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apt. Ihsanti Dwi Rahayu, S.Farm., M.S.Farm.
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Journal of Pharmaceutical and Natural Resources
Published by Universitas Lampung
ISSN : -     EISSN : 31233384     DOI : https://doi.org/10.23960/jpnar
Core Subject : Health,
Medicine & Pharmacology
Journal of Pharmaceutical and Natural Resources (JPNAR) adalah jurnal ilmiah peer-review yang diterbitkan oleh Departemen Farmasi, Fakultas Kedokteran Universitas Lampung, yang memfokuskan publikasi pada penelitian di bidang farmasi, kesehatan, dan sumber daya alam. Ruang lingkup jurnal mencakup teknologi farmasi, kimia farmasi, farmakologi, toksikologi, biologi farmasi, bioteknologi, obat herbal, serta kajian farmasi klinis, komunitas, farmakoepidemiologi, dan farmakoekonomi. Jurnal ini terbit dua kali setahun, setiap Juni dan Desember, berbahasa Inggris, dan dikelola dengan sistem OJS berbasis akses terbuka untuk menjamin transparansi, kualitas, dan kemudahan akses bagi peneliti.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 10 Documents
 1 
Optimization of Tween 80 and Span 80 Combination in the Formulation of Niacinamide-Containing Body Lotion Vica Aspadiah; Nur Illiyyin Akib; Astrid Indalifiany; Rahmat Muliadi; Reza Rosita Layuk
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 1 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i1.pp1-7

Abstract

Body lotion is a liquid emulsion preparation consisting of an oil phase and a water phase stabilized by emulsifiers, functioning to maintain skin moisture and provide protection. One of the most widely used active ingredients in current cosmetic formulations is niacinamide, known for its effectiveness in brightening the skin, enhancing the skin barrier function, and reducing hyperpigmentation. The success of a body lotion formulation depends largely on the appropriate selection and concentration of emulsifiers to achieve emulsion stability and optimal physical characteristics. This study aimed to optimize the combination of Tween 80 and Span 80 emulsifiers in a body lotion formulation containing niacinamide using a 2² factorial design method with the assistance of Design-Expert software. The formulation was evaluated based on several physical parameters, including pH, adhesiveness, spreadability, viscosity, homogeneity, emulsion type, and physical stability, as well as a hedonic test assessing color, odor, and texture. Optimization results indicated that the best formulation was obtained from a combination of 1% Tween 80 and 10% Span 80. The resulting product had a pH of 6.4, adhesiveness of 112 seconds, spreadability of 6.1 cm, viscosity of 16,568.3 cps, good homogeneity, and demonstrated a stable oil-in-water (O/W) emulsion type without phase separation. Therefore, the optimum combination of Tween 80 and Span 80 in concentrations of 1% and 10%, respectively, yields a physically stable niacinamide-containing body lotion.
The Association of Herbal Medicine Consumption Habits with Quality of Life Among Farmers with Chronic Diseases suharmantoarman suharmanto
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 1 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i1.pp8-13

Abstract

Chronic diseases can occur due to unhealthy lifestyle changes that disrupt daily activities and decrease quality of life. This study aims to analyse the association of herbal medicine consumption habits with quality of life among farmers with chronic diseases. This study is an observational analytic study with cross-sectional approach. The study was conducted in Marga Agung Village, Jati Agung District, South Lampung in May-October 2024. The variables used were herbal medicine consumption habits and quality of life. Sampling technique using simple random sampling of 42 farmers. The sample inclusion criteria in this study include aged 25-65 years, able to read and write, and willing to be respondents. The exclusion criteria in this study include households that have a history of disease complications. The independent variables in this study is herbal medicine consumption habits and dependent variable is quality of life. Herbal medicine consumption habits was measured using a questionnaire and quality of life was measured using the WHOQOL-BREF questionnaire, which has 4 domains consisting of physical health, psychological health, social relationships, and family environment. The collected data was then edited, coded, processed, and cleaned. Data analysis using the Chi-Square test. There is a association between the herbal medicine consumption habit and quality of life in the psychological and environmental domains, but it is not related to the physical and social dimensions.
Optimization of a Niacinamide Moisturizing Cream Formula Using a Combination of Virgin Coconut Oil and Tea Tree Oil as the Oil Phase Rahmat Muliadi; Vica Aspadiah; Suryani; Wa Ode Sitti Zubaydah; Fery Indradewi Armadany; Purnama Alia Rizki
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 1 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i1.pp14-19

Abstract

The skin is one of the most important organs of the body to function as a protective barrier against the prevention of water and electrolyte loss. This causes dry skin to look dull, scaly, rough surface, and evenly dry white areas. then facial skin care is needed, one of which is to use moisturizers containing ingredients that work with mechanisms (occlusive), (humectant), and (emollient). The dosage form of moisturizer that is often used is cream. The combination of VCO and tea tree oil as active ingredients in this moisturizing cream formula is expected to have a synergistic effect in increasing the effectiveness of the cream in overcoming dry skin. VCO and tea tree oil are safe to use in skin moisturizing formulations. the purpose of this study is to determine the Optimization of the Niacinamide Moisturizing Cream Formula Combination of VCO and Tea tree oil as an Oil Phase and use a Software Design Expert to determine the physical characteristics and stability of the preparation. Optimization of moisturizing cream formula using factorial design method 22 with VCO factor and Tea tree oil and using viscosity response, dispersion, and adhesion. The stability test compares tests from organoleptic, pH, dispersion, adhesion, and homogeneity before and after phase separation tests and cycling tests. Based on the test results of this study, an optimum formula using VCO and Tea tree oil was obtained showing good dosage characteristics in the form of good organoleptic tests, viscosity before cycling test 12328.735 and after cycling test 12328.731, average pH 6.1 before cycling test and 6.5 after cycling test, average dispersion 6.6 before cycling test and cycling test 6.6, Adhesion 86.33 seconds before cycling test and after cycling test 85.67 seconds after cycling test and homogeneity test showed homogeneous preparations both before and after cycling test. All test values of the characteristics of moisturizing creams that have been stored meet the stability test requirements based on their test parameters.
Systematic Review: Mechanism of Ginger (Zingiber offinale) as Anti-inflammatory Dwi Monika Ningrum; Denih Agus Setia Permana; Atri Sri Ulandari
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 1 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i1.pp20-23

Abstract

The appearance of inflammation is a hallmark of a large number of human diseases, ranging from infection to neurodegeneration. In the treatment of inflammation, a group of drugs that are widely given are non-steroidal anti-inflammatory drugs (NSAIDs). Long-term use of NSAIDs can result in various side effects, namely gastrointestinal disorders, damage to the kidneys, and cardiovascular disorders. Given the side effects that can be caused by the use of NSAIDs, other alternatives are needed to overcome and reduce inflammation. One of the plants that can be used to treat inflammation is ginger. This journal review was conducted by reviewing electronic journals related to the use of ginger as an anti-inflammatory mechanism with the study report method. The inclusion criteria used include ginger as an anti-inflammatory, journals from 2008-2012, journals are scientific journals, in vitro and in vivo, free full text, while the exclusion criteria are the benefits of ginger not as an anti-inflammatory. Ginger as an anti-inflammatory has several mechanisms including inhibiting macrophage activation, increasing endogenous antioxidant activity, inhibiting the production of PGE2, tumor necrosis factor α (TNFα), and cyclooxygenase. Inhibition of cyclooxygenase is selective only for COX-2 activity. COX-1 inhibition is associated with gastrointestinal irritation, selective inhibition of COX-2 will help minimize side effects.
Knowledge, Attitudes, and Beliefs About COVID-19 Vaccine Acceptance During Early Rollout in Urban and Rural Communities of Lampung Province Dwi Aulia Ramdini; Suharmanto; Rano Kurnia Sinuraya; Asep Sukohar; Shela Sandra Kirana; Annisa Tamara Panjaitan
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 1 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i1.pp24-33

