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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol. 52, No. 3" : 13 Documents clear
Analysis of changes in the serum level nt-probnp after ace inhibitors therapy in patients with heart failure Hartoto, Halla Hisan; Zulkarnain, Bambang Subakti; Aminuddin, Muhammad
Folia Medica Indonesiana Vol. 52, No. 3
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Abstract

BNP secreted by left ventricle as response to wall stress in patient with heart failure. Elevated concentration of NT-pro-BNP correlate with severity of heart failure across all stages of the condition and left ventricle ejection fraction in patient. Several clinical trials have demonstrated that neurohormonal modulation on the RAAS decreases NT-proBNP level and results in favorable outcomes. One of the drug used for blocked RAAS system is ACE inhibitor, decrease of NT-proBNP level show response to therapy include therapy with ACE inhibitors. To analize changes in the levels serum NT-proBNP levels after ace inhibitor therapy in patients with heart failure and monitoring creatinine serum. This study was a observational, prospective, non-randomized trial involving patient age 21-75 years, with NYHA class II-III HF, using ACE inhibitor therapy plus other therapy maximum 3 months before study without ARB or beta blocker. We compared serum NT-pro-BNP and creatinin serum parameters before and after two months treatment with ACE inhibitor. This study conducted in cardiovascular ambulatory patient dr. Soetomo hospital Surabaya. Between August-November 2015, 13 patient (38-63 years, 6 woman, 7 men) include in this study. The mean baseline level of NT-proBNP is 2166.92±1236.73 pg/ml, and creatinin serum 1.023±0.601 mg/dL. The NT-pro-BNP were significantly decreased after two months of treatment with ACE inhibitors 1508.23±651 pg/mL (p=0.025), there were no significant differences creatinin serum between two groups 0.951±0.0365 mg/dL (p=0.111). The results demonstrated the benefits of ACE inhibitor on the neurohormonal profile in patients with HF. If necessary we could measure NT-proBNP level to support prognosis data and monitoring effectivity therapy especially ACE inhibitor which had antiremodelling effect towards patients with HF.
Analysis of earphone swab mitochondrial dna as an alternative material for identification examination Yudianto, Ahmad; Sispitasri, Yeti Eka; Margaret, Nola
Folia Medica Indonesiana Vol. 52, No. 3
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Identification include fingerprint, property, medical, dental, serologic and exclusion methods. In the development, identification methods led to molecular forensics, a new field of science evolving since the 1980s, known as DNA fingerprinting. Specimens widely used in DNA assay for identification are blood spots/bloods, semen spots, vaginal swabs, buccal swabs and bones. In addition to these specimens, the last objects often used by the perpetrators/victims can be used, such as hearing aids (headsets/earphones). In its use, earphones are attached to the outer ear skin; thus, the earwax is suspected to adhere to the device. To date, in Indonesia personal identification is performed through swabs of earphones/headsets using the DNA profiling method. In particular, mitochondrial DNA has not been widely used for identification. The present study was of laboratory experimental. Earphones which have been used for 3 days were placed in room temperature for 1, 7, 14 and 20 days. Results showed that the environmental factor of exposure duration had an effect of a significant decrease in the levels of DNA from day 1 to day 20. Only 126-bp mtDNA (HVS II) was detected on the samples of day 1 and continued with sequencing. Mitochondrial DNA has better durability and relatively higher number of copies than those of nuclear DNA. This leads to greater possibility of success in amplification, given the higher number of mitochondrial DNA copies and the fact that mitochondrial DNA is a single locus that allows recombination.
