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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Difference of Heat Shock Protein 70 Serum Level Between Primary Angle Closure Glaucoma and Open Angle Glaucoma Patients: Indonesia Single Center Experience Zuhri, Mohamad Nurdin; Nurwasis, Nurwasis; Retnowati, Endang; Purnomo, Windhu
Folia Medica Indonesiana Vol. 57, No. 3
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Abstract

This study aimed to analyze the differences in Hsp 70 serum levels in patients with primary angle-closure compared to patients with open-angle glaucoma at Dr. Soetomo General Academic Hospital, Surabaya, East Java. This cross-sectional study was conducted on 41 subjects divided into 2 groups consisting of 21 patients with primary angle-closure glaucoma and 20 patients with open-angle glaucoma. Anterior segment examination was assessed by slit-lamp biomicroscope examination. Intraocular pressure on both eyes was measured by Perkin's tonometry. Posterior segment examination was performed with 78 D lens and anterior chamber angle was assessed by goniolens. The serum level of Hsp 70 was assessed using a human Hsp 70 sandwich ELISA kit. The data were statistically analyzed with the Mann-Whitney test. The mean serum levels of Hsp 70 in the primary angle-closure group was 5.55  4.75 ng/ml, while the open-angle group was 3.62  2.39 ng/ml (p = 0.134). There was no difference in Hsp 70 serum levels between the two groups, although the trend obtained serum levels of Hsp 70 patients with primary angle-closure was higher compared to patients with open-angle.
Two-port laparoscopic appendectomy is more benefecial than open appendectomy in early acute appendicitis Budipramana, Vicky S
Folia Medica Indonesiana Vol. 52, No. 2
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Open appendectomy has already commonly been performed to treat acute appendicitis, but the relatively more painful and longer incision scar becomes a cosmetical problem. Two port laparoscopic appendectomy can be performed safely, less painful and leaving only two small incision scars. The aim of the study was to evaluate the benefit of two-port laparoscopic appendectomy and that of with open appendectomy in the case of early acute appendicitis. An observational study was conducted from 2012 to 2014; to compare the operating time, post operative pain and wound infection in early acute appendicitis, performed with two-port laparoscopic appendectomy and with open appendectomy. The statistical analysis in this study uses t-test. There were 114 patients (73 men and 41 women) divided into two groups based on the choice made by the patients themselves. The number of samples performed with two-port laparoscopic appendectomy was 64 and that with open appendectomy was 46. Four patients were excluded from this study. In analysis using t-test, we found that the two-port laparoscopic appendectomy was more beneficial than open appendectomy. There was a significant difference between the two groups, the length of operation time was 37.22 minute in two-port laparoscopic appendectomy and 43.83 minute in open appendectomy (p=0.00), VAS pain score was 1.58 in two-port laparoscopic appendectomy and 2.30 in open appendectomy (p=0.00) and no post operative wound infection in both two groups. The conclusion is two-port laparoscopic appendectomy technique is faster and less painful and the same risk of wound infection than open appendectomy in early acute appendicitis.
Correlation between ldl, hdl, and triglyceride conditions with body fat percentage of universitas padjadjaran professors Saputra, Yosi Wailan; Miftahurachman, Miftahurachman; Lubis, Leonardo
Folia Medica Indonesiana Vol. 53, No. 3
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Elderly is a problem that may disrupt the balance of various molecules in the body, especially fat molecules, which may result in the emergence of various diseases so that blood fat and adipose level examinations need to be done regularly and periodically as an effort of early detection. This study aimed to find correlation between Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), and triglyceride with body fat percentage among professors in Universitas Padjadjaran (Unpad) who were mostly in elderly age. This study was a linear regression analytical study conducted on 52 Unpad professors (♂ 75%, ♀ 25%) based on data of LDL, HDL, and triglyceride levels obtained through laboratory examination, as well as body fat percentage data by using Bio Impedance Analysis (BIA). The correlation between low density lipoprotein (LDL), High Density Lipoprotein (HDL), and triglyceride with body fat percentage in male professors group was R2=0.072; P>0.05 and in female was R2=0.028; P>0.05. As a conclusion, there was no correlation between Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), and triglyceride with body fat percentage in Unpad professors.
The effect of long term administration of glucocorticoid to bone lining cells apoptosis Sari, Gadis Meinar
Folia Medica Indonesiana Vol. 52, No. 4
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Glucocorticoid is widely used in medical treatment as an immune system or an inflammation therapy. However its long term administration can cause life-threatening side effects. One of them is bone mass loss which increases the risk of bone fractures in the long-term use. Bone lining cells derived from mesenchymal stem cells, which serve as a backup cell bone-forming osteoblasts. Glucocorticoids acting directly on osteoblasts, bone lining cells when reduced due to increased apoptosis, the reserve cells to bone formation will be decreased. The aim of this study was to count the amount of apoptotic bone lining cells after long term glucocorticoid administration. This study used Rattus norvegicus females aged 3 months that were divided into 3 groups, each group consisted of 7 rats. The groups are: (1) control group; (2) treatment group 1 were given glucocorticoid 0.01 mg/day; (3) treatment group 2 were given glucocorticoid 0.2mg/day. The treatment carried out for 4 weeks and at the end of treatment, rats were sacrified and continued with preparation, and the number of bone lining cells that undergoing apoptosis was calculated through examination of the femur bone tissue metaphysis section using immunohistochemical technique. All data were analyzed with statistical analysis Anova. The result showed that the number of apoptotic bone lining cells increased in group with glucocorticoid administration 0.01 mg/day and 0.2 mg/day compared to control group with p = 0.000 (p <0.05). The number of apoptotic bone lining cells on the group of glucocorticoid dose 0.2 mg/day higher than the group of glucocorticoid dose 0.01 mg/day with p = 0.000 (p <0.05). In conclusion, long term glucocorticoid administration increase apoptosis of bone lining cells.
Semilunar Sign of Trans-Mediastinal Herniation of Giant Bullae with Tension Hydropneumothrax Tjan, Anastasia; Ayusta, I Made Dwija Putra; Mahiswara, Dewa Gde
Folia Medica Indonesiana Vol. 56, No. 4
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Herniation of bulla across mediastinum is rare, while transmediastinal giant bulla herniation accompanied with hydropneumothorax is even rarer. We report a case of an 18 years old male with dyspnea came to emergency department with trans-mediastinal giant bulla herniation, which appears as semilunar sign on chest x-ray, and righthydropneumothoraks. It appeared that the giant bulla also infected by the presence of air fluid level within. Semilunar sign was seen on the contralateral left mediastinum as the hallmark finding for trans-mediastinal herniation of bulla. Chest CT further confirms the diagnosis. Subsequently chest tube insertion and symptomatic relives were given, however the patient end up dead after 2 days of observation. Heart and lung compression by the lesions were the cause of this patient poor outcome. Bullous lung disease should be evaluated thoroughly and not underestimated since it could cause severe disease progression.
The Effect of Subconjunctival Bevacizumab on Angiogenesis in Rabbit Model Nurwasis, Nurwasis; Yuliawati, Diana; Komaratih, Evelyn; Heriyawati, Heriyawati
Folia Medica Indonesiana Vol. 55, No. 4
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Bone is an important organ for supports the body that stores reserve of calcium, phosphorus, and other minerals. In fracture conditions where bleeding, soft tissue edema, nerve damage, and blood vessels around the bone damage happen, they can cause the mobilization of these minerals in the surrounding tissue. One of the efforts made in the treatment of these fractures is reconnection, in which it works by filling of bone defect with a matrix and administration of anti-infection. Biomaterial filling in defective bone is thought to accelerate the healing process of bone fracture and prevent osteomyelitis. For this reason, this study evaluates the acceleration of bone fracture healing using natural hydroxyapatite (NHA) bone filler in rabbits with bone defect model. Fracture modeling was performed by surgical technique and drilling of bones with a 4.2 mm diameter to form a defect in the rabbit femur. Bone implant contained bovine hydroxyapatite-gelatin-glutaraldehyde (BHA implant) or bovine hydroxyapatite-gelatin-glutaraldehyde-gentamicin (BHA-GEN implant) that was inserted in bone defects. 27 rabbits were divided into 3 groups: the control group who had bone defect, the bone defect group was given BHA implant and the bone defect group was given BHA-GEN implant. Observation of osteoclast, osteoblast, osteocyte, BALP level, and bone morphological integrity was carried out on the 14th, 28th, and 42nd days after surgery. Histological observation of rabbit femur showed a significant difference on the number of osteoclast, osteoblast and osteocyte in all three groups. The BALP level also showed a significant difference in the group given the natural BHA bone implant compared to the control group on day 14 (p = 0.0361). Based on the result of the X-ray, there was also a better integration of rabbit femur bone in groups with the use of BHA or BHA-GEN bone implant. Thus, it can be concluded that the use of a natural BHA implant can accelerate the process of bone repair in the fracture of rabbit femur. In addition, BHA implants were compatible as a matrix for supporting the bone cell growth.
Nigella sativa extract improves seminiferous tubule epithelial thickness in lead acetate-exposed balb/c mice Diana, Alis Nur; I'tishom, Reny; Sudjarwo, Sri Agus
Folia Medica Indonesiana Vol. 53, No. 3
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Lead that enters the body may lead to increased production of ROS (Reactive Oxygen Species) that may affect reproductive system. Black cumin (Nigella sativa) extract contains high antioxidant, tymoquinone, that may be used to suppress oxidative stress induced by lead in animal experiments. This study aimed to prove that black cumin (Nigella sativa) extract improves the thickness of seminiferous tubular epithelium in Balb/c mice exposed to lead (Pb) acetate. This study used post-test only control group design. The subjects in this study were 30 Balb/c male mice (Mus musculus), divided into 5 groups. K-group: control group without lead acetate and black cumin extract, K+ group: group with 50 mg/kgBW of lead acetate for 28 days, P1 group: treatment group with 50 mg/kgBW of lead acetate for 28 days + 0.3 mg/gBW of black cumin extract for 21 days, P2 group: treatment group with 50 mg/kgBW of lead acetate for 28 days + 0.6 mg/gBW of black cumin extract for 21 days, and P3 group: treatment group with 50 mg/gBW of lead acetate for 28 days + 1.2 mg/gBW black cumin extract for 21 days. The results showed that the mean ± standard deviation of the highest thickness of seminiferous tubular epithelium was 45.80 ± 2.73 in the group that was exposed to acetate + 0.6 mg/gBW of black cumin (P2), and the lowest was 32.75 ± 4.07 in the group that was exposed to lead acetate (K+). The results were then analyzed by Anova test. The results showed that there was significant differences in the thickness of seminiferous tubular epithelium between P1, P2, P3 and K+. In conclusion, black cumin extract administration was proved to improve the thickness of seminiferous tubular epithelium in lead (Pb) acetate-exposed Balb/c mice (Mus musculus).
Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation Isyroqiyyah, Nur Moya; Soegiarto, Gatot; Setiawati, Yuani
Folia Medica Indonesiana Vol. 55, No. 1
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Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient's demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.
Antibiogram study and antibiotic use evaluation using gyssen method in patients with diabetic foot Fadlilah, Umul; Hasmono, Didik; Wibisono, Yudi Agung; Melinda, Mia
Folia Medica Indonesiana Vol. 52, No. 3
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Foot infection is a common and serious problem in people with diabetes, which require proper management (diagnostic and therapeutic approaches) that can be cured. Empiric antibiotic regimen should be based on clinical data and bacteria pattern that are available, but definitive therapy should be based on the results of the infected tissue culture. The selection of initial antibiotic therapy was difficult and unwise use can lead to antibiotic-resistant. Evaluation is needed for using antibiotics to benefit wisely. The aim of this research is to analyzed the pattern of bacteria in diabetic foot and to its sensitivity test to antibiotics, analyze empiric antibiotics that can be recommended, and analyzed the use of antibiotics by Gyssen method. Data was analyzed with observational studies (descriptive non-experimental), retrospectively and prospectively in patients diabetic foot infection that met inclusion criteria. Retrospective data are used to analyzed bacteria pattern and its sensitivity test, while prospective data are used to evaluated the use of antibiotics based on bacteria pattern, during the period of late March-early August 2015 at Mardi Waluyo Hospital. Evaluation was conducted by Gyssen method. The results, retrospective data samples obtained 30 infection bacteria during August 2014-March 2015. The prevalence of gram-negative bacteria as 53.33% with most types of bacteria E.coli and Klebsiella oxytoca (13.33%), and gram-positive bacteria as 46.67% with the highest bacteria are Staphylococcus spp. and Streptococcus spp. From the prospective data in inclusion criteria, 13 patients with the highest prevalence of gram-negative bacteria are Klebsiella oxytoca (28.57%), and most gram-positive Staphylococcus auerus (35.71%). While the qualitative analysis of antibiotic use was conducted on 50 types of antibiotics. The results of the qualitative analysis using Gyssens method obtained category as 62%, 2%, 14%, 2B category as 26%, 3A category as 10%, 4A category 52%, 4B category as 6%, 4C category as 8% and there are no use of antibiotics in the category V and VI. Conclusions, Gyessen method can show that the use of antibiotics in diabetic foot patients in Mardi Waluyo hospital is dominated by inaccuracy in choice of antibiotic, and inaccuracies in the interval antibiotics.
Comparison of Length of Stay and Deep Vein Thrombosis (DVT) Incidents in Dr. Soetomo Hospital Hanindito, Elizeus; Airlangga, Prananda Surya; Sulistiawan, Soni Sunarso; Semedi, Bambang Pujo; Andriyanto, Lucky; Utariani, Arie; Rehatta, Nancy Margarita
Folia Medica Indonesiana Vol. 54, No. 4
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Vein thrombosis may occur both in deep and superficial vein of all extremities. Ninety percent of vein thrombosis may progress into pulmonary embolism which is lethal. Deep vein thrombosis (DVT) is frequently found in critically ill patients in ICU, especially patients who are treated for a long time. This study aims to analyse the comparison between length of stay and DVT incidents in critically ill patients. A cross-sectional study was employed. We include all patients who were 18 years or older and were treated in ICU of Dr Soetomo public hospital for at least 7 days. The patients were examined with Sonosite USG to look for any thrombosis in iliac, femoral, popliteal, and tibial veins and Well's criteria were also taken. This study showed that length of stay is not the only risk factor for DVT in patients treated in ICU. In our data, we found out that the length of treatment did not significantly cause DVT. Other risk factors such as age and comorbidities in patients who are risk factors may support the incidence of DVT events. The diagnosis of DVT is enforced using an ultrasound performed by an expert in the use of ultrasound to locate thrombus in a vein. Length of treatment is not a significant risk factor for DVT. Several other factors still need to be investigated in order for DVT events to be detected early and prevented.

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