cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota surabaya,
Jawa timur
INDONESIA
Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558393     EISSN : 2599056X     DOI : -
Core Subject : Education,
Other
Folia Medica Indonesiana publishes articles in the field of medical science in particular and health sciences in general, as well as a variety of other fields related to those two disciplines. Most of the articles are research article, and others are articles on case reports and literature review. In their presentation in the journal, the articles have passed meticulous editing process by the editors and review process and by competent peer reviewers, with national and international reputation, making the articles presented in this journal qualified, updated, and informative.
Arjuna Subject : -
Articles 547 Documents
 51   52   53   54   55 
Hypnopressure as a Non-Invasive Method for Anxiety and Pain Management in Primigravidae during Active Labor Yeni Fitrianingsih; Hanung Prasetya; Rani Widiyanti
Folia Medica Indonesiana Vol. 60 No. 4 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v60i4.64138

Abstract

Highlights:1. This study applied hypnopressure, an innovative method that combines auditory hypnosis with acupressure on effective uterine points, namely the Hegu (LI4) and Sanyinjiao (Sp6) points.2. This innovation offers an effective method for managing labor pain in primigravidae during the active phase of the first labor stage compared to hypnotherapy and acupressure administered separately. AbstractPsychological factors, such as fear and anxiety, are often responsible for prolonged labor. Anxiety affects 58% of primigravidae, while 2–4% experience pain with scores ranging from 30 to 40 out of 50. Hypnopressure is an innovative combination of hypnotherapy and acupressure applied on the Sanyinjiao (SP6) and Hegu (LI4) points for 3–5 seconds in 20 repetitions during the first stage of labor contractions. This study aimed to determine the effect of hypnopressure on the LI4 and Sp6 points in reducing primigravidae's anxiety levels and pain degrees during the active phase of the first labor stage. This research used a double-blind randomized controlled trial methodology with a pretest-posttest design. Eighty subjects were divided into four groups to compare the effects of different interventions and determine which one demonstrated the most effectiveness. Each of the hypnopressure, hypnotherapy, acupressure, and control groups comprised 20 subjects. The treatment interventions were administered during the active phase of the first labor stage, which was subsequently analyzed using the Wilcoxon and Kruskal-Wallis statistical tests (p<0.05). The hypnopressure (p=0.000), hypnotherapy (p=0.000), and acupressure (p=0.002) groups experienced decreasing anxiety levels. The Kruskal-Wallis post-test indicated a significant difference (p=0.000) after treatment, revealing that hypnotherapy resulted in the lowest decrease in anxiety compared to the other three groups. Additionally, the degree of labor pain (p=0.000) was lower in the hypnopressure group (4.00±1.496) than in the other three groups. There was a significant difference across the four groups (p=0.000), with subjects in the hypnopressure group reporting lower pain degrees compared to those in the hypnotherapy (p=0.000), acupressure (0.000), and control (p=0.000) groups. In conclusion, this study suggests that hypnopressure treatment can decrease anxiety levels and pain in primigravidae during active labor.
Efficacy and Safety of Ozoralizumab vs. Moxibustion for Rheumatoid Arthritis Susanti, Luthfiana Rofhani; Mustika, Arifa; Rahmawati, Lita Diah; Wungu, Citrawati Dyah Kencono
Folia Medica Indonesiana Vol. 60 No. 4 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v60i4.64949

Abstract

Rheumatoid arthritis is a chronic inflammatory disease that symmetrically damages the synovial membrane, affecting approximately 13% of the global population. Systemic complications and substantial declines in quality of life may result from untreated rheumatoid arthritis. This study investigated the safety and efficacy of moxibustion and ozoralizumab in reducing disease activity scores in rheumatoid arthritis patients. Between July 2023 and February 2025, we conducted a thorough search on four online databases (PubMed, Cochrane, Scopus, and ProQuest) using keywords, reference searches, and other methods following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The obtained randomized controlled trials (RCTs) were assessed using the Cochrane Risk of Bias 2 (ROB2) tool. MetaInsight version 5.2.1 was utilized to perform the indirect network meta-analysis, using mean difference (MD) as the summary statistics. The measurement of the Disease Activity Score 28 (DAS28) indicated that ozoralizumab had a more significant effect on rheumatoid arthritis compared to placebo (MD=-1.88, 95% CI=-2.24-(-1.52)) and moxibustion (MD=-0.69, 95% CI=-1.07-0.31). Ozoralizumab demonstrated mild, moderate, and severe side effects, whereas moxibustion displayed modest side effects in comparison to placebo. In summary, both ozoralizumab and moxibustion reduced DAS28 in patients with rheumatoid arthritis, with ozoralizumab proving to be the more effective treatment. However, the adverse effects of ozoralizumab were more varied than those of moxibustion.
The Tubarial Glands: Key Anatomical Features and Clinical Significance Dwi Martha Nur Aditya; Winnie Nirmala Santosa; Jefman Efendi Marzuki; Sukarno, Devitya Angielevi; Baharuddin; Dita Sukmaya Prawitasari; Sajuni; Adhimas Setyo Wicaksono; Stephanie Natasha Djuanda
Folia Medica Indonesiana Vol. 60 No. 4 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v60i4.65443

