cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Viskasari P. Kalanjati
Contact Email
fmi@journal.unair.ac.id
Phone
-
Journal Mail Official
fmi@journal.unair.ac.id
Editorial Address
Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
Location
Kota surabaya,
Jawa timur
INDONESIA
Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
 22   23   24   25   26 
Effectiveness of Pre PRP Injection and Post Elevation Flap at Extended Random Flap Rat Skin Nugroho, Thomas Eduardus Sudrajat Wahyu; Rizaliyana, Sitti; Perdanakusuma, David S
Folia Medica Indonesiana Vol. 56, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background:Closure of the defect with a random skin flap is constrained by the extent of the defect area. Several studies have shown the benefits of administration of PRP (Platelet Rich Plasma) in random skin flap. The purpose of this study is to compare the effect of PRP injection given before flap elevation, after flap elevation and control on the extended random skin flap procedures in rats. Methods: This research is experimental with randomized post test only control group design (n = 27, divided into 3 treatment groups) that compare the effectiveness of PRP injection 24 hours prior to the elevation of the flap, after the elevation of the flap, and control in the extended random skin flap in rats. Random skin flap is made in the ratio 1: 5 on the rat skin. Measurement of viable area were observed on days 1, 7 and 14. Results: There were significantly increased viability of random skin flap on the group with PRP injection 24 hours prior flap elevation compared to other group of treatment. The average of viability on day first 39%±13% ;42%±34%; 62%±14%. On day 7th24%±13%; 36%±26%; 62%±12%.On day 14th16%±15%; 28%±22%; 60%±11%. Conclusion: Injection of PRP on extended random skin flap on rat 24 hours before flap elevationincrease viability of the flap compared to control group and group which receive PRP injection on extended random flap on rat skin after elevation of the flap. Viability increased due to angiogenesis stimulation after PRP injection.
Structural Model of Maternal Behavior in Community Setting to Prevent Low Birth Weight in East Nusa Tenggara, Indonesia Anggrahini, Simplicia Maria; Notobroto, Hari Basuki; Irwanto, Irwanto; Suryawan, Ahmad
Folia Medica Indonesiana Vol. 56, No. 1
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Low birth weight (LBW) is still a magnitude problem in Indonesia with a multifactorial causes. Studies revealed that one of cause of LBW-infants birth is mother's behavior in treating her pregnancy, including traditional pregnancy care practices. The purpose was to develop the structural model on community setting that might describe the LBW infants-birth. A case-control study on 50 post-partum mothers with LBW and 50 with normal birthweight infants was held in Kupang, East Nusa Tenggara, Indonesia, November 2016 - May 2017. Mother who have spontaneous birth, singleton, and received integrated ANC were inlcuded. Several data such as maternal characteristics, pregnancy knowledge, perceived behavioral control (PBC), maternal health status, obedience to traditional pregnancy care, were collected using questionnaire and medical records tracing. Statistical analysis was performed using path analysis from SmartPLS 3.2.7 and considered significant path when the coefficients were not zero with P value <0.05. Outer and inner model analysis showed two significant paths, both are come from maternal characteristic that influence the LBW infants-birth through pregnancy knowledge (0.489, P=0.000) and PBC (0,425, P=0,000). In the first path, PBC affect maternal health status (0.217, P=0.021) which in turn will cause LBW (0.201, P=0.001). The second path, PBC affect the obedience to traditional pregnancy care (0.474, P=0.000) and then influence to LBW (0.316, P=0.000). As conclusion, maternal characteristics, pregnancy knowledge, PBC, maternal health status, and obedience to traditional pregnancy care are key points that might be used as a significant variables in preventing LBW-infants birth.
Epiphyseal Closure Time of Radius and Ulna Bones of the Proximal Section Lio, Tiara Mayang Pratiwi; Koesbardiati, Toetik; Yudianto, Achmad; Setiawati, Rosy
Folia Medica Indonesiana Vol. 54, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Accurate determination of age is important in the legal process; when a person's age is unknown or must be authenticated, a forensic age identification method must be applied. One of such methods is to assess the epiphyseal closure on the bone through radiological examination. The main problem associated with the use of this method is the relevance of the reference population provided because epiphyseal closure is influenced by genetics and nutrition. This method needs data to represent each population. Radiological examination of elbow bones of 30 male patients aged 11-30 years and 18 female patients aged 14-28 years in Dr. Soetomo Hospital, Surabaya from January to April 2016 was carried out to determine the time of epiphyseal closure of the radius and ulna distal section. This was cross-sectional descriptive study. In conclusion, epiphyseal closure of proximal radius and ulna is complete at age 16 in males and 14 in females.
