cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Risti Graharti
Contact Email
risti.graharti@gmail.com
Phone
+6281369730011
Journal Mail Official
medulla.fkunila@gmail.com
Editorial Address
-
Location
Kota bandar lampung,
Lampung
INDONESIA
Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 18 Documents
 1   2 
Search results for , issue "Vol 14 No 12 (2024): Medula" : 18 Documents clear
Peran Flavonoid Sebagai Antiulser dan Antioksidan pada Ulkus Duodenum Zahra, Aulia Jannatuz; Susianti, Susianti; Happy, Terza Aflika; Soleha, Tri Umiana
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1415

Abstract

Duodenal ulcer is a pathological condition characterized by damage to the duodenal mucosa due to an imbalance between protective and aggressive factors, such as gastric acid and pepsin. The primary factors contributing to the development of this ulcer include Helicobacter pylori infection. Additionally, prolonged use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is also a significant factor in the occurrence of duodenal ulcers, as these drugs inhibit prostaglandin synthesis, which plays a crucial role in mucosal protection. In Indonesia, the prevalence of duodenal ulcers is estimated to be around 11–14%. Flavonoids, as bioactive compounds with antioxidant, anti-inflammatory, and anti-ulcer properties, have been widely studied for their potential in the management of peptic ulcers, including duodenal ulcers. Flavonoids have been shown to inhibit gastric acid secretion, stimulate mucus production, and protect the gastrointestinal mucosa through cytoprotective and antioxidative mechanisms, specifically by inhibiting reactive oxygen species (ROS). Furthermore, flavonoids have the ability to suppress H. pylori growth, thereby contributing to the prevention of ulcer pathogenesis caused by this bacterium. Flavonoids also enhance blood flow to the gastric mucosa and modulate enzymes involved in epithelial defense. Despite these benefits, the main challenges in utilizing flavonoids are their low bioavailability and potential toxicity at high doses. Therefore, further studies are essential to evaluate the efficacy, safety, and formulation optimization of flavonoids to enhance their availability as a natural therapeutic alternative and their application in the clinical treatment of peptic ulcers.
Pengaruh Pemberian Ekstrak Etanol Lada Hitam (Piper nigrum L) Terhadap Kadar Gula Darah dan Jumlah Spermatogonia Model Diabetes Tikus Putih Jantan (Rattus norvegicus) Galur Sprague dawley Talin, Jinan Naura; Hadibrata, Exsa; Rudiyanto, Waluyo; Windarti, Indri
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1431

Abstract

Diabetes mellitus that is not treated properly can result in infertility. The piperine content in black pepper can help in the quality of spermatogenesis process and blood sugar levels. This study aims to determine the effect of black pepper (P. nigrum L) ethanol extract on blood sugar levels and the number of spermatogonia in a diabetes model of male white rats (R. norvegicus) Sprague dawley strain. The study used a Posttest-only Randomized Control Group on 24 rats divided into 4 groups. All groups were induced with alloxan 150 mg/kgBW except for KN. P1 and P2 were given 122.5 mg/kgBW and 245 mg/kgBW black pepper ethanol extract. Blood sugar levels were checked using Easy Touch GCU with a normal limit of 50-135 mg/dL. The number of spermatogonia was calculated using a tool, namely ImageJ. The data were analyzed using the Shapiro- Wilk normality test and homogeneity test, followed by the Kruskal Wallis non-parametric test and the Post Hoc test. The statistical results of blood sugar levels obtained normally distributed data p>0.05, non-homogeneous data p<0.05, significant Kruskal-Wallis test results and continued Post Hoc test obtained significant results at P2 and K-. The number of spermatogonia obtained normally distributed data p>0.05, non-homogeneous data p<0.05. The results of the Kruskal-Wallis test were significant p<0.05 and continued Post Hoc test obtained significant results at P2 and P1. There was a decrease in blood sugar levels in the administration of black pepper ethanol extract (P. nigrum L) in the diabetes model of male white rats (R. norvegicus) Sprague dawley strain. However, there was no effect of administering black pepper ethanol extract (P. nigrum L) on the number of spermatogonia in the diabetes model of male white rats (R. norvegicus) Sprague dawley strain.
Mekanisme Hiperglikemia Kronis terhadap Densitas Mineral Tulang Dwiputri, Maliya Finda; Larasati, TA; Jausal, Annisa Nuraisa; Carolia, Novita
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1438

