Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
Website

Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

22 23 24 25 26

The performance of derivate FTIR spectrophotometry method compared to colorimetry for tranexamic acid tablet content determination Nugrahani, Ilma; Aulia, Winni Nur
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Recently, FTIR reported has been established as a direct content determination for some tablet dosage forms. In the method, infrared transmittance spectra was converted into the derivated absorbance form. In this present research, the methodâs performance was investigated to quantified tranexamic acid in its tablet dosage form directly. The result then was compared to the colorimetry, which has been developed by another researcher. Correlations between the two methods were analyzed using t-test. The good linearity was shown at concentration range of 0.5 - 1.75% w/w at the wave number of NH group. Furthermore, the recovery, intra- and inter-day precision also fulfilled the validation requirement. Meanwhile, LOD and LOQ of the method were 0.0531%w/w and 0.1770%w/w. These methods were compared with colorimetry has been established before. Afterwards, the t-test proved no significant difference of content determination yielded, between these two methods. In conclusion, FTIR can be used for quantify the content of tranexamic tablet, more accurately than colorimetry, which has been developed before. Moreover, FTIR method also has advantages such as easier, simpler, faster and cheaper than the colorimetry method.Â Â

Aktivitas imunostimulan ekstrak bawang putih tunggal pada mencit yang diinduksi Escherichia coli Agnesa, Oki Sandra; Susilo, Herawati; Lestari, Sri Rahayu
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRAKÂ Bawang putih tunggal telah banyak digunakan masyarakat sebagai obat tradisional salah satunya untuk meningkatkan stamina. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak bawang putih tunggal sebagai imunostimulan melalui pengujian aktivitas dan kapasitas fagositosis makrofag serta berat limpa mencit (Mus musculus) yang diinduksi dengan bakteri Escherichia coli. Mencit jantan (Balb-C, umur 12 minggu, BB 20 Â± 5 g) diberi ekstrak bawang putih tunggal selama 28 hari berturut-turut dengan dosis ekstrak bawang putih tunggal N 0%, P1 0,25%, P2 0,5%, P3 1%, dan P4 2%. Pada hari ke 29, mencit diinduksi dengan bakteri E.coli yang diberikan secara intraperitoneal (1 ml, 1,5 x 105 cfu/ml). Aktivitas fagositosis makrofag dihitung dari sediaan apusan cairan peritoneum. Ekstrak bawang putih tunggal meningkatkan jumlah dan kapasitas makrofag aktif secara nyata pada perlakuan P2, P3, dan P4 (p=0,000;Î±=0,05) dengan berat limpa yang berbeda secara signifikan (p=0,000;Î±=0,05). Hasil penelitian menunjukkan semakin tinggi ekstrak bawang putih tunggal yang diberikan maka semakin tinggi pula aktivitas dan kapasitas fagositosis makrofagnya dengan berat limpa yang semakin kecil.Â Kata kunci: bawang putih tunggal, fagositosis makrofag, imunostimulan.Â ABSTRACT Single garlic has been used as traditional medicine for increasing stamina. This research aim to knew the effect of single garlic as immunostimulant through activity and capacity fagocyte of macrophag test and mice weight spleen that induced by E.coli. Male mice (Balb-C, 12 weeks old, weight 20 Â± 5 g) has been given sigle garlic extract for 28th days with various dosage (N 0%, P1 0,25%, P2 0,5%, P3 1%, and P4 2%). on day 29, mice ware induced by E.coli through intraperitoneal injection (1 ml, 1,5 x 105 cfu/ml). Fagocyte activity of macrophag counting by peritoneum liquid smear. Single garlic extract increase amount and capacity active macrophage in P2, P3, and P4 (p=0,000;Î±=0,05) with significant various spleen weight (p=0,000;Î±=0,05). The result show that the higher sigle garlic extract can make higer activity and capacity fagocyte of macrophag with lower spleen weight.Â Keywords: single garlic, macrophag, immunostimulant.

Formulation and physical stability test of oleanolic acid cream and gel Kartini, Kartini; Fitriani, Endang Wahyu; Tansridjata, Laurances
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Plantago major has been empirically used for wound healing. One of its chemical compounds, oleanolic acid, exhibited wound healing activity on hyperglycemic rats. The aims of this study were to (1) formulate oleanolic acid into topical dosage forms i.e. cream and gel; and (2) evaluate the physical stability of the products. Oleanolic acid was formulated into the dosage forms using stearic acid, isopropyl palmitate and cetyl alcohol as the cream base and carbomer as the gel base. Cream and gel were then subjected into accelerated (40Â±2Â°C/75Â±5% RH) and room temperature (27Â±2Â°C/73Â±5% RH) stability test for six weeks. Physical stability was determined using parameters of visual appearance, specific gravity, viscosity and flow properties, for both gel and cream, as well as the type of emulsion and particle size for the cream. Data analysis were performed using one-way ANOVA and paired t-test. It is concluded that gel and cream of oleanolic acid were able to maintain their visual appearance, specific gravity, viscosity and flow properties during six weeks of storage. In addition, oleanolic acid cream could also maintain its particle size and type of emulsion during testing.Â

Antiobesity and antihypercholesterolemic effects of white tea (Camellia sinensis) infusion on high-fat diet induced obese rats Shiyan, Shaum; Herlina, Herlina; Bella, Annisa Mutiara
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Obesity may cause the lipid metabolisms disorder so that a risk factor for hypercholesterolemic. Catechin and epigallocatechin gallate in white tea potentially inhibit lipase activity. Caffeine compounds and catechin derivatives have a role as antihypercholesterolemic. The objective of this study was to explore antiobesity and antihypercholesterolemic activity from white tea infusions to lipase and total cholesterol in rats model fed a high-fat-diet. Twenty-five rats were divided into five groups. Negative control group was administered with distilled water. The positive control group was administered with orlistat dose 14.2 mg/kgBW. Group 3rd, 4th, and 5th were treated with white tea infussion doses of 125, 250 and 500 mg/kgBW/day, respectivelly. period and feed intake was calculated daily during the treatment. White tea doses of 500 mg/kgBW decrease the total cholesterol by 37.16Â±11 mg/dL, lipase level of 23.70Â±0.64 U/L, weight up to 3.53Â±1.21 g/day and decrease feed intake by 12.71Â±1.76 g/day. The infusion of white tea can decrease total cholesterol level, lipase level, body weight and feed intake. This study concluded that infusion of white tea has antiobesity and antihypercholesterolemic effect on rats fed high-fat-diet.

Screening of Antiradical Activity From Some Central Sulawesi Mangroves Dewanto, Didit Kustantio; Tanod, Wendy Alexander; Finarti, Finarti; Renol, Renol
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antiradicals are substances with important functions for human health. Mangrove leaves are one of potential sources of natural antiradical. The objective of this research was to identify the type and fraction of mangrove leaves extract with the highest antiradical activity. The research procedure included sampling and extraction of mangrove leaves, assay of antiradical activity (DPPH), phytochemical assay and determination of IC50 for the fraction with the highest inhibition percentage. Mangrove leave samples (Rhizophora sp., Avicennia sp. and Sonneratia sp.) used in this study were collected from the Palu Bay coastal. Results showed the highest yield of extracts was from Rhizophora sp., followed by Avicennia sp. and Sonneratia sp. Inhibition percentage was higher from dried compared to fresh mangrove leaves. Additionally, the inhibition percentages of the ethanol fraction was higher than that of the ethyl acetate and n-hexane fractions, while Sonneratia sp. gave a higher inhibition percentage than Avicennia sp. and Rhizophora sp. The ethanol fraction IC50 was determined for

