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Indonesian Journal of Global Health Research
Published by Global Health Science Group
ISSN : 27149749     EISSN : 27151972     DOI : https://doi.org/10.37287/ijghr
Core Subject :
Indonesian Journal of Global Health Research is a open access, peer reviewed and refereed international journal. Indonesian Journal of Global Health Research aim to publish original research paper devoted to various area of all health sciences. Indonesian Journal of Global Health Research provides a forum for sharing timely and up-to-date publication of scientific research, health care and promoting the development of nursing, public health, community, environmental and occupational health. The journal publishes original research papers of health sciences. High priority will be given to articles on public, nursing, adolescent, community, environmental and occupational health, pharmaceutical technology, social pharmacy, traditional medicine, pharmacology, and so on.
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Articles 1,005 Documents
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Herbal Cooling Roll-On (Aloe Vera–Lavender) for the Management of Vasomotor Symptoms in Menopausal Women Mutiara Solechah; Rissa Nuryuniarti; Sri Susilawati; Nunung Yulia
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1899

Abstract

Hot flashes are the most common vasomotor symptom experienced by women during the climacteric phase, often accompanied by sleep disturbances and anxiety. Hormone therapy is effective, but not all women can use it due to contraindications and the risk of long-term side effects. Therefore, non-hormonal interventions based on topical products are a potential alternative. Researcher are developing a cooling roll-on based on aloe vera, lavender hydrosol, and menthol in concentrations safe for skin application. The purpose of this study was to develop and evaluate the effectiveness of a cooling roll-on based on aloe vera, lavender hydrosol, and menthol as a non-hormonal intervention in reducing the intensity and frequency of hot flashes in menopausal women. This study used an experimental laboratory design followed by a pilot clinical trial. The initial phase involved the formulation of two cooling roll-on preparations based on aloe vera and lavender hydrosol, one with and one without added menthol. Evaluation of the preparation quality was carried out through pH testing using a calibrated pH meter and microbial contamination testing using the Total Plate Count (TPC) method. Furthermore, initial safety testing was conducted through patch tests on 10 respondents to assess potential skin irritation. Data were analyzed descriptively to assess the safety, stability, and feasibility of the product before proceeding to the clinical trial phase. The findings in this study are based on laboratory tests on coolant roll-on preparations, both with and without menthol, obtained data based on pH parameters. Preparations with menthol have an average pH of 5.91 and preparations without menthol have an average pH of 5.98. while microbial contamination (Total Plate Count/TPC) in both preparations has a TPC value <1.0 x 101 CFU/ml. Implications for Product Feasibility Based on these two parameters, it can be concluded that Initial safety is met (both formulations have met the basic criteria for topical safety, both in terms of pH and microbial contamination) and the formulation is stable (there are no significant changes due to the addition of menthol to).
Nephroprotective Effects of Celery Extract (Apium graveolens L.) on Unilateral Ureteral Obstruction Models Shafira Audy Prameswari; Yoana Rizki Deviriandra; Ariadne Hapsari Putri Taufik; Rizky Aliyah Putri; Athaya Helia Untari; Afifah Afifah
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1907

Abstract

Renal fibrosis represents the final pathological endpoint of chronic kidney injury, characterized by excessive extracellular matrix deposition and irreversible structural damage, ultimately leading to end-stage kidney disease (ESKD) necessitating renal replacement therapy. Given the largely irreversible nature of established fibrosis, current therapeutic approaches primarily aim to suppress fibrogenesis and delay further renal deterioration. Celery (Apium graveolens L.) contains bioactive compounds with potential nephroprotective properties. Unilateral ureteral obstruction (UUO) is a well-established experimental model of renal fibrogenesis, in which persistent obstruction leads to tubular injury and activation of profibrotic signaling pathways. This study aimed to evaluate the nephroprotective effect of celery ethanol extract on renal injury in UUO rat model. A post-test-only control group design was conducted using 25 rats randomly assigned into five groups: sham control, negative control (UUO), and three treatment groups receiving celery extract (125, 250, and 500 mg/kg body weight) for 14 days. Serum creatinine levels were measured from blood samples, while renal tubular injury scores were assessed through histopathological examination of kidney tissues. One-way ANOVA followed by a least significant difference (LSD) post hoc test revealed significant differences among groups (p < 0.05), with the 250 mg/kg dose showing the most pronounced effect, suggesting potential nephroprotective activity. These findings necessitate further investigations, including toxicity assessment and clinical studies, to establish its therapeutic applicability.
Factors Associated with Inpatient Hospitalization Costs in Stroke Patients Undergoing Mechanical Thrombectomy or Coiling Ardy Oktaviandi; Pinto Desti Ramadhoni; Legiran Legiran
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1940

