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All Journal Medula Indonesian Journal of Urology JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Indonesian Journal of Nursing and Health Sciences (IJNHS) Jurnal Ilmiah STIKES Yarsi Mataram JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Hadibrata, Exsa
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Agriculture, Biological Sciences & Forestry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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INFLUENCE OF DIABETES MELITUS, BMI, AND HBA1C IN HIGH GRADE PROSTATE CANCER hadibrata, exsa; Danarto, H R
Indonesian Journal of Urology Vol 24 No 1 (2017)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v24i1.297

Abstract

Objective: This study aims to determine the effect of diabetes mellitus (DM) and body mass index (BMI) on the risk of prostate cancer and high grade prostate cancer. Materials & method: This study is a retrospective observational study with cross-sectional design, using secondary data to determine the relationship of diabetes mellitus, body mass index and HbA1c levels with the degree of differentiation histopathologic prostate cancer. Data were analyzed using Chi-Square test, T-test and Man Whitney test with a confidence level of p<0.05 and a=0.05. Results: There are 78 samples diagnosed with prostate cancer. A total of 12 (15.4%) samples are diabetes mellitus, 18 (22.9%) samples classified as body mass index more than 23.4 (5.1%) samples have elevated levels of HbA1c levels >6.5. On histopathologic examination, it was found as many as 45 (57.7%) samples with high grade prostate cancer, as much as 9 (11.5%) samples with moderate grade prostate cancer, and as many as 24 (30.8%) samples with low grade prostate cancer. In bivariate analysis diabetes mellitus, BMI>23, and HbA1c level relationship with high grade prostate cancer is not statistically significant with p>0.05. Conclusion: There were no statistically significant relationship between diabetes, BMI and increased levels of HbA1c with high grade prostate cancer.
THE QUALITY OF SPERM AND FEMALE AGE AS FACTORS INFLUENCING PREGNANCY IN INTRACYTOPLASMIC SPERM INJECTION (ICSI) Hadibrata, Exsa; Utomo, Trisula
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.480

Abstract

Objective: To evaluate the quality of sperm and the female age influence on fertilization and pregnancy rate after Intracytoplasmic Sperm Injection (ICSI) procedure. Material & Methods: This study was an observational analytic study with a retrospective cohort design. The data of infertile and subfertile male undergoing ICSI for five years were analyzed and evaluated to determine factors influencing pregnancy post-ICSI in Central General Hospital Dr. Sardjito. The Data were analyzed by using Chi-squared test, Kolmogorov-Smirnov test, and Mann-Whitney U test with the confidence level of p<0.05 and α=0.05. Results: There was 52 male included in this study. A total of 52 males were infertile, with azoospermia, oligozoospermia, and oligoasthenoteratozoospermia. 2 patients (3.8%) were patients with oligozoospermia, 32 patients (61.5%) were patients with azoospermia and 18 patients (34.6%) were patients with oligoasthenoteratozoospermia. We evaluated 52 ICSI cycle, the percentage of fertilization and pregnancy are 84.6% and 36.5%, respectively. Bivariate analysis showed a significant relationship between wife under 37 years old variable and pregnancy post ICSI procedure with p=0.021 and OR 9.0 (95% CI 1.05-76.4). There was no significant difference between azoospermia, oligozoospermia, and oligoasthenoteratozoospermia and the occurrence of pregnancy post ICSI procedure, p=0.986. Conclusion: The percentage of fertilization and pregnancy post ICSI procedure were 84.6% and 36.5%. Azoospermia, oligozoospermia, and oligoasthenoteratozoospermia variables were not significantly associated with pregnancy post ICSI procedure. ICSI procedure must be carried out immediately before the age of the wife 37 years because of the high success rate.
SURVIVAL OF PROSTATE CANCER PATIENTS WITH COMBINATION HORMONAL-RADIOTHERAPY BETTER THAN HORMONAL THERAPY Hadibrata, Exsa; Tranggono, Untung
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.583

Abstract

Objective: This study aims to determine the survival of prostate cancer (PCa) patients who did not undergo radical prostatectomy, but received hormonal therapy or a combination of radiotherapy and hormonal therapy. Material & Methods: This study was an observational analytic study with a retrospective cohort design, using secondary data to determine baseline data and diagnosis of patients, and using primary data to determine the survival of prostate cancer patients who received combination hormonal and radiotherapy therapy compared with hormonal therapy alone. The analysis was performed using chi-square and contingency coefficients to assess the relationship between survival with factors such as age, stage T, N, M, clinical stage, type of therapy, and prognosis. It also used the Kaplan Maeier curve to assess the survival picture of prostate cancer patients at Sardjito General Hospital. Results: 79 patients met the inclusion criteria. The mean age of the patients was 68 ± 8.4 years. A total of 52 (65.8%) patients received hormonal therapy, and 27 (34.2%) patients received combination hormonal and radiotherapy. There were 41 (51.9%) patients remain life, while 38 (48.1%) of patients died during the monitoring. We found that the Gleason score, PSA level, and clinical stage were significantly associated with patient survival with p <0.005. The 5 years survival rate patient with local, locally advanced clinical stage and PSA level ≤20 ng/ml who received combination hormonal and radiotherapy achieved 100%. Conclusion: Combination of hormonal and radiotherapy was more improving patient survival compared with hormonal therapy only in patient with locally advanced clinical stage, PSA level ≤20 ng/ml and Gleason score ≤7.
SURVIVAL OF PROSTATE CANCER PATIENTS WITH COMBINATION HORMONAL-RADIOTHERAPY BETTER THAN HORMONAL THERAPY Hadibrata, Exsa; Tranggono, Untung
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.583

Abstract

Objective: This study aims to determine the survival of prostate cancer (PCa) patients who did not undergo radical prostatectomy, but received hormonal therapy or a combination of radiotherapy and hormonal therapy. Material & Methods: This study was an observational analytic study with a retrospective cohort design, using secondary data to determine baseline data and diagnosis of patients, and using primary data to determine the survival of prostate cancer patients who received combination hormonal and radiotherapy therapy compared with hormonal therapy alone. The analysis was performed using chi-square and contingency coefficients to assess the relationship between survival with factors such as age, stage T, N, M, clinical stage, type of therapy, and prognosis. It also used the Kaplan Maeier curve to assess the survival picture of prostate cancer patients at Sardjito General Hospital. Results: 79 patients met the inclusion criteria. The mean age of the patients was 68 ± 8.4 years. A total of 52 (65.8%) patients received hormonal therapy, and 27 (34.2%) patients received combination hormonal and radiotherapy. There were 41 (51.9%) patients remain life, while 38 (48.1%) of patients died during the monitoring. We found that the Gleason score, PSA level, and clinical stage were significantly associated with patient survival with p <0.005. The 5 years survival rate patient with local, locally advanced clinical stage and PSA level ≤20 ng/ml who received combination hormonal and radiotherapy achieved 100%. Conclusion: Combination of hormonal and radiotherapy was more improving patient survival compared with hormonal therapy only in patient with locally advanced clinical stage, PSA level ≤20 ng/ml and Gleason score ≤7.
Efikasi dan Keamanan Extracorporeal Shock Wave Lithotripsy (ESWL) tipe Piezoelektrik Pada Pasien Batu Ginjal Hadibrata, Exsa; Tjahjo, Mars Dwi; Fadli, Muhammada Yogi; Priyono, Angga Hendro
Jurnal Kedokteran Universitas Lampung Vol 4, No 2 (2020): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v4i2.2874