Correlation between blood glucose level and thinking concentration Marbun, Putri Itonami Gaol; Mardiani, Tengku Helvi
Folia Medica Indonesiana Vol. 52, No. 3
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Abstract

Cognition function specifically about thinking concentration has not much yet been studied. Society view shown that glucose has role thinking quality. Few studies shown that glucose has role in specific memory quality but not in complex thinking. This study purpose to see correlation between blood glucose level with thinking concentration before eating (preprandial), after eating (postprandial), and the effect of blood glucose rise on thinking concentration. Subjects that accomplished study's requirement were recruited until forty six people and were followed within thirty minutes. Blood Glucose level was measured by glucose meter at initial admission, thinking concentration were measured with trail making test at initial admission, and compared after eating on the thirtieth minute. Descriptive analytic shown that preprandial blood glucose level in all subject is 55-119 mg/dl with 98.2 mg/dl mean. Postprandial blood glucose level in all subject is 103-171 mg/dl with 134.5 mg/dl mean. Preprandial thinking concentration in all subject is 28-93 seconds with 56.42 seconds mean. Postprandial thinking concentration in all subject is 24-73 seconds with 47.5 seconds mean. Correlation analysis showed that no significance between preprandial blood glucose level and thinking concentration (p = 0.556), postprandial blood glucose level and thinking concentration (p = 0.533), and increase in blood glucose and thinking concentration (p= 0.928). In conclusion there is no significant correlation between blood glucose level and thinking concentration.
In vitro fertility test of human spermatozoa membrane protein fertilin beta antibody in mice (mus musculus balb/c) as immunocontraceptive candidate I'tishom, Reny; Soebadi, Doddy M; Hinting, Aucky; Lunardhi, Hamdani; Yudiwati, Rina
Folia Medica Indonesiana Vol. 52, No. 3
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Abstract

One of the materials as potential candidates immunocontraception material is spermatozoa. Fertilin beta is spermatozoa membrane protein and is found only in mature spermatozoa and ejaculate, which serves as an adhesion molecule. Spermatozoa membrane protein that is used as an ingredient immunocontraception candidate, must have specific criteria that the specificity of spermatozoa, the role of antigen in the fertilization process, which includes the formation of immunogenicity sufficient antibody response has the potential to block fertilization. Antibodies against spermatozoa affect the stages before fertilization of the reproductive process and can hinder the development of the embryo after fertilization. Until now very little research data spermatozoa membrane protein as an ingredient immunocontraception are up to the test of experimental animals. The research objective is to prove the role of the resulting antibody induction of antibodies fertilin beta protein in the membrane of human spermatozoa induce agglutination and reduce motility thus reducing the number of in vitro fertilization. Research conducted at the IVF Laboratory, Department of Biology of Medicine, Faculty of Medicine, University of Airlangga. This research includes: Test the potential of antibody protein beta fertilin membrane of human spermatozoa and inhibit the role of antibodies in vitro fertilization in mice (Mus musculus Balb/c). In vitro studies have resulted in fertilization figure of 25% is smaller than the number that is equal to control fertilization of 58.7%, whereas previously the spermatozoa were incubated first with a beta membrane protein antibody fertilin human spermatozoa. While the percentage of inhibition of sperm to fertilize an oocyte by 33.75%. Potential imunokontraseptif considered effective if it decreased significantly (P <0.05) than the numbers fertilization in the treatment group compared with the control group. This shows fertilin beta membrane protein antibody has the ability to inhibit human spermatozoa to fertilize oocytes that reduce the number of fertilization.
Case report: stent dislodgedment Oktaviono, Yudi Her
Folia Medica Indonesiana Vol. 52, No. 3
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Abstract

Male 61 years old who presented with stable angina since 1 month ago, with Risk factor of CAD: hypertension, Dyslipidemia and heavy smoker. The ECG showed inferior old myocardial infarction. Diagnostic coronary angiography found: bifurcatio lesion at distal LMCA with significant stenosis 60% at the distal LM and 85% at the osteal LCx (Medina score 1-1-0), high D1 and diffuse disease with maximal stenosis 85% at the distal LAD after D2, Significant stenosis 85% at the osteal LCx and CTO at the distal after OM1, diffuse disease with maximal stenosis 85% at the mid RCA. A 6-Fr JR 4.0 guiding catheter (Launcher, Medtronic) was engaged into the right coronary artery ostium via the femoral artery. GW pilot 50 (Hi-Torque Pilot 50) inserted to distal RCA. Perform Balloon support by Saphire II inserted to mid RCA and dilated, after that perform balloon to proximal RCA and dilated. Stent DES Firebird II (Rapamycin) to mid RCA and dilated. Stent BMS Apollo 3.0x36 mm inserted to proximal-mid RCA, overlapping with previous stent, but was loss or dislodged and insert to the guiding catheter. BMS stent was pulled out with small balloon ex stent. GC 6F 4.0 inserted to ascending Aorta and engaged at ostium RCA. BMS stent Arthos PICO 3.0x 34 mm inserted to proximal-mid RCA, overlapping with previous stent and dilated. Final angiography confirmed successful pull out of loss stent and dilation of the RCA.
