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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Correlation between coping mechanism and safety behavior in construction workers of fabrication division in a steel construction company Widajati, Noeroel; Martiana, Tri; Mulyono, Mulyono
Folia Medica Indonesiana Vol. 52, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Unsafe act become the most cause of accidents. One of human factors causing accidents is work stress. The aim of this study was to analyze correlation between coping mechanism and safety behavior at workers of fabrication division in a steel construction company. The study was carried out with cross-sectional analytical observational methods. The study population was 200 workers of fabrication division in a steel construction company. By using simple random sampling method, the number of samples was 134 respondents. Data collection was performed by observation, interviews, and questionnaires. The independent variables were age, education level, K3 experience, coping mechanism, emotional focused coping, and problem focused coping, while the dependent variable was safety behavior. Intervariables correlation were tested by Chi-square test (α=0.05). Correlation between age and safety behavior was categorized on relation (p=0.016; r=0.301). Correlation between education level and safety behavior was not categorized on relation (p=0.260; r=0.315). Correlation between tenure and safety behavior was categorized on relation (p=0.001; r=0.422). Correlation between coping mechanism and safety behavior was not categorized on relation (p=1.0; r=0.015). The conclusion was age and tenure have unidirectional and strong relation with safety behavior, while the level of education and coping mechanism have no relation with safety behavior. Company should have given understanding to workers about safety behavior through K3 training and safety talk and held safety inspection and or safety patrol to supervise workers.
Analysis of antibiotics use in pediatric pneumonia patients aged 3 months - 5 years Aryani, Dhita Evi; Hasmono, Didik; Zairina, Nun; Setiawan, Landia
Folia Medica Indonesiana Vol. 52, No. 2
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Abstract

Pneumonia is an infectious disease that causes acute inflammation of the lung parenchyma and compaction exudate in the lung tissue. In addition to causing significant morbidity and mortality, pneumonia is also difficult to diagnose, treatments are less precise and less taken seriously. Pneumonia caused the death of 14% of children under five in Indonesia, with a mortality rate of 83 children per day. The difficulty of diagnosis, the selection of a less appropriate antibiotics, side effects, differences in pharmacokinetics and pharmacodynamics of the drug in infants and antibiotics resistance is to be a problem in itself. Therefore it is necessary to study the analysis of the use of antibiotics in patients with pneumonia of children aged 3 months till 5 years. The aim of this research to analyze antibiotics therapy in patients with pneumonia of children aged 3 months till 5 years. Method: an observational cohort analysis was carried out in the Pediatrics Respirology Division Dr. Soetomo Hospital Surabaya. Data was collected from February to May 2014. Patients who met the inclusion criteria were observed prospectively and the quantity and quality of antibiotics usage assessed with Gyssens category. Result: from February to May 2014 period, prospectively, the antibiotics usage quantitative evaluation used DDD/patient days shows that ampicillin 34.39DDD/100 patient days. Qualitative evaluation using Gyssens category on 75 antibiotics therapy shows that 32% considered appropriate. So, this study showed that ampicillin is most widely and qualitative analysis, only 32% of rational use of antibiotics.
The Efficacy of Psidium guajava Linn Leaf Extractsfrom Selangor Region Against Gram-Positive and Gram-Negative Bacteria Zuhaira, S; Nizam, Noorhaniz Mohd; Ridzuan, PM
Folia Medica Indonesiana Vol. 54, No. 4
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Abstract

Antibiotic is a type of medication that helps in fighting bacterial infection. Treating bacterial infections in clinical setting become more complicated and costly due to drug resistance. This study was conducted to determine the antibacterial potential of Psidium guajava Linn leaf extracts against Gram-positive and Gram-negative bacteria. P. guajava Linn leaf was obtained from Research Orchards at University Putra Malaysia (UPM). Leaves were extracted using three types of extracts; hot, cold and methanol extract. Freeze dried was used in this study and temperature was set at -104°C for 24 hours. Antibacterial testing was determined using disc diffusion and well diffusion method. Antibacterial activity was evaluated by measuring the inhibitory zone of the tested bacteria. Phytochemical analysis was conducted by adding few drop of diluted NaOH (Sodium Hydroxide) solution to detect the active flavanoid from leaves extract. Antimicrobial activity showed all extracts were effective against Gram-positive and Gram-negative bacteria. Phytochemical analysis of P. guajava Linn leaf extracts showed the methanol extract indicating the presence of tannins, phenols, flavonoids, terpenoids, glycosides and saponins. Results showed that P. guajava Linn leaf was effective against Gram-positive and Gram-negative bacteria, and pythochemical analysis also exhibited a few active compounds that were determined. P. guajava Linn leaf had potential natural product that may be used for further analysis in the future research.
Analysis of Quality of Antibiotic Usage on Patient with Internal and Surgical Service Ma'rifah, Nurul; Hasmono, Didik; Hadi, Usman; Kuntaman, Kuntaman
Folia Medica Indonesiana Vol. 57, No. 1
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Abstract