Abstract

Medical technological advancements have revealed previously unknown anatomical features in the nasal cavity known as tubarial glands. However, many questions remain unanswered concerning these glands. Through this systematic review, we sought to analyze the tubarial glands, including their major discovery, anatomical and histological features, and clinical significance. Articles were identified according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, with data collected from Scopus, ScienceDirect, SpringerLink, and PubMed until September 2024. Medical Subject Headings (MeSH) were utilized with various terminology: "tubarial gland*", "tubarial salivary gland*", and "radiotherapy”. The inclusion criteria were: (1) resources categorized as original research reports, case reports, case studies, letters to the editor, brief communications, commentaries, editorials, and news; (2) publications with accessible full text; and (3) articles providing information on the tubarial glands. The exclusion criteria were: (1) papers categorized as systematic reviews, meta-analyses, or bibliometric analyses; and (2) articles not published in English. The identification yielded 37 resources from around the world, including 19 original research reports (51.3%), 3 case reports (8.1%), 6 letters to the editor (16.2%), 2 brief communications (5.4%), 7 commentaries (18.9%), 1 editorial (2.7%), and 1 news article (2.7%). The research subjects comprised 1 healthy patient (2.7%) out of 26 subjects, 12 prostate cancer patients (32.4%) out of 612 subjects, 3 head and neck cancer patients (8.1%) out of 38 subjects, 1 nasopharyngeal carcinoma patient (2.7%) out of 240 subjects, 1 Sjögren's syndrome patient (2.7%) out of 29 subjects, 1 patient with oncocytic papillary cystadenoma (2.7%), and 20 patients with other conditions (54.0%). This systematic review suggests that the newly discovered glands exhibit similar morphological, histological, and physiological properties to salivary glands and may have a function in the lubrication and maintenance of the upper airway.
The Differences between Pre- and Post-Therapy Levels of Platelet Count and Platelet Indices in Children with Immune Thrombocytopenia Purpura -, Regina Rania Cahya Kusumaningrum; Mia Ratwita Andarsini; Yetti Hernaningsih; Pradana Zaky Romadhon
Folia Medica Indonesiana Vol. 60 No. 4 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v60i4.65626

Abstract

Highlights:1. This study was the first to analyze the therapeutic response in children with ITP at Dr. Soetomo General Academic Hospital, Surabaya.2. This study analyzed the response of platelet count and indices, including MPV, PDW, P-LCR, and PCT to therapy, which provides a more comprehensive perspective on therapy response in children with ITP.3. This study explored the effectiveness of various therapeutic approaches based on ITP categories, offering new insights into the most effective treatment options for children with ITP. AbstractImmune Thrombocytopenia Purpura (ITP) is an autoimmune disorder triggered by antiplatelet autoantibodies. Clinically, ITP is classified into three phases including Newly-Diagnosed ITP, Persistent ITP, and Chronic ITP, each with distinct durations and therapy implications. Patients with ITP who do not receive appropriate or optimal treatment are at a heightened risk of morbidity and mortality related to bleeding complications, the condition could worsen, potentially resulting in fatal consequences. In ITP patients, platelet counts decrease, accompanied by abnormal shifts in platelet indices, including Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Large Cell Ratio (P-LCR), and Plateletcrit (PCT). Thus, therapeutic response in ITP patients can be evaluated through increased platelet counts and normalization of platelet indices. This study aimed to assess the therapeutic response of platelet counts and platelet indices in pediatric ITP patients by comparing pre- and post- therapy levels overall by category, across all medication types administered, and according to the specific medication used within each category. The result of this study are expected to provide an overview of the most effective treatments across all ITP categories in order to prevent severe complications and reduce the risk of mortality. This retrospective study included ITP patients under 18 years old at Dr. Soetomo General Academic Hospital, Surabaya, conducted from September 2023 to March 2024. Platelet count and platelet indices pre- and post-therapy levels were analyzed using the Paired T-test for normally distributed data and the Wilcoxon test for non-normally distributed data, with significance set at p < 0.05. In summary, there were notable changes in the pre- and post-therapy levels of platelet, MPV, PDW, P-LCR, and PCT in each ITP category and for all therapies. Platelet count and PCT increased, while MPV, PDW, and P-LCR decreased. Patients treated with prednisone exhibited the best therapeutic response. Among the categories, Newly Diagnosed ITP demonstrated the most optimal therapeutic response. Overall, ITP therapy led to significant differences between pre- and post-therapy levels, marked by an increase in platelet counts and normalization of platelet indices.
THE EFFECT OF ASTAXANTHIN ON TUMOR NECROSIS FACTOR ALPHA (TNF-α) AND INTERLEUKIN 10 (IL-10) EXPRESSION IN UV-B-INDUCED RATS MODEL Akhmad Setyo Rahman; Theresia Indah Budhy; Jusak Nugraha; Nur Lailatul Fadhilah
Folia Medica Indonesiana ON PROGRESS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The skin, the largest organ in the human body, serves as a protective barrier against external factors. Exposure to UV-B radiation accounts for approximately 90% of skin damage, leading to aging characterized by dryness and wrinkles. Proper nutrition has been associated with skin repair and delayed aging. Astaxanthin, known for its pharmacological properties including anti-cancer, anti-diabetic, anti-inflammatory, and antioxidant activities has garnered attention for its ability to improve damaged skin when administered as a daily supplement. This study investigated the roles of TNF-α and IL-10 as inflammatory markers in skin damage and repair, which remain underexplored. A true experimental randomized posttest-only control group design was employed using 24 male white rats divided into four groups: (1) normal group (N), untreated rats; (2) control group (C), rats administered with olive oil (5 ml/kg BW); (3) treatment group 1 (P1), rats exposed to UV-B and administered with olive oil (5 ml/kg BW); and (4) treatment group 2 (P2), rats exposed to UV-B and administered with astaxanthin (10 mg/kg BW) combined with olive oil (5 ml/kg BW). ANOVA and Games-Howell post-hoc tests revealed significant differences (p < 0.05) among groups, except between the control (C) and normal (N) groups. Astaxanthin (10 mg/kg BW) demonstrated both curative and protective effects by reducing TNF-α expression (pro-inflammatory) and increasing IL-10 expression (anti-inflammatory) in UV-B-induced rats. These findings highlight astaxanthin's potential as a therapeutic agent for UV-B-induced skin damage.
Assessment and Identification of Bacteria in Sagu Lempeng Sold in Ambon City, Indonesia Dilya Maghfirah Taher; Melda Yunita; Yuniasih Mulyani Jubeliene Taihuttu; Siti Nur Azizah
Folia Medica Indonesiana ON PROGRESS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights:1. This study is the first to analyze the microbiological quality of sagu lempeng in traditional markets around Ambon, Indonesia, providing a new reference for the food safety assessment of regional traditional foods.2. The research identified Klebsiella pneumoniae ssp. pneumoniae and Staphylococcus arlettae as bacterial contaminants, highlighting potential risks from both environmental and human-related sources.3. The findings emphasize the role of packaging materials and market hygiene in bacterial contamination, offering practical recommendations for safer food handling and storage. AbstractMaluku Province in Indonesia is known for its diverse traditional foods, including sagu lempeng, which is widely consumed across different social groups. However, poor hygiene during its preparation, packaging, and sale in traditional markets can serve as a medium for microbial contamination, posing potential health risks. In Ambon City, the capital of Maluku, no research had been conducted concerning the total plate count (TPC) analysis and identification of food-contaminating bacteria in sagu lempeng, which are crucial for ensuring its microbiological safety. Therefore, this study aimed to assess the microbiological quality of sagu lempeng according to Indonesian National Standards (INS 7388:2009) and to identify any presence of food-contaminating bacteria. This research employed a quantitative descriptive methodology with a true experimental laboratory approach. The samples used were sagu lempeng collected from three traditional markets in Ambon, Indonesia. The TPC analysis was conducted to estimate the number of bacterial colonies per gram of samples, while Gram staining and biochemical testing were carried out for macroscopic and microscopic bacterial identification. The results showed that the highest TPC was found in sagu lempeng from Waiheru Market at 8.1 × 10⁵ CFU/g, while the lowest was from Mardika Market at 5.95 × 10³ CFU/g. The identified bacteria included Klebsiella pneumoniae ssp. pneumoniae and Staphylococcus arlettae. Although bacterial contamination was detected, the TPC of sagu lempeng from all sampled markets remained under the maximum allowable limit set by Indonesian National Standards (1 × 10⁶ CFU/g). In conclusion, sagu lempeng sold in traditional markets around Ambon complies with microbiological safety standards and is considered safe for consumption.
Detection of Serotypes and Knockdown-resistance Mutations in Dengue and Other Flavivirus Samples Collected from Mengare Island, East Java, Indonesia Tasya Amalia Dwiyanti; Teguh Hari Sucipto; Khoirunnisa Suhandarini; Azizia Kanya Fathiarachman; Nastiti, Helena Putri; Anika Rahma Putri; Shifa Fauziyah; Prihartini Widiyanti; Hariyono; Rehman, Saifur
Folia Medica Indonesiana ON PROGRESS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights:1. By investigating knockdown-resistance (kdr) mutations associated with insecticide resistance, this research addresses a critical gap in understanding how these mutations may affect vector control strategies on Mengare Island, Gresik, Indonesia.2. This study provides essential data on the current status of dengue virus serotypes and resistance mutations in mosquito populations across the region, guiding local health authorities in developing targeted vector control strategies. AbstractDengue fever, caused by the dengue virus (DENV), poses a significant public health challenge, particularly in tropical regions. This study aimed to detect flavivirus presence, DENV serotypes, and knockdown-resistance (kdr) mutations in mosquito samples collected from Mengare Island, Gresik, Indonesia. A cross-sectional experimental design was employed, utilizing reverse transcription polymerase chain reaction (RT-PCR) for flavivirus detection and serotyping, as well as for identifying kdr mutations. Ribonucleic acid (RNA) extraction was performed using the Quick-RNA™ Miniprep Plus Kit (Zymo Research, Irvine, CA, USA), followed by RT-PCR with specific primers for DENV serotypes 1–4 and kdr mutations (V1016G and F1534C). Six adult female Aedes albopictus mosquitoes were analyzed in this study. The results revealed no evidence of flavivirus infection or DENV serotypes in the mosquito samples, as no complementary deoxyribonucleic acid (cDNA) bands corresponding to expected base pair sizes were observed on the agarose gels. Similarly, the analysis of kdr mutations showed that all samples were homozygous wildtype, with no mutations detected at the V1016G or F1534C loci. In conclusion, these findings suggest the absence of active dengue virus transmission or notable insecticide resistance in the studied mosquito population from Mengare Island. This study highlights the importance of continuous monitoring of flavivirus presence and resistance mutations. The variability in kdr mutation frequencies across regions underscores the need for sustained surveillance and effective control measures to mitigate potential outbreaks in high-risk areas such as Mengare Island.

Page 55 of 55 | Total Record : 547

 51   52   53   54   55 

Filter by Year

2015 2025


Reset
Filter By Issues
All Issue ON PROGRESS Vol. 60 No. 4 (2024): December Vol. 60 No. 3 (2024): September Vol. 60 No. 2 (2024): June Vol. 60 No. 1 (2024): March Vol. 59 No. 4 (2023): December Vol. 59 No. 3 (2023): September Vol. 59 No. 2 (2023): June Vol. 59 No. 1 (2023): March Vol. 58 No. 4 (2022): December Vol. 58 No. 3 (2022): September Vol. 58 No. 2 (2022): June Vol. 58 No. 1 (2022): March Vol. 57 No. 4 (2021): December Vol. 57 No. 3 (2021): September Vol. 57 No. 2 (2021): June Vol. 57 No. 1 (2021): March Vol. 56 No. 4 (2020): December Vol. 56 No. 3 (2020): September Vol. 56 No. 2 (2020): June Vol 56, No 1 (2020): March Vol. 56 No. 1 (2020): March Vol. 55 No. 4 (2019): December Vol. 55 No. 3 (2019): September Vol. 55 No. 2 (2019): June Vol 55, No 1 (2019): March Vol. 55 No. 1 (2019): March Vol. 54 No. 4 (2018): December Vol. 54 No. 3 (2018): September Vol. 54 No. 2 (2018): June Vol. 54 No. 1 (2018): March Vol. 53 No. 4 (2017): December 2017 Vol. 53 No. 3 (2017): September 2017 Vol. 53 No. 2 (2017): JUNE 2017 Vol. 53 No. 1 (2017): JANUARY - MARCH 2017 Vol. 52 No. 4 (2016): OCTOBER - DECEMBER 2016 Vol. 52 No. 3 (2016): JULY - SEPTEMBER 2016 Vol. 52 No. 2 (2016): APRIL - JUNE 2016 Vol. 52 No. 1 (2016): JANUARY - MARCH 2016 Vol. 51 No. 4 (2015): Oktober - December 2015 Vol. 51 No. 3 (2015): July - September 2015 More Issue