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e-Journal Pustaka Kesehatan
Published by Universitas Jember
ISSN : 2355178X     EISSN : 27213218     DOI : -
Core Subject : Health, Science,
Health Professions Library & Information Science
e-Journal “Pustaka Kesehatan” merupakan jurnal elektronik ilmiah berISSN (ISSN: 2355-178X) yang menerbitkan artikel hasil penelitian di bidang kesehatan secara umum meliputi: Kedokteran, Kedokteran Gigi, Kesehatan Masyarakat, Farmasi, dan Ilmu Keperawatan. Artikel yang dikirim belum pernah dipublikasikan atau tidak dalam proses penerbitan dalam jurnal ilmiah lain. e-Journal “Pustaka Kesehatan” diterbitkan tiga kali dalam setahun, yaitu bulan Januari, Mei, dan September.
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Articles 621 Documents
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Determinan Kejadian Stunting pada Anak Balita Usia 12-36 Bulan di Wilayah Kerja Puskesmas Randuagung Kabupaten Lumajang (Determinants of Stunting among Children Aged 12-36 Months in Community Health Center of Randuagung, Lumajang Distric) Dicka Indo Putri Priyono; Sulistiyani Sulistiyani; Leersia Yusi Ratnawati
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Stunting was linear growth disorder caused by chronic malnutrition nutrient intake andchronic or recurrent infections indicated by the value of the z-score of height for age(TB/U) <-2 SD based on WHO standards. It was also a public health problem becauseassociated with increased risk of morbidity and mortality. Randuagung was the highestprevalent stunted that 34,63% form 25 community health center in Lumajang distric.Based on result of the first study done to 30 children ini community health center ofRanduagung, Lumajang distric, acquired amount of 11 children endured the stunted.This study aimed to analyzed the determinants of stunting among children aged 12-36months in Puskesmas Randuagung, Lumajang. This study was observational analyticwith cross sectional design. The sample size were 86 toddlers were taken by simplerandom sampling. Bivariate analyzed with chi square test and multivariate analyzedwith multiple logistic regression. The results show that 53.5% sample were stunted. Theanalysis show there were relationship between zinc consumption level, infectiousdiseases, and genetically with the incidence of stunting. The level of zinc consumptionand genetic were the risk factor of stunting among children age 12-36 month.Keywords: Stunting, children, risk factor
Sintesis asam 2-(2-(4-kloro-N-(2,6-Diklorofenil)benzamida) fenil)asetat sebagai salah satu turunan diklofenak yang merupakan kandidat obat penghambat COX (siklooksigenase) (Synthesis 2-(2-(4-Chloro-N-(2,6-dichlorophenil)benzamido)phenil)acetic acid as dic Wahyu Novandari Herdiyanti; Ayik Rosita Puspaningtyas; Ika Oktavianawati
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Sodium diclofenac is an analgetic agent as an antimetabolite that used for treating pain. Several compound as a derivative diclofenac has been synthesis for increase its activity and reduce side effect. 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid is a derivate of Sodium diclofenac that synthesized for development new drugs. Synthesis 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic has benzoylation reaction between Sodium diclofenac and 4-Chlorobenzoil Chloride to give the target compound (2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid).This compound has been purified by Column Chromatography and give yellow color with melting point 143-145oC and then fix identification by H-NMR 400 MHz and KBr FTIR. 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid can synthesized and resulted 8.39 % of yield.   Keywords: Sodium diclofenac, 2-(2-(4-Chloro-N-(2,6-dichlorophenyl)benzamido)phenyl)acetic acid, pain.
Aktivitas antibakteri Pleurotus ostreatus varietas Grey Oyster pada Staphylococcus aureus dan Pseudomonas aeruginosa Evi Hanizar; Dwi Nur Rikhma Sari
Pustaka Kesehatan Vol 6 No 3 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i3.9776

Abstract

Oyster mushroom Pleurotus ostreatus varieties Gray oyster is often consumed by the community because it tastes delicious and contains nutrients for health but utilization for medical treatment has not been studied. The aim of this research was to analyze antimicrobial potential compounds in P. ostreatus and to investigate the inhibitory effect on the growth of Staphyllococcus aureus and Pseudomonas aeruginosa. This research was experimental type with treatment variation 0.1; 0.25; 0.5; 1; 1.5 and 2% of P. ostreatus extract, with 5 replicates. Antimicrobial potential compounds was analyzed by qualitative phytochemical test while antibacterial activity evaluated by calculating the inhibition zone diameter presented as the bright zone formed in the surroundings paper discs on bacterial cultures using solid medium. Phytochemical analysis obtained positive results for flavonoid, tannin and terpenoid compounds. The effect of mushroom extract on the bacterial growth inhibition were analyzed by One Way Anova test. The result showed that the inhibitory growth diameter for both bacteria was not significantly different. It meant that the difference in concentration variations of P. ostreatus extracts of 0.25 and 0.50 did not cause different inhibitory effects on S. aureus and P aeruginosa bacteria and 0.1% concentration was capable of causing inhibitory effect.
Optimasi Polimer Hidroksipropil Metilselulosa K-4M dan Carbopol 940 pada Sediaan Patch Dispersi Padat Meloksikam (Optimization of Hydroxypropyl Methylcellulose K-4M and Carbopol 940 as Polymer in Solid Dispersion Meloxicam Patch) Indarto Adikusumo; Lidya Ameliana; Dwi Nurrahmanto
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Meloxicam is non steroidal antiinflammatory drug (NSAID) of the enolic acid class which is widely used in treatment of rheumatoid arthritis. Its adverse effects of oral route, which are nausea dan diarrhea could be evaded by using transdermal patch. Meloxicam is practically insoluble in water, therefore it should be made into solid dispersion.The aims of this research was to determine the effect of combination of hydroxypropyl methylcellulose (HPMC) K-4M and carbopol 940 on the in-vitro drug release and moisture content (MC) and to obtain the optimum formula of those polymers using design experts software. Meloxicam patches were prepared into three formulas based on simplex lattice design with the ratio of HPMC K-4M : carbopol 940 that were 1: 0 ; 0.5 : 0.5 and 0 : 1. The results of this research showed that the patch with HMPC K-4M : carbopol 940 of 0:1 gave the best in-vitro drug release and MC. The optimum formula was HPMC K-4M and carbopol 940 with the ratio of 0 : 1 Keywords: meloxicam, solid dispersion, patch, HPMC, carbopol.
Hubungan Merokok Bernikotin terhadap Penurunan Volume Saliva pada Perokok di Kabupaten Tulungagung (Relationship of Smoke Containing Nicotine to Decrease in the Volume of Saliva in Smokers at Tulungagung District) Ichdanisa Fitriasani; Pujiana Endah Lestari; Leni Rokhma Wati
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Back Ground: Nicotine is one of the contents of cigarette that bad for health. Nicotine has an influence on the nervous system, which one led to decrease in saliva production. Object: Tulungagung is a district where has a high number of smokers, also there is an identical smoking habit called nyethe. The aim of this study was to determine relationship of the effect of smoking that contains nicotine to decreased in saliva production. Method: The research method used an analitic obsevational study with cross sectional observation. The study was conducted by taking saliva samples of 100 smokers and 100 non smokers at district Tulungagung. Result: The pearson correlation test result showed that the significancy value (sig (2-tailed)) was 0.00 which was smaller than α (0.05) and had a value of peason correlation 0f -0,566. Conclusion: The test result obtained from the pearson correlation was able to explained that nicotine had a relation with saliva volume decreased. The result showed that smoke containing nicotine had influence on reducing the volume of saliva, more often smoke containing nicotine so the lower volume of saliva produced. Keywords: cigarette, nicotine, saliva, tulungagung
Efektivitas Antibakteri Ekstrak Daun Sirih Merah (Piper Crocatum) dan Sirih Hijau (Piper Betle L.) sebagai Bahan Alternatif Irigasi Saluran Akar (The Efectiveness of Red Piper Betle (Piper Crocatum) Leaf and Green Piper Betle (Piper Bettle L) Leaf Extract Hafida Mariyatin; Ekiyantini Widyowati; Sri Lestari
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background: Root canal irrigation is one, of important in endodonti treatment because if ignored can lead to failure. 3% Hydrogen peroxide (H2O2) is one of irrigation solution is often used. To reduce the effects of toxicity of root canal irrigation, it can be used for alternative materials canal irrigation are safe to use. One is piper betle plant. Based on previous research phytochemical test, the piper betle leaf has anti-bacterial effect. Purpose: This study aimed to determine the antibacterial effect, difference antibacterial effect and effectiveness of red piper betle leaf extract and green piper betle leaf compared with 3% H2O2 solution to Streptococcus viridans. Methods: This study is an experimental laboratory with research design post only control design. This study uses pitting. Each petridish divided into 6 holes, spilled A 3% H2O2, B sterile distilled water, C 50% red piper betle leaf extract, D 50% green piper betle leaf extract, E 100% leaf extract a red piper betle and F 100% green piper betle leaf extract. All incubated for 24 hours at 37 ° C and the inhibition zone diameter measured. Results: The results showed significant difference between the extracts of green and red piper betle. Statistical test with Mann Whitney test showed a significant difference between each group except 3% H2O2 and 50% green piper betle extract. Conclusions and Recommendations: Conclusions from this research are green piper betle leaf extract and red piper betle leaf extract can inhibit the growth of bacteria S. viridans. There were significant differences antibacterial effect between green piper betle leaf extract and red piper betle leaf extract with 3% H2O2 to S. Viridans. 100% Green piper betle leaf extract effective as an antibacterial against S. viridans. Need more research on the use of green piper betle leaf extract and red piper betle leaf extract as an alternative material of root canal irrigation. Keywords: antibacterial, red piper betle leaf, green piper betle leaf, H2O2 3%, root canal irrigation  
Hubungan Dukungan Sosial Keluarga dengan Perilaku Perawatan Diri pada Klien Diabetes Melitus Tipe 2 di Wilayah Kerja Puskesmas Kaliwates, Jember Wahyuningtias Rahmadani; Hanny Rasni; Kholid Rosyidi Muhammad Nur
Pustaka Kesehatan Vol 7 No 2 (2019): Volume 7 No. 2, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i2.19124

Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disease that can cause various chronic complications and they can be minimized by self-care. One of the factors that affect self-care in diabetic clients is family social support. The aim of the research was to analyze the correlation between family social support and self care behavior client with T2DM)in the area of Kaliwates public health center, Jember. This research applied an observational analytic design with cross-sectional approach. A total of 84 respondents were enrolled in this study by using purposive sampling technique. The data collection method used the HDFSS (Hensarling Diabetes Family Support Scale) and SDSCA (Summary of Diabetes Self Care Activity) questionnaires, it conducted on January 7th-22nd 2019. The data analysis used Spearman correlation test with a significance level of 0.05.The result showed that median of the family social support was 86 with a minimum value of 69 and a maximum value of 106, whereas the mean value of self-care behaviour was 2,27 days with a standard deviation of 0.45 days. There was a significant positive correlation between family sosial support and self-care behaviour (p value: 0.001; r; +0.378), meaning that the higher the level of family social support the better the self-care behaviour. This study suggests the importance of assessing family social support to improve self-care in clients with type 2 diabetes mellitus.
Efek Ekstrak Kulit Mangga (Mangifera indica L.) Arumanis terhadap Lama Perdarahan Mencit Putih Jantan (The Effect of Arumanis Mango (Mangifera indica L.) Peel Extract on the Bleeding Time of White Male Mice) Komang Dewi Fridayanti; Cicih Komariah; Jauhar Firdaus
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The inhibition of cyclooxygenase 1 (COX-1) enzyme leads to the decrease of tromboxane A2 (TXA2) and decrease the activity of platelet aggregation that marked by the lengthening of bleeding time. This mechanism is important to prevent the occurence of patology that can lead to thrombosis. Flavonoid, polyphenol present in the mango peel, is known to have activity for blocking the COX-1 enzyme. The aim of this research was to know the effect of Arumanis mango peel extract for lengthening the bleeding time on white male mice. The research was true experimental. The sampel was treated for seven days and the bleeding time was measured on the seventh day. The result of analyses Kruskal Wallis shows that there are significant difference intern-treatment group with significance (p) 0.033. The Mann Whitney analyses test shows significant difference between treatment group 2 (P2), treatment group 4 (P4), treatment group 5 (P5) and negative control group (K-). So, it can be concluded that arumanis mango peel extract can lengthening the bleeding time of white male mice.The dosis of 16,8 mg.grBBof mango peel extract givesthe longest mean bleeding timeand it exceeds the mean of positive control group. Keywords: bleeding time, mango, flavonoid
Daya Antibakteri Ekstrak Kulit Apel Manalagi (Malus sylvestris Mill.) Terhadap Pertumbuhan Streptococcus mutans (Antibacterial Activity of Manalagi Apple Peel (Malus sylvestris Mill.) Extract on The Growth of Streptococcus mutans) Jannata Hafidata Rabbani; Gunadi Achmad; Ermawati Tantin
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Apple is a popular fruit which is consumed by many people in Indonesia. Manalagi apple's peel contains polyphenols that have antibacterial effects. Streptococcus mutans is the normal flora that can cause oral disease. One of alternative medications to prevent the disease by using natural products as antibacterial. This research is aimed to determine the antibacterial activity manalagi apple's peel extract on the growth of S. mutans and minimum concentration to inhibit growth. The method of this research is well diffusion method with 8 samples for each treatment. Samples consisted of five treatment groups which is manalagi apple's peel extract with concentration of 100%, 50%, 25%, positive control group (chlorhexidine 0.2%), and negative control group (aquadest sterile). Data were analyzed using the Kruskal-Wallis and Mann-Whitney test. The results of this research showed that manalagi apple's peel extract at all concentrations have antibacterial activity against the growth of S.mutans. Minimum inhibition concentration of manalagi apple's peel extract is 25%. The conclusion of this research proves that manalagi apple's peel extract has antibacterial activity against S.mutans growth.   Keywords: Antibacterial activity, manalagi apple's peels, Streptococcus mutans, well difussion method.
Hidrolisis Protein Isolat Biji Melinjo (Gnetum gnemon L.) menggunakan Alkalase Terimobilisasi dan Aktivitasnya sebagai Antihipertensi (Hydrolysis of Melinjo Seed (Gnetum gnemon L.) Isolated-Protein using Immobilized Alcalase and Its Activity as Antihyper Nur Fauziah Matra; Endah Puspitasari; Tri Agus Siswoyo
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6612

Abstract

Hypertension is ranked third on the cause of death in Indonesia for all ages (6.8 %). Protein isolate of melinjo seeds (Gnetum gnemon L.) hydrolyzed with free alcalase has been known to have antihypertensive activity. However, the use of free alcalase is uneconomical since it can only be used once, thus we studied the immobilized alcalase effectivity to hydrolise the melinjo seeds protein isolate to be used as angiotensin converting enzyme (ACE) inhibitor. The immobilization method used entrapment method with DMDMOS/TMOS as matrix. Characterization of the immobilized enzyme was observed by FTIR and effectiveness of repeated hydrolysis was observed by the value of the degree of hydrolysis. The success of the hydrolysis process was determined by SDS-PAGE electrophoresis. Antihypertensive activity test was determined by the ability to inhibit ACE. The results showed that the alcalase has been immobilized in the matrix of silane and SDS-PAGE protein profile showed melinjo seed proteins had been successfully hydrolyzed. Hydrolysis process repeatedly demonstrated that immobilized alcalase was effective to hydrolyze protein isolates of melinjo seeds twice. Based on ACE inhibitory test, there were no significant differences between the protein isolate hydrolyzed by immobilized alcalase (Gg-PH), protein isolates hydrolyzed with free alcalase (Gg-PHB), and captopril. These findings suggest that the antihypertensive activity in Gg-PH is the same with that of captopril. Keywords: hypertension, antihypertensive, melinjo, enzymes immobilization, ACE inhibitor

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