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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
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Articles 455 Documents
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Optimization of Glycerin and Sorbitol in Hand Sanitizer Cream with Centella asiatica (L.) Extract Novela, Yuven; Yuliani, Sri Hartati
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.25629

Abstract

The use of alcohol-based hand sanitizers can cause dry skin. Centella asiatica (L.) extract can be used as an alternative to alcohol because it contains triterpenoids, especially asiatic acid, potentially an antibacterial and inhibitor of the SARS-CoV-2 virus. Cream is a preparation that can moisturize and protect the skin. Glycerin and sorbitol are humectants often used in cream preparations and have a large percentage in the cream preparation's formula so that they can affect the physical properties of the cream. This study aims to obtain the optimum composition range of glycerin and sorbitol and determine the effect of glycerin and sorbitol as humectants on the physical properties and stability of the hand sanitizer cream with Centella asiatica (L.) extract. The composition optimization was done using a factorial design method on two factors and two levels using the Design Expert 13 (free trial) application. The data on the physical properties and stability of the cream were statistically analyzed using a two-way ANOVA test at a 95% confidence level. The results of qualitative phytochemistry screening showed that the extract contained triterpenoid. The average test of physical properties and stability of physical properties meet the desired criteria: cream type O/W, viscosity 120–170 dPa.s., spreadability of 5-7 cm, shift of spreadability, and shift of viscosity below 10%. The optimum area shows that the formulas F1, FB, and FAB meet the desired criteria.
Standardization of Snakehead Fish (Channa striata) Concentrates Obtained from Sungai Itik Village, Kubu Raya District, West Kalimantan Aulia, Yunita Hananda; Andrie, Mohamad; Wintari , Wintari
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.26746

Abstract

Standardization is the method of identifying properties based totally on superb parameters to advantage the identical diploma of satisfaction. it has been proven that vitamins decided in snakehead fish (Channa striata) from herbal assets can be implemented as a possibility to hasten the recuperation of wounds. With the assistance of the techniques of freeze drying, this examination sought to set up the standardization of snakehead fish pay attention from Sungai Itik Village in Kubu Raya Regency, West Kalimantan as an uncooked material for prescribed drugs that treat wounds. Standardization carried out on concentrate samples consisted of specific and non-specific parameters. Specific parameters consist of organoleptic, water-soluble essence content, protein, and albumin. While the non-specific parameters tested were moisture content, ash content, acid-insoluble ash content, and drying shrinkage. The test results showed that the water content contained in snakehead fish was 7.21% ± 0.165, ash content was 10.47% ± 1.06, acid insoluble ash content was 1.40% ± 0.115, water-soluble essence content was 77.10% ± 0.54, dry shrinkage rate was 13.973% ± 0.193, the protein was 99.49% and albumin was 7.03 g/dl. The standardization parameters have not met all the tests so it can be said that snakehead fish concentrate has not met the standard and has not been standardized for natural wound healing medicinal ingredients.
Optimization of Liquid Shampoo Formula from Chia Seed Oil (Salvia hispanica L) Using the Simplex Lattice Design Method Amalina, Faidatul; Rahmayanti, Mayu; Afrizal, Muhammad; Nastiti, Ginanjar Putri; Syarifuddin, Sadli
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.28081

Abstract

Hair is one of the most essential parts of the human body, both men and women; one of the problems with hair that often occurs is hair loss. Chia plants contain sebum gland-stimulating agents with a keratin protein concentration of 23%. The sebaceous glands play a role in facilitating the growth of hair follicles so that hair can thrive and prevent hair loss. This research aims to determine the optimum composition of the prediction formula using Design Expert software and the physical characteristics and stability of liquid shampoo preparations. Optimization was carried out using Design Expert 13 software with two material components, namely HPMC and SLS, and two responses, namely viscosity and foam height. The optimum formula obtained was subjected to characteristic tests and stability tests. The stability test was carried out using the cycling test method by storing the preparation at temperatures of 4◦C and 40◦C for 48 hours. The results of the prediction formula show that component X1 is 0.589307% and X2 is 9.41069%. The one-sample t-test showed that the results were not significantly different at p>0.05 in the two responses. Testing of the optimum formula's physical characteristics and physical stability meets the reasonable requirements for organoleptic tests, homogeneity tests, viscosity tests 414,80±9,94 cPs, foam height tests 7,060±0,11 cm, and pH tests 7,39±0. The 8th run is the optimum formula with a composition of X1 0.589307% and X2 9.41069 % meets the requirements for good physical characteristics tests and physical stability tests.
Assessing Direct Medical Costs and Quality of Life In Elderly Patients Using High-Alert Medications at Wongsonegoro Hospital Supadmi, Woro; Endang Darmawan; Rizky Budi Santoso; Sri Sulistyorini
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.30368

Abstract

High Alert Medications (HAM) are drugs that pose a significant risk of causing harm to patients if used incorrectly. This study aimed to evaluate the direct medical costs and quality of life of elderly patients aged 60 years and above using HAM at Wongsonegoro Hospital. An observational prospective cohort study design was employed, utilizing both secondary and primary data collection methods. Secondary data included patient demographics, medication usage, and direct medical costs obtained from hospital records and the finance department. Primary data on quality of life were gathered using the European Quality of Life 5 Dimensions (EQ-5D-5L) questionnaire. A total of 25 elderly patients were identified as users of HAM, with a gender distribution of 48% male and 52% female; 64% of these patients were aged between 60 and 70 years. The most prevalent medical condition among participants was diabetes mellitus, affecting 44% of one group and 32% of another. Sodium Chloride (NaCl) 500 mL infusion at a concentration of 3% was the most frequently administered medication (27.5%). The average direct medical cost for elderly patients using HAM was IDR 4,255,050. Additionally, the quality of life assessment revealed that 20% of patients experienced significant challenges in self-care activities. These findings highlight the impact of HAM on healthcare costs and quality of life among elderly patients, emphasizing the need for careful monitoring and management strategies to mitigate risks associated with high-alert medications.
Formulation of Body Lotion Ethanol Extract of Kepundung Bark (Baccaurea Macrocarpa (Miq.) Mull Arg.) and Antioxidant Activity Test Putri, Noni Rahayu; Sari, Tisa Mandala; Rahma Z, Sri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.25872

Abstract

The bark of kepundung (Baccaurea macrocarpa (Miq.) Mull Arg.) contains secondary metabolite compounds from polyphenols such as flavonoids, phenolic, terpenoids, and alkaloids, which have the potential for natural antioxidants. This research aims to evaluate of ethanol extract from kepundung bark and formulate the body lotion to test its antioxidant activity using the DPPH method. Body lotion formulas were made with variations in the concentration 0.4, 1.0, and 1.6% of ethanol extract of kepundung bark as active ingredients. The evaluation of body lotion included organoleptic, pH, homogeneity, type of body lotion, stability, viscosity, irritation, and antioxidant activity tests. The results of the physical evaluation of the body lotion meet the requirements. Namely, all formulas are homogeneous, according to skin pH, the viscosity of the preparation ranges from 2500 cP, stable, and does not irritate. The value IC50 antioxidant activity of ethanol extract of kepundung bark was 4.04 ppm. The value IC50 antioxidant activity body lotion at F1, F2, and F3 respect 41.91, 36.98, and 33.13 ppm. The result showed the best formula is F3 with a value IC50 33.13 ppm. Based on the study, the ethanol extract of depending bark and the body lotion has very strong antioxidant activity.
Physical Stability and Antioxidant Peel-Off Kefir Mask Arachi (Arachis Hypogaea L) Khairunnisa, Amalia; Kartinah, Nani; Viogenta, Pratika; Mulia, Mulia
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.28501

Abstract

The fermented product sector can produce kefir for use in cosmetic preparations. Kefir has weak storage stability and strong antioxidant properties, making it a suitable raw material for cosmetic formulations. The purpose of this study is to determine the best concentration of peanut kefir in Peel-off mask Arachi through antioxidant activity and physical stability during seven cycles of room temperature storage and freeze-thaw (4±2ºC and 40±2ºC). Using the DPPH method based on the IC50 value, the antioxidant activity test was conducted. It was retested after 7 cycles or 28 days. At ambient temperature and freeze-thaw temperature, organoleptic tests, pH, adhesion, and spreadability were conducted in cycles ranging from 0 to 7. The peel-off kefir mask preparations with F1 (0.5%), F2 (1%), and F3 (2%), concentrations created a homogeneous, viscous preparation that was stable at room temperature and freeze-thaw stable for seven cycles, according to the results. In terms of the pH test, the sample showed a drop in pH following storage, stable adhesion for up to seven cycles. However, for F1, the adhesion was not stable in either scenario. With a significant activity category, the formula's antioxidant activity also declines in IC50 values. Therefore, it can be said that even though the peel-off mask preparation changed after storage in a few different ways, it still falls short of the threshold in terms of the physical characteristics of the cosmetic preparation.
Prescription Patterns in the Outpatient Unit of XYZ Hospital, Pekanbaru: A Study from 2022 Iskandar, Benni; Tiara Tri Agustini; Mira Febrina; Rahmadhani; Rickha Octavia
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.30388

Abstract

This study aims to assess the rationality of drug prescribing practices in the Outpatient Department of XYZ Hospital Pekanbaru using the World Health Organization (WHO) prescribing indicators. The research is an observational study with a descriptive nature, employing systematic random sampling to analyze data extracted from prescription records in the pharmacy department of XYZ Hospital Pekanbaru. A total of 660 prescription samples were evaluated, revealing an average of 2.91 drugs prescribed per prescription sheet, indicating a lack of adherence to diagnostic considerations. The findings show that the percentage of generic drug prescriptions was 64.04%, while antibiotic prescriptions accounted for 32.57%. Additionally, prescriptions for injectable forms constituted 1.36%, and adherence to the national formulary was at 72.27%. Out of the five prescribing indicators assessed, only the prescribing of injectable forms met the WHO’s prescribing indicators standard. These results highlight the necessity for improved adherence to rational prescribing practices to enhance treatment efficacy, minimize adverse drug reactions, and ensure cost-effectiveness in patient care. Regular monitoring and education of healthcare providers regarding rational drug use principles are essential for improving healthcare service quality.
A Design and Evaluation of a SNEDDS-Based System for Temu Ireng (Curcuma aeruginosa Roxb.) Extract: Enhancing Antioxidant Efficacy Using the SLD Technique Waznah , Urmatul; Oktaviani, Riska Kurnia Oktaviani; Ainin, Shabrina; Khafid, M. Iskandar; Mugiyanto, Eko
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.30268

Abstract

Temu Ireng (Curcuma aeruginosa Roxb.) is known for its strong antioxidant properties, primarily due to its bioactive compounds such as curcumin. However, these chemicals' lipophilia and instability in traditional formulations frequently limit their bioavailability. To address these challenges, a Self-Nanoemulsifying Drug Delivery System (SNEDDS) was developed using the Simple Lattice Design (SLD) method to improve the chemical and physical properties of Temu Ireng extract by forming a stable nanoemulsion that is uniformly distributed in the digestive system. This study aimed to formulate and evaluate a SNEDDS of Temu Ireng extract using the SLD approach, with a focus on enhancing its antioxidant activity. The formulation involved selecting suitable oils, surfactants, and cosurfactants, followed by optimization based on solubility studies, phase diagrams, and thermodynamic stability tests. The SNEDDS was characterized for physical properties such as emulsification time, transmittance, particle size, zeta potential, and polydispersity index. The optimized SNEDDS formulation exhibited excellent characteristics, including an emulsification time of less than 1 minute, near 100% transmittance, a particle size of 9.77 ± 1.33 nm, zeta potential of 0.9 ± 0.1 mV, and a polydispersity index of 0.302 ± 0.033. Antioxidant testing using the DPPH method showed that the 0.1% SNEDDS formulation of Temu Ireng extract had an inhibition concentration (IC50) value of 58.482 mg/L, indicating strong antioxidant activity. The results suggest that the SNEDDS formulation using the SLD method could be an effective strategy to enhance the bioavailability and therapeutic efficacy of Temu Ireng extract as an antioxidant agent.
Cost Effectiveness Analysis (CEA) of Antihypertensives Use in Inpatient Hemodialysis Patients at Abdoel Wahab Sjahranie Hospital Samarinda Sri Setianingsih, Diah; Nur Chairin Hanifa, Deasy
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.30730

Abstract

Hypertension is the first comorbid disease that can occur in patients with damaged kidney function. Apart from that, hypertension is a complicating disease that often occurs during the hemodialysis process.  The large variations in the use of antihypertensives in patients with chronic renal failure on hemodialysis therapy can affect the cost incurred by these patients. The purpose of this study was to optimize the use of the most cost-effective and pharmacological antihypertensive drugs in patients undergoing hemodialysis therapy. This research is a descriptive study with a pharmacoeconomic approach using the Cost Effectiveness Analysis (CEA) method. The measurement indices used to analyze the data are ACER and ICER. Data collection was conducted retrospectively, taken from the medical records of inpatient hemodialysis patients by reviewing the inclusion data of patients who were eligible to be research objects. Direct medical costs were taken from the average cost of hemodialysis, other procedures, room costs and drug costs. The effectiveness of drug therapy was determined based on the Mean Arterial Pressure (MAP) value that met the normal value. Research data is grouped based on therapy patterns and then analyzed to obtain cost – effective therapy. The results of the study showed that the percentage effectiveness of antihypertensive therapy with Furosemide was 46%, the combination of Amlodipine and Candesartan was 69% and the combination of Furosemide, Amlodipine, and Candesartan was 56%. Based on the ACER value of Rp. 1,726,133.4, the combination of antihypertensive Amlodipine and Candesartan is the most cost-effective therapy option and based on the ICER value of Rp. -6,697,330.3, the combination of antihypertensive Amlodipine and Candesartan is also the most cost-effective therapy option.
Identification of Volatile Compounds in Lemon, Local Lemon and Lime Peel Extract Using Gas Chromatography – Mass Spectrometer Ihsan Pratama, Muhammad; Yulianis, Yulianis; Sanuddin, Mukhlis
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.19749

Abstract

Orange peel is one of the main sources of essential oil. Lemon orange can also be found in an area of Jambi City, commonly referred to as local lemon, but the shape and characteristics differ slightly from common lemons. The identification results of local lemon peels indicate that these oranges are a cross between lemons and limes (Citrus medica × Citrus aurantifolia). This study aims to analyze and determine the differences in the components of the peels of lemon, local lemon, and lime using gas chromatography–mass spectrometer (GC-MS). The contribution of this research lies in providing scientific data on the chemical composition of local lemon peels, which have not been widely studied, thereby offering potential applications for the development of natural products, essential oil industries, and local biodiversity utilization. This research was conducted by extracting the peels from lemons, local lemons, and limes using acetone as a solvent. The extracts were then analyzed for their components using GC-MS. The GC-MS analysis of acetone extracts from lemon, local lemon, and lime peels revealed 19 compounds in each sample. Four compounds were found to be common across all three samples, namely 2-pentanone, 4-hydroxy-4-methyl; β-bisabolene; bis (2-ethylhexyl) phthalate; and 2H-1-Benzopyran-2-one, 5,7-dimethoxy. Meanwhile, 15 other compounds showed different contents, indicating that the hybrid nature of local lemons influenced their chemical composition. These findings highlight the unique characteristics of local lemon peels and their potential as a valuable source of bioactive compounds.

Page 27 of 46 | Total Record : 455

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