It is well-known that hospitals are health facility with the widely use of antibiotics. It is about 13-37% from the total hospitalized patients in developed countries use antibiotic, even in developing countries can reach 30-80%. There is identified correlation between antibiotic use and the development of bacterial resistance. Even though the resistance cannot be eliminated, but its development can be suppressed by the increasing of prudent use of antibiotics. The aim of this study was to determine the quality of antibiotic use on internal medicine and surgical patients in Aisiyah Hospital Bojonegoro. The study was a prospective cross sectional observational analytical study of among patients of internal and surgical who received antibiotic therapy in the period of August - September 2017. The total 50 samples were collected in this study which consists of 33 internal medicine and 17 surgical patients. From 50 samples, there were 16 types of antibiotics with the total use of 81 of antibiotic use. As the result, in internal medicine patients there were 22 (40%) of appropriate use of antibiotics, 4 (7.27%) of inappropriate use and 29 (52.73%) use of antibiotics without indication. In surgical patients, there were 12 (46.15%) of appropriate use of antibiotics, 2 (7.69%) of inappropriate use and 12 (46.15%) use of antibiotics without indication. This study showed that more than 50% of antibiotic use were inappropriate, and mainly antibiotic with no indication, among patients hospitalized in Aisyiyah Hospital Bojonegoro.
Ratio of CD68/CD163 in Breast Carcinoma with and without Axillary Lymph Node Metastatic Wiratama, Priangga Adi; Sandhika, Willy
Folia Medica Indonesiana Vol. 56, No. 1
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Abstract

Tumor and its microenvironment can interact each other. Macrophage is part of tumor microenvironment. New drugs targeting specific superficial receptor of macrophage or cytokine of macrophage polarization have been found. Therefore, macrophage phenotype and its ratio of M1/M2 macrophage need to be identified. This identification could lead us to prognose breast cancer and monitor its therapy. Analytical observational study with cross sectional approach, conducted on paraffin block sample of breast carcinoma from Anatomical Pathology Laboratory of Dr. Soetomo General Hospital. The samples divided into four groups based on nodal metastasis staging (N0, N1, N2, and N3) and stained with antibody against CD68 and CD163. The ratio of CD68 and CD163 were analyzed with Anova test. There were difference expression of CD68 as M1 macrophage marker in various axillary node metastasis groups (p=0.015). There were difference ratio of CD68 as M1 macrophage marker and CD163 as M2 macrophage marker in various axillary node metastasis groups (p=0.005). There were difference ratio of macrophage M1 and macrophage M2 between N0 and N3 group, N2 and N3 group also.
High Sensitive Troponin I and Extended Range C-Reactive Protein as Markers to Predict Cardiotoxicity in Locally Advanced Breast Cancer with Neoadjuvant CAF (Cyclophoshpamide, Adriamycin/Doxorubicin, 5Fluorouracil) Therapy Hidayat, Yusfik Helmi; Ishardyanto, Hantoro; Anniwati, Leonita
Folia Medica Indonesiana Vol. 56, No. 2
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Abstract

The limitation of echocardiography to measure chemotherapy cardiotoxicity at left locally advanced breast cancer with large ulcer is still serious problem. HsTnI and erCRP are biomarkers to detect cardiotoxicity that are cheap, easy to examine and available at Dr.Soetomo Hospital Surabaya. This study was to compare HsTnI, erCRP and echocardiography as cardiotoxicity predictors in locally advanced breast cancer with neoadjuvant CAF therapy. This study used one group pretest and posttest design among 23 locally advanced breast cancer patients. All patients underwent echocardiography, HsTnI, and erCRP examinations before and after 3 times chemotherapy and compared. The average age was 49.78±8.7. Statistically significant decrease in LVEF was found after treatment (67.98%±4.06 and 64.07%±3.53, p=0.000). HsTnI was significantly increased after treatment (0.007 µg/mL±0.004 and 0.043 µg/mL±0.051 p=0.000). erCRP was significantly decreased after treatment (1.043mg/dL±0.913 and 0.573mg/dL±0.444 p=0.044). Decreased LVEF and increased HsTnI was compared by its cardiotoxic cut-off. HsTnI was significantly better and faster to detect cardiotoxicity (0.033±0.051 p=0.002). In conclusion, strong correlation is present in the detection of cardiotoxicity between HsTnI and LVEF. HsTnI is faster than echocardiography, and could be alternative diagnostic to detect early cardiotoxicity.
Inhibitory Effect of Garlic and Vitamin C on Candida Albicans Lufthansyahrizal, Muhammad Fauzi; Andriana, Kusuma; Nurainiwati, Sri Adila
Folia Medica Indonesiana Vol. 58, No. 3
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Abstract

