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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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FORMULASI GEL EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) DENGAN VARIASI GELLING AGENT SEBAGAI SEDIAAN LUKA BAKAR Lena Maulina; Nining Sugihartini
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Pericarp of mangosteen is waste that has been shown have efficacy as an anti-inflammatory and accelerate the proliferation of fibroblasts. Therefore Â it need to be formulated in the form of gel to make easy in the use of preparation. It is needed an appropriate gelling agent to produce the good character of gel. This research aimed to know the type of the gelling agent who has the physical properties gel and the activity of the best treat burns. There are three gel formula designed with various Â type ofÂ the gelling agent i.e. FI (the gelling agent carbopol); FII (the gelling agent CMC na); FIII (the gelling agent tragacanth). The obtained gels were tested organoleptic, of homogeneity, pH, spreadibility, adhesivity, consistency and the effect of healing burns in nine groups. The collected data were analyzed statistically using SPSS version 16 with kolmogorov-smirnov and continued one way ANOVA or Â Kruskal-Wallis, with level of trust 95 %. The results show that all formula mixed homogeneous gel. Formula I have a pH 3,5 while formula II and III having a ph 5 (p < 0,05). The greater spreadibility given by formula III (p < 0,05) and the longest time of adhesivity given by formula II (p < 0,05). The best activity of wound healing given by formula I (p > 0,05). Based on the result show that type of gelling agent can influence the physical properties and activity in the treating burns. Type of gelling agent that show the best physical properties is CMC Na.

VALIDASI ST EUROPEAN QUALITY OF LIFE-5 DIMENSIONS (EQ-5D) VERSI INDONESIA PADA PASIEN HIPERTENSI DI PUSKESMAS KOTAGEDE II YOGYAKARTA Andriana Sari; Nidia Yuni Lestari; Dyah Aryani Perwitasari
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hypertension is a major risk factor for the occurrence of deaths from non-communicable diseases in the world. In the World Health Statistics 2012, WHO reported that approximately 51% of deaths from stroke and 45% of coronary heart disease due to hypertension. Patients with obsesitas, hypertension, and diabetes can worsen patientâ€™s quality of life both physically and mental status. This study aims to assess the quality of life by the European Quality of Life-5 Dimensions (EQ-5D) questionnaire. This study aims to determine the validity and reliability of the EQ-5D in Indonesian version as an instrument for measuring the quality of life of patients with hypertension in the Health Center Kotagede II Yogyakarta. The method of this study was descriptive observational. Data were collected using a questionnaire conducted at a particular time. The instrument used in this study is the EQ-5D which has been translated into Indonesian. Affordable population in this study were all patients with hypertension in Health Center Kotagede II Yogyakarta at May to June 2014. The sample in this study are in accordance with the criteria for inclusion and exclusion criteria. Analysis of the validity was construct's validity with Pearson method. Test reliability was Cronbach's alpha coefficient. From the data analysis for 51 patients Hypertension Pearson correlation coefficient obtained results are above 0.30, so it can be concluded instrument EQ-5D questionnaire Indonesian version is valid. Results Cornbach'sÎ± is 0718 so it can be concluded instrument EQ-5D questionnaire Indonesian version is reliable.

Formulation of orodispersible atenolol-Î²-cyclodextrin tablets with co-processed crospovidone-croscarmellose sodium and poloxamer 188 Karina Citra Rani; Nani Parfati; Linda Yosanti; I Gusti Ayu Yulivia Rosa Indah
Pharmaciana Vol 9, No 2 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The use of conventional tablets in geriatric patients is currently limited because of a decrease in their physiological functions, such as tremor and difficulty of swallowing pills, which lowers their compliance with drug therapy. Hypertension, one of the degenerative diseases suffered by geriatric patients, is treatable with atenolol tablets or capsules that are less soluble in water or, in other words, has a poor dissolution. This research attempted to improve the dissolution of atenolol by formulating it into orodispersible tablets (ODTs), and as such, the disintegration time was modified by adding co-processed crospovidone-croscarmellose sodium in 1:1 ratio. Moreover, PoloxamerÂ® 188 was added to the formulation of atenolol-Î²-cyclodextrin inclusion complex. The post-compression test revealed that ODTs disintegrated quickly within 36.67Â±1.21 seconds (<60 seconds) and had physical characteristics that met the pharmaceutical requirements. The amount of atenolol dissolved within 30 minutes in the dissolution study was 84.39% (%Q30 minutes). The results of the accelerated stability study (at 40 Â°C and RH 75Â±5 %) for two weeks proved that the physical and chemical characteristics of the produced orodispersible atenolol tablets were stable.

