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Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 808 Documents
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In silico study: secondary metabolites from malay apple (Syzygium malaccense (L.) Merr. & L.M. Perry) as potential breast cancer treatments Riska Prasetiawati; Nawadhir Fauzan; Meilia Suherman
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.26537

Abstract

Breast cancer has the highest prevalence of all cancers. Breast cancer has overtaken lung cancer as the leading cause of global cancer incidence in 2020, accounting for 2,261,419 new cases, or 11.7% of all new cancer cases worldwide. Among the efforts that can be done are efforts to find breast cancer medications that are safe and selective for the treatment and prevention of cancer, particularly those derived from medicinal plants. The Malay apple (Syzygium malaccense (L.) Merr. and L.M. Perry) is one plant that has been extensively examined and proved to have an antiproliferative effect. The pharmacophore modelling, molecular docking, and molecular dynamic approach was conducted on 155 active compounds of Malay apple to alpha and beta estrogen receptors. According on the results of ER-lamda docking, numerous substances have binding free energy values less than 4-OHT yet are not bound to important amino acids, as the result, it is not continued to the next test. On other side, with a fit score of 45.81, rutin was potentially selective for ER-beta receptors, molecular docking to ER-beta obtained that rutin was predicted to have breast cancer activity with a free binding energy value of -10.6 kcal /mol with better conformation and affinity compared to native ligand (genistein), and bound to essential amino acids as anticancer breast at ARG 346, GLU 305,  and molecular dynamics simulations show that the compound has good stability when binding to the receptor. In silico toxicity prediction from rutin showed outcomes that match the requirements for the candidate drug. However, because it does not match the ADME prediction and Lipinsky's rule of five, rutin must be optimalization to improve its pharmacokinetic and pharmacological profile before it can be further explored as a therapeutic option for the treatment of breast cancer that targets the ER- receptor.
Combination of polyherbal Phyllanthus reticulatus with Zingiber officinale and Cymbopogon citratus to optimize the antioxidant capacity Elizabeth Betty Elok Kristiani; Sri Kasmiyati; Yohanes Martono
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.28002

Abstract

Currently, the public is interested in polyherbal-based foods and beverages as a source of natural antioxidants. The aim of the study is to evaluate the antioxidant properties and the phenolic and flavonoid compounds of formulations containing Z. officinale, C. citratus, and P. reticulatus (ZCP). Each sample was extracted using the maceration process in an ethanol solvent at room temperature for three 72-hour periods. There were fourteenth formulation of Z. officinale rhizome, C. citratus leaves, and P. reticulatus fruit which used Design of Expert (DoE). The DPPH method was used to determine the power of antioxidants. The flavonoid content of the extract was measured using the colorimetric method and AlCl3 reagent, while phenolics content using Folin-Ciocalteu. The formulations ZCP 1:0:0, 0:0:1, and 1:1:1 showed the antioxidant capacity in a strong categorization, with an IC50 value less than 50 µg/ml, while ZCP 0:1:0 was in a weak categorization (IC50 > 250 µg/ml). Another ZCP formulation was in a medium category. The ZCP 1:1:1 formulation was suggested as the best one for this investigation, which contains three plant samples. This formulation is interesting for further toxicity studies and in vivo testing so that it can be applied as an antioxidant-rich supplement product.
In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors Caroline Caroline; Martha Ervina; Muhammad Rizki Fadhil Pratama; Maria Anabella Jessica
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.26964

Abstract

Coronavirus-2 (SARS-Cov-2) is a virus that attacks the respiratory system and causes the Covid-19 pandemic. After the pandemic, prevention and appropriate therapy research continue to be carried out to anticipate the emergence of more dangerous viruses. In line with the culture of consuming herbs that has arisen due to the effects of the pandemic, in this study, an insilico screening was carried out for essential oil compounds produced by ginger and thyme herbs which have been widely consumed by the public. The aim of the research was to find the essential oil content that has the most potential as an antiviral against coronavirus-2. The research method was carried out in silico, including ligand preparation, receptor and method validation, and analysis of ligand-receptor binding interactions using the AutoDoc 4.2.6 program. As a comparison, a study was conducted on remdesivir and favipiravir, which have been used as antivirals. The three components that have the most potential based on the calculation of the free energy value, were determined by the ADMET parameters using the Admet lab 2.0 program. The results showed that the three components in the essential oil exhibited better interactions when compared to remdesivir and favipiravir at the 3-Cl protease and spike glycoprotein receptors. The results of the insilico study and ADMET prediction test showed that of the three most potent compounds, lamda-farnesen was the most potent and safe to use
Antibiotic consumption and resistance: a 3-years ecological study for four critical groups of bacteria in a general regional hospital Dwi Arymbhi Sanjaya; Nyoman Budiartha Siada; Rr Asih Juanita; I Putu Yudistira Mahaputra; Made Gek Adisti Kamalia; Herleeyana Meriyani
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27321

Abstract

Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae are the most critical groups of multi-drug resistant (MDR) bacteria that cause a threat in hospitals. This study identified the trend of antibiotic consumption, antibiotic resistance pattern, and the relationship between antibiotic consumption and antibiotic resistance in a critical group of bacteria in a general regional hospital. This ecological study was based on retrospective data from inpatient databases in a general regional hospital over three years (2017-2019). The trend for annual antibiotic consumption over 2017-2019 was defined as defined daily doses/100 bed-days. The relationship between total antibiotic consumption and the percentage of antibiotic resistance among four isolated critical bacteria was explored in time series analysis and linear regression. The most frequently used antibiotic was ampicillin (220.33 DDD/100 bed-days), ciprofloxacin (126.86 DDD/100 bed-days), and ampicillin-sulbactam (126.34 DDD/100 bed-days). There was a significant relationship between antibiotic consumption (ampicillin, ampicillin-sulbactam, ceftazidime, gentamicin, amikacin, and ciprofloxacin) in DDD/100 bed-days and antibiotic resistance in E. coli, K. pneumoniae, and P. aeruginosa (p<0.05) but not statically significant in A. baumannii (p=0.062). The annual usage fluctuated or remained stable, with no statistically significant trends change. The relationship between antibiotic consumption and antibiotic resistance was significant in three out of four critical groups of bacteria.
The determination of antioxidant and lead content of hemiparasite Dendrophthoe vitellina (F. Muell) Tiegh on Nutmeg Anna Helena Sabandar; Sri Kasmiyati; Djohan Djohan
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.26780

Abstract

 Mistletoe, a parasitic plant growing on nutmeg trees, is conventionally perceived as a parasitic entity with limited regard for its potential medicinal value. On the other hand, mistletoe has a remarkable potential source of valuable medicinal compounds, particularly in traditional healthcare, due to its secondary metabolites such as flavonoid, phenolic, ascorbic acid, and antioxidant activity. Nevertheless, both the host tree and the environment, like Pb, influence the adaptive responses of secondary metabolites. This study aimed to determine the secondary metabolites, such as flavonoids, phenolics, ascorbic acid, antioxidant activity, and Pb content in the leaves of D. vitellina and nutmeg (M. fragrans). The samples were obtained via maceration using ethanol. The spectrophotometric analysis method was used to measure several parameters, using particular reagents for phenolic compounds using Folin-Ciocalteu, flavonoids using AlCl3, and ascorbic acid using sulfosalicylic acid), antioxidant activity using DPPH, and Pb using the AAS method. The results indicated that D. vitellina possesses a higher concentration of flavonoid and phenolic compounds, followed by 3.36 ± 1.92 % (w/w) and 18.45 ± 2.35 % (w/w) respectively. Conversely, nutmeg had a significant ascorbic acid concentration of 3.99 ± 4.38 % (w/w). The significant presence of phenolics and flavonoids had a crucial role in the antioxidant activity seen in D. vitellina, which exhibited exceptionally potent antioxidant properties. All samples contain Pb, ranging from 0.00001–0.00021 % (w/w), within the maximum allowable limits. Therefore, mistletoe is notable for being a reliable and encouraging plant species that can provide a natural supply of antioxidants and be safely used in traditional medicine.
Ethnopharmacology study of medicinal plants utilization for antidiarrheal remedies by Tengger tribe in Tosari District, Indonesia Indah Yulia Ningsih; Virda Fitra Mandasari; Antonius Nugraha Widhi Pratama; Mochammad Amrun Hidayat
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.28099

Abstract

Tengger is one of the tribes in East Java Province, Indonesia practising traditional medicine by using mantras and medicinal plants. A disease with a high incidence rate and widely treated with medicinal plants in Indonesia, including in Tosari District, Pasuruan Regency, is diarrhoea. To conserve traditional medicine, mainly the utilization of medicinal plants as anti-diarrhoea agents, it is necessary to develop a database that keeps up with technological advances. The study aimed to determine medicinal plants utilization for antidiarrheal remedies by the Tengger tribe in four villages of Tosari District, Pasuruan Regency, namely Wonokitri, Tosari, Ngadiwono, and Podokoyo. The study employed the snowball sampling method, which involved conducting semi-structured interviews. The result showed nine medicinal plants for traditional antidiarrheal remedies, with Musaceae (23%) as the most widely used plant family. Most informants used immature plant (56.25%) and fruits (89.58%). In addition, most plants were administered orally (98%) without specific compounding methods (76%). The value of Factor of the informant's consensus (Fic) of plants used for diarrhoea was 0.74. The highest Fidelity Level (FL) and Choice Value (CV) were obtained from Elaeocarpus longifolius Blume at 69% and 2.4, respectively. Based on the findings of the study, E. longifolius has the potential to be further investigated for development in antidiarrheal treatment.
Interprofessional education applied in first-year and third-year health students: cross-sectional study Dyah Aryani Perwitasari; Faridah Baroroh; Andriana Sari; Putri Rachma Novitasari; Nurul Kodriati; Ratu Matahari; Barkah Djaka Purwanto
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27253

