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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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In silico toxicity prediction of 1-phenyl-1-(quinazolin-4-yl) ethanol compounds by using Toxtree, pkCSM and preADMET Yeni, Yeni; Supandi, Supandi; Merdekawati, Fajar
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The 1-phenyl-1-(quinazolin-4-yl) ethanol compounds are alkaloids of quinozoline class found in many Hydrangeaceae families. A survey revealed that most of the identified quinazolin derivatives have anticancer activity. Toxicity prediction of 1-phenyl-1-(quinazolin-4-yl) ethanols were performed to obtain the best three compounds with high activity and the lowest toxicity. Toxicity prediction was conducted using Toxtree, pkCSM and PreADMET. 2D structure of compounds were formed using ChemDraw. The decision tree approach was used in Toxtree application with endpoints including Cramer rules, Kroes TTC, carcinogenicity (genotoxic and non genotoxic) and in vitro mutagenicity. Graph based signature was used in pkCSM application with endpoints including mutagenicity, maximum daily dose, LD50 and hepatotoxicity. In PreADMET application, a method based on drugs similarity and ADMET properties was used with endpoints including mutagenicity, carcinogenicity to rat and mice. The results of data analysis showed that the best three anticancer compounds that have high activity and the lowest toxicity are compounds 14, 16 and 19.

The physical properties and stability of purple yam (Ipomoea batatas (L.) Lam ) lipstick susmiatun, susmiatun; kusuma, Anjar mahardian; Budiman, Arif; Hapsari, Indri
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ubi jalar ungu memiliki antosianin yang bermanfaat sebagai pewarna alami yang lebih aman dari pewarna sintesis. Antosianin mempunyai daya antioksidan yang dapat menangkap radikal bebas. Tujuan dari penelitian ini adalah untuk menilai pengaruh penggunaan konsentrasi ekstrak ubi ungu terhadap sifat fisik dan stabilitas fisik lipstik.. Lipstik dibuat dalam 3 macam formula yaitu L01, L02, L03. Untuk evaluasi kualitas produk tersebut maka dilakukan uji sifat fisik dan uji stabilitas terhadap lipstik ubi ungu. Uji sifat fisik terdiri atas uji organoleptik, uji titik leleh, uji kekerasan, uji homogenitas, uji daya oles, uji pH lipstik dan pengujian stabilitas lipstik dilakukan dengan menyimpan lipstik selama 30 hari dalam suhu ruang 25Â°C kemudian dilakukan pengamatan terhadap adanya perubahan bentuk, warna dan aroma selama penyimpanan. Sebagai pembanding digunakanÂ lipstick top leader market di Indonesia yaitu merk âWâ. Data pengamatan titik leleh, kekuatan dan pH lipstik dianalisis dengan menggunakan One Way Anova dan dilanjutkan dengan Turkey serta data organoleptik, homogenitas, daya oles dan stabilitas lipstik dijelaskan secara deskriptif. Hasil penelitian menunjukan tidak ada perbedaan bermakna antara lipstik L01, L02, L03 pada organoleptik lipstik, titik leleh, kekerasan lipstik, homogenitas, daya oles lipstik, pH serta stabilitas fisik lipstik. Â Namun apabila dibandingkan dengan lipstik merk âWâ terdapat perbedaan bermakna pada titik leleh, kekerasan dan daya oles antara lipstik L01, L02, L03 dengan lipstik merk âWâ. Kesimpulannya penggunaan ekstrak ubi ungu dengan bermacam konsentrasi tidak berpengaruh terhadap sifat fisik lipstik ubi ungu dan stabilitas lipstik ubi ungu yang dihasilkan.Â Kata kunci : Lipstik, Ubi ungu, Sifat fisik, StabilitasÂ

Anti Inflammatory And Anti Bacterial Activity Of Sumbawa Oil Sugara, Taufan Hari; Nurbaety, Baiq
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.8010

Sumbawa oil is a traditional ingredient that known as local wisdom of the island society of Sumbawa. It is believed to treat wounds, sprains, rheumatism, thrush and toothache. This study aims to determine the the effectiveness of anti-inflammatory and antibacterial activity of sumbawa oil products based on the types of raw materials and its phytochemical compounds. There are 3 stages in this research, consists of collecting various trademark of sumbawa oil product, determining type of raw material and analysis of phytochemical compound, followed by pharmacological activity test (Anti-inflammatory and antibacterial). Anti-inflammatory test was performed by observing the decrease of percentage inflammation of 21 white rats in 7 groups of egg white injection treatment. Antibacterial test using TSA method by observing the inhibition zone against S. aureus and E. coli bacteria. The results showed that Sumbawa oil products are known to contain secondary metabolite compounds of saponins, Triterpenoids, steroids and Flavonoids. All samples of Sumbawa oil products showed anti-inflammatory activity based on a decrease in the percentage of inflammation in the white rats leg for 6 hours of observation. Sumbawa oil also shows antibacterial activity in the strong category and has a wide spectrum because it can inhibit the growth of gram positive and negative bacteria each of 11,83-14,67 mm and 10,67-12,33 mm.Â This study concluded that Sumbawa oil was shown to have antiinflamatory and antibacterial activity even though its value was still lower than standard drug.

