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e-Journal Pustaka Kesehatan
Published by Universitas Jember
ISSN : 2355178X     EISSN : 27213218     DOI : -
Core Subject : Health, Science,
Health Professions Library & Information Science
e-Journal “Pustaka Kesehatan” merupakan jurnal elektronik ilmiah berISSN (ISSN: 2355-178X) yang menerbitkan artikel hasil penelitian di bidang kesehatan secara umum meliputi: Kedokteran, Kedokteran Gigi, Kesehatan Masyarakat, Farmasi, dan Ilmu Keperawatan. Artikel yang dikirim belum pernah dipublikasikan atau tidak dalam proses penerbitan dalam jurnal ilmiah lain. e-Journal “Pustaka Kesehatan” diterbitkan tiga kali dalam setahun, yaitu bulan Januari, Mei, dan September.
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Articles 621 Documents
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Hubungan antara Kadar Feritin dengan Malondialdehyde pada Pasien Talasemia β Mayor di RSD dr. Soebandi Jember Trinita Diyah Permatasari; Rini Riyanti; Desie Dwi Wisudanti
Pustaka Kesehatan Vol 7 No 1 (2019): Volume 7 No. 1, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i1.17592

Abstract

Repeated blood transfusions, increased iron absorption, and ineffective erythropoiesis in major β thalassemia patients lead to iron overload characterized by elevated ferritin levels. Free iron will catalyze reactive oxygen species (ROS) formation by Fenton reaction that cause oxidative stress. Malondialdehyde (MDA) is the lipid peroxidation end product used to measure the oxidative stress. This study aimed to determine the correlation between ferritin levels and MDA levels in major β thalassemia patients at dr. Soebandi Hospital Jember. An analitic observational study with cross sectional study design which the subjects were 15 patients with major β thalassemia in the Pediatric Department at dr. Soebandi Hospital Jember who met inclusion and exclusion criteria. Ferritin levels measured by Enzyme-Linked Fluorescent Immuno Assay (ELFA) method and MDA levels measured by Thiobarbituric Acid Reactive Substances (TBARS) method using spectrophotometer at 535 nm. Data was analyzed with Shapiro Wilk normality test and Pearson correlation test. The mean of ferritin levels was 3540,46±3925,37 ng/mL and MDA levels was 4,77±2,03 nmol/mL. The result showed that there is strong positive correlation between ferritin levels and MDA levels with p value=0,001 and r=0,786 in major β thalassemia patients at dr. Soebandi Hospital Jember.
Pengaruh Stimulasi Kognitif terhadap Tingkat Pengetahuan tentang Penyakit Tuberkulosis Paru Pasien Rawat Inap di Rumah Sakit Paru Jember (The Effect of Cognitive Stimulation on the Level of Knowledge about the Pulmonary Tuberculosis in-patient at Jember Moh Halim Mukhlasin; Anisah Ardiana; Roymond H Simamora
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Cognitive stimulation is one of the options that influence the level of knowledge. The intention is to provide information in order to improve the knowledge and thus, leads to the changes on behavior. This research examines the effect of cognitive stimulation on the level of knowledge of the pulmonary tuberculosis in-patient. This research employs one group pretest-posttest design through the help of purposive sampling collection technique. The number of sample involved in this research is 18 individuals. The data analysis is performed using the Spearman’s correlation test. The result of the analysis generated the r value of 0.559 which means strongly and positively correlated. The bivariate testing results in the p value of (0.016)<α(0.05), meaning that the effect of the cognitive stimulation on the patient’s level of knowledge exists. It is suggested that the health care services optimizes the counseling sessions conducted to patients and their families by employing the cognitive stimulation aimed at improving the patient’s level of knowledge as well as their compliance in taking their medication to help recover from the pulmonary tuberculosis, respectively.   Keywords: Cognitive Stimulation, Knowledge, Pulmonary Tuberculosis
Sintesis 1-(4-metoksibenzoiloksimetil)-5-fluorourasil sebagai Agen Antikanker . Ifada; Ayik Rosita Puspaningtyas1; Ika Oktavianawati; Yuni Retnaningtyas; Nia Kristiningrum
Pustaka Kesehatan Vol 1 No 1 (2013)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