The Correlation between icaA and icaD Genes with Biofilm Formation Staphylococcus epidermidis In Vitro Rachmawati, Dian; Kuntaman, Kuntaman; Alimsardjono, Lindawati
Folia Medica Indonesiana Vol. 55, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study was conducted to identify the presence of icaA and icaD genes in S. epidermidis and to analyze the relationship between the presence of icaA and icaD genes with the ability of in vitro biofilm formation in S. epidermidis. S. epidermidis isolates from patients and healthy people were collected and PCR was examined to detect icaA and icaD genes. which then continued to examine the ability of biofilm formation by the method of Congo Red Agar. The results of this genotypic and phenotypic examination were then tested for correlation with statistical tests using SPSS 23.0. A total of 40 S. epidermidis isolates were collected, consisting of 20 clinical isolates and 20 isolates of normal flora. The icaA gene was positive in 5 isolates (12.5%), and 8 isolates (20%) were positive for the icaD gene, 3 isolates with icaA and icaD were both positive. One hundred percent of isolates with icaA or icaD positively formed biofilms, but there were 15 isolates (42.9%) who did not have the icaA gene but showed the ability to form biofilms, while 12 isolates (37.5%) who did not have the icaD gene also formed biofilms. Fifty percent of S. epidermidis isolates showed the ability to form biofilms at CRA. The Fisher Exact test showed a significant relationship between the icaA gene and the ability of biofilm formation (p=0.047 (p<0.05)) as well as the icaD gene (p=0.03 (p<0.05)). The icaA and icaD genes have a significant relationship to biofilm formation in S. epidermidis. There was another mechanism in the formation of biofilms that are not dependent on the ica gene.
Body Mass Index and Urinalysis Markers in the Seemingly Healthy Young Adults Pradana, Krisnawan Andy; Kalanjati, Viskasari P; Tirthaningsih, Ni Wajan
Folia Medica Indonesiana Vol. 56, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Higher prevalence of albuminuria, glycosuria, and haematuria was reported in the obese people than control. We aimed to analyze the BMI and urinalysis markers among the university students aged 18-21 years old in the IIKBW, Kediri to study any correlations and differences between these variables, which to the best of our knowledge has yet widely reported in Indonesia. This study has ethics approval from Universitas Airlangga, Surabaya. The BMI was analyzed from the body weight and height of male (n=74) and female (n=76) students with no health problems recorded. The pH, nitrites, protein, erythrocytes, glucose in the urine were measured qualitatively with a dip-stick method, blinded, using the midstream urine sample collected in the morning. Data were analyzed using SPSS 17, with a level of significance of p<0.05. Abnormal pH (n=75), positive nitrites (n=24), haematuria (n=6), and proteinuria (n=149) were recorded. About 22% of students suffered from type I obesity, and 8.7% of type II. Males were significantly suffered from the obesity whilst females from the overweight (p<0.05). No significant correlations between the BMI and each urinalysis marker (BMI and nitrites p=0.936; BMI and protein p=1; BMI and pH p=0.835; BMI and blood, p=0.486; respectively); no one were found with glycosuria. No significant differences either on the BMI or the 5 urinalysis markers between male and female groups (p>0.05). Whilst no positive glycosuria samples were identified; 18.9% of males and 13.2% of females have positive nitrites, 100% of males and 98.7% of females have positive proteinuria, 2.7% of males and 7.9% of females have positive haematuria. There were 7.33% of males and 6% of females having an increased pH; whilst 20.66% of males and 16% of females having a decreased pH. Amongst the seemingly healthy university students, we found cases of urinalysis marker impairment, although no significant correlations on the BMI to the urinalysis markers that may be representing early detection for renal diseases were observed.
8-Hydroxydeoxyguanosine Urine and Total Nitric Oxide Serum in Chronic Kidney Disease Ahadini, Putri Aliya; Thaha, Mochammad; Mustika, Arifa
Folia Medica Indonesiana Vol. 58, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: • Oxidative markers 8-Hydroxydeoxyguanosine and Nitric Oxide was found high in hemodialysis and non-hemodialysis chronic kidney disease patients. • There is no correlation between 8-Hydroxydeoxyguanosine and Nitric Oxide in hemodialysis and non-hemodialysis chronic kidney disease patients. Abstract: Oxidative stress is essential to chronic kidney disease (CKD). Several markers include 8-Hydroxydeoxyguanosine (8-OHdG) and Nitric Oxide (NO). Reactive oxygen species (ROS) and Reactive Nitrogen Species (RNS) increased in CKD and had a role in renal impairment progressivity. There are some controversies regarding oxidative markers in CKD patients in several studies. This study aimed to understand oxidative markers 8-OHdG and NO and explained the correlation of both markers in hemodialysis and non-hemodialysis CKD patients. Twenty hemodialysis patients and forty-nine non-hemodialysis patients were enrolled in this cross-sectional study. Urine patients were collected to measure 8-OHdG using the enzyme-linked immunoassay (ELISA) method, and NO was measured from serum patients using the Griss Saltzman method. Based on Bivariate Pearson analysis, there was no significant correlation between 8-OHdG urine and total NO serum in the hemodialysis group (p= 0,510, p>0.05) and in the non-hemodialysis group (p= 0.801, p>0,05). In this study, DNA oxidative marker, 8-OHdG, was not correlated with NO in CKD patients.
Biofilm bacteria plays a role in csom pathogenesis and has significant correlation with unsafe type csom Artono, Artono; Purnami, Nyilo; Rahmawati, Rosydiah
Folia Medica Indonesiana Vol. 51, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Chronic suppurative otitis media (CSOM) may cause severe morbidity and mortality and remains a major health problem worldwide. The incidence of CSOM in Indonesia (1994-1996) is estimated at about 8.36 million people and CSOM general prevalence is 3.8% (Helmi 2005). This study aims to prove the existence of bacterial biofilm in patients with safe type and hazard type CSOM from mastoidectomy. The design was observational analytic with cross sectional approach. This study was conducted at the Teratai Wards, IBP Dr. Soetomo Hospital, and Electron Microscopy Unit, Faculty of Medicine, Airlangga University Surabaya, from November 2013 to June 2014. Samples of pathological tissues were taken by consecutive sampling and bacterial biofilms examination was done by SEM. SEM results categorized the biofilm bacteria as positive or negative. Biofilm bacteria tested positive when it shows three-dimensional representation of bacteria with clear shapes and sizes and clusters, the formation of amorphous material consisting of glycocalyx material surrounding the bacteria, and surface attachment. Biofilm bacteria was regarded as negative when there is no bacterial cluster, glycocalyx and surface attachment. This study was performed on 33 CSOM patients. Samples were divided into unsafe type CSOM (17 patients) and safe type CSOM (16 patients). Positive biofilm bacteria was found in 12 patients with unsafe type (75%) and 6 patients with safe type (35.35%). Negative biofilm bacteria was found in 4 patients with the unsafe type (25%) and 11 patients with safe type (67.9%). Logistic regression analysis revealed p value = 0.027, indicating the biofilm bacteria have a significant correlation with unsafe type CSOM (p <0.05). In conclusion, biofilm bacteria plays a role in CSOM pathogenesis of biofilm bacteria has significant correlation with unsafe type CSOM.
Analysis of Minichromosome Maintenance-2 (MCM-2) and Cyclin D1 Expression in Meningioma Kurniawati, Yuliana; Fauziah, Dyah
Folia Medica Indonesiana Vol. 54, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

World Health Organization histopathological grading of meningioma is associated with recurrence and clinical outcome. Grade II meningioma can be difficult to distinguish with grade I especially in case in which mitosis is not easily identified. MCM-2 and Cyclin D1 play crucial role in cell cycle and have been reported overexpressed in many malignant tumors. The aim of this observational analytic study was to analyze the differences and correlation between MCM-2 and Cyclin D1 in various meningioma grading. Immunohistochemystry with MCM-2 and Cyclin D1 was performed on 25 paraffin blocks of grade I, II and III meningiomas at the Laboratory of Anatomical Pathology, Dr. Soetomo Hospital. The immunoexpression are evaluated using Labelling Index, then analyzed statistically. The results showed significant difference in expression of MCM-2 within various meningioma grading (p=0.000) and significant difference in expression of Cyclin D1 within grade I and II also within grade I and III (p<0.050), but not in grade II and III (p>0.050). There was also positive correlation between MCM-2 and Cyclin D1 expression in various meningioma grading (rs=0.683, p=0.000). MCM-2 may play role in distinguishing various meningioma grading. Cyclin D1 can distinguish grade I and II also grade I and III, but not grade II and III. Overexpression MCM-2 was along with Cyclin D1 in various meningioma gradings.
Effects of blue light emitting diode (led) and doxycycline to sebaceous gland in acne vulgaris Listiawan, M Yulianto; Prakoeswa, Cita Rosita Sigit; Handamari, Dhyah Aksarani; Indira, Regitta
Folia Medica Indonesiana Vol. 53, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acne vulgaris (AV) is an inflammation of pilosebaceous unit especially in young adult. The pathophysiology is the elevation of sebum production, keratinization of abnormal pilocebaseous follicles, and inflammation caused by immune response to Propionibacterium acnes. Therapy combination of oral antibiotics (doxycycline) and physical therapy (blue light) in moderate-severe acne is one option to reduce antibiotic resistance. Doxycycline is a commonly antibiotic used. The effects of photosensitive can increase the penetration of blue light by sebaceous glands. There was a total decrease in sebum and clinical improvement of combination therapy of blue light and doxycycline in seven patients. The combination therapy has been shown to improve its therapeutic effect, but more clinical trials are needed to prove the effectiveness of blue light with doxycycline than without blue light.
Effects of Golden Sea Cucumber Extract (Stichopus Hermanii) on Fasting Blood Glucose, Plasma Insulin, and MDA Level of Male Rats (Rattus Norvegicus) Induced with Streptozotocin Prawitasari, Dita Sukmaya; Safitri, Indri; Notopuro, Harianto
Folia Medica Indonesiana Vol. 55, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus (DM) is one of disease that its incidence increases every year worldwide. The condition of DM can cause various complications caused by oxidative stress. Stichopus hermanii (SH) or golden sea cucumber extract contains antioxidant compounds that have been proven to reduce oxidative stress conditions. The purpose of this study was to investigate the effect of Stichopus hermanii extract on condition of diabetes mellitus by looking at changes in fasting blood glucose, plasma insulin, and malondialdehyde levels in animal models of Wistar rats. This study was a laboratory experimental study using Randomized Control Trial Design with Post-test only control group design. Thirty-five male Wistar rats divided into five groups, i.e normal control group, positive control, negative control and two treatment groups with SH extract dose 8.5 and 17 mg / kgBW for 14 days once daily after induction of Streptozotocin at the Biochemistry Laboratory of the Faculty of Medicine, Airlangga University. Fasting blood glucose level was measured by a glucometer, plasma insulin measured by ELISA and MDA level was measured by a spectrophotometer. Data were analyzed statistically by using One Way ANOVA test and Kruskal Wallis. There were significant results of SH extract can reduce fasting blood glucose (Kruskal Wallis, p=0.030) and MDA (Kruskal Wallis, p=0.042) but not in plasma insulin (ANOVA, p=0.130). The lowest MDA level occurs in the K4 group that given SH extract dose 17 mg/kg BW than another experimental group. As the conclusion, this study showed SH extract can decrease fasting blood glucose and oxidative stress in diabetic-induced rats.

Page 24 of 58 | Total Record : 571

 22   23   24   25   26 

Filter by Year

2016 2025


Reset
Filter By Issues
All Issue Vol. 61, No. 2 Vol. 61, No. 1 Vol. 60, No. 4 Vol. 60, No. 3 Vol. 60, No. 2 Vol. 60, No. 1 Vol. 59, No. 4 Vol. 59, No. 3 Vol. 59, No. 2 Vol. 59, No. 1 Vol. 58, No. 4 Vol. 58, No. 3 Vol. 58, No. 2 Vol. 58, No. 1 Vol. 57, No. 4 Vol. 57, No. 3 Vol. 57, No. 2 Vol. 57, No. 1 Vol. 56, No. 4 Vol. 56, No. 3 Vol. 56, No. 2 Vol. 56, No. 1 Vol. 55, No. 4 Vol. 55, No. 3 Vol. 55, No. 2 Vol. 55, No. 1 Vol. 54, No. 4 Vol. 54, No. 3 Vol. 54, No. 2 Vol. 54, No. 1 Vol. 53, No. 4 Vol. 53, No. 3 Vol. 53, No. 2 Vol. 53, No. 1 Vol. 52, No. 4 Vol. 52, No. 3 Vol. 52, No. 2 Vol. 52, No. 1 Vol. 51, No. 4 Vol. 51, No. 3 More Issue