Abstract

Stroke is a catastrophic disease with a significant economic burden, particularly for neurointervention procedures such as mechanical thrombectomy and coiling. A disparity exists between standard costs and actual billing charges for these procedures at Dr. Mohammad Hoesin Hospital Palembang. This study aimed to analyze the factors influencing hospitalization costs of stroke patients undergoing mechanical thrombectomy or coiling. This was an analytical cross-sectional study with retrospective data collection from medical records of stroke patients who underwent mechanical thrombectomy or coiling at Dr. Mohammad Hoesin Hospital Palembang from January 2024 to September 2025. The study included 32 patients who underwent mechanical thrombectomy and 67 who underwent coiling. Sampling technique used was total sampling. Bivariate and multivariate analyses were performed to identify factors influencing hospitalization costs. The mean actual hospitalization cost for mechanical thrombectomy was IDR 97,679,947 ± 80,403,149, while for coiling it was IDR 119,286,035 ± 77,330,119 (approximately 20% higher). In the mechanical thrombectomy group, multivariate analysis revealed length of stay as the only significant independent factor influencing hospitalization costs (p<0.05). Meanwhile, in the coiling group, four significant independent factors were identified: complications, aggravating factors, NIHSS score, and number of coils (p<0.05). The factors influencing hospitalization costs differ between mechanical thrombectomy and coiling. For mechanical thrombectomy, length of stay is the dominant factor, whereas for coiling, clinical severity (complications, aggravating factors, NIHSS score) and procedural complexity (number of coils) are the main cost determinants.  
Aging Effects on Carpal Tunnel Syndrome: Severity and Functional Decline Andryano Liong; Teuku Arief Dian; Lilik Djuari
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1991

Abstract

Carpal tunnel syndrome is a cumulative trauma disorder affecting the forearm and wrist, characterized by loss of sensation, weakness, and tingling in the thumb and the first two fingers. The prevalence of this condition continues to rise each year, with an incidence rate of 276 cases per 100,000 individuals. This study aims to analyze the relationship between age and the severity and functional status of carpal tunnel syndrome in the elderly at the Santo Yosef Nursing Home in Surabaya. The study employed an analytical observational design with a cross-sectional approach. The study population consisted of all 145 elderly residents at the Santo Yosef Senior Care Home in Surabaya, with a sample of 70 respondents selected using purposive sampling. Data were collected through interviews using a questionnaire and analyzed using Spearman’s correlation test with the aid of SPSS version 23. The results showed that age group had a significant relationship with SSS (p=0.017) and FSS (p=0.049). However, the Spearman test results showed r values of 0.284 and 0.236, indicating that the strength of the correlation between age and the severity or functional impact of carpal tunnel syndrome is relatively weak. Thus, there is a significant relationship between age and the severity and functional status of carpal tunnel syndrome, although the strength of this relationship is relatively low.
An Integrative Analysis of Therapeutic Communication, Nurse Competence, and Nursing Service Quality on Patient Satisfaction in Primary Health Care Centers: A Literature Review Hasniati Hasniati; Iwan Ardian; Muh. Abdurrouf; Wahyu Endang Setyowati
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.2024

Abstract

Patient satisfaction is a key indicator of service quality in primary health care centers. However, it remains influenced by suboptimal therapeutic communication, nurse competence, and the quality of nursing care. Empirical evidence regarding the relationships among these factors is still fragmented and lacks integration. This literature review aims to analyze the influence of therapeutic communication, nurse competence, and the quality of nursing care on patient satisfaction in primary health care settings. A systematic search was conducted in PubMed, ScienceDirect, Google Scholar, and DOAJ for studies published between 2020 and 2025, following the PRISMA 2020 guidelines. The search strategy was guided by the PICO framework using the keywords “Nurse Competence,” “Patient Satisfaction,” “Primary Health Care Centers,” “Service Quality,” and “Therapeutic Communication.” Inclusion criteria comprised original research articles with cross-sectional designs involving healthcare patients and examining therapeutic communication, nurse competence, service quality, and patient satisfaction. A total of 1,972 articles were initially identified, of which 524 duplicates were removed. After the screening process, 15 articles met the inclusion criteria. Study quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal tool. All included studies demonstrated a statistically significant association between therapeutic communication, nurse competence, and the quality of nursing care with patient satisfaction (p < 0.05). Service quality emerged as the dominant factor, mediating the relationship among variables. Patient satisfaction is influenced by the integration of therapeutic communication, nurse competence, and service quality. Strengthening these three aspects is essential to improve the quality of care in primary health care centers.
Cytochrome P450 Monooxygenase and Pyrethroid Resistance in Anopheles: A Narrative Review I Gusti Ayu Avinya Chintya Devi; Dewa Ayu Agus Sri Laksemi; Putu Ayu Asri Damayanti
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.2054

