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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
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Articles 12 Documents
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Search results for , issue "Vol 57, No 2 (2025)" : 12 Documents clear
Correlation of Nutritional Status, HbA1c, and Duration of Diabetes Mellitus with Amputation Incidence in Patients with Diabetic Foot Ulcers Hapsari, Putie; Kharisma, Surti Wulan; Yarman, Indra Prasetya; Faried, Ahmad; Djajakusumah, Teguh Marfen; Maryani, Euis
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4094

Abstract

Diabetic foot ulcer (DFU) is a severe complication of diabetes that significantly impairs quality of life and  may often lead to amputation, particularly when infections become extensive. This study investigated the correlation of nutritional status, HbA1c levels, and duration of diabetes exposure with the incidence of amputation in DFU patients. Using an observational analytic study with a retrospective cohort design, data from 47 DFU patients treated at the Vascular and Endovascular Surgery clinic and Emergency Room  of a hospital from 2019-2024 were analyzed. The majority of subjects were men aged 40-60 years (59.57%). Among the amputee group, 55.31% experienced neuropathy, primarily classified as Wagner's degree 4. Patients requiring amputation had significantly higher levels of urea, creatinine, and leukocytes compared to those who did not. A significant correlation was observed between the incidence of amputation and nutritional status—specifically, serum albumin (r=-0.616) and Body Mass Index (BMI) (r=0.823)—as well as HbA1c levels (r=0.806) and duration of diabetes exposure (r=0.445) (p<0.05). However, the Subjective Global Assessment (SGA) did not show a significant relationship with amputation incidence. The findings of this study suggest that nutritional status, HbA1c levels, and duration of diabetes exposure are significantly correlated with the likelihood of amputation in patients with diabetic foot ulcers (DFU).
Prognostic Nutritional Index (PNI) at Admission Predicts In-Hospital Mortality of COVID-19-Infected Patients Haryati, Haryati; Isa, Mohamad; Rudiansyah, Mohammad; Juhairina, Juhairina; Nor, Muhamad; Arganita, Fidya Rahmadhany
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3930

Abstract

Corona Virus Disease-2019 (COVID-19) was declared a pandemic in March 2020 and caused considerable deaths in all parts of the world. Mortality is influenced by the immune system status and increased vulnerability to infection, both related to nutritional status. The Prognostic Nutritional Index (PNI), calculated using lymphocyte count and albumin levels, may have the ability to more accurately characterize the nutritional and inflammatory conditions of COVID-19 patients. This retrospective study analyzed 967 COVID-19 patients at Ulin Hospital Banjarmasin, Indonesia, by examining demographic data, laboratory results, and PNI in relation to survival outcomes. The study revealed that factors such as age, sex, comorbidities (including hypertension, diabetes mellitus/DM, obesity, etc.), number of comorbidities, and disease severity correlated with mortality. Leucocyte count, lymphocyte count, albumin levels, and PNI all showed significant correlations with survival (p<0.001), suggesting that these factors may serve as useful prognostic indicators for COVID-19 patient’s survival. The PNI was associated with an increased risk of mortality, with a univariate odds ratio (OR) of 0.923. Receiver operating characteristic (ROC) analysis demonstrated that a PNI cut-off value of p<41.9 had a sensitivity of 44.9% and a specificity of 82.4%, with an area under the curve (AUC) of 0.666 (p<0.001). Hence, PNI at admission, which reflects patients' immune system and nutritional status upon hospital admission, can be used as a simple, cost-effective, and reliable predictor of mortality in COVID-19 patients.
Factors Associated with Soil-Transmitted Helminths Infections in Children Aged 24-59 Months in Bandung District, Indonesia Hafidz, Athar Zaidan; Adrizain, Riyadi; Setiabudi, Djatnika
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4135