UJI ANTIOKSIDAN EKSTRAK ETANOL DAUN DAN KULIT BATANG MANGGIS Garcinia mangostana L. Diniatik Diniatik; Suparman Suparman; Dewi Anggraeni; Ibnu Amar
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antioxidant was a compound which possessed an activity as scavenger of free radicals. This study was aimed to examine the antioxidant activity of ethanolic extract from leaves and skin barks of Garcinia mangostana. Antioxidant activity were evaluated by using DPPH method for ethanolic extract in serial concentration of 800, 400, 200 and 100ug/mL. The result found that ethanolic extract of leaves and skin barks of Garcinia mangostana showed antioxidant activity with IC50 value of 674.947 ug/mL and 565.759 ug/ml, they were eleven and ten times weaker than d-Î±-tocopherol (IC50 57,114 ug/mL) which were used as a control. In conclusion, EE from leaves and skin barks of Garcinia mangostana exhibited an activity as scavenger of free radicals from DPPH.

ANALISIS KEPUASAN MAHASISWA TERHADAP KUALITAS PELAYANAN TENAGA ADMINISTRATIF DI FAKULTAS FARMASI UNIVERSITAS AHMAD DAHLAN YOGYAKARTA Ana Hidayati; Achmad Fudholi; Sumarni Sumarni
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Student satisfaction measurement has been done with populatif observation and data collectedprospectively at the fourth level students of the Faculty of Pharmacy Ahmad Dahlan University. Thepurpose this study to describe and determine student satisfaction ratings gap that arises from servqual.The results obtained indicate generally that the service element in the Faculty of Pharmacy is namelyemployees has not given in accordance with the expectations of student performance is characterizedby a range of values of each gap there is nothing close to the ideal of zero (0). Gap values ofemployees in the education ministry on Tangible dimensions with a gap value -0,90, Reliability withthe gap value -0,90, Assurance gap value -0,90, Empathy with the gap value -1,10 andResponsiveness to the value gap -1,10 . While the reliability of the employee dimension into the first rank and dimensions of responsiveness on the faculty is considered the most excellent service tostudents.

Karakteristik kasus pada Visum et Repertum di RSUP dr. Soeradji Tirtonegoro Klaten 2014-2016 idha arfianti wiraagni; Edy Widihartono
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Since the opening of forensic services at RSUP dr. Soeradji Tirtonegoro Klaten since 2014, many forensic cases were handled. Based on the type of case, in the death cases, there are traffic accidents, crime, and other deaths. While in life cases, there are sexual violence, physical violence, and psychiatry. Research on basic characteristic patientsâ€™ are very important to do, especially for the police, government, hospital, and community. The purpose of this study was to determine the basic characteristic patientsâ€™ of Visum et Repertum in RSUP dr. Soeradji Tirtonegoro Klaten 2014-2016. This research was a cross-sectional study, with a total sampling method. The data were taken from Visum et Repertum duringÂ Â Â 2014 - March 2016. There were 242 life cases (124 women, 118 men), and 23 death cases (6 women, 17 men). Most patients were productive age (22-40 years old), with 33.5% life cases and 30.4% death cases. The highest number of life cases was physical abuse (109 cases; 45%), then all of death cases was accident. The highest profession of patients were students (30.6% in life cases), while in the death cases were private (43.5%). Head trauma was the most common injury in patients (45.9% life cases and 82.6% death cases). Most of the perpetrators were unknown people (77.7% life cases, as well as 82.6% of death cases). From both cases, the patients were from productive age, distribution of fatal wound was in the head, and the prepetators were unknown. These data are very important in educational process of society.

KINETIKA ADSORPSI-REDUKSI ION Au(III) PADA ASAM HUMAT HASIL ISOLASI DARI TANAH GAMBUT RAWA PENING Dian Prasasti; Sri Juari; Sri Sudiono
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Isolation of peat soil humic acid and its application for adsorption reduction of Au(III) have beenconducted. Humic acid was isolated from peat soil that was collected from Rawa Pening, Central Java. Isolation ofhumic acid from peat soil was based on conventional alkaline extraction method. Humic acid was extracted frompeat soil with NaOH 0.1 M, then precipitated with 0.1 M HCl, and purified with 0.1 M HCl/0.3 M HF 1/1. Theisolated humic acid was characterized by FTIR spectroscopy, then applied for adsorption and reduction process ofAu (III).Adsorption kinetics on adsorption reduction process of Au (III) also were studied. The gold metal formedwas confirmed by XRD diffractogram, and photo optical microscope. The adsorption rate constant (k) withSantosa kinetics model for humic acid is 0.0065 min-1.Peaks of gold particles in the difractogram are 2 = 38, 44,and 64.