Abstract

Malaria remains a major global public health problem, with approximately 282 million cases reported in 2024. Although vector control interventions such as long-lasting insecticide-treated nets (LLINs) and indoor residual spraying (IRS) have significantly reduced malaria transmission, their effectiveness is increasingly compromised by pyrethroid resistance in Anopheles mosquitoes. This review examines the role of cytochrome P450 monooxygenase enzymes in mediating pyrethroid resistance. A literature search was conducted in PubMed, Springer, and Google Scholar for articles published between 2016 and 2026 using the keywords “Cytochrome P450,” “P450 monooxygenase,” “Insecticide Resistance,” “metabolic resistance,” “Pyrethroid,” “Anopheles,” and “malaria vector.” Of 10,854 articles identified, 142 were screened, and six relevant studies were included, focusing on resistance mechanisms, P450 characteristics, gene regulation, and vector control implications. The findings indicate that overexpression of specific P450 genes significantly enhances the detoxification of pyrethroids, thereby reducing insecticide susceptibility. Furthermore, interactions between metabolic resistance and target-site mutations contribute to elevated resistance levels. Recent evidence suggests that non-coding RNAs (ncRNAs) regulate detoxification pathways and contribute to adaptive resistance. In conclusion, insecticide resistance in Anopheles is a multifactorial process involving genetic, biochemical, and regulatory mechanisms. Understanding these mechanisms is crucial for developing more effective and sustainable vector control strategies.
Postoperative Neurological Monitoring and Care Stratification in Adult Patients After Craniotomy: A Systematic Literature Review Imanuella Imanuella; Fayza Asyahlaa Rihastara; Fiza Paluphi Andita Nugroho; Nurur Rachman Machmudy; Muhammad Muttaqien; Ika Yuni Widyawati
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.2096

Abstract

The postoperative period following craniotomy is a critical phase because patients are at risk for early neurological deterioration, the need for escalation of care, delirium, delayed awakening, and other complications that can impact safety and clinical outcomes. An appropriate approach to neurological monitoring, including the selection of the care unit and stratification of observation intensity, is a crucial issue in modern neurosurgical practice. Synthesizes current scientific evidence regarding postoperative neurological monitoring and care stratification in adult patients after craniotomy, specifically regarding the safety of non-intensive care unit (non-ICU) care, the use of prediction scores, and postoperative clinical outcomes. This review used a systematic literature review design following the PRISMA 2020 principles and has been registered with PROSPERO (CRD420261350040). Searches were conducted in PubMed, Scopus, Web of Science, SAGE, and Springer Nature for articles published between 2020 and 2026. Methodological quality was assessed using the Joanna Briggs Institute Critical Appraisal Tools according to study design. Due to the heterogeneity of designs, interventions, and outcomes, the synthesis was conducted narratively and thematically. Of the initial 534 articles, 18 studies met the inclusion criteria. Four studies were of high quality and fourteen studies were of moderate quality. Three main themes were identified: (1) non-ICU monitoring pathways in selected patients can be safe when supported by structured neurological observation; (2) prediction scores and risk stratification help adjust monitoring intensity; and (3) structured postoperative pathways, including same-day discharge in selected patients, have the potential to reduce length of stay, costs, and ICU use without showing significant safety signals. Available evidence suggests that structured, risk-based postoperative neurological monitoring supported by strong nursing competencies has the potential to improve resource efficiency without compromising patient safety. However, the evidence remains largely based on observational studies.  
Determinants of Diabetes Mellitus Complication Prevention in Rural Communities Hurmia Hurmia; Fahmi Ichwanyah; Radhiah Zakaria; Meutia Zahara; Maidar Maidar
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.2120