Abstract

Soil-transmitted helminth (STH) infections remain a major public health concern in developing countries, particularly among lower- to middle-income populations with poor sanitation, limited access to healthcare, and inadequate clean water. Preschool-aged children are especially vulnerable due to their developing immune systems and increased nutritional needs. This study aimed to identify factors associated with STH infections among children aged 24–59 months in Bandung District, Indonesia. A case-control design was employed using secondary data from helminthiasis surveillance conducted between October 2019 and January 2023, involving a total of 261 children. The Kato-Katz technique was used to examine stool samples for the detection of STH species. Among them, 30 (11.49%) were infected with soil-transmitted helminths (STH), comprising ascariasis (11.11%), trichuriasis (0.38%), and hookworm infection (0.38%). Bivariate chi-square analysis revealed significant associations with fathers’ education level (p = 0.0003), BPJS-Healthcare participation (p = 0.015), water source (p = 0.015), distance from the water source to the latrine (p = 0.003), and nail hygiene (p = 0.018). Multivariate logistic regression confirmed that distance between water source and pit latrine (OR = 0.265; 95% CI: 0.76–0.92), nail hygiene (OR = 0.318; 95% CI: 0.13–0.76), and participation in BPJS-healthcare program (OR = 0.364; 95% CI: 0.15–0.91) were key determinants of STH infection. These findings highlight the importance of addressing environmental and behavioral factors through public health interventions, including improving access to clean water, promoting personal hygiene, and enhancing parental, particularly paternal education, as essential strategies for reducing the risk of STH in children.
Maternal Anemia in Patients with Preterm Delivery in Indonesia Mayangsari, Nastiti Hemas; Suhaimi, Donel
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3719

Abstract

Preterm delivery remains one of the leading causes of fetomaternal morbidity and mortality worldwide. Anemia during pregnancy is also a significant concern, and may contribute to adverse pregnancy outcomes including preterm birth, intrauterine growth restriction (IUGR), and postpartum hemorrhage (PPH). This study aimed to assess the prevalence of maternal anemia in women with preterm delivery and to evaluate its association with preterm-related complications. A retrospective cross-sectional study was conducted at the Obstetrics and Gynecology Department of Arifin Achmad Hospital, Pekanbaru, Indonesia. Anemia was defined according to the CDC criteria as hemoglobin levels below 11 g/dL in the first and third trimesters or below 10.5 g/dL in the second trimester. Data were collected from medical records of 654 preterm deliveries, of which 359 met the inclusion criteria. Among these, 204 women (56.82%) had anemia, while 155 women (43.18%) had normal hemoglobin levels. A significant association was found between anemia and preterm delivery (p=0.010). Maternal anemia was associated with preterm premature rupture of membranes (PPROM) (p=0.035, contingency coefficient=0.110, 95% CI). These findings suggest that maternal anemia is significantly correlated with preterm birth and its complications, particularly PPROM. Screening and early management of anemia in pregnancy may help reduce the risk of preterm delivery and improve maternal and neonatal outcomes.
Effect of Spinal Anesthesia on Blood Pressure During Cesarean Section in Private Indonesian Hospital Nanmi, Nassya Putri; Lailly, Husnul; Armyanti, Ita; Novitarini, Poppy; Handoko, Willy
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4104

Abstract

The 2018 Indonesian Basic Health Research Data presented an increase in the number of cesarean sections from the previous years, with an increase of 17.6%. In Anugerah Bunda Khatulistiwa Hospital, a private hospital in Pontianak, Indonesia, cesarean section was performed in 689 and 641 cases in 2021 and 2022, respectively. This trend highlights the importance of understanding the anesthesia methods used during this procedure, including spinal anesthesia. Despite the common use of this type of anesthesia, spinal anesthesia an cause changes in the maternal blood pressure. This study aimed to determine the effect of spinal anesthesia on patients’ blood pressure during cesarean section. This retrospective observational analytical study was conducted at the Anugerah Bunda Khatulistiwa Hospital Pontianak, Indonesia, from May 2023 to January 2024. Medical records were selected from 246 patients using consecutive sampling method. Most patients aged between 27 and 29 years, with 207 were in the productive age group (20-35 years). The mean weight was 72.77 kg (±10.43) and the mean height was 156.70 cm (±5.85). The majority were overweight based on the BMI score (n=111), and the spinal anesthesia dose used was 15 mg bupivacaine. The Friendman test on the systolic and diastolic blood pressures before and after anesthesia to determine the effect of spinal anesthesia on blood pressure. The results showed a p-value of 0.000 (p<0.05) for both systolic and diastolic observations. This indicates that spinal anesthesia influences the blood pressure of patients undergoing cesarean sections under spinal anesthesia.
Correlation Between ERCP Implementation Time and Outcomes of Patients with Acute Cholangitis Due to Choledocholithiasis Ayundra, Muhammad Hilmy; Rudiman, Reno; Hapsari, Putie
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3965

Abstract

Acute cholangitis is a serious condition, and timely ERCP is essential for effective management. This prospective cohort study was conducted at Dr. Hasan Sadikin Hospital in Bandung, Indonesia, from June 2023 to April 2024, to evaluate the feasibility of performing ERCP beyond 48 hours in the presence of various limitations. The study included patients with acute cholangitis caused by common bile duct stones. The ERCP timing was categorized into three groups: less than 48 hours, 48-72 hours, and more than 72 hours. Outcomes measured were hospital stay duration, ICU admission, and 30-day mortality. Of these patients, 52.8% underwent ERCP at 48-72 hours, 27.8% after 72 hours, and 19.4% before 48 hours. The median hospital stay was 7.5 days (IQR 3-15). ICU admissions occurred only in patients receiving ERCP after 72 hours (30.0%), a significantly higher rate compared to the other groups (p=0.014). A strong correlation was found between delayed ERCP and longer hospital stays (r=0.711, p<0.01), as well as ICU admission (r=0.405, p=0.014), though no significant correlation with mortality was observed (r=-0.021, p=0.905).
Potential of Binahong Leaf Extract (Anredera cordifolia) for Anemia Treatment in Anemic Rat Model Dewajanti, Anna Maria; Stephanus, Chealsea A.; Mano, Ivanna G; Purnamawati, Purnamawati; Rumiati, Flora; Sumbayak, Erma Mexcorry; Limanto, Agus
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3873

Abstract

Anemia, characterized by low hemoglobin (Hb) and erythrocyte counts, can be induced by reactive oxygen species (ROS) or known as hemolytic anemia. Binahong (Anredera cordifolia) has been explored for its potential in managing anemia; yet, its efficacy against ROS-induced anemia remains under investigated. This study, conducted from January to May 2023, aimed to evaluate the potential of Binahong leaf extract (BLE) in treating anemia caused by oxidative stress. Anemia was induced by administering NaNO2 to 24 rats (Rattus norvegicus), followed by the administration of BLE at doses of 50,100, and 200 mg/kgBW for seven days. Hemoglobin levels were measured using Sahli method and erythrocytes count were determined using a Hemocytometer at three stages: pre anemia (HA), before-treatment (H0), and after-treatment (H7). Results showed that BLE significantly increased the Hb level by 1.3g/dL (p=0.000), 3.87g/dL (p=0.034), and 4.53g/dL (p=0.016) at 50 mg/kgBW, 100mg/kgBW, and 200 mg/kgBW, respectively, after treatment. Additionally, a dose of 200 mg/kgBW significally increased the erythrocyte count by 3.84 x 106 L/mm3 (p=0.033). These findings suggested that BLE has the potential to improve Hb levels and erythrocyte counts in ROS-induced anemia, indicating a promising natural approach to managing anemia.
Local Tumor Control Affects Survival of Patients with Osteosarcoma and Ewing Sarcoma Suryawan, Nur; Syifannisa, Ilma; Anantha, I Made Brahmystha Valqy
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4082

Abstract

Osteosarcoma and Ewing sarcoma are the most common primary malignant bone tumors in children. This study aimed to analyze the characteristics of osteosarcoma and Ewing sarcoma patients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from 2020 to 2023 and compare the one-year survival rates between patients who underwent complete treatment (surgery for local tumor control and chemotherapy) and those who received chemotherapy alone. This study used a descriptive-analytical observational design with a retrospective approach by reviewing electronic medical records from the Indonesian Pediatric Cancer Registry (IPCAR). A total of 44 osteosarcoma patients and 14 Ewing sarcoma patients who met the inclusion criteria were included. The majority of patients were boys (osteosarcoma=61.36%; Ewing sarcoma=64.29%), with a mean age of 13.5 years for osteosarcoma and 9.1 years for Ewing sarcoma. Osteosarcoma was most commonly found in the femur and tibia (90.92%), whereas Ewing sarcoma was primarily located in the axial region (71.43%). Most patients underwent chemotherapy without local tumor control (osteosarcoma=61.36%; Ewing sarcoma=57.14%). The analysis revealed a significant difference in one-year survival between patients who received local tumor control combined with chemotherapy and those who underwent chemotherapy alone (osteosarcoma p=0.000; Ewing sarcoma p=0.010). In conclusion, local tumor control significantly improves one-year survival in both tumor types.
HbA1c Level in Type 2 Diabetes Mellitus Patients With and Without Obesity in An Indonesian Regional Hospital Tinangon, Fritsal; Luciana, Linny; Sihombing, Martina Rentauli; Edward, Harny
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3990

Abstract

Diabetes Mellitus (DM) is a disease characterized by hyperglycemia due to insulin deficiency or impaired insulin function. The International Diabetes Federation (IDF) estimated that approximately 463 million people aged 20 to 79 years old were affected by DM worldwide in 2019. Indonesia is the third highest with a prevalence of 11.3%. More than 90% of diabetic patients are obese which reduced insulin sensitivity. This study aimed to determine the difference in HbA1c levels between obese and non-obese patients with Type 2 Diabetes Mellitus (T2DM) at Tarakan Regional Hospital, Indonesia. Data from medical records of T2DM patients from January to December 2023 were collected based on inclusion and exclusion criteria using consecutive sampling method, resulting in 128 samples. The results of the study, as determined using the Mann Whitney test, indicated a significant difference in the HbA1c levels between T2DM patients with and without obesity (p=0.031), with non-obese T2DM patients tend to have better HbA1c control compared to their obese counterparts. Thus, it can be inferred that obesity affects the blood glucose control in diabetic patients. However, this result needs to be further researched as there are a few limitations inherent to this study, particularly the partial availability of certain medical record information, such as duration of diagnosis and medication adherence.
Prevalence, Severity, and Self-Medication for Dysmenorrhea among Female Adolescents in Indonesia Zulimartin, Handika; Harzif, Achmad Kemal; Shadrina, Amalia; Harahap, Juliana Sari; Tanjung, Anton; Muharam, R.
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dysmenorrhea, commonly referred to as menstrual pain, is a prevalent condition affecting many reproductive-aged women, particularly female adolescents, with varying degrees of intensity. Dysmenorrhea affects 64.5% of female adolescents in Indonesia, with the highest prevalence rates found in West Java (98.8%) and Jakarta (87.5%). Over the years, various therapy modalities have been developed for treating this condition based on its pathophysiology. However, in Indonesia, a country renowned for its rich natural resources and medicinal herbs, there is a prevailing belief in the efficacy of traditional medicine. Female adolescents in Indonesia are often engaged in self-medication practices, combining traditional medicine with nonsteroidal anti-inflammatory drugs (NSAIDs). This study aimed to analyze the prevalence, severity, and self- medication practices for dysmenorrhea among female adolescents in Indonesia. The study was conducted from January to December 2020 using an online survey that included questions about menstrual pain, family history, and the use of traditional medicine and NSAIDs. This study comprised 362 participants recruited through convenience sampling. Results showed that 92.5% of participants experienced dysmenorrhea with varying degrees of pain. A total of 216 (59.9%) female adolescents experienced frequent dysmenorrhea, while 118 (32.6%) reported experiencing this condition every menstrual cycle. Of all participants, 33.1% used traditional medicine as a treatment option, and 16.9% used NSAIDs. According to the self-reported visual analog scale (VAS), the use of natural remedies, such as traditional medicine, was associated with lower pain levels, suggesting their potential benefits in healthcare services for dysmenorrhea.

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