Abstract

Sejak diperkenalkan pada 1980-an, Extracorporeal Shock Wave Lithotripsy (ESWL) telah menjadi standar prosedur rawat jalan non-invasif yang digunakan untuk tata laksana batu ginjal dan batu ureter proksimal. Keberhasilan ESWL diukur dalam hal fragmentasi batu dan stone free rate. Sedangkan ESWL dinilai gagal bila terjadi trauma pada parenkim ginjal yang tidak perlu akibat gelombang kejut dan terjadinya komplikasi. Penelitian ini bertujuan untuk mengetahui efikasi dan komplikasi daritindakan ESWL dengan tipe Piezoelektrik sebagai tata laksana pasien batu ginjal non-invasif di RSUD Abdul Moeloek. Penelitian ini merupakan studi prospektif analitik yang dilakukan sejak bulan Maret hingga Agustus 2019. Data mengenai stone free rate, jumlah dan intesitas gelombang kejut, residual fragment, tindakan tambahan pasca ESWL, dan komplikasi pasca ESWL diperoleh dari catatan medik pasien untuk dilakukan penilaian. Terdapat 100 subjek penelitian yang memenuhi kriteria inklusi. Rerata usia subjek 49,5 ± 12 tahun, laki- laki sebanyak 57 orang (57%) dan perempuan sebanyak 43 orang (43%). Sebanyak 77% subjek berhasil mencapai complete stone clearance pada prosedur pertama ESWL, sedangkan lainnya memerlukan prosedur tambahan untuk mencapai complete stone clearance. Lokasi batu menjadi variabel yang paling signifikan dalam menentukan complete stone clearance dengan p < 0,05. Hasil terbaik didapatkan pada subjek dengan ukuran batu < 2 cm dengan lokasi batu selain kaliks inferior. Komplikasi yang terjadi pada subjek penelitian antara lain demam (2%), nyeri pinggang (6%), nyeri suprapubik (1%), steintrase (1%) sedangkan pada 91% subjek tidak terjadi komplikasi setelah tindakan ESWL. Berdasarkan hasil tersebut dapat disimpulkan bahwa tindakan ESWL memiliki efikasi yang baik dan komplikasi yang minimal. Kata Kunci: batu ginjal, efikasi, ESWL, stone free rate
Systematic Review: Hubungan Obesitas dengan Risiko Benign Prostat Hiperplasia Armadani, Melni; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.978

Abstract

Benign prostatic hyperplasia (BPH) is a non-malignant growth of prostate tissue. The incidence of BPH is influenced by various risk factors such as metabolic syndrome, obesity, and genetic predisposition. The prevalence of obesity in Indonesia with a male population over 18 years old was recorded at 26.60%. The research used a systematic review method. The databases used are NCBI and PUBMED with bulletions namely Benign prostate hyperplasia AND obesity, Benign prostate hyperplasia AND cholesterol, or Benign prostate hyperplasia AND body mass index. Obesity can trigger pro-inflammatory conditions, one of which is micro vascular disease which results in inflammation triggering ischemia and oxidative stress. Obesity can involve changes in the expression of genes such as A2M in the stroma and TFFB3 in the prostate gland and induce sIL-1ra levels.Obesity is associated with the risk of BPH through inflammatory response mechanisms from cellular and humoral microvascular inflammation, programmed cell death, gene expression and sIL-1ra levels.
Nutrional Management in Chronic Kidney Disease Patients: Manajemen Gizi pada Pasien Chronic Kidney Disease (CKD) Al Farisi, Ahmad Fathin; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.982

Abstract

Chronic Kidney Disease (CKD) is kidney function disorder for >3 months. CKD is also a concern because of its relatively high prevalence and is one of the most common causes of death in Indonesia. A number of treatments that can be carried out in CKD patients depend on the symptoms, comorbidities, and complications in the patient. Management of CKD patients can be medical, operative, to conservative. Assessment of nutritional status is also a concern in patients with CKD because it is not uncommon for a decrease in nutritional status to occur. CKD patients undergoing dialysis treatment are more prone to experience protein-energy wasting (PEW). There are a number of nutritional therapies that can be performed on CKD patients, namely a low-protein diet, regulation of energy intake, oral supplementation, and IPPN/IPAA
Manajemen Terapi Acute Kidney Injury (AKI) Suherman, Auriva Renasha; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.983

Abstract

Acute Kidney Injury (AKI) is a syndrome characterized by decreased urine production and increased serum creatinine. AKI is a complication in 10 to 15% of patients in hospital and the incidence of AKI in the Intensive Care Unit (ICU) is 20 to 50%. AKI has 3 stages and based on etiology it is divided into 3, namely pre-renal, renal, and post-renal. AKI can be a complication of disease and can cause complications up to end-stage kidney disease. Biomarkers of AKI are not only a guide in diagnosis, but also a guide in the management of AKI. Prevention and management of AKI needs to be carried out in patients. Several AKI treatments that can be carried out include the administration of isotonic crystalloid, Hydroxerthylstarch, vasopressors, diuretics, vasodilators, GF intervention, glycemic control, and nutritional support.
Diagnosis And Treatment of Testicular Torsion Hilmi, Tamadar; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.987

Abstract

Testicular torsion is an urgent medical condition that occurs when one or both testicles experience rotation or reversal in the scrotum, thereby disrupting blood flow to the testicles. Testicular torsion usually occurs in young male patients (<25 years). If this occurs it can cause rapid testicular ischemia. Furthermore, if ischemia is not treated immediately, it can threaten the safety of the testicles and affect men's reproduction and quality of life. This disease causes 10% to 15% of acute scrotal disease in children, and causes an orchiectomy rate of 42% in boys undergoing testicular torsion surgery. This article discusses testicular torsion, including definition, symptoms, diagnosis, and management. Testicular torsion is characterized by complaints of pain, swelling and/or tenderness in the scrotum, loss of cremaster reflex, Deming's sign and Angell's sign. Apart from that, we will also discuss early detection techniques for testicular torsion, such as physical examination and ultrasound, which are very important for diagnosing this condition quickly. Testicular viability decreases significantly 6 hours after the onset of symptoms therefore early diagnosis is key. Immediate treatment with manual detorsion or surgery is necessary to restore blood flow to the testicle affected by torsion. Delay in action can cause permanent damage to the testicular tissue. Since testicular torsion is a very time-sensitive diagnosis, it may also be subject to many medicolegal challenges.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEJADIAN DISFUNGSI EREKSI PADA PASIEN BENIGN PROSTAT HIPERPLASIA DI RS YUKUM MEDICAL CENTRE Kamalia, Avissa Medina; Hadibrata, Exsa; Susianti, Susianti; Sutyarso, Sutyarso
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1116

Abstract

Benign Prostate Hyperplasia (BPH) is the second most common urology’s disease in Indonesia. This disease occurs due to hyperplasia of stromal cells and epithelial cells of the prostate. The clinical manifestations of this disease consist of obstruction symptoms, irritation symptoms, and post void symptoms. People with BPH often complain about the decrease of their quality of life. One of the factor that Impaired to their quality of life is erectile dysfunction. This study aims to identify the factors that impact the incidence of erectile dysfunction in BPH patients at Yukum Medical Centre Hospital. There were 67 men with bph was obtained from Yukum Medical Centre Hospital in January-September 2021. Data were collected with International Index of Erectile Function-5 questionnaire and medical records. Data were analysis with chi-square test using SPSS and a p-value (<0,05 was considered significant). The result showed that 39 BPH patients had erectile dysfunction. Mean age of BPH patiens with erectile dysfunction was 66,74 (SD±6,51) and mean IIEF-5 scores of the BPH patients was 19,41 (SD±4,23). Age and prostate volume had significant impact with p-value 0,004 and 0,002 respectively. Treatment and medication didn’t have significant impact with p-value 0,193, and 0,856 respectively. Age and prostate volume have a significant impact on the incidence of erectile dysfunction in BPH patients. However, treatment and the type of medication doesn’t impact the risk of incident erectile dysfunction in BPH patients.
Co-Authors Ade Yonata, Ade Al Farisi, Ahmad Fathin Alfahri, Farhan Dzaki Armadani, Melni Atri Sri Ulandari Bayu Anggileo Pramesona Betta Kurniawan, Betta Daulay, Suryani A. Dwiputri, Maliya Finda Endah Setyaningrum, Endah Fadli, Muhammada Yogi FAUZAN ABDILLAH Fauzi Ahmad Muda Febrianta, Muhammad Kaisar Firdaus, Purna Fredison, Fredison H R Danarto Happy, Terza A Hasbullah, Faza Hendri Busman Hilmi, Tamadar Ikhsan, Muhammad Al Indri Windarti Intanri Kurniati Isvari, Gusti Ayu Made Prathita Iswandi Darwis Jausal, Anisa Nuraisa Kamalia, Avissa Medina Larasati, Ratri M. Lusina, Septia Eva Mayasari, Diana Muhammad Maulana Nadifa, Shallu Afdha Oktadoni Saputra, Oktadoni Priyono, Angga Hendro Rahmayani, Fidha Ramdini, Dwi Aulia Rasyid, M. Fauzan Abdillah Risal Wintoko Risti Graharti Rizki Hanriko Rudiyanto, Waluyo Siregar, Bintang Abdi Suharmanto Suherman, Auriva Renasha Susianti Susianti Susianti Sutyarso Sutyarso Sutyarso Talin, Jinan Naura Tjahjo, Mars Dwi Trisula Utomo Ulya, M. Ridho Ulya, Ridho Untung Tranggono, Untung War, Muhammad Fitra Wardhana, Muhammad Fitra Widia, Chyci Wiwi Febriani Yunianto, Andi Eka Yuningrum, Hesti Yusmaidi, Yusmaidi