Abstract

Health professions work together to provide the best service in health care facilities by collaborating with patients, families, worker and the community. Interprofessional education (IPE) were practice of collaboration between two or more students from different health profession programs. The purpose of study was to compare IPE results from first and third year batches. The two batches included 345 first-year students and 460 third-year students, from three different health disciplines, including medicine, pharmacy, and public health. These students met for four weeks to increase interprofessional collaboration, improve communication skills, foster respect and increase knowledge of the various roles each discipline, especially case management, conflict management and team work. Before IPE program, the students were given pre-questionnaire to assess their prior understanding of IPE. Each group of first-year students presented the outcomes of their discussions in the fourth week, while the third-year students created a poster about the subject and presented it in the second week. The students complete the program and post-questionnaire after their presentation. The International Collaborative Competencies Attainment Survey served the development the IPE questionnaire (ICCAS). The result of pre-IPE domains’ score revealed substantial disparities in the team work domain, with third-year students score was lower than the first students, whereas first-year students had the highest score in the most of IPE categories, unless collaboration and conflict management (p>0.05). The post-IPE domains’ score showed significant differences in all of the domains. Most of the IPE domains had higher score in first year students, excluding communication and team work.
Enzymatic virgin coconut oil effect on urea and creatinine levels of hypercholesterolemia-diabetics induced Wistar male rats Niluh Puspita Dewi; Syafika Alaydrus; Nadila Nadila; Magfirah Magfirah; Joni Tandi; Viani Anggi; Nani Astria
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27489

Abstract

Coconut (Cocos nucifera) is an Indonesian commodity that has high economic value tall. Virgin Coconut Oil (VCO) is one of the processed coconut products whose selling value is very high, because The composition of VCO consists of medium-chain fatty acids that can maintain a healthy body and prevent various diseases. The process of making VCO used in This research is an enzymatic method using pineapple weevil as a bromelain enzyme. This study aims to determine the effect of enzymatic administration of VCO and an enzymatic dose of VCO which is effective in reducing urea and creatinine levels in hypercholesterolemic-diabetic male white rats (Rattus norvegicus). This study was an experimental laboratory with a modified pretest and posttest randomized controlled group design using 30 test animals which were divided into 6 treatment groups. Each group consisted of 5 test animals, namely normal control, negative control, and positive control, with doses of 0.2, 0.4, and 0.8 mL/kg BW. The data obtained were analyzed using a One Way Anova and non- parametric statistical test by Kruskal Wallis. test and followed by a further Mann Whitney test to determine differences between treatments. The results showed that enzymatic VCO at a dose of 0.8 mL/kg BW was an effective dose in reducing urea and creatinine levels with an average decrease of 17.40 mg/dL and 0.36 mg/dL. The novelty in this study showed that the enzymatic VCO had an effect on reducing urea and creatinine levels in diabetic hypercholesterolemic male white rats.
Repurposing drugs in endometrial cancer using genomic variants database Darmawi Darmawi; Donel S; Wiwin Suhandri; Winarto Winarto; Wirawan Adikusuma; Lalu Muhammad Irham; Wiwit Ade Fidiawati; Renardy Reza Razali; Auren Nathania; Leina Putri Zahra
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Sunscreen effectivity and physical characterization of avocado oil in nanoemulsion using isopropyl myristate variations Ayu Shabrina; Zuhriya Muna Firdausi; Agnes Theresya Poerba; Diana Anisa Setyani; Junvidya Heroweti
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.28214

Abstract

Unsaturated fatty acids in avocado oil can help reduce erythema brought on by prolonged UV-B exposure. The effectivity of sunscreen absorption into the skin will be enhanced by the use of isopropyl myristate (IPM) in nanoemulsion. The purpose of this study was to determine the physical characteristics and sunscreen effectiveness of avocado oil nanoemulsion (AVN) modified with IPM. 1% (FI), 3% (FII), and 5% (FIII) IPM variation were used to make AVN with 5% oil. The AVN were tested for physical characteristics such as organoleptic, pH, viscosity, rheology, particle size and polydispersity index (PI). The products were also tested for sunscreen effectivity by in vitro and Minimum Erythemal Dose (MED) method. The data obtained were analyzed statistically. The results showed that the AVN was pale yellow and clear with transmittance percentage were 96%. The rheogram showed that the products were newtonian. The pH values range were from 6.62 to 6.66; viscosity 1.65-1.84 dPa.s; particle size < 17 nm, zeta potential was in range of -30,54±1,72 to -37,85±3,11 and PI < 0.5 for all formula. In vitro SPF values were 16.43 ± 4.50 (FI), 16.27 ± 4.20 (FII) and 17.88 ± 3.20 (FIII) (p >0.05), and categorized as ultra protection. MED value were 12.28 ± 1.34 (FI); 12.51 ± 1.68 (FII); and 13.22 ± 1.84 (FIII) (p< 0.05) and categorized as maximum protection. Isopropyl myristate increased the sunscreen product's MED value without changing its physical characteristics.

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