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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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The Effect of The Cucumber Consumption To The Level of Sodium Potassium in Mus Muscullus's Urine Production Elicia, Vincensa; Tjipto, Bambang Wasito; Novita, Bernadette Dian
Folia Medica Indonesiana Vol. 57, No. 3
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Abstract

Cucumber (Cucumis sativus L.). was known for lowering blood pressure agents. Some researches show that Cucumber had a similar mechanism with a loop diuretic (Furosemide), exceeding sodium and potassium excretion. However, a part of Cucumber that gives a better effect on managing water and sodium balance remains unknown. This study was to explain the differences potential diuretic among parts of Cucumber (Cucumis sativus L.). This study was using a post-test only control group designed in animals. There were 44 male Mus musculus tested in this study. All of the animal testings was divided into 9 different treatment groups and 2 control groups. All Mus musculus got 1 mL methanol extract of Cucumber (Cucumis sativus L.) according to their group. The animal testing was put on metabolic cage to measure urine volume for 24 hours. The flesh and rind part of Cucumber (Cucumis sativus L.) showed a similar result with furosemide as diuretics agents. However, whole part of the fruit of Cucumber (Cucumis sativus L.) (flesh, rind, and seed) showed as natriuretic dan kaliuretic, Cucumber (Cucumis sativus L.) has a similar potential diuretic with Furosemide. Even in low concentrations of Cucumber extract, it led to having a potential diuretic, with natriuretic and kaliuretic effects in the whole part of the fruit. This could be suggested to people with chronic kidney diseases to prevent hyperkalemia.
Radiological Aspects of HR-CT Scan on Temporal Bone Ferriastuti, Widiana; Ramayuda, Ida Bagus
Folia Medica Indonesiana Vol. 58, No. 1
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Abstract

Highlight: • High-resolution computed tomography (HRCT) scan has advantage for best image reconstruction and informative in interpreting images of the temporal bone. • The essential primary aspect in HRCT of the temporal bone scan is technique and protocol. Abstract: The high-resolution computed tomography (HRCT) scan used in the 1980s offers a distinct advantage in interpreting images of the temporal bone. To obtain a right image reconstruction and to provide meaningful information, a certain degree of tilt is required so that radiologists and clinicians can get more real imaging information on structural abnormalities in the temporal bone and its soft tissue constituents. The technique or protocol in HRCT of the temporal bone becomes an essential primary aspect in presenting the analyzed structure, the assessment of the small form of the auditory bones, the soft tissue of the inner ear and the cranial nerves that pass through the temporal bone structure is much easier to analyze, of course with the help of reconstruction according to the HRCT protocol for temporal bone, however, soft tissue evaluation is preferable to MRI. In the end, the standard structure, congenital abnormalities and pathological problems in the temporal bone structure can be identified and informed to the clinician as a step to determine further treatment action.
The effects of physical exercises on c-reactive protein in patients with post ischemic stroke Laswati, Hening; Andriana, Meisy; Subadi, Imam; Yuanita, Ida
Folia Medica Indonesiana Vol. 52, No. 3
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Abstract

Several studies have recently highlighted the important role of physical exercise in regulation inflammatory status, but there is relatively little known about markers of inflammation levels after physical exercise in post ischemic stroke patients. The aims of this study to provide the effects of physical exercise using Partial Body-Weight Supported Treadmill Training –Audio Cues (PBWSTT-AC) and Traditional method on the level of inflammatory markers C-Reactive Protein (CRP). This study using pretest-postest control group design, 14 post ischemic stroke patients were randomized and allocate to two groups: Group1 (control group) received traditional walking exercise and group 2 received PBWSTT-AC. The walking exercise study were conducted for 20 minute 3 times a week for 12 sessions (4 weeks). Before and after 12 session of exercises, the serum levels of CRP were determined using immunoserology. All statistical test were carried out using SPSS 17 and statistical significance was set at p<0.05 for all analysis. The CRP levels between group were compared using Student t test or Mann-Whitney test. From multiple comparisons statistic result, no significant difference between groups (p=0.898), that seem in this study the levels of CRP of poststroke patients is not influenced by the Traditional training and PBWSTT-AC. The conclusion of this study that both traditional method and PBWTT-AC in 4 weeks exercise training seem have no effect on CRP levels.
Diabetes risk factor screening in adults using perkeni questionnaire and oral glucose tolerance test in socah county, bangkalan Kamal, Radin H; Novendrianto, Dwiki; Chadijah, Faizah; Prasetya, Galan Budi; Pratama, Gilang Satria; Ariadnya, Mentari Octarina; Larasati, Nikita Gladys; Darain, Nur Lia F; Nanda, Ovitrani; Mavita, Silvi; Usamah, Usamah; Prajitno, Jongky Hendro
Folia Medica Indonesiana Vol. 53, No. 3
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Abstract

There are 8.4 million diabetes adult patients in Indonesia and most remained undiagnosed. Screening process for diabetes is very important. PERKENI has recommended the use of questionnaire and Oral Glucose Tolerance Test (OGTT) as risk factor screening tools. This study aimed to find out the use of PERKENI questionnaire and OGTT in adults as diabetes risk factor screening tools. This was a descriptive cross sectional study conducted in 2015 in Socah County Bangkalan. Participants (n=91) were interviewed regarding diabetes risk factor using PERKENI questionnaire. Anthropometric (height, weight, and abdominal circumference) measurements were also taken. The results were categorized into: very low risk, increased risk, moderate risk and high risk. Only those categorized as high risk were asked to take OGTT. Exclusion criteria were participants who had been diagnosed with diabetes by a physician and/or routinely taking anti diabetic medication, consumed drugs during the previous two weeks and does not finish the required procedures. From 91 eligible participants, only 9 (9.89%) were categorized as high risk. The result of OGTT were: 4 were within normal limit, 1 had impaired glucose tolerance (IGT) and 4 were newly diagnosed with diabetes. The use of PERKENI questionnaire and OGTT in high risk adult population as a diabetes risk factor screening tool increased new findings of diabetes cases. Our analysis may support the adoption of diabetes risk factor screening methods through questionnaires and OGTT in high risk adult population, especially in low resource setting.
Effect of Ethanol Extract of Date Palm Fruit (Phoenix dactylifera. L) on Spermatozoa Concentration of BALB/c Mice (Mus Musculus) Exposed to 2-Methoxyethanol Yassin, Tita Rudini; Yaudiwati, Rina; I'tishom, Reny
Folia Medica Indonesiana Vol. 56, No. 2
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Abstract

Antioxidants are important compounds for the human body because they function to capture free radicals causing degenerative diseases. Flavonoid and phenolic compounds in dates have antioxidant activity that can inhibit the increase in lipid peroxide and protein oxide. This study aims to prove the increase in the concentration of mice (Mus musculus) spermatozoa given ethanol extract dates and exposed to 2-methoxyethanol. Experimental animals used 35 mice (Mus musculus), divided into 5 groups (7 mice per group). The negative control group (K-) was the control group without administration of 2-methoxyethanol and date ethanol extract, the positive control group (K+) was given 200 mg/kg 2-methoxyethanol + CMC 0.5%, the treatment group 1 (P1) was given 200 mg/kg BW 2-methoxyethanol + 3.5 mg/gBW of ethanol extract dates, treatment group 2 (P2) were given 200 mg/kg BW 2-methoxyethanol + 7 mg/gBW of date palm ethanol extract, and treatment group 3 (P3) were given 200 mg/kg 2-methoxyethanol + 10.5 mg/gBW of ethanol extract dates. The results showed there were significant differences in spermatozoa concentrations between the positive control group (K+) and the negative control group (K-), treatment group 1 (P1) and treatment groups 2 and 3. mice (Mus musculus) exposed to 2-methoxyethanol.
The Effect of Antinociceptive Flavonoid on Leea Indica Leaves for Orofacial Pain of Adult Zebra Fish (Danio Rerio) Daya, Mei Putra; Saleh, Arman Yurisaldi; Astari, Riezky Valentina
Folia Medica Indonesiana Vol. 57, No. 2
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Abstract

Pain affects millions of people and is one of the most frequent complaints in the medical office. Pain involves various behavioral and emotional aspects. When it is persistent, it can become debilitating, impairing occupational performance, and producing negative impacts for the economy and public health costs. In general, commercial drugs can improve chronic pain patients' quality of life which can result in adverse reactions. Therefore, the search for new capsules as an opportunity remedy for ache is a challenge. Pain occurs due to stimuli from pain receptors called nociceptors. One pain known in the medical world is orofacial, defined as pain that occurs in soft and hard tissue in the head, face, and neck area. This study determined the antinociceptive effect of flavonoids isolated from the Leea Indica plant, on orofacial pain in zebrafish (Danio rerio) as a test model for behavior or locomotor activity. To study the orofacial pain of zebrafish induced with glutamate, this study was a true experiment. The parameter used was the number of times the fish crossed the line between the caudran from the glass petri dish during 0-5 minutes and 15-30 minutes. The Anova one-way test showed that there were differences in locomotors activity measured from 0-5 minutes and 15-30 minutes by giving flavonoids that could affect zebrafish locomotors activity or an increase in zebrafish locomotors activity. The antinociceptive effect of flavonoids was similar to tramadol. The flavonoids from Leea Indica had an antinociceptive effect on orofacial pain in adult zebrafish. The flavonoid dose of 2.5 mg/ml was a dose that had a significant difference in all treatment groups.
Completion Total Thyroidectomy in Occult Thyroid Cancer Patients after Partial Thyroidectomy Syahrudi, Syahrudi; Wijayahadi, R Yoga
Folia Medica Indonesiana Vol. 57, No. 1
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Abstract

Thyroid cancer is one of the commonest cancer while the incidence of occult thyroid cancer is only 0,05%. Completion total thyroidectomy as one of the treatment choice for thyroid cancer which initially diagnosed preoperatively as benign thyroid mass, remains controversial. The aim of this study is to understand the effectiveness of completion total thyroidectomy after partial thyroidectomy, by analyzing from: proportion of malignant contralateral thyroid tissue, post operative complications, and recurrence of cancer. This retrospective study collected medical record datan between 2011 and 2016. Total sample were 16 patients (15 females, 1 male). There was no significant difference on contralateral thyroid tissue malignancy proportion between completion total thyroidectomy and without total thyroidectomy (p=0,375). It was found 3 surgical complications (50%) from 6 patients with completion total thyroidectomy and 3 complications (30%) from 10 patients without completion total thyroidectomy. The complications were temporary injury of recurrent laryngeal nerve (p=0,511), seroma (p=0,375), and hypoparathyroidism (p=0,375). No recurrence event after 4 years follow up amount both groups. In conclusion, there is no advantage in completion total thyroidectomy analized from proportion of malignant contralateral thyroid tissue, post operative complication and recurrence in 4 years-follow up.
Case report: post esophagectomy esophageal reconstruction in esophageal injury due to caustic materials Danardono, Edwin
Folia Medica Indonesiana Vol. 53, No. 4
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Abstract

The esophageal caustic injury is rare, but it requires precise and complex management. A variety of reconstruction techniques have been done, but despite the increasing volume, the incidence of complications is still relatively high. We reported the experience in our center in handling esophageal reconstruction in patients with caustic esophageal injury that caused oesophageal stricture between 2014-2017. This study used case series method with literature review. The results showed that between 2014-2017, there were 3 patients with caustic esophageal injury. All patients undergoing esophageal reconstruction surgery were included under conditions of malnutrition. Two were caused by HCl and the rest by NaOH. All patients underwent a resection of stricture segment of the esophagus, either using partial or total esophagectomy. Anastomosis leakage occurred in all cases, but improved with conservative treatment. The average length of hospitalization was 27 days. The intraoperative blood loss in patients ranged from 450-700 cc. In conclusion, proper preliminary management can provide approppiate preparation of the patients for definitive or reconstructive surgery, especially to avoid malnutrition. The ideal reconstruction still could not be established, and the rate of postoperative complications was still high. The length of patient hospitalization was also relatively long.
Effects of Arak Bali Administration on Spermatozoa DNA Fragmentation and Testosterone Level of Rats (Rattus norvegicus) Hayati, Alfiah; Winarni, Dwi; Antari, Ni Wayan Sukma; Resita, Inne Ninda; Fauziah, Erlyn Nurul
Folia Medica Indonesiana Vol. 54, No. 1
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This study aimed to determine the effects of arak bali on the fragmentation of spermatozoa and testosterone in rats (Rattus norvegicus). This study used 24 rats (170-200 g), divided into four groups: one control and three treatments (receiving arak bali containing 40% alcohol as much as 0.1 and 0.5 mL and synthetic alcohol (40%) as much as 0.1 mL, for 45 days). The observation of DNA fragmentation was done using acridine orange staining and the measurement of testosterone level used ELISA method. The results showed that the provision of arak bali in experimental animals increased the occurrence of spermatozoa DNA fragmentation. The higher the volume of arak bali given, the higher the fragmentation of spermatozoa DNA. The administration of arak bali also decreased testosterone level. The higher the volume of arak bali given, the lower the rats' testosterone level.
Plasma lactate versus c-reactive protein as prognositic indicator in urosepsis Prilistiyo, Dwimantoro Iman; Santoso, A; Anniwati, L; Pudjirahardjo, W J
Folia Medica Indonesiana Vol. 53, No. 2
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Urosepsis occurs in 20-30 % of septic case. Early diagnosis were undoubtfully important to improve the results of sepsis management. Bacteriological confirmation may be difficult to obtain and negative cultures do not exclude the presence of infection. Increased understanding of inflammatory cascade mechanisms provided several indicator of infection and prognosis. Lactate measurement in patients with infection and possibly severe sepsis to help identify patients at high risk of death in order to apply aggressively therapy. Elevation in serum C-reactive protein (CRP) is also associated with an increasing risk of death in patients with infection. This study was to determine the plasma lactate and CRP levels of patients with urosepsis as a prognostic indicator. This is an analytic observational study to compare the correlation and significance of plasma lactate and CRP with prognosis of urosepsis. Each subject was measured for plasma lactate and serum CRP at time of admission. All subjects were managed according to standard protocol. At the 14th day of treatment, patients were evaluated with a clinical severity score. The outcome was classified as follows: 1=good condition/improved, 2=morbid/worsened and 3=death. The statistical analysis used Spearman's rho test, ρ<0.05 was considerated to indicate significance. We enrolled 25 subjects with urosepsis. 14 patients who were septic, nine patients had severe sepsis and 2 patients had septic shock. Mean plasma lactate level in patients based on outcome (improved/worsened/death) was 2.08 mmol/L; 4.16 mmol/L and 5.27 mmol/L. The mean value of CRP was 13.41 mg/L; 22.28 mg/L and 24.62 mg/L. These were statistically significant (p 0.008 vs 0.016) in determining the outcome of the urosepsis patient. The coefficient correlation is better with plasma lactate than CRP (0.517 vs 0.475). In conclusion, the measurement of plasma lactate and CRP level can be used as a prognostic marker for the outcome of patient with urosepsis. Plasma lactate showed higher correlation with outcome of urosepsis than CRP.

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