Comparison effect of cv 12, st 36 and st 40 ea on short term energy balance regulation in high fat diet rat Rejeki, Purwo Sri; Harjanto, Harjanto; Argarini, Raden; Subadi, Imam
Folia Medica Indonesiana Vol. 52, No. 3
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The aim of this study was to determine the comparative effects of EA (EA) on the CV12, ST36 and ST40 to weight gain prevention over the short-term regulation of energy balance. The study was conducted with a completely randomized design. Rats were divided into five groups: negative control group (no treatment, n=5), positive control (sham EA/back, n=5), EA CV 12 (n=6), EA ST 36 (n=6) and EA ST 40 (n=7). Rats were exposed to high-fat diet for two weeks and EA was simultaneously performed once daily, five days a week for two weeks with 2 Hz, for 10 minutes with continuous wave. Body weight, BMI, front limb circumference and rear were measured during study. Levels of blood glucose, cholesterol, triglycerides, LDL and HDL were measured at the end of the study; which reflects the short-term regulation of energy homeostasis. For weight loss, EA CV12, ST36 and ST40 group have lost weight significantly compared to the negative and positive control group. The ST40 group has a significant decrease than ST36 and CV12. The most significant decrease in BMI found in the ST40 group. EA did not affect blood glucose levels, but modulated blood lipid profile. In ST 40 group there was a significant decrease in cholesterol, LDL and triglycerides. EA at point ST 40 is potential in preventing increased body weight and BMI in rats exposed to high-fat diet compared to the CV 12 and ST 36. ST 40 is a point with a potential of lowering LDL and triglycerides serum so that it can play a role in the short term regulation of energy homeostasis but also in the prevention of dyslipidemia.
The mechanism of alpha lipoic acid on reducing the mda level and mcp-1 expression in endothelial dysfunction of hypercholesterolemia rat (rattus norvegicus) model Sari, Dewi Perwito; Susilo, Imam; Khotib, Junaidi
Folia Medica Indonesiana Vol. 52, No. 3
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Abstract

Endothelial dysfunction is an initial condition of atherosclerosis and other vascular diseases where one of the risk factors is hypercholesterolemia. Blood cholesterol levels is associated with an increase in the production of reactive oxygen species (ROS). The increasing of ROS production can cause increased oxidative stress which in turn resulting in endothelial dysfunction. Alpha lipoic acid (ALA) is one of the antioxidant compound that has been developed and studied. In this study we found that the use of ALA in Rattus norvegicus rats signifficantly lower the total cholesterol levels at dose 60 mg/kgBW (p=0.020). ALA also inhibit the expression of Monocyte Chemoattractant Protein-1 (MCP-1) at dose 60 mg/kgBW (p=0.044) and reduces the formation of Malondialdehyde (MDA) at dose 120 mg/kgBW (p=0.009), which is the initial stage of the atherogenic development and prognosis of events, thus, ALA can reduce the risk of further damage to the endothelium.
Effect of sandblasting time on the roughness of the metal cobalt-chromium (co-cr) during denture metal framework production Kusdarjanti, Endang; R, Dwiyanti Feriana; Inayati, Eny
Folia Medica Indonesiana Vol. 52, No. 3
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One of the stages of manufacture of denture metal framework that is sandblasting, ie cleaning the remnants of investment material after metal casting process and remnants of metal oxide on the surface. After fitting in the master model, then the metal framework dentures do sandblasting again until smooth before elektropolishing. The tools used are sandblaster, material Al2O3 (aluminum oxide) size of 250 lm. The time it takes about 1 minute, but the time of 1 minute when applied to student practicum D3 is still not clean and there are still remnants of planting material castings and metal oxide on the surface of the Co-Cr. Objective: To determine the effect of time on pembutan teeth iruan sandblasting the metal frame of the metal surface roughness Co-Cr. This study is experimental laboratories. A sample of tablet shape with a diameter of 7mm, 2mm thick metal. Number of samples 24 tablets were divided into 4 groups each group consisting of six tablet samples. Distribution of the sample group of the study are as follows; Group 1; Sandblasting metal surfaces with 250 µm Al2O3 time of 1 minute, Group 2; Sandblasting metal surfaces with Al2O3 250 ?m 2 minutes, Group 3; Sandblasting metal surfaces with Al2O3 250 µm 3 minutes, Group 4; the group did not do sandblasting. Data were analyzed with ANOVA statistical analysis of the lane with 0:05 significance level. If there is a significant difference between groups duiji with HSD test. There were significant differences in surface roughness Co-Cr metal between the control group without sprayed with the spray group at 1 minute, 2 minutes and 3 minutes. In conclusion, the surface of a metal frame that is not done sandblasting coarser than done sandblasting. The longer the time sandblasting increasingly produce a smooth surface of a metal frame. Sandblasting is perfectly need sufficient time is 2-3 minutes.
Effect of cognitive behavioral therapy for serotonin level, depression score and quality of life in cervical cancer patients Soetrisno, Soetrisno; Sulistyowati, Sri; Respati, Supriyadi Hari; Nasrudin, Muhamad
Folia Medica Indonesiana Vol. 52, No. 3
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Cervical cancer is the most common cause of death among gynaecological neoplasms. Management of advanced cervical cancer currently has not been able to improve the prognosis. Standard intervention therapy, chemotherapy and radiotherapy, as well as the emerging pain could lead to psychological stress till depression, thus reduce patients' quality of life. CBT for psychological stress and depression is expected to improve the fruitfulness of standard therapy. Serotonin is a neurotransmitter which plays a role in the patophysiology of depression. The aim of this study is to analyze the effect of cognitive behavioral therapy on serotonin level, depression score and quality of life in advanced cervical cancer patient with experimental quasi pre and post test design methods. The samples are 15 subjects in both intervention and control groups. Intervention group was given CBT and standard therapy, while control group was given standard therapy only. Study was held in Department of Obstetric and Gynecologic Dr. Moewardi Hospital Surakarta and Prodia Laboratory, in January to March 2015. Independent variable was advanced cervical cancer patients underwent CBT intervention and dependent variables were serotonin level, depression score and quality of life score. The result, serotonin level and quality of life scores were higher after intervention compared with control, (219.43±33,42 vs 89.57±23.23) and (85.13±14.62 vs 41.86±7.24), respectively. Depression score was lower after intervention than without CBT intervention (11.20±4.94 vs 17.00±4.86) and statistically significant (p < 0.05). So, there were effects of cognitive behavioural therapy on serotonin level, depression score and quality of life score in cervical cancer patients and were statistically significant.
Modified vac dressing in sternal wound infection management. Cheap and feasible technique in developing country Sembiring, Yan Efrata
Folia Medica Indonesiana Vol. 52, No. 3
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Sternal wound infection is a rare but serious complication of cardiac surgery leading to prolonged hospital stay and higher mortality. In the last decades several treatment modalities have been described, of which vacuum-assisted closure (VAC) shows the most promising results. However, the VAC therapy system is expensive, requires extensive amounts of product and needs a power source at all times. Modified VAC dressing to treat sternal wound infection is cheap and feasible technique to use in develop country. This technique can be use as an alternative to the original vacuum-assisted closure and hadshown to serve its function in providing adequatevacuum pressure for wounds.

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