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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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The performance of derivate FTIR spectrophotometry method compared to colorimetry for tranexamic acid tablet content determination Ilma Nugrahani; Winni Nur Aulia
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Recently, FTIR reported has been established as a direct content determination for some tablet dosage forms. In the method, infrared transmittance spectra was converted into the derivated absorbance form. In this present research, the methodâ€™s performance was investigated to quantified tranexamic acid in its tablet dosage form directly. The result then was compared to the colorimetry, which has been developed by another researcher. Correlations between the two methods were analyzed using t-test. The good linearity was shown at concentration range of 0.5 - 1.75% w/w at the wave number of NH group. Furthermore, the recovery, intra- and inter-day precision also fulfilled the validation requirement. Meanwhile, LOD and LOQ of the method were 0.0531%w/w and 0.1770%w/w. These methods were compared with colorimetry has been established before. Afterwards, the t-test proved no significant difference of content determination yielded, between these two methods. In conclusion, FTIR can be used for quantify the content of tranexamic tablet, more accurately than colorimetry, which has been developed before. Moreover, FTIR method also has advantages such as easier, simpler, faster and cheaper than the colorimetry method.Â Â

PENGARUH UMUR DAN PENYAKIT PENYERTA TERHADAP RESIKO INFEKSI LUKA OPERASI PADA PASIEN BEDAH GASTROINTESTINAL Imaniar Noor Faridah; Tri Murti Andayani; Inayati Inayati
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Surgical Site Infection/SSI is the result of the contamination of bacteria whichenter the body during surgery. High risk of SSI is occured in gastrointestinal surgeryand influenced by the characteristics of the patients such as age and comorbidity sincethey deal with immunity system of the body. The research was aimed to identity theinfluence of age and comorbidity to the high risk of SSI in gastrointestinal surgerypatients. The research was a cross sectional research conducted prospectively at PKUMuhammadiyah Hospital Yogyakarta from January to March 2012. The researchsubjects were all inpatients undergoing gastrointestinal surgery, having visiblesurgical site and using antibiotic to prevent surgical site infection. There are 68patients in the research. Data that were analyzed comprised the characteristics ofpatients such as age and congenital disease to the risk of surgical site infection. Theresult of this research indicated that 2 patients (2,94%) suffering SSI. Based on the age,SSI happened to 2 patients in the age range of 41-60 years old. However, based on thestatistical result, there was no correlation between age and the existence of SSI(p>0.05). SSI also occured in 2 patients with comorbidity. However, there wascorrelation between the existence of comorbidity and SSI (p<0.05).

PEMURNIAN ETANOL HASIL FERMENTASI KULIT UMBI SINGKONG (Manihot Utilissima Pohl) DARI LIMBAH INDUSTRI KERUPUK SANJAI DI KOTA BUKITTINGGI BERDASARKAN SUHU DAN WAKTU DESTILASI Mhd. Riza Marjoni
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Bukittinggi city with approximately 132 industry crackers Sanjai spend 300-500 kg ofcassava per day for each industry. Solid waste production process results Sanjai crackers thisone is skin cassava. Cassavaâ€™s peel produces 15-20% carbohydrate content of 68-85% of theweight of the bulb, so it has great potential to be converted into bioethanol.Carbohydrates in the tuber peel can be processed into ethanol by fermentation and for separatingethanol from itâ€™s mixture used method of distillation. Distillation temperature and time used affects the quality and quantity of bioethanol produced. This study aims to determine the besttime and temperature distillation to produce bioethanol at the highest levels. Ethanol contentanalysis was conducted using the specific gravity using line arregression equation and Tablegravity of Indonesian Pharmacopoeia. The results showed that the highest levels of ethanoldistillate obtained in the distillation temperature of 71o C for 5 hours is 16.60% using regressionmethods and 14.1% according to Table Pharmacopoeia with yield ranging between 2.30%-5.80% and the efficiency of distillation 28, 94% -57.50%. Time and temperature distillationhave a real impact on the levels of ethanol produced atthe level of 5%.

HUBUNGAN JUMLAH OBAT YANG DIRESEPKAN DENGAN POTENSIAL PENGGUNAAN OBAT YANG TIDAK TEPAT PADA PASIEN PENYAKIT GINJAL KRONIS DI RS PKU MUHAMMADIYAH YOGYAKARTA Evi Mulyani; Endang Darmawan; Mustofa Mustofa
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Age-related decrease of physiological function caused some healt problem in elderly, so the problem of treatment in the elderly is also not uncommon found as polypharmacy and Potentially Inappropriate medication (PIMs). The purpose of this study to determine the relationship of the number of drug prescribed with PIMs in elderly patients with CKD in PKU Muhammadiyah Yogyakarta Hospital. PIMs identification by STOPP criteria, while the number of drugs prescribed seen by drugs control books. To assess the patient's medical history by interviews and search records. Patient characteristics were analyzed descriptively, correlations between variables were analyzed with chi square test. From 53 samples, PIMs identified 17% and average one sample got one PIMs, while of the 410 drugs that prescribed average patient receivingÂ 8 drugs (> 6). Bivariate test results showed that no significant relationship between the number of drug prescribed with PIMs.