Antioxidant activity of methanolic extract from yellow paprika (Capsicum annuum, L.) by DPPH radical scavenging method Warsi, Warsi; Guntarti, Any
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Yellow paprika (Capsicum annuumL.) is one of fruit that contains of carotenoid compounds as an antioxidant. This reasearch was aimed to know an antioxidant capacity of methanolic extract from yellow paprika with 2,2âdiphenylâ1âpicrylhydrazyl (DPPH) radical scavenging method. The fresh yellow paprika was determined of its loss of drying by gravimetric. The yellow paprika extract was obtained by maceration using methanol as solvent. The content of Î²âcarotene from this extract was analyzed qualitively by thin layer chromatography and UV-Vis spectrophotometer. The antioxidant activity of methanolic extract from yellow paprika was determined base on measurement of residual DPPH by UVâVis spectrophothometric at wavelength of 515.6 nm. The data was used to calculate % inhibition. Furthermore, IC50 value was determined to know potency of its antioxidant. The result of loss of drying yellow paprika fruit was obtained 6.33 Â± 0.02 %. The analysis with thin layer chromatography and UV-Vis spectrophotometer showed that this fruit was contain of Î²âcarotene. The result of antioxidant activity analysis from yellow paprika fruit was obtained IC50 value of 0.3028 Â± 0.0093 mg/mL. The result of the research showed that the antioxidant potency of yellow paprika was less than Î²âcarotene (IC50 0.0852 Â± 0.0009 mg/mL).

Cytotoxic effect of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b] furan-4,5-dione compound from the bark of faloak (Sterculia quadrifida R.Br) in breast cancer cells T47D Rollando, Rollando; Alfanaar, Rokiy
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara for drug plant. The information of the active compound contained in the faloak bark yet specifically published. This study aims to determine the active compound contained in the faloak bark that have cytotoxic activity to T47D breast cancer cells. Extraction process using maceration method, isolation process using gradien isolation method, elusidation using combination of information of IR spectra, 1D-NMR, 2D-NMR and LC-MS, and cytotoxic activity test on T47D breast cancer cells using MTT method. The isolation result obtained that isolate of naphthoquinone derivative compound is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione with IC50 value on T47D breast cancer cell was 9,88 Âµg/mL and with an index selectivity value was 30,23.Â

In vitro penetration of alpha arbutin niosome span 60 system in gel preparation Desnita, Rise; Luliana, Sri; Anggraini, Silvana
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Alpha arbutin is a hydrophilic compound which is difficult to pass trough the stratum corneum. One of the effort to increase the penetration of the drug through the stratum corneum is by making in niosome system. This study aims to determine the optimum concentration of span 60 to improve the entrapment efficiency of niosome and investigate the increasing penetration of alpha arbutin using the niosome system in the preparation of the gel in vitro. Niosome consist a mixture of span 60 and cholesterol it made by thin layer hydration method. Concentration of span 60 was varied into three formulas were 100, 150 and 200 ÂµmoL. The formulation of gel was made in two formulas including formulation of niosome alpha arbutin and alpha arbutin in gel. The determination of enterapment efficiency showed that formula 100Âµmol has an optimum enterapment efficiency by 99.09%Â±0.1. The in vitro penetration tests with shed snake skin membrane showed that usage span 60 as a niosome composer could increase penetration of alpha arbutin in gel formulation with cumulative numbers of diffusion in 8 hours was 91.62%Â±2.32 compared to alpha arbutin in gel without niosome system about 73.00%Â±0.94.7.

Chemometrics-assisted spectrophotometry for simultaneous determination of sodium benzoate and citric acid in beverage products Rahardian, Ganjar Wahyu; Monica, Sausa; Wasito, Hendri; Susilowati, Sri Sutji
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The development and validation of chemometrics-assisted spectrophotometry have been successfully performed for determination of sodium benzoate and citric acid that have overlapping of ultra violet absorption spectra. The study aimed to develop, validate, and apply spectrophotometric method with chemometrics approach for determination of both compounds in beverage products simultaneously. The analytical method was performed by making a calibration model using 16 training sets and 10 test sets of mixed solution followed by absorbance measurenment at wavelength of 190 nm up to 400 nm. In addition, the absorbance data was processed by multivariate calibration models of principal component regression (PCR) and partial least square-1 (PLS-1) and validated internally and externally to obtain optimum model. Validation of analytical methods was done by evaluating some parameters such as linearity and ranges, accuracy, precision, detection limits and quantification limits. The results showed that the optimum wavelength was 235 nm to 250 nm for sodium benzoate and 220 nm to 240 nm for citric acid with the selected optimum principal components (PCs) value were 6 (PCR) and 4 (PLS-1) for sodium benzoate and PCs 2 (PCR and PLS-1) for citric acid. The parameters of the analytical method validation developed were suitable and the analytical methods could be applied for the determination of the sodium benzoate and citric acid contents simultaneously in the beverage products.Â

Effectiveness of banana leaves extract (Musa paradisiaca L.) for wound healing Putra, Dimas Ariandi Candra; Lutfiyati, Heni; Pribadi, Prasojo
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Banana leaves (Musa Paradisiaca, L.) has not been widely used in the treatment purpose of this study was to examine the wound healing activity of the gel of banana leaves (Musa paradiasiaca L.) and determine the most effective concentration for wound healing.Target research is to provide natural wound treatment alternatives. The method used is eksperimental.Prosedur research study began with the identification of a banana leaf, banana leaf extraction, formulation of banana leaf extract gel with a concentration of 1%, 5%, 10% and testing to the test animals were harmed .Animal test are grouped into 5 groups the negative control group (base gel), a positive control (bioplacenton), and 3 groups treatment. Measuring ofÂ diameter wound on day-1 through day 7. The observation was tested by using ANOVA and Post Hoc Tukey HSD. ANOVA test results showed a significant difference between the mean percentage of wound healing all groups Treatment .The result ofÂ Post hoc Tukey HSD at the 95% confidence level showed significant differences in the negative control group when compared to the positive control group and the treatment group gel 5% and 10% .It indicates that the positive control, gel 5% and 10% have a wound healing effect. Positive control group compared with the group treated gel 5% and 10% showed significant differences that the average value of the percentage of wound healing is higher than the positive control treatment group. It means the difference meant that the positive control has better activity. While the group gel 5% when compared with the 10% gel group no significant difference in this case means the group gel 5% with 10% having a comparable effectiveness of wound healing.

Page 24 of 81 | Total Record : 808

22 23 24 25 26

Filter by Year

2011 2025

Filter By Issues

All Issue Vol. 15 No. 3 (2025): Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana Vol 14, No 1 (2024): Pharmaciana Vol 13, No 3 (2023): Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana Vol 13, No 2 (2023): Pharmaciana Vol 13, No 1 (2023): Pharmaciana Vol 12, No 3 (2022): Pharmaciana Vol 12, No 2 (2022): Pharmaciana Vol 12, No 1 (2022): Pharmaciana Vol 11, No 3 (2021): Pharmaciana Vol 11, No 2 (2021): Pharmaciana Vol 11, No 1 (2021): Pharmaciana Vol 10, No 3 (2020): Pharmaciana Vol 10, No 2 (2020): Pharmaciana Vol 10, No 1 (2020): Pharmaciana Vol 9, No 2 (2019): Pharmaciana Vol 9, No 1 (2019): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5 No 1, 2015 Vol 5, No 2 (2015): Pharmaciana Vol 5, No 2 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol. 4 No. 2 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 1: Mei 2013 Vol 3, No 1 (2013): Pharmaciana Vol 3, No 1 (2013): Pharmaciana Vol 2, No 2 (2012): Pharmaciana Vol 2, No 2: November 2012 Vol 2, No 2 (2012): Pharmaciana Vol 2, No 1 (2012): Pharmaciana Vol 2, No 1: Mei 2012 Vol 2, No 1 (2012): Pharmaciana Vol 1, No 2: November 2011 Vol 1, No 2 (2011): Pharmaciana Vol 1, No 2 (2011): Pharmaciana Vol 1, No 1 (2011): Pharmaciana Vol 1, No 1 (2011): Pharmaciana Vol 1, No 1: Mei 2011 More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

Phone -

Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA