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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
Arjuna Subject : -
Articles 455 Documents
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Antibacterial activity of Sappan (Caesalpinia sappan L.) wood methanol extract against Staphylococcus epidermidis Waro Atunnisa; Irfan Zamzani; Siti Nashihah
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.21900

Abstract

The entry and proliferation of microorganisms, such as bacteria, cause skin infections. One of the bacteria that causes skin infections is Staphylococcus epidermidis. Sappan (Caesalpinia sappan L.) wood has been known to have various pharmacology activities, one of which is antibacterial, so its activities need to be developed and improved. This study aimed to determine the activity of the methanol extract of Sappan (C. sappan L.) wood as an antibacterial against S. epidermidis. This research was conducted by extracting Sappan wood powder with 96% methanol as solvent using the Ultrasound-Assisted Extraction (UAE) method and testing for antibacterial activity with concentrations of 25%, 50%, 75% and 100% using the disc method. Results showed that the methanol extract of Sappan wood had an antibacterial activity; the highest inhibition zone at a concentration of 75% was 29.25 mm. Sappan wood was expected to be a promising alternative therapy for overcoming acne problems and can increase economic value for the wider community. 
The level of community knowledge about the use of antibiotics Hajar Sugihantoro; Ismea Munawaroh; Fidia Rizkiah Inayatillah; Yen Yen Ari Indrawijaya
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.23917

Abstract

Knowledge and use of antibiotics play a large and important role in the success of treatment, so that they do not cause negative effects, such as the cause of antibiotic resistance. The purpose of this study was to determine the profile and level of knowledge of the community regarding the use of antibiotics in Banyior Village, Sepulu District, Bangkalan Regency, East Java, Indonesia. This research is a cross-sectional descriptive study. The measurement is a closed questionnaire. Data were analyzed using SPSS version 18. The survey was conducted from October 2021 to December 2022 on 325 residents of Banyior Village. The result is that the antibiotic most often used by respondents is amoxicillin with a percentage of 47%. The majority of respondents, 45 percent, get antibiotics from drugstores or stalls. The knowledge level of the general public shows a good level of knowledge of 6.82%, an average level of knowledge of 19.60% and a low level of knowledge of 73.57%. The most widely used antibiotic by respondents in this study was amoxicillin, where the most common way to obtain it was through drug stores/stalls and public knowledge of the use of antibiotics was still low.
Mapping rheumatoid arthritis susceptibility through integrative bioinformatics and genomics Nining Medi Sushanti; Wirawan Adikusuma; Arief Rahman Afief; Anita Silas La’ah; Firdayani Firdayani; Rockie Chong; Zainul Amiruddin Zakaria; Barkah Djaka Purwanto; Rahmat Dani Satria; Riat Khair; Abdi Wira Septama; Lalu Muhammad Irham
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.24912

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that influences several organs and tissues, especially the synovial joints, and is associated with multiple genetic and environmental factors. Numerous databases provide information on the relationship between a specific gene and the disease pathogenesis. However, it is important to further prioritize biological risk genes for downstream development and validation.  This study aims to map RA-association genetic variation using genome-wide association study (GWAS) databases and prioritize influential genes in RA pathogenesis based on functional annotations. These functional annotations include missense/nonsense mutations, cis-expression quantitative trait locus (cis-eQTL), overlap knockout mouse phenotype (KMP), protein-protein interaction (PPI), molecular pathway analysis (MPA), and primary immunodeficiency (PID). 119 genetic variants mapped had a potential high risk for RA based on functional scoring. The top eight risk genes of RA are TYK2 and IFNGR2, followed by TNFRSF1A, IL12RB1 and CD40, C5, NCF2, and IL6R. These candidate genes are potential biomarkers for RA that can aid drug discovery and disease diagnosis.
Relationship between knowledge and behavior levels of antibiotic usage among pharmacy patients in sub-districts puguh and tegorejo Kendal Monica Lita Amay Sonia; Gilang Rizki Al Farizi; Ovikariani Ovikariani
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.25497

Abstract

Antibiotic resistance is a very serious condition for public health care around the world. This situation is due to improper use of antibiotics that can be affected by self-medication or improper consumption of antibiotics due to lack of knowledge and lack of public awareness of antibiotic use. This study is aimed to determine the relationship of the level of knowledge of the behavior of the use of antibiotics in Pharmacy patients in sub-districts of Puguh and Tegorejo Kendal. This study was an observational study with a cross sectional approach in the research period of May-June 2022. The data collection was carried out by purposive sampling with a total of 130 respondents. The instruments used in the study are structured. Spearman test results showed that there is a relationship with the level of knowledge of antibiotic use behavior (p = <0.05) ; r = 0.549. The conclusion of the study is that there is a relationship between the level of knowledge of antibiotic use behavior in pharmacy patients in sub-districts of Puguh and Tegorejo Kendal.  
Effect of Red Betel (Piper crocatum) Leaf Ethanol Extract On Increased Creatinine and Ureum Levels In White Rat Wistar Strain Induced Streptozotosin-Nikotinamid Franz June Navirius; Gunawan Pamudji; Rina Herowati
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.25457

Abstract

Red betel (Piper crocatum) is a herbal plant that has various bioactivities including antioxidant activity. Red betel leaf can be used in the treatment of diabetes mellitus and has properties as an antioxidant. This study aims to find the activity of normal levels of creatinine and urea induced by Streptozotosin-Nicotinamide in diabetic rats. Red betel leaves are extracted by soaking in 96% ethanol solvent. Phytochemical screening is used to test the class of compounds in red betel leaf extract using the test tube method. Experimental animals in the study were placed in 6 treatment groups, namely no treatment (CMC 1%), negative control (STZ-NA), positive control (Glibenclamide), dose 1 (125 mg/kg BW), dose 2 (250 mg/kg BW), and dose 3 (500 mg/kg BW). A UV-Vis spectrophotometer was used to measure creatinine and urea on days 24, 31, and 39. One Way ANOVA and Post Hoc Test Multiple Comparisons-Tukey HSD were the data analyzers used. Flavonoids, tannins, saponins and alkaloids were shown from the phytochemical screening. Data analysis showed that the 500 mg/kg BW ethanol extract of red betel leaves was able to produce creatinine and urea better than the 125 mg/kg BW and 250 mg/kg BW ethanol extracts of red betel leaves. This situation is due to red betel leaf extract 500 mg/kg BW Data analysis showed that the 500 mg/kg BW ethanol extract of red betel leaves was able to produce creatinine and urea better than the 125 mg/kg BW and 250 mg/kg BW ethanol extracts of red betel leaves.
Evaluation of the use of Antibiotics Quantitatively and Qualitatively in Pharyngitis Patients at Banda Sakti Public Health Center Lhokseumawe Yuziani Yuziani; Rizka Sofia; Fely Syah Imara Siregar
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.26122

Abstract

Pharyngitis is inflammation that occurs in the pharynx and often spreads to surrounding tissues which is one of the causes is a bacterial infection. Antibiotics are the main drug of choice for bacterial infection. Evaluation of the use of antibiotics can be done quantitatively and qualitatively. The importance of evaluating the use of antibiotics in pharyngitis patients can reduce drug side effects and prevent resistance. This study's objective was to evaluate if giving antibiotics to pharyngitis patients at Banda Sakti Public Health Lhokseumawe was appropriate, quantitatively using the Defined Daily Dose (DDD) method and qualitatively using the Gyssens method. This research is descriptive. The sampling technique used purposive sampling with a time-limited sampling method. The result showed that the use of antibiotics quantitatively using the DDD method found the highest total DDD was amoxicillin of 10,35 DDD/1000 patients, while the qualitative evaluation using the gyssens method for amoxicillin was classified as category IIIB because the gift was too short, cefadroxil was classified as category IVB because other antibiotics were safer, ciprofloxacin was classified as category V because it is not indicated. This study concludes that the use of antibiotics quantitatively using the DDD method found the highest total DDD was amoxicillin, while the evaluation of the use of antibiotics qualitatively classified inappropriate.
Relationship between Appropriate Antibiotics Used based on 2019 ATS/IDSA Guideline and Clinical Improvement in Inpatient Community Pneumonia Patients Mensiana Ayu Maju; Christianus Heru Setiawan
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.24463

Abstract

Community pneumonia is a serious infection obtained from the community environment, and one of the causes is bacteria. This infection causes lung inflammation and leads to death if not treated properly. The appropriate of empirical antibiotics can increase the success of therapy and prevent the emergence of bacterial resistance to various kinds of antibiotics. This study aims to assess the appropriateness of empiric antibiotic selection in community pneumonia using the 2019 ATS/IDSA antibiotic guideline and analyze its relationship with the patient's clinical response. This study is a retrospective cohort design type. Medical record data obtained, namely antibiotics and clinical response, were analyzed using the Mann-Whitney statistical test. There were differences in the average clinical improvement, including body temperature, heart rate, and respiratory rate, in the group of community pneumonia patients who used empiric antibiotics according to the guideline and those who did not follow the guidelines 2019 (P<0.05). According to the result, empiric antibiotics based on the 2019 ATS/IDSA guideline can increase therapy outcomes in inpatient community pneumonia patients.
Online Learning Evaluation of Drug Information Service Lectures : Study on Learning Process, Learning Outcomes, and Student Perceptions Putu Dyana Christasani; Yosef Wijoyo
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.26271

Abstract

The COVID-19 pandemic impacted the need for new adaptations in the learning process, namely by implementing an online learning system. This method remains a trend in the future, so it is necessary to conduct research to evaluate the online lectures. The evaluation process evaluates at the microlevel, namely the process, learning outcomes, and student perceptions of the Drug Information Services course.This research is evaluative and descriptive, with a cross-sectional design and quantitative and qualitative approaches. Research was conducted at the Faculty of Pharmacy, Sanata Dharma University. The respondents were 124 USD Pharmacy S-1 students who took the Drug Information Services course in the odd semester of 2020–2021. Student learning outcomes and perceptions were obtained using validated assessment rubrics and reflection questionnaires.The results showed that the implementation of Drug Information Services lectures went according to the semester learning plan; there were minor revisions to improve the dynamics of student discussions. Students learning outcomes are in the "very good" category, except for the OSCE examination, which is relatively sufficient. Student have a positive perception of this online lecture. In conclusion, this online lecture can be maintained for the future with a slight modification to the oral exam, which uses the offline method by implementing strict health protocols.
Antibacterial Activities Of Papaya Seed (Carica papaya L.) Ethanol Extract With MAE And UAE Extraction Methods Towards Staphylococcus aureus Fini Hartanti; Devi Nisa Hidayati
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.24704

Abstract

Ethanol extract of papaya seeds produced by the maceration method has been shown to have antibacterial activity against S. aureus, P. aeruginous, S. thypi, and E. coli. This study aims to compare the antibacterial activity of the ethanol extract of papaya seeds obtained using the Microwave Assisted Extraction (MAE) and Ultrasound-Assisted Extraction (UAE) extraction methods on the growth of Staphylococcus aureus bacteria.Papaya seed powder was extracted using MAE and UAE extraction methods using 70% ethanol as a solvent in concentrations of 20%, 40%, 60%, and 80%. DMSO was used as negative control and chloramphenicol 30 g/disk as a positive control. The antibacterial activity test method used the disk diffusion method. The parameter observed was DDH (Diameter of Inhibitory Area) which was statistically analyzed using Two Way Anova at a 95% confidence level.The results showed that the ethanol extract of papaya seeds produced from the MAE and UAE extraction methods had antibacterial activity against Staphylococcus aureus in all concentration series. The statistical test showed a significant difference (p<0.05) in antibacterial activity against Staphylococcus aureus extracts obtained from two extraction methods: MAE and UAE. UAE method is recommended use. 
The potential of Sumbawa Honey (Apis dorsata) As a Natural Antioxidant Gharsina Ghaisani Yumni; Fina Listiana; Septi Puspita Sari; Siti Nadhiroh; Sumantri Sumantri
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.24705

Abstract

Honey is a natural ingredient that Indonesian people widely use to maintain a healthy body. One of the benefits of honey is as an antioxidant. This antioxidant activity is influenced by the producing bee, the source plant, and the producing area. This study aims to determine the antioxidant activity of Sumbawa honey originating from NTT. Honey samples were collected and dried using the freeze-drying method and then macerated with 70% ethanol. The viscous extract obtained was then fractionated using a liquid-liquid extraction method using n-hexane, ethyl acetate and ethanol-water as solvents so that the n-hexane (NF), ethyl acetate (EF) and water (WF) fractions were obtained. Each sample was tested for its antioxidant activity using the ABTS method with Trolox as a comparison. The results obtained were ethanol extract, NF, EF and AF had IC50 values respectively 96.054; 106,953; 70,206; and 101,649 g/ml. That indicates that the ethyl acetate fraction has a higher antioxidant activity than other solvents. 

Page 26 of 46 | Total Record : 455

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