Highlight: 1. Garlic and Vitamin C effect on Candida Albicans. 2. Vitamin C has the ability to inhibit C. albicans in PBS media but it did not have significant MIC due to the presence of glucose in the media if combined with garlic petroleum extract. Abstract: Garlic can downregulate ECE1, a gene that regulates the production of candidalysin as a virulence factor for C. albicans. Allicin in garlic has antifungal properties because allicin can penetrate cell membranes and damage cell organelles such as vacuoles and mitochondria, causing irreversible structural and functional damage that leads to cell death. Garlic that is processed into extracts also has antifungal abilities. Purely squeezed garlic extract had a MIC of 50%, while the ethanol extract of garlic had a MIC of 40%. This difference is thought to be due to differences in the use of concentrations used and the use of extract solvents. Vitamin C can inhibit C. albicans in PBS media, there is an active metabolism and oxygen, low free iron concentration, there is mitochondrial inhibition ongoing, and in the early stationary growth phase. However, the combination of garlic petroleum ether extract and vitamin C did not show significant MIC due to the presence of glucose in the media, which could increase the growth of C.albicans.
Phosphatidylglycerol study as fetal lung maturation parameter after dexamethasone administration for women at risk of preterm birth Rahmadani, Rizal Umar; Sulistyono, Agus; Yulistiani, Yulistiani; Yahya, Muhammad
Folia Medica Indonesiana Vol. 52, No. 4
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Phosphatidylglycerol is an important indicator of fetal lung maturation, which plays a role in stabilizing surfactant lipoprotein complex. Corticosteroid antenatal can stimulate the synthesis of pulmonary surfactant in infants with preterm birth. The objective of this study is to examine the phosphatidylglycerol levels as fetal lung maturation parameter after dexamethasone administration in women with preterm birth compared to L/S ratio parameter. This study was prospective longitudinal (cohort). The samples were pregnant women with preterm birth risk at 28-34 weeks gestation getting the therapy of antenatal dexamethasone 6 mg IM every 12 hours given 4 times in 48 hours. The samples were 17 patients. Determination of L/S ratio and PG levels was performed by ELISA. The study was conducted from May - November 2015 and reviewed to obtain ethics eligibility permit by the research ethic committees of Dr. Soetomo General Hospital. The results show that the mean value of L/S ratio is 2.28 with a range of 1.35 to 9.06 and the mean of PG level is 1.17 with a range from 0 to 3.79. L/S ratio and PG show no significant relationship between the two of them. Increased levels of PG on the gestational age of 28-32 weeks have not demonstrated clinically significant changes yet. The highest PG level occurs in the gestational age of 32-34 weeks.
Human Sperm Motility, Viability, and Morphology Decreased after Cryopreservation Darsini, Ninik; Hamidah, Berliana; Suyono, Seso Sulijaya; Ashari, Faisal Yusuf; Aswin, R Haryanto; Yudiwati, Rina
Folia Medica Indonesiana Vol. 55, No. 3
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The aim of this study was to analyze human sperm motility, viability, and morphology before and after cryopreservation. This true laboratory experimental study had pre and post randomized one group design. The study was conducted at the Embryology, Andrology, and Genetics Laboratory, Department of Medical Biology, Faculty of Medicine, Universitas Airlangga from August to November 2017. The eighteen samples of fresh semen were collected from male volunteers who agreed and signed the informed consent of the study. Samples were analyzed their motility, viability, and morphology before and after cryopreservation. Results of this study indicated differentiation between motility before and after cryopreservation. Cryopreservation process decreased progressive motility (42.22 + 9.46%; 17.83 + 6.24%; p< 0.0001) and increased the number of immotile spermatozoa (35.44 + 10.15%; 60.11 + 12.53%; p< 0.0001). Cryopreservation also decreased human sperm viability (73.78 + 8.91%; 40.83 + 12.89%; p< 0.0001) and morphology (10.94 + 4.96%; 7.39 + 3.90%; p< 0.0001). Cryopreservation of human spermatozoa caused the decreased of motility, viability, and morphology.
Comparison of Irisin Serum Healthy Untrained Males on Treadmill Exercises by Increasing Gradually Speed Vs Inclination Uda'a, Budiyanto; Tinduh, D; Masduchi, HR; Laswati, Laswati; Wibisono, S; Soenatalina, Soenatalina; Theodora, S
Folia Medica Indonesiana Vol. 56, No. 1
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Abstract

Aerobic exercise can improve cardiorespiratory fitness in young people. Irises released into the bloodstream function to execute regulation of energy metabolism, triggering browning white adipose, which is useful in mitochondrial biogenesis. The American College of Sport Medicine (ACSM) recommends moderate intensity cardiorespiratory fitness training with a frequency of 3-5 times a week, duration of 20-60 minutes, using a treadmill. Study subjects (n = 20) were divided randomly into 2 groups, namely the moderate intensity Treadmill training group with gradual speed improvement and gradual inclination increase. Serum slices are measured on the first and last day of exercise. There was an increasing of irisin serum in the moderate intensity Treadmill training group by increasing gradually speed after 2 weeks of exercise, both 30 minutes pre-exercise (p = 0.02) and 1 hour post exercise (p = 0.01). Medium intensity Treadmill training with 2 weeks gradual speed increase with frequency 3 times a week can increase serum slice in men, healthy untrained young men.

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