A new compound from 5-fluorouracil (5-FU) derivatives, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil has been synthesized in a two steps reaction, alkylation (5-FU and formaldehyde to form 1-hydroxymethyl-5-fluorouracil) and esterification (1-hydroxymethyl-5-fluorouracil and 4-methoxybenzoylchloride to form 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil). Reaction product purified by chromatography column, the product has been characteryzed for physical apperance is a yellowish white, crystal and melting range 168-169OC. Based on the FTIR and 1H-NMR spectra, it showed that the purified product does not contain a single compound. This fact is supported by Thin Layer Chromatography (TLC) result showing two spots for the pressure of 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil and 4-methoxybenzoate acid. Keywords: 5-fluorouracil derivates, anticancer, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil, benzoylation.
Pengaruh Pendidikan Perawatan Bayi Baru Lahir dengan Metode Syndicate Group terhadap Pengetahuan Kader Posyandu di Desa Sumberdanti Wilayah Kerja Puskesmas Sukowono Kabupaten Jember (The Effect of Newborn Care Education Using Syndicate Group Method to the Rizqi Fauziyah Rofif; Hanny Rasni; Lantin Sulistyorini
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Newborn (BBL) has a high risk of mortality. It happened because the public’s knowledge and practiceabout simple treatments such as prevention of hypothermia, giving colostrum and exclusivebreastfeeding is still very poor. Cadre is one closest person of newborn‘s mother who can affectmaternal behavior, so she can provides a good information to newborn‘s mothers and families whenher knowledge has been good. The aim of this research is to obtain information from the analysis ofthe effect in newborn care education by Syndicate Group methods on cadres’ knowledge inSumberdanti village. This research used pre-experimental method with one group pretest-post testdesign that used 24 cadres’ of Sumberdanti Village who registered by the village midwife. Beforegetting intervention, there were 50% cadres who belong to category of having enough knowledgeand there were 58.3% cadres who belong to the category of having good knowledge after gettingintervention. Analysis of hypothesis used Wilcoxon Signed Rank test with α = 0.05 which obtained pvalue = 0.001, indicating a significant effect of newborn care education by Syndicate Group methodon cadres’ knowledge. Hopefully, the Sukowono Public Health Center and the midwives can continueimproving the cadres’ knowledge by interactive methods such as Syndicate Group and othermethods, so that their role can be more optimal.Keywords: Posyandu Cadres, Knowledge Of Newborn Care, Syndicate Group Method
Kadar Fosfor (P) dalam Cairan Sulkus Gingiva pada Penderita Periodontitis Kronis (Phosphorus Level of Gingival Crevicular Fluid of Chronic Periodontitis) Deasy Kusuma Ardiani; Agustin Wulan Suci Dharmayanti; Peni Pujiastuti
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background: The prevalence of periodontal disease in Indonesia is 60%. Chronic periodontitis is one of periodontal disease which affects Indonesian. The primary cause of periodontal disease is bacterial plaque. Adhesions and accumulation of bacterial plaque can cause inflammation and destruction of periodontal tissue following by increasing of gingival crevicular fluid flows and releasing of its components, one of the components is phosphorus that excreted from sulcular epithelium. Soluble phosphorus along blood stream is from gingival crevicular fluid which the flow is increased and excreted by sulcular epithelium. Objective: To know phosphorus levels in the gingival sulcus of chronic periodontitis. Methods: The subjects of the study were patients who came to the Dental Hospital University of Jember and occupied as inclusion and exclusion criteria. The subjects who had inclusion criteria were divided into 2 groups based intra-oral examination; gingivitis and chronic periodontitis. Gingival crevicular fluid sampling was taken from tooth with gingivitis or chronic periodontitis using paperpoint. Phosphorus level measurement used UV-Vis Spectrophotometer with a wavelength of 883 nm. The results were analyzed by Mann-Whitney test. Results: There were phosphorus in the gingival crevicular fluid of chronic periodontitis and it higher than gingivitis. Conclusion: There is phosphorus level in the gingival crevicular fluid in patients with chronic periodontitis.   Keywords: Chronic periodontitis, gingival crevicular fluid, phosphorus
Pengembangan Sensor untuk Mendeteksi Kesegaran Buah Durian (Durio zibethinus Murr.) Kupas Berbasis Indikator Alami Ekstrak Kayu Secang (Caesalpinia sappan L.) Nur Alfi Syahrin; Bambang Kuswandi; Lestyo Wulandari
Pustaka Kesehatan Vol 8 No 2 (2020): Volume 8 No. 2, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i2.14338

Abstract

Durian is a famous native fruit from Southeast Asia and usually sold within durian-cut packaging in the supermarket because it is handy and ready to serve. However, its freshness level is unknown. Sensor, made by sappanwood decoct extract, can be used to detect the fruit freshness within the packaging. The aim of this research was to develop a sensor to detect cut durian freshness based on natural indicators from sappanwood extract. Indicator solution of sappanwood decoction consist of sappanwood decoct extract, phosphate buffer pH 7,5 and polyvinyl alcohol (PVA). The color change from sensor was examined by ImageJ software to get mean red. Durian pulp was examined every day to get pH and SSC (Solid Soluable Concentration) value in for 5 days of storage at room temperature. The result of rotten pulp durian was showed by the color-changing of the sensor from red purplish to yellow with mean red 224,215 ± 0,161. Durian pulp freshness in room temperature decreased as the pH decreased from 7,46 to 4,20 and as the SSC decreased from 7,60 to 2,40, followed by the color-changing of the sensor. Furthermore, the level of durian pulp freshness can be detected by freshness sensor based on natural indicators from sappanwood extract at room temperature storage.
Efektivitas Seduhan Daun Yakon (Smallanthus sonchifolius) terhadap Kadar Low Density Lipoprotein (LDL) dan High Density Lipoprotein (HDL) pada Tikus Diabetik yang Diinduksi Streptozotocin (The Efectivity of  Yacon Leaves (Smallanthus sonchifolius) Infusion to Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) Level in Diabetic Rats Induced by Streptozotocin) Vitta Permata Sarie; Roedy Budirahardjo; Budi Yuwono
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by elevated level of blood glucose abnormalities associated with the metabolism of carbohydrates,lipids and proteins. Lipids metabolism disorder can increase LDL and lower HDL level. One of plants in Indonesia, that has potential as antihyperglycemic and hypolipidemic agent is yakon (Smallanthus sonchifolius) containing chlorogenic acid (CGA). This study aimed to determine the effect of yacon leaves infusion to LDL and HDL level in diabetic rats induced by streptozotocin (STZ). This study was an experimental research laboratories with the post test only control group design. Rats checked the blood glucose early then induced by STZ with dose 65 mg / kg BW. At 3 days post injection, they were checked the blood glucose. Then the rats were divided into 2 groups the control and treatment group. The treatment group was given yacon leaves infusion ( 3.6 ml/200 g BB rats ) for 14 days. Then they were checked LDL and HDL level by using electrospectrofotometer. Statistical analysis showed that there were significant differences in LDL level and no significant difference in HDL level. It could be concluded that the yacon leaves infusion could lower LDL level in diabetic rats induced by STZ, while HDL level had not change. Keywords: Diabetic, HDL, LDL, yacon
Pengaruh Komposisi Hidroksi Propil Metil Selulosa K-15 dan Etil Selulosa N-22 terhadap Prosentase Kelembapan Air dan Pelepasan Meloksikam dari Sediaan Plester (The Influence of Hidroxy Propyl Methyl Cellulose K-15 and Ethyl Cellulose N-22 Ratio on Procent Monica Iwud Rully Pramesthie; Lidya Ameliana; Budipratiwi Wisudyaningsih
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The present research has been undertaken with the aim to develop a transdermal patch of meloxicam with ratio of hydroxy propyl methyl cellulose (HPMC) K-15 and ethylcellulose (EC)N-22 as a matrix were 1:9 (Formula 1), 2:8 (Formula 2), 3:7 (Formula 3).The physicochemical parameters like organoleptic and % moisture content were evaluated. Released test using dissolution apparatus were carried out in 500 mL of phosphate buffer saline pH 7.4 ± 0.05 at temperature 37 ± 0.5°C with speed of swirl 50 rpm. Results were analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% (α = 0,05).The results of evaluation of patch dosage, transdermal patches were found yellow, odorless and dry. Result of moisture content F(1) 1.168 ± 0.009 %; F(2) 1.841 ± 0.019 % and F(3) 2.584 ± 0.025 %. Result of in vitro drug release F(1) 364.865 ± 0.701 µg/cm2.menit1/2; F(2) 397.212 ± 0.441 µg/cm2.menit1/2 and F(3) 439.277 ± 0.559 µg/cm2.menit1/2. It can be concluded that the combination ofHPMC K-15 and EC N-22 at ratio 7:3 was the best choice for manufacturing transdermal patch based on physicochemical and the release profile.   Keywords: transdermal patch, meloxicam, hydroxypropylmethyl celulosa, ethylcellulosa
Uji Sitotoksisitas Ekstrak Pektin Limbah Kulit Buah Kopi Robusta (Coffea canephora) pada Kultur Sel Fibroblas Pulpa Gigi Manusia (Cytotoxicity Effect of Pectin Extract from Coffea Robusta (Coffea canephora) Fruit Peels on Human Dental Pulp Fibroblasts Cel Kharishah Muslihah; Agus Sumono; Dwi Warna Aju Fatmawati
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.7154

Abstract

Background: Coffee has a by-product (waste product) that generated from coffee processing. Coffee fruit's peels contains active compound, that is pectin. Pectin has several benefits in health, as a regeneration of hard and soft tissue that can be applied in dentistry and pectin has the potential as an anti-cancer substance. Pectin as a biomaterial must have biocompability. Biocompatibility of the material can be tested by cytotoxicity test by MTT method on human dental pulp fibroblasts cell culture. Objective: To know the toxicity of extract pectin from coffee robusta fruit peels on human dental pulp fibroblasts cell culture. Method: This research is a experimental laboratory with post-test only control group design. Culture of fibroblast cells at the well was exposed by pectin extract for 24 hours, then each well was given MTT and incubated for 4 hours. The effects of cytotoxicity were measured by calculating cell viability (%). Data were analyzed using Probit test, One-way ANOVA followed by LSD. Result: Each group has a cell viability value above 50%. Conclusion: Extract pectin from Robusta coffee fruit peel's had no cytotoxic effect on human dental pulp fibroblsts cell culture Keywords: coffe robusta fruit peels, cytotoxicity, human pulp fibroblst cell culture, pectin
Studi Penggunaan Antibiotik pada Pasien Penyakit ISPA Usia Bawah Lima Tahun di Instalasi Rawat Jalan Puskesmas Sumbersari Periode 1 Januari-31 Maret 2014 (Study of Antibiotics Use on ARI Patients in Under Five Years Outpatient Clinic, Sumbersari Health Tika Sugiarti; Arya Sidemen; Wiratmo Wiratmo
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Acute respiratory tract infections (ARI) disease often occurs on children. The episode of cough and cold disease on toddlers in Indonesia is estimated to be 3 to 6 times each year. The high prevalence of respiratory disease and its effect have brought the high consumption of free drugs and antibiotics. This study aimed to determine the profile of the patients, the treatment of respiratory diseases, antibiotic usage patterns and congruence with of the standards of Indonesian Health Ministry in 2012 based on the exact parameters indication, the right type, and the right dosage. The results showed that the amount of male patients (53%) were more than the amount of female patients and the largest age group in ARI patients were ages 13-24 months (30%). Drugs given to patients consist of two kinds, namely antibiotics and supportive therapy drugs. Antibiotic therapy given in ARI was amoxicillin and co-trimoxazole. Syrup is dosage form mostly used. Based on compliance with the standards of Indonesian Health Ministry in 2012, can be concluded that the use of antibiotics were 24.2% exact indication, 100% right type, and 8.9% correct dose. Keywords: acute respiratory tract infections (ARI), toddler, antibiotic, standards of Indonesian Health Ministry in 2012

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