EFEK TOKSISITAS FRAKSI ETIL ASETAT AKAR SENGGANI (Melastoma affine D.Don ) PADA ORGAN HEPAR, GINJAL DAN TESTIS Moch Saiful Bachri
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Melastoma affine (MA) is a medicinal plant commonly found in south East Asia and China. The aim of the study is to investigate the toxicity effect of MA toward vital organs. Thirty two Wistar adult male rats were divided into five groups consisting of six animals each the rats in group except control group, eight animals. The rats in group I (control) were administered 0.5% CMC Na orally, while CMC Na suspension of ethyl acetate fraction of MA root (62.5, 125, 250,and 500 mg/kg body weight) were given to the II, III, IV and V groups, respectively. The CMC Na suspensions of ethyl acetate fraction of MA root were administered for 22 days. Rats were sacrificed at the 23th day. Liver, kidney, testis were collected for histopathological observation. The observation result on liver and kidney showed no difference compare to control groups, meanwhile on testis, the administration of ethyl acetate fraction of MA root at dose (250, 500 mg/kg body weight) caused necrosis on seminiferus tubules and decreasing sperm counting. The conclusion, administration of ethyl acetate fraction of MA root caused toxicity effect on testis with necrosis on seminiferus tubules.

Comparison of antioxidant activities from four species of piper Muhamad Insanu; Lia Marliani; Nabila Pandu Dinilah
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Some species from Piper genus were known for traditional medicine and ornamental plant. Previous studies showed that Piper betle and Piper acre had antioxidant activities. But, the study of antioxidant activity from other species of Piper was still limited. Because of that, the purposes of this study were to determine the antioxidant activity, and total flavonoid content of Piper nigrum, Piper aduncum, Piper retrofractum, and Piper crocatum. Extraction was done by gradient maceration using n-hexane, ethyl acetate, and ethanol as solvents. The extracts were concentrated by rotary evaporator. Antioxidant activity was evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl) free scavenging method. Total flavonoid determination was done by colorimetry method using aluminum chloride (AlCl3) as a reagent. The result showed that the IC50 values of Piper nigrum, Piper aduncum, Piper retrofractum, and Piper crocatum were ranged between 58-1249 Î¼g/mL. The total flavonoid values of all extracts were between 1.4-8.3 mg QE/100 mg. The extract which had the strongest antioxidant activity was the ethanol extract of Piper nigrum with an IC50 value was Â 57.72 Î¼g/mL. The highest values of total flavonoid was showed by the ethanol extract of Piper aduncum which was 8.3 mg QE/100 mg extract.

UJI SITOTOKSITAS DAN ANTIPROLIFERATIF SEL KANKER PAYUDARA T47D DAN SEL VERO BIJI Nigella sativa, L. Laela Hayu Nurani
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Black cumin seeds contain oil classes atisiri, terpenes, and alkaloids that can beused for traditional medicine as anticancer. The purpose of this study was to assess thecytotoxic effects of ether extract, ethanol, and infusa seed Nigella sativa, L. (Blackcumin) to inhibit the growth of T47D and normal (Vero) cells and its effect on thekinetics of T47D breast cancer cells proliferation. This study were used extracts ofether, ethanol, and black cumin seeds infusa that obtained by maceration method andinfundasi. Cytotoxicity test was performed by incubating T47D breast cancer cells at a2 x 104 density with concentrations series of 2000; 1000; 500: 250: 125; 62.5; 31.25and 15.625 microg/ml for 24 hours. Vero cell with a density of 2 x 104 withconcentrations series of 4000; 2000; 1000; 500; 250; 125 and 62.5 microg/ml. Thenumber of cells was calculated by direct counting method and the calculated the deathpercentage. The LC50 values calculated using probit analysis. Observations on thenature of the growth inhibition were done by observing kinetics of cell proliferationwith the addition of trypan blue at-24, 48 and 72 to determine its doubling time. Theresults showed that the ether extract, ethanol, and black cumin seeds infusa arecytotoxic to T47D breast cancer cells with successive LC50 of 32.63: 10.02, and 23.82mg mL. Vero cell cytotoxicity test to produce successive LC50 of 300.6; 328.41, and778.64 g/ml. Antiproliferative test results showed that in 62.5 ug/ml and 31.625microg/ml prolong the doubling time. Ethanol extract of cumin seeds have a higherpotential due to the highest security index compared to ether extract and infusa.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA