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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 974 Documents
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PREOPERATIVE CARDIAC REHABILITATION IN A 28 YEARS-OLD WOMAN WITH VALVULAR HEART DISEASE Sri Hastuti Barata; Erna Setiawati; Endang Ambarwati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.29289

Abstract

Background: Valvular heart disease (VHD) is one third of all heart disease. In industrialized countries, the prevalence is estimated at 2,5% and in developing countries is between twenty to thirty cases per-1000 people. VHD presents a huge health burden worldwide. If heart failure has occured, surgery is the treatment of choice. Cardiorespiratory fitness declined in post-surgical patients. Preoperative cardiac rehabilitation is considered to be able to increase the cardiorespiratory fitness baseline so that postoperative outcomes are better.Case Presentation: We reported 28 years-old female with severe MS and MR as well as mild TR with symptoms dyspnea on effort which improves with rest. She was the candidate for mitral valve replacement. She was given a 14-days preoperative cardiac rehabilitation program including breathing exercise by pursed lips breathing, effective cough exercise, range of motion exercise, ankle pumping exercise, endurance exercise based on the result of the 6 minutes walking test (6MWT) and inspiratory muscle training (IMT) using threshold IMT. Conclusion: Preoperative cardiac rehabilitation program improved pulmonary functional capacity, cardiorespiratory fitness and functional activity.Keyword: valvular heart disease, cardiac rehabilitation, pulmonary functional capacity, cardiorespiratory fitness.
Selectivity of Ethanol Extract of Parijoto (Medinilla speciosa) Fruit in HepG2, Widr, 4T1, and Vero cell lines widyandani sasikirana; eva Annisaa'; nuraini ekawati; Intan Rahmania Eka Dini; Estevina Tumbilaka
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.32010

Abstract

Background: Parijoto, one of the melastomaceae family, has been known to have cytotoxic activity in some cancer cell lines, such as HeLa, MCF-7, and T47D. Aims: We aim to know about the selectivity of ethanol extract of Parijoto fruit in cell line HepG2, WiDr, 4T1, and Vero. Cytotoxic was determined by MTT assay. Method: Extract was added in three serial concentration three serial concentrations (125 µg/mL–500 µg/mL), while the positive  control doxorubicin gives in 2,5 µg/mL – 20 µg/mL for cancer cell and 40 µg/mL -100 µg/mL for Vero cell.  Results: Results showed that ethanol extract of parijoto fruit gave low activity in HepG2 and Vero cell (IC50: 250 µg/mL) and moderate activity in WiDr and 4T1 (IC50: 81,58 µg/mL and 158,72 µg/mL). Conclusion: The highest selectivity index is given in WiDr cell (SI> 3) means that the ethanol extract of parijoto fruit is a promising cytotoxic agent for colorectal cancer therapy.
SCREENING OF HEARING DISORDER IN CHILDREN AGED 13-14 YEARS IN TEGAL Ilma Mufidatul Aufa; Yanuar Iman Santosa; Dwi Marliyawati; Zulfikar Naftali
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30021

Abstract

ABSTRACT Background: Hearing loss is an impairment or inability of hearing, which is a threshold value of hearing more than 40 decibels (dB) in adults or more than 30 decibels (dB) in children. Hearing loss can result in decreased learning achievement at school, problems in communication, psychological problems, and if complications have occurred, it will cost more for the treatment.Aim : This study aims to determine characteristics of hearing loss in children aged 13-14 years.Methods : This study is a descriptive study with a total sample of 61 students taken by simple random sampling method from a total of 599 students aged 13-14 years.  The data were obtained from the questionnaires and physical examination of the ear. Simple auditory function was examined using a tuning fork.Results : The results in this study indicate that the largest group is 14 years old and male gender (52%).  It was found that 13 students (21%) had a tympanic membrane and 1 student (2%) had a tympanic membrane perforated in the right ear. In the hearing function, it was found that 1 student with a conductive type disorder.  From the questionnaire on the risk factors for hearing loss, there were the use of cotton buds for 53 students (87%), routine checkups for 1 student (2%), use of headsets for 48 students (79%), allergic rhinitis 9 students (15%), chronic tonsillitis 17 students (28%) and ISPA 1 student (2%).Conclusion : The percentage of hearing loss is 2%, the type of hearing loss is CHL (Conductive Hearing Loss).  Percentage of risk factors for hearing loss using cotton buds (87%), headset use (79%), allergic rhinitis (15%), chronic tonsillitis (28%), ARI (1%), routine check-ups (1%). Keywords : Hearing loss, hearing function examination, risk factors for hearing loss
DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMEN Wafi Banadzir Resya; Novi Kusumaningrum; Santoso Jaeri; Astika Widy Utomo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30029

Abstract

Background: Acne vulgaris is a chronic inflammatory disease in the pilosebaceous gland of the skin which can cause depression and anxiety. IL-23 is a cytokine that is involved in autoimmune diseases, including acne vulgaris. IL-23 affects the differentiation process of Th17 which further produces IL-17, an important component in the pathogenesis of acne vulgaris. IL-17 plays a significant role in the grade of skin damage caused by the inflammation process.Objective: To find out differences in IL-23 serum levels and the grade of AV severity in women.Methods: An observational study with a cross-sectional design approach conducted from June until October 2020 in 15 women with AV aged 15-25 years old, not consuming anti-inflammatory drugs, antibiotics, retinoid group of drugs and free from other inflammatory diseases. Subjects were divided into three groups based on the AV severity grade: specifically mild (n=5), moderate (n=5) and severe (n=5). Subjects had venous blood taken for IL-23 serum content by the ELISA method. Data on IL-23 serum content in the three groups were tested using the One-Way ANOVA method to determine the differenceResults: Average age from the 3 groups was 21 (17-23 ) years old. The results showed that there is no significant difference in IL-23 rate from the 3 groups of AV severities (p=0,490).Conclusion: : There is no significant difference of IP-23 rate between the 3 groups of AV severites in women. 
EFFECT OF LEMON AROMATHERAPY ON THE ANXIETY LEVEL OF DENTAL EXTRACTION PATIENTS IN RSND SEMARANG Hayuratri Purwalalita Laksmidevi; Devi Farida Utami; Arinta Puspita Wati; Maria Belladonna Rahmawati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30522

Abstract

Background: Dental treatment that is often done is the tooth extraction procedure. The treatment and the use of sharp instruments such as syringes, pliers, bein during extraction can cause anxiety. Anxiety will be responded by several changes in the body such as the increasing of MAP, pulse rate, and respiratory rate. Handling anxiety can be done with aromatherapy, one is lemon aromatherapy.Aim: To determine the effect of lemon aromatherapy on anxiety levels and the correlation of anxiety levels with the results of MAP, pulse rate, and respiratory rate in tooth extraction patients at RSND SemarangMethod: Experimental study with pretest and posttest control group design with sampling simple random to get 40 respondents that indicated as extraction teeth patient. Respondents were divided into 2 groups: 20 control respondents and 20 intervention respondents. Anxiety level was measured by the Modified Dental Anxiety Scale (MDAS) questionnaire. Data that was not distributed normally were the difference in pulse rate and the difference in respiratory rate, while the results of the homogeneity test obtained data that were not homogeneous were the difference between the MDAS questionnaire and the difference in the MAP. The rest of the mentioned data above were all distributed normally and homogeneous. Analysis of differences in anxiety levels between before and after lemon aromatherapy was given using paired t-test, analysis of differences in anxiety levels between the control group and the intervention group using the independent t-test, and to analyzing the correlation of anxiety levels with the results of MAP, pulse rate, and respiratory rate using the Spearman test..Results: There was a significant difference in anxiety scale between before and after lemon aromatherapy was given p = 0,000135 (p <0.05) and between the control group and the intervention group p = 0.000002 (p <0.05). There was a positive correlation between anxiety levels with the results of MAP, pulse rate, and respiratory rate.Conclusion: Anxiety of tooth extraction patients shows a decreased after inhaling lemon aromatherapy. When someone is anxiety, there will be an increase in MAP, pulse rate, and respiratory rate.Keywords: Anxiety, tooth extraction, lemon aromatherapy, MAP, pulse rate, respiratory rate.
DIFFERENCES IN TEAR SECRETION BEFORE AND AFTER PHACOEMULSIFICATION SURGERY USING SCHIRMER I TESTS Raditya Pradana Daryosta; Arnila Novitasari Saubig; Maharani Cahyono; Trilaksana Nugroho
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30110

Abstract

Background: Cataract is a serious problem in the world because it is the biggest cause of blindness in the world. Cataract healing can only be done with operative measures, one of them is phacoemulsification. The phacoemulsification technique is the latest operative technique for cataract healing but both conventional techniques or phacoemulsification techniques can cause a decrease in tear secretion after cataract surgery. The reduction in tear secretion can be evaluated using the Schirmer I test. In this study an analysis of differences in tear secretion before and after phacoemulsification surgery.Aims: Knowing, comparing, and analyzing the differences in tear secretion before and after phacoemulsification surgery using the Schirmer I test.Methods: 22 cataract eyes consisting of 15 patients who will undergo phacoemulsification surgery were collected by consecutive sampling at the Sultan Agung Eye Center, Sultan Agung Hospital, Semarang from August to September 2019, examined using the Schirmer I test. After the data was collected, data analyzed with Wilcoxon rank test.Results: A total of 15 cataract patients consisting of 10 female patients and 5 male patients with a total of 22 eye samples. The average tear secretion before and after phacoemulsification surgery was 12.77 ± 2.74 mm and 11.00 ± 1.95 mm. Data were tested with the Wilcoxon rank test, p = 0,000 (p <0.05) which showed a difference in average tear secretion before and after phacoemulsification.Conclusion: There are differences in tear secretion before and after phacoemulsification surgery.
Association Between Birth Weight and Quality of Life in Early and Middle Adolescence Eva Latifatun Ni&#039;mah; Dimas Tri Anantyo; Adhie Nur Radityo Suswihardhyono; Teddy Wahyu Nugroho
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30073

Abstract

Background: Children with low birth weight tend to have a higher risk of experiencing abnormal growth and developmental delays. While the risk of developing obesity in the later years is higher in children with high birth weight. Physical and psychological conditions can affect the quality of life of adolescents.Objective: To analyze the association between birth weight and quality of life in early and middle adolescents.Methods: This cross-sectional study involved 120 students aged 13-16 years in Semarang City in which a consecutive sampling method was used.  The study was conducted in August 2020. Research subjects need to fill up the PedsQL, PAQ, birth history, and socio-economic questionnaires. Statistical analyses used were Chi-square and logistic regression tests.Results: Birth weight was significantly associated with quality of life (p=0.002). A history of abnormal birth weight increases the risk of experiencing poor quality of life as a teenager (p=0.002; OR=3.987). Low birth weight was associated with decreased physical function (p=0.001), whereas high birth weight was associated with reduced social and school functioning (p=0.013; 0.032). Gender was significantly associated with quality of life (p=0.016). Girls tend to have a higher risk of experiencing poor quality of life (p=0.021; OR=4.021).Conclusion: Birth weight has a significant association with quality of life in early and middle adolescents. Adolescents with a history of LBW or HBW were more likely to experience decreased quality of life than adolescents with a history of NBW.Keywords: Adolescence, Birth weight, Quality of Life.
MACROSCOPICS AND MICROSCOPICS FEATURE OF WITAR RATS LIVER AFTER IMMERSION IN GRADUAL CONCENTRATION OF RANDU HONEY Putri Ariani Kusuma; Tuntas Dhanardhono; Saebani Saebani; Ratna Damma Purnawati; Hermawan Istiadi
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30045

Abstract

Background Formaldeyde is main substance used for organ embalming and even for foods preservations. However, long and high exposure of formaldeyhde lead to various organs irritations. Honey is well-known for its natural preservative activity expected to be the soultion for the problem so there is safe alternative for organ preservations.Aim Observation and examintaion the difference of macroscopic and microscopics feature of Wistar rats liver after immersion of formaldehyde and randu honey.Methods Experimental with post-test only control group design using 24 male Wistar rats as sample, randomly divided into 4 groups consist of: Group C (preserved with 10% formaldehyde solutions), P1 (preserved with 10% randu honey solutions), P2 (preserved with 20% randu honey solutions) and P3 (preserved with 30% randu honey solutions). The sampels were preserved for 24 hours then macroscopic (smell,color and size) and microscopic study with Hematoxylin-Eosin (HE) stain  using 400x observation performed. Manja Roenigk score were used to accessed the degree of live microsopic damage.Results There are normal cells, mild damage, moderate damage and severe damage respectively in the group C: 36%,47%,17%,0% ; P1: 0%,27%,46%,27% ; P2: 0%,77%,17%,6% ; P3: 47%,33%,17%,3%. Kruskal-Wallis test showed significant results with p=0.000. With Mann-Whitney test, significant results were found between group C with P1 (0.000), C with P2 (0.006), P1 with P2 (0.000), P1 with P3 (0.000) and P2 with P3 (0.003). However, test result were not significant berween group C with P3 (0.684).Conclusions There were differences in macroscopics and microscopic features between Wistar rats liver after immersion in formaldehyde and randu honey. The best features showed in samples preserved in 30% Randu Honey solutions.
TIME IN THERAPEUTIC RANGE (TTR) IN ATRIAL FIBRILLATION WITH WARFARIN THERAPY IN SEMARANG, INDONESIA Della Dafina Sekarsari; Pipin Ardhianto; Erwin Kresnoadi; Mochamad Ali Sobirin
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30046

Abstract

Background: Atrial fibrillation is one of the factors forming thromboembolism. The thromboembolism can be prevented with warfarin. A side effect of warfarin is increasing the occurrence of bleeding, these therapy requires an evaluation of its usage. These evaluations can be seen in the Time in Therapeutic Range (TTR) patients. TTR is the duration in which the International Normalized Ratio (INR) patients in referral value are 2.0-3.0. TTR > 70% can prevent bleeding on FA patients with warfarin therapy.Aim: To determine TTR in patients receiving warfarin with atrial fibrillation.Methods: This study was descriptive with a cross-sectional design for six months at Dr. Kariadi Hospital Semarang. TTR was calculated using Rosendaal's Methods after collecting three INRs and patients' demographics.Results: Total subject was 111 patients with an average age of 52,63 and the TTR average is 53,75. TTR in this study was divided into two groups, that groups were poor TTR (TTR < 70%) with 82 patients (73.88%) and good TTR (≥70%) with 29 patients (26.12%).Conclusions: The average TTR in FA patients with warfarin therapy was 53,75%. 
DIFFERENCES IN PLAQUE INDEX AND NUMBER OF BACTERIAL COLONIES OF ORAL CAVITY BEFORE AND AFTER BEING EDUCATED WITH MODEL STUDY AND VIDEO Alfi Dian Uly Noor; Rebriarina Hapsari; Ira Anggar Kusuma
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30116

Abstract

Background: Based on the results of Riskesdas in 2018, the 10-14 years old group had a prevalence of daily brushing behavior of 96.5%. However, only 2,1% brush their teeth correctly. The ability of brushing teeth can be improved by providing an oral health education.Aim: Was determined the differences of plaque index scores and the number of bacterial colonies growing in oral cavity before and after being educated using study model and video.Methods: This study was a true-experimental research with pre-test and post-test study design with a subject of 20 students. The students devided into 2 groups, 10 students with study model and 10 students with video. The results of plaque index scores and the number of bacterial colonies were taken before and after the students being educated. This study use the Paired T Test and Wilxocon statistical tests.Results: There were significant differences of plaque index scores and the number of bacterial colonies growing in oral cavity before and after being educated using study model and video. (p < 0,05).Conclusion: An oral health education using study model and video were able to decrease plaque index scores and the number of bacterial colonies growing in oral cavity. The video method was more effective than the study model.

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