Abstract

Diabetes mellitus is a major global public health problem that contributes significantly to morbidity, mortality, and decreased quality of life due to its long-term complications. Rural communities are particularly vulnerable to diabetes mellitus complications because of limited access to healthcare services, inadequate health education, low socioeconomic status, and insufficient preventive health behaviors. The purpose of this study is to analyze the determinants of diabetes mellitus complication prevention in rural communities. This quantitative study with a cross-sectional design in May 2025. The study population consisted of 348 respondents with a sample of 186 respondents selected using random probability sampling. Data were collected through questionnaires. The results showed that all questionnaire items were valid, with r-count values ranging from 0.412 to 0.845, exceeding the r-table value. Reliability testing was conducted using Cronbach’s Alpha, and all variables demonstrated good internal consistency, including diabetes complication prevention (0.892), knowledge (0.846), motivation (0.874), and health examination (0.831). Analyzed using logistic regression. The results showed a significant relationship between education (0.000), type of employment (0.000), income level (0.00), knowledge (0.000), attitude (0.000), self-motivation (0.000), family support (0.000), and access to health services (0.000) with efforts to prevent DM complications. In contrast, age (0.067), gender (0.291), and anxiety level (0.080) were not significantly related. The most dominant variable was self-motivation with an OR of 144.7. The conculsion is education, occupation, income, knowledge, attitude, family support, healthcare access, and especially self-motivation significantly influenced diabetes complication prevention efforts in rural communities.
Denture Services for Older Adults Within the Framework of Universal Health Coverage: A Scoping Review Using the who Universal Coverage Cube Rika Meutia; Dharina Baharuddin; Meutia Zahara; Surna Lastri; Basri Aramico
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.2150

Abstract

Older adults are particularly vulnerable to oral health problems, especially tooth loss, which affects chewing function, nutritional status, and quality of life. Dentures are an important rehabilitative intervention to address these issues. Although many countries, including Indonesia, have implemented Universal Health Coverage (UHC), coverage of denture services for older adults remains variable and limited. Objective isTo map denture services for older adults within the Universal Health Coverage framework using the WHO Universal Health Coverage Cube. Methods is This scoping review followed the Joanna Briggs Institute methodology and was reported in accordance with the PRISMA-ScR guidelines. Literature searches were conducted across multiple scientific databases and relevant grey literature sources. Eligible studies were analyzed descriptively and mapped according to the three dimensions of UHC: population coverage, service coverage, and financial protection. The results: A total of 20 studies were included in the review. The findings revealed considerable variation in denture services for older adults across countries. In terms of population coverage, older adults were not consistently prioritized as beneficiaries. Regarding service coverage, coverage was generally limited to basic removable dentures, with restrictions on materials and replacement frequency. In the financial protection dimension, older adults remained exposed to out-of-pocket payments despite formal inclusion of denture services in health policies. These findings indicate an imbalance across the three UHC dimensions. Conclusion is Although the UHC framework has been widely implemented, coverage of denture services for older adults remains suboptimal. Strengthening equity, service comprehensiveness, and financial protection is necessary to ensure more responsive health systems for ageing populations. The WHO Universal Health Coverage Cube provides a useful framework for identifying policy gaps.
Atypical Cutaneous Larva Migrans with Rapid Improvement after Initial Albendazole Therapy: A Case Report Jilly Selena Pradipta; Marrietta Sugiarti Sadeli
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.2416

Abstract

Cutaneous larva migrans (CLM) is a zoonotic helminthiasis caused by the penetration of animal hookworm larvae into the human epidermis and characterized by pruritic serpiginous lesions. This disease is commonly found in tropical and subtropical regions due to exposure to soil or sand contaminated with dog or cat feces. Lesions typically appear on the lower extremities due to direct contact with the soil, but can occur in other locations, posing diagnostic challenges. This study aims to describe the clinical presentation of CLM with unusual lesion locations and highlight the rapid clinical response following initial albendazole therapy. This study used a descriptive observational design with a single case report approach. The study subject was a single patient diagnosed with Cutaneous Larva Migrans with atypical clinical manifestations based on history, physical examination, and the clinical judgment of the treating physician. The patient was selected purposively because of her atypical clinical presentation and interesting therapeutic response to report. The analysis was conducted descriptively, presenting the chronology of the disease course, diagnostic process, response to therapy, and clinical outcomes of the patient. The patient received 400 mg of albendazole once daily for three days and 10 mg of cetirizine once daily. After the first dose of albendazole, the sensation of larval movement and pruritus disappeared. A gradual evaluation revealed a decrease in lesion activity after the second dose, as well as drying of the migration path after the third dose. On the fifth day after therapy, the lesions appeared to be drying out with reduced erythema, indicating a rapid clinical response to anthelmintic therapy. CLM can occur in non-predilection sites such as the trunk and upper extremities, potentially presenting diagnostic challenges. A rapid clinical response to albendazole not only effectively halts larval migration but also has important diagnostic value in atypical presentations.

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