Neuropharmacological Activity of Nut Grass (Cyperus Rotundus L.) Rhizome Fraction Dwita, Lusi Putri; Dewanti, Ema; Ladeska, Vera; Sediarso, Sediarso; Muntashir, Adnan; Safni, Ulfa; Sari, Rahma Wulan
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Research in the area of herbal neuropharmacological effects has increased markedly over the past decades. This research was aimed to further investigate neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring hypnotic-siccative and anticonvulsant activities. The exploratory behavior test was performed using Hole Board method while motor coordination was assessed using Rotarod Test. The result showed that the 70% ethanol fraction of Cyperus rotundus rhizome in has significant (p <0,05) neuropharmacological activities. All three fractions tested (ethanol, ethyl acetate, and n-hexane), the ethanol fraction showed the best hypnotic-sedative and anticonvulsant activities. Ethanol Cyperus rotundus rhizome fraction could decrease the duration of HLE equal to sodium valproate and potentiated the phenobarbital-induced sleep by decreasing the onset and prolonging the duration of sleep. The highest dose of 70% ethanol fraction of Cyperus rotundus rhizome (356.7 mg/kg) showed the best anxiolytic activity comparable to diazepam (p> 0.05). In conclusion, Teki ladang (Cyperus rotundus) rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetics drugs.Â

Isolation, identification, phytochemical screening, and antibacterial activity of Aspergillus sp. MFD-01, an endophytic fungus derived from Mesua ferrea Hartanti, Dwi; Andestia Sinaga, Risda Yunita; Djalil, Asmiyenti Djaliasrin; Wahyuningrum, Retno
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

We have successfully isolated and identified endophytic fungi from medicinal plant Mesua ferrea L. grown at Banyumas were for the first time. One of those fungi was MFD-01. In this study, we report the isolation, identification, antibacterial activity, and phytochemical screening of Aspergillus sp. MFD-01. The endophytic fungus was isolated from the leaves of M. ferrea by subsequent inoculation on potato dextrose agar (PDA). The identification was based on its morphology and ITS-DNA sequence. The antibacterial activity was determined by dilution method. The identification of compounds in ethyl acetate extract of it was conducted according to the standart phytochemical screening method. MFD-01 was identified as Aspergillus sp. MFD-01. The ethyl acetate extract of Aspergillus sp. MFD-01 inhibited the growth of both Staphylococcus aureus, and Escherichia coli. At concentration of 1000 ppm, its diameter of inhibitory zone against those bacteria was 10.53 and 11.84, respectively. The extract contained flavonoids, alkaloids, saponins, terpenoids, and tannins, which might responsible for its antibacterial activity against both tested bacteria.

The validation of patient knowledge questionnaire for patients with diabetes mellitus and hyperlipidemia Saputri, Ginanjar Zukhruf; Dania, Haafizah; Faridah, Imaniar Noor; A, Faiza Chusnuni
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Prevalence of Diabetes Mellitus (DM) with Hyperlipidemia increased in Indonesia, where both diseases have a risk of complications towards cardiovascular disease. DM patients with hyperlipidemia require proper management to control blood sugar, total cholesterol and LDL cholesterol. Knowledge is one of the important factors in improving adherence therapy and quality of life of DM-hyperlipidemia patients, especially in controlling blood glucose level and total cholesterol levels. This study aims to develop a patient questionnaire of DM-hyperlipidemia.The study used cross sectional method. Inclusion criteria were patients aged 18 â 70 years old, diagnosed DM-Hyperlipidemia, getting at least 1 oral antidiabetic and oral anti-cholesterol. The questionnaire item of knowledge was developed based on gudeline therapy and previous research reference. Expert validation is done on Doctor who had expert in DM and clinical psychologist. The pilot test was performed on 10 healthy patients and 10 patients of DM-hyperlipidemia who had eligible inclusion criteria. Validation of questionnaire was done on 30 patients of DM-Hyperlipidemia who undergoing therapy at outpatient clinic of PKU Muhammadiyah Hospital Yogyakarta. Data collection was done by interviewing questionnaires in patients. Analysis of data using SPSS with product moment validation test and cronbach alpha to see the reliability of questionnaire.Validation results show there are some invalid items that are in questions 9, 11, 12, 15, 16 and 17, the range of questions about knowledge about hyperlipidemia, medication and general health. Re-validation without invalid item was done and obtained value r> 0.3, with value of Cronbach alpha 0,715.The DM-Hyperlipidemia patient questionnaire was valid and reliable to measure the level of knowledge of DM patients with Dysipidemia.Â Â

Antifertility activities of srikaya leaves (Annona squamosa L.) ethanol extract against reproduction system : spermatogenesis and quality sperm study Hidayati, Nur Laili Dwi; Nopianti, Tita; Dewi, Yuliana; Suryani, Yani
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Has done research about antifertility activities of Srikaya leaves (Annona squamosa L.) ethanol extracts against reproduction system. There are classified into 4 groups: negative control (suspension PGA 1%), I dose (0.00448 g/200 g BW rat), II dose (0.00967 mg/200 g BW rat), and III dose (0.01934 mg/200 g BW rat). Administration of the test preparation is done orally for 48 days. Parameters observed were spermatogenesis and quality of sperm. Spermatogenesis parameters measured were testis index (%), seminiferous tubule diameter (Âµm), the number of spermatogonia and spermatocytes cells. Spermatozoa quality parameters measured were sperm motility, concentration, and morphology. Study parameters were statistically analyzed using ANOVA. The results showed that ethanol extract of Srikaya leaves can lower the index of the testis and seminiferous tubule diameter, decrease the number of spermatogonia and spermatocytes cells significantly. The ethanol extract of Srikaya leaves can reduce sperm motility, concentration, and increasing abnormality significantly.

In silico study of the active compounds in bitter melon (Momordica charantia L) as antidiabetic medication Ruswanto, Ruswanto; Mardianingrum, Richa; Lestari, Tresna; Nofianti, Tita; Tuslinah, Lilis; Nurmalik, Dudi
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antidiabetic are many drugs available in the market, but most medications have side effects that are relatively high and cause toxicity, so it needs tobe develoved search of new drug compounds were more potent drugs with side effects as low. Various research have shown that bitter melon (Momordica charantia L) has an effect antidiabetic. But it is not known specifically as antidiabetic compounds that act on bitter melon (Momordica charantia L). This study was conducted to predict the active compounds of bitter melon (Momordica charantia L)potent as antidiabetic in silico, through the molecular docking, Drug scan, PreADMET and molecular dinamics simulation. The results of the 26 active compound bitter melon (Momordica charantia L) obtained one potential compounds that are active against nuclear reseptor RORÎ± that is goyaglikosida-h and more potent than Rosiglitazon

Antibacterial activity of dialkyl-aginate biosurfactant cream againts Staphylococcus aureus an Pseudomonas aerugynosa Kintoko, Kintoko; Sugihartini, Nining; Rukaya, Benazir Evita
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Dialkyl-alginate biosurfactant is an amphifilik rhamnolipid biosurfactant that has the potential to be developed into an antibacterial agent. The purpose of this study was to prove that the biosurfactant of dialkyl alginate both before and after creams has antibacterial activity especially against Staphylococcus aureus and Pseudomonas aeruginosa. Test of antibacterial activity of biosurfactant dialkyl alginate at concentrations of 5%, 10% and 20% to Staphylococcus aureus and Pseudomonas aeruginosa using Hammond, et al (2011) modified quantitative method. EnbaticÂ® 1% is used as a positive control and sterile aquadest as a negative control. Determination of antibacterial activity of dialkyl alginate biosurfactant followed by analysis of leakage of protein and nucleic acids using UV-vis Spectrophotometry and leakage of Ca2 + and K + metal ions using Atomic Absorption Spetrophotometry (AAS). The most active concentration was formulated into cream and then performed physical evaluation (organoleptic, pH, adhesion, spreading and viscosity) and tested antibacterial activity using the well method. The test results showed that the biosurfactants of dialkyl-alginate before and after the cream was treated as antibacterial activity. The concentration of 10% was the most active concentration having activity which did not differ significantly to positive control with p value of 0,05

Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation Desnita, Rise; Luliana, Sri; kasim, zainab
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Niacinamide is one of the components of cosmeceutical products that reported to have skin benefits for the treatment of skin pigmentation, acne and wrinkles. However, the dermal penetration of niacinamide is poor. The carrier system which can be selected to carry the compound through the stratum corneum layer is the niosome system using span 60. This study was aimed to determine the concentration of span 60 that can trap niacinamide optimally and the ability of niosome system span 60 to increase in vitro penetration of niacinamide in gel formulation. The different formulations of nicotinamide niosome were formulated with variance concentrations of Span 60, that is, formula A 100 Î¼mol, formula B 150 Î¼mol, and formula C 200 Î¼mol. The entrapment efficiency testing was conducted using dialysis membrane. The gel formulation was prepared in two formulas, niacinamide niosome gel and niacinamide gel (without niosomes) and tested diffusion using Franz diffusion cell flow-through type. The result show that Formula A provides the most optimum entrapment efficiency of 99.03Â±0.026%. The results of the in vitro skin penetration studies for 8 hours indicate that the niosomal formulation using Span 60 could increase skin penetration with the percent cumulative amount of niacinamide niosomes was 82.87Â±1.6932% compared to niacinamide in gel without noisome system about 70.27Â±5,3212%.

Page 26 of 81 | Total Record : 808

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA