75/0.90, p: 0.617, odds ratio 0.333 (0.032-3.515). However, Receiver Operating Characteristic (ROC) curve of TTF- 1 show AUC 0.614 (95CI, 0.35- 0.878). TTF-1 examination has a moderate strength in determining EGFR mutation on lung adenocarcinoma patients at Dr. Saiful Anwar Hospital.         
Analysis of Lamina Papyracea Area and Ethmoid Sinus Volume in Indonesian Patients Undergoing Paranasal Sinus CT Scan Wahyuni, Wahyuni; Idris, Nurlaily; Muis, Mirna; Zainuddin, Andi Alfian; Perkasa, Muhammad Fadjar; Ilyas, Muhammad
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.01.6

Abstract

Of the rhinosinusitis (CRS) patients, half of whom require surgical intervention. Functional endoscopic sinus surgery (FESS) is a standard treatment of CRS and sinonasal polyposis. Orbito-ocular complications can occur during FESS. The lamina papyracea (LP) is the weakest point of the medial wall of the orbit. The variability in the size and shape of the paranasal sinuses is important in the FESS procedure. The ethmoid sinus is the most complex paranasal sinuses. Preoperative evaluation using computed tomography (CT) is mandatory for all patients undergoing FESS. This study aimed to determine the lamina papyracea area and ethmoid sinuses volume in patients who underwent a CT scan of paranasal sinuses. This study was a descriptive study on 103 patients who underwent a CT scan of paranasal sinuses in the Radiology Department of Hasanuddin University General Hospital, Makassar, from January to August 2019. The lamina papyracea area and ethmoid sinus volume were measured based on age and gender. The results showed that the average of lamina papyracea size and ethmoid sinus volume was greater in males than in females. There was a correlation between age and posterior height of left lamina papyracea (p=0.02), but no correlation between ethmoid sinuses volume and age.
Effects of Pulmonary Vascular Resistance Index on Oxygen Saturation in Patients with Atrial Septal Defect Supomo, Supomo
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.058 KB) | DOI: 10.21776/ub.jkb.2020.031.01.13

Abstract

Atrial septal defect (ASD) is a congenital lesion in atrium septum. The lesion may cause pulmonary hypertension due to the high pressure in the right ventricle. This condition leads to cyanosis in ASD patient, but the pathophysiology of cyanosis in ASD patient is still unknown. This study aimed to identify the pathophysiology of cyanosis in ASD patients using the Pulmonary Vascular Resistance index (PVRi). The design of this study was retrospective cohort study. The data used in this study were the results of right heart catheterization procedure taken from forty ASD patient medical records at Dr. Sardjito general hospital. The exclusions criteria were the history of previous vasodilator administration and incomplete medical records. The median age of the patients was 30 (18-55) years old. The mean of the Qp/Qs ratio was 1.210 (0.57-6.33). Optimum oxygen saturation was found in vessel leaving the heart. The PVRi median is 61.98 (-15.58-676.64). The PVRi has a significant correlation with oxygen saturation, except in the right atrium. There is a significant correlation between PVRi and oxygen saturation in various heart chambers. Pathophysiology of cyanosis in ASD patients is central cyanosis.
Effect of Javanese Turmeric (Curcuma xanthorrhiza) Extract on Hepatitis Model of Alcohol-Induced Mice Puteri, Agnes Ilene Suprapto; Sandhika, Willy; Hasanatuludhhiyah, Nurina
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.798 KB) | DOI: 10.21776/ub.jkb.2020.031.01.8

Abstract

Alcoholic hepatitis is a common cause of non-viral hepatitis. Javanese turmeric (Curcuma xanthorrhiza) contains xanthorrhizol and curcuminoid that have antioxidant and anti-inflammatory effects. The purpose of this research was to detect the effect of Curcuma xanthorrhiza in decreasing hydropic degeneration and lymphocytes in alcohol-induced mice. This experimental research used post-test only controlled design. Randomly, 35 mice were divided into five groups. Four groups were induced by alcohol 30% of 4ml/kgBW in 10 days, and one group was normal group (negative control). Three of the four alcohol-induced groups were given Curcuma xanthorrhiza extract at doses of 42, 84, and 168 mg/kgBW in 10 days, 1 hour after alcohol induction. Mice livers were taken for Hematoxylin Eosin (HE) staining.  Hydropic degeneration and lymphocytes in the liver lobules were examined under a microscope. The statistical analysis used in this research was the Kruskal-Wallis, the Mann-Whitney test, and the Independent Sample T Test. P-value is significant if <0.05. The result of this research were all doses of Javanese turmeric extract significantly reduced hydropic degeneration. Doses of 84 and 168 mg/kgBW also reduced inflammatory lymphocytes (p<0.05). The dose of 168 mg/kgBW reduced the lymphocyte inflammation maximally. There was no significant difference between increasing Javanese turmeric dose and decreasing hydropic degeneration and lymphocytes (p>0.05). This research shows that Javanese turmeric (Curcuma xanthorrhiza) can attenuate hepatitis by decreasing hydropic degeneration and lymphocytes in alcohol-induced liver.
IDENTIFIKASI MUTASI GEN CYSTATIONINE-β SYNTHASE (CBS) DAN GEN METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) PADA PENDERITA PREMATUR INFARK MIOKARD AKUT DENGAN HIPERHOMOSISTEINEMI Muliartha, I Ketut Gede; Sargowo, Djanggan; Iskandar, Abdillah
Jurnal Kedokteran Brawijaya Vol 24, No 3 (2008)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (618.881 KB) | DOI: 10.21776/ub.jkb.2008.024.03.3

Abstract

ABSTRACT Hyperhomocysteinemia appears to be an independent risk factor for coronary heart disease. Elevated levels of  plasma  total  homocysteine  (tHcy)  was  caused  by  genetic  or  nutrient-related  disturbances  in  the transsulfuration  or  remethylation  pathways  for  homocysteine  metabolism.  This  study  observed  premature myocard  infarct  acute  patients  with  hyperhomocysteinemia.The  aim  of  the  research  was  to  determine Cystarhionine-β  Synthase  and  Methylenetetrahydrofolate  Reductase  genes  mutations  in  premature  acute myocard  infarct  patients  with  hyperhomocysteinemia.This  study  was  a  cross  sectional  study  in  premature acute myocard infarct patients. Twenty three patients were examined for plasma total homocysteine, vitamin B6, vitamin B12 folic acid and lipid profile. Total DNA isolated from patients with hyperhomocystememia and normal  folic  acid,  vitamin  B6,  vitamin  B12  levels  and  lipid  profile.  Five  patients  were  assayed  for Cystathionine-β  Synthase  and  gen  Methylenetetrahydrofolate  Reductase  genese  mutations  by  Polymerase Chain  Reactions  (PCR).  Five  from  23  patients  (  21,7%  )  plasma  total
EFEK EKSTRAK DAUN CIPLUKAN (Physalis minima L) TERHADAP RELAKSASI OTOT POLOS TERPISAH TRAKEA MARMUT (Cavia porcellus) Priyantoro, Sigit Tri Yus; Sudjari, Sudjari; Karyono, Setyawati S.
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (132.636 KB) | DOI: 10.21776/ub.jkb.2004.020.01.7

Abstract

Physalis minima L’s leaf contains atropin and skopolamin which possess anti cholinergic effect. Cholinergic agent has constriction effect to the smooth muscle of respiratory tract. In asthma bronchiale there is an airway constriction. This experiment was to observe the effect of Physalis minima L’s ethanol extract on the relaxation of the guinea pig’s trachea’s smooth muscle which was induced with histamin by the method of in vitro. Isolated trachea of 5 male guinea pig’s was used as samples in this experiment. Transducer, amplifier and mac lab computer were used to create  the trachea’s contraction–relaxation curve. The independent variabel was Physalis minima L’s leaf ethanol extract dosage andthe dependent variabel was the trachea’s contraction. 4 dosage of Physalis minima L’s leaf ethanol extract were used (1 control, 3 comparable dosage), the dosage of 0.5 % Physalis minima L’s leaf extract showed significant relaxation of trachea (anova, p<0.05). There was a positive corelation between theincreasing dosage of Physalis minima L’s leaf ethanol extract and the relaxation of trachea (regression, r = 0.770, p< 0.05). The conclusion of this study is that the Physalis minima L’s leaf ethanol extract has positive effect in relaxing isolated trachea of guinea pig’s induced by histamin and there is a positive correlation between increasing dosageof Physalis minima L’s leaf ethanol extract and the relaxation of isolated trachea. Keywords:trachea smooth muscle’s relaxation, histamine, Physalis minima L’s leaf ethanol extract.
PENGARUH PAPARAN SINAR MATAHARI PAGI TERHADAP PENURUNAN TANDA IKTERUS PADA IKTERUS NEONATORUM FISIOLOGIS Puspitosari, Ratih Dewi; Sumarno, Sumarno; Susatia, Budi
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.453 KB) | DOI: 10.21776/ub.jkb.2006.022.03.8

Abstract

Physiological jaundice is a sign usually happens tonewborn infants. The cause of icterus is the increase of indirect bilirubin that makes the skin yellow that usually disturb the people. Treatment of this yellow baby is  by exposing them to the morning sun. Sun exposure can reduce jaundice skin by changing the bilirubin indirect molecule. This research aim was to know the effect of morning sun exposure thatcan decrease jaundice skin through jaundice skin level measurement on babies. The special goal of the research was to know the jaundice skin and the difference before and after expos to the sun. The research was a quasi experimental study. The samples consisted of 5 babies,  selected by quota sampling. The measured variables were morning sun exposure and jaundice skin level. The research was done by exposing the samples on the morning sun for 30 minutes, then the jaundice skin measured in minutes 0,  5th, 10th, 15th, 20th, 25th, and 30thby using Corel Photo-Paint 12 Program. Data analysis was done with ANOVA and was continued by correlation-regression test, with confidence interval 99%.
Adhesin 61 kDa OMP C.pneumoniae Menghambat Apoptosis Makrofag Halim, Andrew; Murwarni, Sri; Sumarno, Sumarno
Jurnal Kedokteran Brawijaya Vol 26, No 4 (2011)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (504.941 KB) | DOI: 10.21776/ub.jkb.2011.026.04.5

Abstract

Banyak bukti menunjukkan Chlamydia pneumoniae dapat menginduksi terjadinya aterosklerosis dan rupturnya plak aterosklerosis. Hal ini diperantarai oleh berbagai hal, salah satunya adalah mekanisme penghambatan apoptosis makrofag. Penelitian ini menguji keterlibatan protein struktural adhesin 61 kDa pada Outer Membrane Protein (OMP) C.pneumoniae dalam menghambat apoptosis makrofag. Makrofag diperoleh dari monosit darah perifer individu sehat. Rancangan penelitian berupa penelitian eksperimental laboratorik in vitro, post control design only. Pada penelitian ini digunakan 4 sampel monosit. Pada setiap sampel dilakukan isolasi dan kultur, serta pemberian Phorbol Myristate Acetate (PMA) agar monosit berdiferensiasi menjadi makrofag. Makrofag kemudian dipapar dengan adhesin 61 kDa OMP C.pneumoniae (kecuali pada kontrol positif) dan diinduksi agar apoptosis dengan H2O2 berbagai macam konsentrasi (5mM, 10 mM, 15mM, 20mM, 25mM, 25mM pada kontrol positif) selama 6 jam. Deteksi apoptosis makrofag dilakukan dengan menggunakan metode imunositokimia, menggunakan antibodi monoklonal terhadap kaspase 3. Hasil dianalisis secara statistik menggunakan ANOVA satu arah, α=0,05. Hasil penelitian menunjukkan adanya perbedaan bermakna jumlah makrofag yang apoptosis diantara perlakuan dan kontrol positif. Dapat disimpulkan adhesin 61 kDA OMP C.pneumoniae memiliki kemampuan menghambat apoptosis makrofag.Kata Kunci: Apoptosis, adhesin 61 kDA OMP, C.pneumoniae, H2O2, makrofag
Efek Asam Alfa Lipoat pada Kadar MDA dan Histologi Ginjal Tikus Wistar Diabetes Melitus Tipe1 Putri, Novita Fahrianti; Lyrawati, Diana; Sarwono, Imam
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1071.539 KB) | DOI: 10.21776/ub.jkb.2015.028.03.3

Abstract

Asam alfa lipoat (ALA) telah banyak digunakan dalam pencegahan dan mengatasi komplikasi diabetes akibat spesies oksigen reaktif (ROS). Penelitian ini bertujuan untuk membuktikan bahwa ALA dapat mencegah peningkatan stres oksidatif pada ginjal tikus diabetes mellitus (DM) tipe 1. Penelitian eksperimental menggunakan Post Test Only Control Group dilakukan terhadap 30 tikus Wistar jantan. Sampel dipilih secara acak ke dalam kelompok normal (NTA), DM (DTA), DM dengan terapi per oral ALA 80 (DA80), 200 (DA200), dan 500 (DA500) mg/kg berat badan/hari. Variabel yang diukur pada penelitian ini adalah kadar malondialdehid (MDA) yang diukur dengan spektrofotometri, bobot dan histologi ginjal dengan pewarnaan hematoksilin dan eosin. Hasil penelitian menunjukkan bahwa kadar malondialdehid tertinggi ialah pada kelompok DA80 (45,500 ± 9,4538; p=0,870) dan rasio bobot ginjal/berat badan tertinggi ialah pada kelompok DA200 (0,013 ± 0,0060; p =0,537) namun secara statistika hasilnya tidak bermakna. Pengamatan histologi pada glomerulus ginjal menunjukkan adanya kerusakan (pembentukan stroma dan pengecilan ukuran inti sel) pada kelompok DTA, DA80, DA200, dan DA500. Kesimpulan dari penelitian ini adalah pemberian ALA per oral dalam waktu empat minggu tidak bisa menurunkan stres oksidatif maupun memperbaiki histologi ginjal pada DMT1, bahkan memperburuk gambaran histologi ginjal.Kata Kunci: Asam alfa lipoat, DM1,histologi ginjal, malondialdehid
Efek Kurkumin terhadap Sekresi Estrogen dan Ekspresi Reseptor Estrogen β Kultur Sel Granulosa Babi Folikel Sedang Syarif, Rul Afiyah; Soejono, Sri Kadarsih; Meiyanto, Edy; Wahyuningsih, Mae Sri Hartati
Jurnal Kedokteran Brawijaya Vol 29, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2016.029.01.7

Abstract

Kurkumin merupakan senyawa yang diisolasi dari Curcuma longa L. Secara empirik C. longa L dikonsumsi masyarakat selama folikulogenesis untuk mencegah kehamilan. Pertumbuhan dan perkembangan sel granulosa tergantung pada FSH, LH, PGF2α, estrogen dan reseptor estrogen β (ERβ). Penelitian ini bertujuan untuk mengkaji efek kurkumin terhadap sekresi estrogen dan ekspresi ERβ pada sel granulosa babi folikel sedang yang dirangsang FSH, LH dan PGF2α. Penelitian ini merupakan penelitian eksperimental laboratorium dengan rancangan post test-only control group. Sel granulosa diisolasi dari folikel ukuran sedang ovarium babi dan disubkultur dalam medium kultur. Penelitian  dilakukan pada  16 kelompok yang terbagi dalam 4 kelompok perangsangan (sel granulosa tidak dirangsang apapun, dirangsang FSH atau LH atau PGF2). Empat kelompok perangsangan dibagi menjadi 4 kelompok perlakuan yaitu kelompok tidak diberi perlakuan dan kelompok diberi kurkumin 3 peringkat konsentrasi. Kadar estrogen dan ekspresi ERβ sel granulosa dianalisa secara enzyme immuneassay. Kadar estrogen dan ekspresi ERβ pada kelompok yang diberi kurkumin tidak berbeda bermakna dengan kelompok kontrol (p&gt;0,05). Kadar estrogen dan ekspresi ERβ pada kelompok yang dirangsang FSH atau LH dan diberi kurkumin berkonsentrasi rendah lebih rendah bermakna daripada tanpa diberi kurkumin (p&lt;0,05). Kadar estrogen sel granulosa yang dirangsang PGF2α dan diberi kurkumin lebih tinggi bermakna daripada tanpa kurkumin (p&lt;0,05), dan tidak ada perbedaan yang bermakna ekspresi ERβ antara kelompok yang dirangsang PGF2α dan diberi kurkumin dengan kelompok tanpa kurkumin (p&gt;0,05). Kurkumin mampu menurunkan estrogen dan ekspresi ERβ sel granulosa yang dirangsang FSH atau LH dari folikel babi ukuran sedang. Dengan demikian, kurkumin dapat mengganggu folikulogenesis dan berpotensi sebagai agen antifertilitas.

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