Abstract

Hyperglycaemia or high levels of glucose in the blood is the hallmark of diabetes mellitus. Diabetes mellitus type 2 (DMT2) significantly impacts bone health, leading to a condition known as diabetic bone disease, characterized by decreased bone mineral density and an increased risk of fractures. This condition arises from metabolic disturbances triggered by hyperglycemia, insulin resistance, and inflammatory factors that compromise bone structure. Research indicates that over 35% of DMT2 patients experience reduced bone density, with approximately 20% meeting osteoporosis criteria. The pathophysiology involves several mechanisms, including the accumulation of advanced glycation end-products (AGEs), which hinder bone formation and increase resorption. Insulin deficiency further exacerbates this issue by impairing osteoblast function and reducing the synthesis of key bone matrix proteins like collagen and osteocalcin. Treatment options such as metformin have shown potential in improving bone health, while other medications like sulfonylureas and SGLT-2 inhibitors may have detrimental effects on bone density. Therefore, careful management of diabetes is essential to mitigate the risks of osteoporosis and fractures in patients with DMT2. Ongoing research is needed to deepen the understanding of diabetic bone disease and optimize treatment strategies to protect bone health in these patients.
Aktivitas Antibakteri Epigallocatechin Gallate (EGCG) Teh Hijau pada Bakteri Gram Positif dan Bakteri Gram Negatif Afifah, Syafira Hasna; Apriliana, Ety; Setiawan, Gigih; Berawi, Khairun Nisa
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1446

Abstract

Epigallocatechin gallate (EGCG) is a catechin compound found in green tea and is known for its various health benefits, including antioxidant, anti-inflammatory, and antibacterial activity. Research on the antibacterial effects of EGCG shows that this compound has significant potential in inhibiting the growth of various pathogens, both Gram-positive and Gram-negative bacteria. Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumoniae, are more sensitive to EGCG than Gram-negative bacteria. The antibacterial mechanism of EGCG in Gram-positive bacteria involves disrupting cell membrane integrity and inhibiting biofilm formation, while in Gram-negative bacteria, EGCG can increase the permeability of the outer membrane and increase the penetration efficiency of antibiotics. However, the main challenge in using EGCG against Gram-negative bacteria is the structural barrier present in the outer membrane, which limits the penetration of the compound. The use of EGCG in combination therapy with antibiotics shows great potential in overcoming antibiotic-resistant infections, strengthening antibacterial activity, and reducing side effects. Although EGCG shows promise as an antibacterial therapy, challenges related to bioavailability, stability, and formulation need to be overcome to optimize its potential in the treatment of difficult-to-treat bacterial infections.
Faktor-faktor yang Memengaruhi Menarche Dini pada Remaja Perempuan Hafizha, Syifa; Angraini, Dian Isti; Mayasari, Diana; Perdani, Roro Rukmi Windi
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1452

Abstract

Adolescence is a critical phase of rapid growth characterized by the maturation of reproductive organs, known as puberty. In females, puberty is marked by the onset of menstruation, with menarche being the first occurrence of menstruation, typically between the ages of 12 and 14 years. However, the average age of menarche in Indonesia has declined over the years, leading to an increase in early menarche cases. Early menarche occurs at an age of < 11 years (9-10 years) that is primarily driven by elevated estrogen levels in the female body. Factors influencing early menarche include genetics, nutritional status, lifestyle, dietary intake, physical activity, stress management, socioeconomic conditions, sexual behavior, and media exposure. This literature review aims to examine the correlation between these factors and the decreasing age of menarche among adolescent girls in Indonesia. Nutritional status and imbalanced dietary patterns are external factors strongly associated with early menarche. Genetic factors, particularly maternal menarche age, significantly influence the likelihood of early menarche in daughters. Low levels of physical activity contribute to increased ovarian activity and elevated estrogen levels, thereby raising the risk of early menarche. Furthermore, insufficient physical activity is directly linked to early menarche. External influences such as media exposure shape sexual behaviors, which may accelerate menarche onset. Poor stress management also disrupts estrogen regulation, further contributing to early menarche.
Potensi Daun Jambu Air (Syzygium aquem) sebagai Fitofarmaka : Literature Review Febrianti, Arlin; Susianti, Susianti; Kusumaningtyas, Intan; Mustofa, Syazili
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1456

Abstract

Traditional medicine widely utilizes plant extracts from various parts of plants due to their secondary metabolite content, which possesses therapeutic effects. One plant with high pharmacological potential is the water apple leaf (*Syzygium aqueum*), belonging to the Myrtaceae family and commonly found in tropical regions such as Indonesia, Malaysia, and India. Water apple leaves have been used as phytopharmaceuticals because they contain various bioactive compounds that can be extracted and utilized for treating different diseases. The active compounds commonly found in water apple leaves include alkaloids, flavonoids, steroids, triterpenoids, and coumarins. Studies have shown that water apple leaf extracts exhibit various pharmacological activities, including antibacterial, antioxidant, anti-inflammatory, anticancer, antimicrobial, and antidiabetic properties. Additionally, the bioactive compounds in water apple leaves have the potential to be further developed as natural therapeutic agents for treating degenerative diseases and infections. This pharmacological potential positions water apple leaves as a promising phytopharmaceutical candidate for development in the pharmaceutical and healthcare industries. However, further research is required to explore the mechanisms of action, efficacy, and potential toxicity of the active compounds in water apple leaves. A comprehensive study in this area will enable the optimization of water apple leaves as a safe and effective natural therapy for various diseases.
The Role of Between Scenario Quality and Prior Knowledge on the Effectiveness of Tutorial Discussions in Problem-Based Learning (PBL): Literature Review Mu'izabby, Iffah Salma; Oktafany, Oktafany; Ratna, Maya Ganda; Lisiswanti, Rika
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1460