AKTIVITAS ANTIMIKOSIS EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.) Didi Rohadi
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Prevalence of Candidiasis is still in high level. Some antimycosis have been less effective so it needs to explore novel sources of antimycosis, one of candidate is the soursop leaves (Annona muricata L.) The aims of this study to observe antimycosis activity of the ethanol extract of soursop leaves at concentration of 15 %, 30 %, and 60 % against Candida albicans ATCC 10231 with agar diffusion method . The results showed that all of the ethanol extract of soursop leaves have exhibited antimycosis activity which concentration-dependent.

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL HERBA PEGAGAN (Centella asiatica (L.) Urb) DENGAN METODE FOSFOMOLIBDAT Nina Salamah; Liani Farahana
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antioxidant compound extends widely used to prevent degenerative disease. Centella asiatica(L.) Urb or known as pegagan is a plant which grown in Indonesia and itâ€™s leaves contain somecompounds reported to have antioxidant activities. The research aimed to know antioxidant activity ofethanolic extract of pegagan herbs by mechanism of reducing power. The antioxidant activity analyzedusing visible spectrophotometric with phosphomolybdate method. Antioxidant activity of ethanolicextract of pegagan was expressed as mg quercetin equivalence/gram extract). The result showed thatusing this method the ethanolic extract of pegagan activity had antioxidant activity which is43.198 Â± 2.048 mg mgQE/gram extract.

Penetapan kadar gentamisin dalam sediaan krim dengan kromatografi lapis tipis - densitometri Isnaeni Yudi Haryanto; Achmad Burhanudin; Achmad toto poernomo
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The used of Gentamicin is still regarded for overcoming infectious diseases. Several preparations of the gentamicin are available in the market as injection, eye or ear drops, and topical dosage forms. Based on the standard method, determination of the gentamicin is carried out by microbiological assay. Several instrumental method have been reported. In this research, Thin Layer Chromatography-Densitometry (TLC-Densitometry) has been validated and used for determining gentamicin in cream dosage form. The TLC was carried out on a Silica gel GF254 using KH2PO4 20% and ninhidrin 2% solution (in ethanol 96%) as eluent and spots visualization respectively. Three spots appeared on the chromatogram having Rf value 0.51, 0.47, and 0.36. All the spots gave maximum absorption at 400 nm. The spot with Rf value of 0.51 was the highest intensity. Limit of Detection (LoD) and Limit of quantitation (LoQ) of the major component was 0.019 and 0.064 respectively. The other validation characteristics met the requirement for determination of gentamicin in the cream dosage form.

KERAGAMAN ISOLAT ACTINOMYCETES BERDASARKAN ANALISIS RFLP TERHADAP GEN NRPS Nanik Sulistyani
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Actinomycetes is one of the types of microorganisms that is essential forproducing the active compounds, one of which is an antibiotic. Isolation ofActinomycetes from the rhizosphere of rice plant (Oryza sativa L.) and tin plant (Ficuscarica L.) has yielded 13 isolates of antibiotic-producing Actinomycetes. This studyaims to determine the diversity of isolates by RFLP analysis (Restriction FragmentLength Polymorphism) of the NRPS (Non Ribosomal Peptide Synthetase) gene. Thestudy was carried out by isolating Actinomycetes isolate DNA and performed PCR onthe 16SrRNA and NRPS genes. The RFLP analysis of the NRPS gene PCR products isthen performed using the enzyme HaeIII. Identify the presence of DNA, the PCRproduct and RFLP results was performed by agarose gel electrophoresis. The diversityof isolates was analyzed by multivariate analysis. The results showed that the diversityof 13 isolates of Actinomycetes can be grouped into 5 groups: isolates 5 (group 1),isolates 8 (group 2), isolates 11 (group 3), isolates 6,7,9 (group 4) and isolates1,2,3,4,10,12,13 (group 5).

Aktivitas imunostimulan ekstrak bawang putih tunggal pada mencit yang diinduksi Escherichia coli Oki Sandra Agnesa; Herawati Susilo; Sri Rahayu Lestari
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRAKÂ Bawang putih tunggal telah banyak digunakan masyarakat sebagai obat tradisional salah satunya untuk meningkatkan stamina. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak bawang putih tunggal sebagai imunostimulan melalui pengujian aktivitas dan kapasitas fagositosis makrofag serta berat limpa mencit (Mus musculus) yang diinduksi dengan bakteri Escherichia coli. Mencit jantan (Balb-C, umur 12 minggu, BB 20 Â± 5 g) diberi ekstrak bawang putih tunggal selama 28 hari berturut-turut dengan dosis ekstrak bawang putih tunggal N 0%, P1 0,25%, P2 0,5%, P3 1%, dan P4 2%. Pada hari ke 29, mencit diinduksi dengan bakteri E.coli yang diberikan secara intraperitoneal (1 ml, 1,5 x 105 cfu/ml). Aktivitas fagositosis makrofag dihitung dari sediaan apusan cairan peritoneum. Ekstrak bawang putih tunggal meningkatkan jumlah dan kapasitas makrofag aktif secara nyata pada perlakuan P2, P3, dan P4 (p=0,000;Î±=0,05) dengan berat limpa yang berbeda secara signifikan (p=0,000;Î±=0,05). Hasil penelitian menunjukkan semakin tinggi ekstrak bawang putih tunggal yang diberikan maka semakin tinggi pula aktivitas dan kapasitas fagositosis makrofagnya dengan berat limpa yang semakin kecil.Â Kata kunci: bawang putih tunggal, fagositosis makrofag, imunostimulan.Â ABSTRACT Single garlic has been used as traditional medicine for increasing stamina. This research aim to knew the effect of single garlic as immunostimulant through activity and capacity fagocyte of macrophag test and mice weight spleen that induced by E.coli. Male mice (Balb-C, 12 weeks old, weight 20 Â± 5 g) has been given sigle garlic extract for 28th days with various dosage (N 0%, P1 0,25%, P2 0,5%, P3 1%, and P4 2%). on day 29, mice ware induced by E.coli through intraperitoneal injection (1 ml, 1,5 x 105 cfu/ml). Fagocyte activity of macrophag counting by peritoneum liquid smear. Single garlic extract increase amount and capacity active macrophage in P2, P3, and P4 (p=0,000;Î±=0,05) with significant various spleen weight (p=0,000;Î±=0,05). The result show that the higher sigle garlic extract can make higer activity and capacity fagocyte of macrophag with lower spleen weight.Â Keywords: single garlic, macrophag, immunostimulant.

Clearance profile of radioactive gold nanoparticle (198Au) conjugates-poliamidoamin generation 4-nimotuzumab ; potential radio-pharmaceutical theranostic agent Nurhatidjah Awaliyah Halid; Abdul Mutalib; Anung Pujiyanto; Adang Hardi Gunawan
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Theranostic agents are agents that combine diagnostic and therapeutic capabilities into a single agent. The presence of conjugated cancer which is therapeutic agents such as nimotuzumab monoclonal antibodies with radioactive gold nanoparticles stabilized with Polyamidoamine Generation 4 (PAMAM G4) dendrimer can actively interact with specific cancer cells. Radioactive gold (198Au) as a radiation transmitter Î² (961 keV) capable for killing cancer cells and (412 keV) Î³ rays that give a golden image in the body, thus acting as a theranostic agent. The purpose of this study was to obtain confident results of conjugate safety by observing the constituent clearance of 198AuNP-PAMAM G4-Nimotuzumab. The result of the conjugate clearance will be the reference for the metabolic state as a new, stable and complete radiofarmaka upon reaching the desired target. This study began with the synthesis of the conjugate of 198AuNp-PAMAM G4-nimotuzumab and then tested the clirens and analyzed the results of urine and mouse feces that had been injected with conjugate. Total clearance was obtained about 47.38% of the 198AuNP-PAMAM G4-Nimotuzumab conjugates that have been excreted through urine (18.26%) and stool (29.11%.). Urine and feces were analyzed with SDS-PAGE giving the spot above the 150 kDa band and showing the conjugate molecular weight. FTIR analysis of urine and feces by showing aldehyde functional groups (C = O), alcoholic groups (O-H), amine groups (C-N), and amine groups (N-H) indicating the presence of AuNP-PAMAM G4-Nimotuzumab conjugates in urine and mouse feces. The results of urine and fecal excretion of the conjugate are still conjugate-shaped supported by SDS PAGE analysis, UV-Vis spectrophotometer absorption analysis and functional group analysis with FTIR that has been conducted.

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Muhammad Syahrir

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m.syahrir7406@unm.ac.id

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nurkhasanah@pharm.uad.ac.id

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Kota yogyakarta,

Daerah istimewa yogyakarta

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