Abstract

The study was conducted at the beginning of the COVID-19 vaccine rollout in Indonesia and aimed to assess the correlation between knowledge, attitudes and beliefs towards the acceptance of the COVID-19 vaccine in the community of Umbul Niti Village, Jati Agung Sub-district, South Lampung. Umbul Niti Village can be used as an illustration of the village community's acceptance of the COVID-19 vaccine, because it is located not far from Bandar Lampung City. This study is an analytical observational study with a cross sectional approach. The instrument used was the Knowledge, Attitude and Practice Questionnaire. A total of 350 respondents, more than half of them (62.85%) had good knowledge of the COVID-19 vaccine, along with 94% of respondents showing a positive attitude towards vaccine acceptance. Based on the acceptance survey or vaccine acceptance by the community in several provinces, 64.8% stated that they accepted, 27.6% “did not know” and 7.6% “refused”. The success of the vaccination program is largely determined by the level of public acceptance in an effort to achieve herd immunity. Based on statistical analysis, it is known that attitudes and beliefs have a significant relationship with the acceptance of the COVID-19 vaccine (p<0.05). The majority of respondents also viewed the COVID-19 vaccine as safe. Overall, the respondents' level of acceptance of the COVID-19 vaccine was good, with attitudes and beliefs playing an important role in influencing vaccine acceptance. These findings can form the basis of risk communication strategies for future vaccination programs.
Indonesian Medicinal Plants for Anticancer Syazili Mustofa
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 2 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i2.pp1-10

Abstract

The potential of Indonesia's natural wealth of plants to be developed as anticancer agents is enormous, thanks to its abundant biodiversity. Indonesia has become a "natural laboratory" with various plants traditionally used for treatment, including cancer, by local communities. This potential is supported by several primary factors: extensive biodiversity, bioactive compound content, and empirical use in traditional medicine. Several studies have identified several Indonesian plants that show potential as anticancer agents: Tapak Dara (Vinca rosea), Taxol (Taxus sp), Lempuyang Wangi (Zingiber zerumbet), Temu Kunci (Boesenbergia pandurata), Melinjo/Tangkil (Gnetum gnemon), Soursop leaves (Annona muricata), Cloves (Syzygium aromaticum), and Typhonium flagelliforme (Typhonium flagelliforme). Despite its great potential, developing anticancer drugs from Indonesian plants faces several challenges: scientific proof, standardization, high research and development costs, and regulatory and patent aspects. To address these challenges, a comprehensive development strategy is needed, including: Enhancing collaboration between research institutions, universities, the pharmaceutical industry, and the government; Conducting ethnobotanical studies to document traditional knowledge of medicinal plants; Developing standardized herbal formulas (phytopharmaceutics) that have supporting scientific data; Strengthening basic research to identify and test specific bioactive compounds; and Encouraging innovation in the extraction and purification of active compounds.
Systematic Review: The Antihelminthic Effect of Turmeric Rhizome Extract on Ascaris Parasitic Worm ratri mauluti larasati ratri mauluti larasati
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 2 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i2.pp11-16

Abstract

Worm infections remain a significant health issue globally, including in Indonesia. The primary treatment for worms is the use of deworming medication, but this can have side effects. Turmeric produces various secondary metabolites that can be developed as drugs against pathogenic infections. Therefore, a literature review is needed to examine the anthelmintic activity of turmeric against Ascaris worms. This review employed a literature review method, searching for primary data sources in the form of national and international journals from the past 10 years. The results indicate that turmeric rhizomes contain various active antihelminthic compounds that can treat Ascaris worm infections through various mechanisms, including inhibition of microtubulin proteins, muscle paralysis that inhibits motility, and disruption of worm digestion, leading to death. The active compounds in turmeric rhizomes have been shown to have a high affinity for beta-tubulin proteins, which play a key role in Ascaris worm motility.
Potentially Inappropriate Prescribing (PIP) based on Beers Criteria in Geriatric Patients at the Inpatient Unit of a Hospital in Bandar Lampung Citra Yuliyanda Pardilawati; Jessy Dewi Awali; Tri Umiana Soleha; Rasmi Zakiah Oktarlina; Yulianasari Pulungan
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 2 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i2.pp17-24

Abstract

Geriatric patients often experience polypharmacy due to multimorbidity. This is a factor that increase the risk of Potentially Inappropriate Prescribing (PIP), which can cause serious health problems. Beers Criteria are one of the guidelines used to identify PIP in geriatric patients. This study aims to evaluate PIP in geratric patients using Beers criteria. This study used a cross-sectional approach. The sampling technique was purposive sampling. The study subjects were the medical records of geriatric patients at the inpatient installation of one of the hospitals in Bandar Lampung, totaling 76 subjects. Geriatric patients at the inpatient unit of one of the hospitals in Bandar Lampung were predominantly male with 48 (63.2%) patients, aged group 60 – 69 years with 45 (59.2%) patients, and receiving ≥5 types of medications with 74 (97.4%) patients. The incidence of PIP was found in 26 (34.2%) patients with a total of 33 PIP events consisting of PIP category 1, 2 and 4, are 16 (48.48%), 9 (27.27%) and 8 (24.24%) events respectively.
Evaluation Of Medication Errors In The Prescribing Phase Outpatients With Acute Respiratory Tract Infections At The X Health Center In East Lampung In 2025 Anna Aufa Nurrohmah; Nurma Suri; Ervina Damayanti; Yulianasari Pulungan
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 2 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i2.pp25-28

Abstract

Medication errors are considered as avoidable or preventable events which can lead to inappropriate medication use, potentially detrimental to the patient's condition, and it can occur in patients with ARI. The aim of this study is to determine the incidence of medication errors during the prescribing phase in patients ARI and the relationship between medication errors and age and number of courses of therapy. It was an observational analytical study with a cross-sectional design. Moreover, sampling was conducted by using accidental random sampling from April 2025 at the X Community Public Health Center. In addition, data were analyzed by using the Chi-square test and it was presented in tabular form. The characteristics of ARI patients are 39% male and 59.4% female, with a predominant age group of 34.3%. 83.3% of patients receive ≤ 4 courses of therapy. The incidence of medication errors is 82.3% which occurs in both administrative and pharmaceutical aspects. There is a relationship between the number of courses of therapy and medication errors (p-value <0.05) which shows that the number of therapy received by the patient is a factor in the incidence of medication errors. There is no relationship between age of the patients and medication errors (p-value >0.05). There is a relationship between the number of therapies and the incidence of medication errors. However, there is no relationship between age and the incidence of medication errors.
A Cross-sectional study: The Relationship of Family Support Toward Level Adherence Therapy and Hospitalization in Outpatient Treatment of Schizophrenia Dwi Aulia Ramdini; Melisa Intan Barliana; Nanda Restiana; Citra Yuliyanda Pardilawati; Ramadhan Triyandi; Nurma Suri; Yulianasari Pulungan
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 2 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i2.pp29-39

Abstract

Adherence is one of the essential components in the management of schizophrenia. However, adherence levels remain suboptimal, ranging from 20-89%. Multiple factors, including sociodemographic characteristics and family support have been reported to influence medication adherence and hospitalization rates. This study aimed to investigate relationship between family support, medication adherence, and hospitalization among patients with schizophrenia at the Mental Health Hospital Lampung Province. A cross-sectional study design was employed, and data were collected through patient interviews. Medication adherence was assessed using the Medication Adherence Rating Scale (MARS), while family support was measured using validated and reliability-tested family support questionnaire. A total of 106 patients met the inclusion criteria, of whom 65% demonstrated high levels of medication adherence. The factor including sex (p=0,047), employement status ( p=0,004), and family support (p<0.000) were significantly associated with medication adherence. In addition, age (p=0.019), family support (p<0.001), and medication adherence (p<0,000) were significantly associated with hospitalization. These findings indicate that family support has a positive influence on medication adherence and serves as a protective factor againts at worsening prognosis, as reflected by reduced hospitalization. This study emphasizes the crucial role of family support in achiving successful treatment outcomes in patients with schizophrenia.

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