Abstract

Problem-Based Learning (PBL) is a learning method that puts students at the centre of the learning process, encouraging them to learn independently through problem solving. One of the main approaches in PBL is tutorial discussion, which plays an important role in promoting deep learning. The effectiveness of tutorial discussions is influenced by three main aspects: the quality of the problem scenario, students' prior knowledge, and tutor performance. The scenario should be authentic, relevant to the students' level of understanding, and able to stimulate independent learning. Students' prior knowledge also affects their contribution to the discussion, as adequate understanding allows for more active engagement. In addition, the tutor's role in facilitating the discussion also influences the success of the PBL method. The quality of the scenario and prior knowledge play an important role in the effectiveness of Problem-Based Learning (PBL) discussions, although their relationship is not always statistically significant. The quality of a well-designed scenario can stimulate meaningful discussions, motivate students, and support the achievement of learning objectives. Prior knowledge, while not necessarily determining the success of the discussion, influences how students integrate new information. Groups with lower prior knowledge can show higher discussion effectiveness through active exploration. Overall, the effectiveness of PBL is influenced by the interaction between the quality of learning design and student characteristics, suggesting the need for a holistic approach in designing PBL scenarios.
Edukasi Bahaya Penggunaan Cotton Buds: Upaya Pencegahan Risiko Kesehatan Setiawan, Salsabila Alifiyah; Imanto, Mukhlis
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1466

Abstract

A common practice in the community is to clean the ears independently to remove earwax that is considered annoying. The act of cleaning the ear canal by using ear cotton aids, actually causes the cerumen to be pushed deeper, which can close the tympanic membrane, causing temporary hearing loss. Cleaning the ear itself is inserting objects into the ear canal with the aim of removing earwax is a practice that has the potential to disrupt the natural cleaning mechanism, and is a risk factor for injury to the ear. Community service activities in the form of counseling “Education on the Dangers of Using Cotton Buds” were carried out on Thursday, January 25, 2024 which took place on the 3rd floor of the Poli Dr. H. Abdul Moeloek Hospital Lampung Province. This activity was attended by 12 audiences who were patients who were checking themselves to the ENT-KL Poly and Poly on the 3rd floor of the Poly Building of Dr. H. Abdul Moeloek Hospital Lampung Province. Pre and Post Tests were conducted as a measuring tool to evaluate the increase in audience knowledge after being given counseling. An increase in percentage was obtained, from 60% in the pretest results and 97% in the post-test results. This counseling activity proved to be effective in increasing community knowledge so it is recommended to be carried out regularly. Lack of knowledge about the dangers of using cotton buds could potentially increase the risk of ear injury. Therefore, it is important to educate the community on the correct way to care for the ears, as well as the dangers of improper use of cotton buds. Through this counseling activity, it is hoped that it can increase public awareness and understanding of the importance of safe and healthy ear care.

Page 2 of 2 | Total Record : 18

 1   2 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol 14 No 10 (2025): Medula Vol 15 No 3 (2025): Medula Vol 15 No 2 (2025): Medula Vol 15 No 1 (2025): Medula Vol 14 No 12 (2024): Medula Vol 14 No 11 (2024): Medula Vol 14 No 9 (2024): Medula Vol 14 No 8 (2024): Medula Vol 14 No 7 (2024): Medula Vol 14 No 6 (2024): Medula Vol 14 No 5 (2024): Medula Vol 14 No 4 (2024): Medula Vol 14 No 3 (2024): Medula Vol 14 No 2 (2024): Medula Vol 14 No 1 (2024): Medula Vol 13 No 4.1 (2023): Medula - Edisi Spesial (Special Sense) Vol 13 No 7 (2023): Medula Vol 13 No 6 (2023): Medula Vol 13 No 5 (2023): Medula Vol 13 No 4 (2023): Medula Vol 13 No 3 (2023): Medula Vol 13 No 2 (2023): Medula Vol 13 No 1 (2023): Medula Vol 12 No 4 (2022): Medula Vol 12 No 3 (2022): Medula Vol 12 No 2 (2022): Medula Vol 12 No 1 (2022): Medula Vol 11 No 4 (2021): Medula Vol 11 No 3 (2021): Medula Vol 11 No 2 (2021): Medula Vol 11 No 1 (2021): Medula Vol 10 No 4 (2021): Medula Vol 10 No 3 (2020): Medula Vol 10 No 2 (2020): Medula Vol 10 No 1 (2020): Medula Vol 9 No 4 (2020): Medula Vol 9 No 3 (2019): Medula Vol 9 No 2 (2019): Medula More Issue