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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Published by Universitas Wahid Hasyim Semarang
ISSN : 16937899     EISSN : 27163814     DOI : 10.31942
Core Subject : Health,
Medicine & Pharmacology
Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.
Arjuna Subject : -
Articles 349 Documents
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Aktivitas Antijamur Fraksi N-Heksana Kulit Buah Citrus sinensis (L.) Osbeck Melzi Octaviani; Wiwin Suryani; Nofri Hendri Sandi
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.9991

Abstract

The sweet orange (Citrus sinensis (L.) Osbeck) is a fruit that is loved by all walks of life because of its sweet taste. The flesh part of the fruit is consumed, while the fruit peel is discarded. However, the fruit peel also contains secondary metabolites, which have various biological activities. The peel of this sweet orange fruit contains secondary metabolites of alkaloids, flavonoids, phenolics, steroids, and terpenoids. This study aims to determine the antifungal activity of the n-hexane fraction against Trichophyton mentagrophytes and Candida albicans using the disc diffusion method and the Minimum Inhibitory Concentration (MIC). The results of measuring the diameter of the inhibition zone formed on the fungus Trichophyton mentagrophytes at a concentration of 50; 25; 12.5; 6.25; 3.125 and 1.5625% w/v, respectively 12.29±0.08; 11.14±0.12; 9.54±0.17; 7.01±0.12; 6.19±0.03; 6.06 ± 0.03 mm, with a MIC of 1.5625 %. Results of measuring the diameter of the inhibition zone formed against Candida albicans fungi respectively 9.97 ± 0.02; 9.05±0.18; 8.32±0.38; 7.09±0.07; 6.00±0.00; 6.00±0.00 mm, with a MIC of 6.25%. The results of data analysis using one-way ANOVA statistics showed that there was a significant difference (p<0.05) between variations in the concentration of the test fraction with positive control and negative control. Based on the research that has been carried out, it can be concluded that the n-hexane fraction of sweet orange peel has activity in inhibiting the growth of the test fungus, with the best antibacterial activity at a concentration of 50% w/v.
The Potential of Avocado Oil for Topical Use: A Narrative Review Ratna Hapsari Tri Mustika Dewi; Niswatus Sholihah; Rima Nofitasari; Dhimas Adhityasmara; Ayu Shabrina
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.11218

Abstract

Skin aging is a multifaceted biological process that is impacted by both internal (genetics, hormones, cellular metabolism, and metabolic processes) and external (long-term exposure to UV light, pollution, ionizing radiation, chemicals, and toxins) aspects. Monounsaturated fatty acids, especially oleic acid, found in avocado oil are beneficial for wound healing, moisturizing, and anti-aging. Finding avocado oil's role as an active ingredient in cosmeceuticals was the aim of this investigation. The study's article review technique entails a thorough search of the Pubmed, Google Scholar, Proquest, Springer Link, and Science Direct databases for articles published between 2018 and 2024. The sample utilized in this study consisted of research publications that satisfied the inclusion criteria, resulting in a total of 12 articles. The result of this study showed that avocado oil is mostly formulated in emulgel and cream preparation.  Avocado oil can be used as sunscreen due to the presence of the unsaturated fatty acid such as oleic acid and linoleic acid. All of the topical application of avocado oil showed the potential of this oil as antioxidant, anti-aging and sunscreen. Avocado oil is potential as cosmeceutical at the concentration of 3% to 20%.
Studi In-Silico Senyawa Flavonoid Herba Kumis Kucing (Orthosiphon Stamineus B.) Sebagai Penghambat Enzim Siklooksigenase-2 Dandy Rifaldy Rifaldy; Rosario Trijuliamos Manalu
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8299

Abstract

Inflamasi adalah respons tubuh terhadap rangsangan yang dianggap berbahaya, namun inflamasi yang tidak tertangani akan menyebabkan inflamasi semakin memburuk. Penghambatan enzim siklooksigenase-2 (COX-2) oleh Non Steroidal Antiinflammatory Drug (NSAID) dapat mengurangi proses inflamasi, namun NSAID memiliki banyak efek samping negatif. Penelitian ini bertujuan menguji senyawa flavonoid herba kumis kucing (Orthosiphon stamineus B.) sebagai kandidat alternatif obat antiinflamasi, dengan melakukan studi in silico yang meliputi identifikasi sifat mirip obat, molecular docking, dan prediksi sifat farmakokinetik. Dari hasil analisis didapatkan dua senyawa flavonoid herba kumis kucing (Orthosiphon stamineus B.) yang memiliki afinitas lebih kuat dan stabil dalam pengikatan enzim siklooksigenase-2, yakni cirsimaritin dan pilloin dengan skor molecular docking -79,64 dan -80,61, dibandingkan ligan alami IMN skor -78,46 dan ligan pembanding ibuprofen skor -78,05, dengan memiliki pengikatan situs aktif yang mirip yakni pada residu asam amino Ser 530. Senyawa tersebut juga memenuhi kriteria sifat mirip obat dan diprediksi >90% molekulnya dapat diabsorpsi di usus, dimetabolisme oleh CYP3A4 di hati, dan tidak menyebabkan hepatotoxic, sehingga cirsimaritin dan pilloin berpotensi dikembangkan lebih lanjut untuk dijadikan kandidat obat antiinflamasi.
Peran Bedaquiline dan Penggunaannya pada Tuberkulosis Resisten Obat : Sebuah Kajian Naratif Fiddina, Nisriyati; Yulistiani, Yulistiani
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 2 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i2.8505

Abstract

Tuberculosis, caused by infection with Mycobacterium tuberculosis, is still a global concern. The existence of resistance to the first line of anti-TB, namely isoniazid and rifampicin, is an urgent need for the development of new drugs that are effective and safe against tuberculosis. Bedaquiline has received approval from the FDA as a new anti-TB drug discovered to treat drug-resistant tuberculosis. This article aims to review the role of bedaquiline in the treatment of drug-resistant tuberculosis mechanisms, evidence, effectiveness, and adverse events. This narrative review uses a literature study approach by identifying various literature and research articles through databases as relevant references. Bedaquililine belongs to the diarylquinoline class inhibits ATP-synthase activity and suppresses the growth of active and dormant mycobacteria. Various clinical trials conducted previously have evaluated the use of bedaquiline-based regimens for the treatment of adults with drug-resistant tuberculosis. Bedaquiline-based regimens showed efficacy and were generally well tolerated in numerous studies. Currently, further evaluation is needed regarding its efficacy, safety, and tolerability in drug-resistant tuberculosis patients in Indonesia. 
Optimasi Quercetin Kombinasi Avobenzone dalam Sediaan Spray Lotion Tabir Surya Budipratiwi Wisudyaningsih; Elok Rimadani; Lidya Ameliana; Lusia Oktora Ruma Kumala Sari; Yudi Wicaksono; Kuni Zu’aimah Barikah
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.9230

Abstract

Excessive exposure to ultraviolet radiation can cause various skin problems. This problem can be prevented by using cosmetic products that contain sunscreen ingredients. In this study, optimization of the combination of quercetin and avobenzone in sunscreen spray lotion was carried out using the factorial design method. The aim of this study was to determine the optimum concentrations of avobenzone and quercetin which could provide optimum physicochemical properties and effectiveness of in vitro sunscreen spray lotion. The formula is made with a low concentration of 0.5% quercetin and an upper limit of 3%, while avobenzone has a low level of 2% and an upper level of 4%. Based on the research that has been done, the optimum formula prediction is obtained with a concentration of 0.934% quercetin and 4% avobenzone. The optimum formula has a desirability value of 0.958 and shows the predicted value of software to have an SPF in vitro value of 33.311, a %TE 0.058%, a %TP 0.002%, a viscosity of 10 dPa.s, and a pH of 5.689. The results of the analysis using the t-test (one sample t-test) with a 95% level of confidence between the software prediction results and the observation results showed a value of > 0.05, which means that there was no significant difference between the software prediction results and the observation group.
Green Synthesis Nanopartikel Perak Menggunakan Ekstrak Daun Bayam Duri (Amaranthus spinosus L.) dan Aktivitasnya Sebagai Antibakteri Setya Restu Pambudi; Ismi Rahmawati; Teuku Nanda Saiffulah Sulaiman
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.10224

Abstract

Spinach leaves contain flavonoids and phenolic compounds. The hydroxyl groups in phenolic compounds can be used in the synthesis of silver nanoparticles. The aim of this research is to determine the optimal time and pH for reducing silver ions (Ag+) into silver nanoparticles (Ag0) with ethanol extract of spinach leaves as bioreductor seen from the maximum wavelength response and absorbance value using the Central Composite Design method, characteristics of the synthesis results and activity antibacterial Escherichia coli and Staphylococcus aureus bacteria. Extraction using maceration method in 80% ethanol. Optimization of synthesis using Central Composite Design resulted in 13 experiments with time reaction and pH as dependent variables, Surface Plasmone Resonance (SPR) response wavelength and absorbance as independent variables. Formation of silver nanoparticles can be seen from the SPR. Characterization of nanoparticles at particle size, distribution, stability, surface morphology and particle composition. Observation of antibacterial activity was using a diffusion method. Result screened phytochemicals spinach extract contains flavonoids, phenolics, tannins, and saponins. The ethanol extract spinach leaves can reduce AgNO3 into silver nanoparticles at concentration of 1 mM AgNO3 with ratio of 3 mL extract and 30 mL AgNO3, temperature 70oC, time 60 minutes, and pH 9.05. The colloidal particle size of AgNPs is 90.4 ± 1.2 nm, the zeta potential -35.633 ± 0.478 mV. The particle morphology of AgNPs was non homogeneous with an average particle size 136 nm. The chemical composition shows that the silver (Ag) element dominates with a weight concentration of 67.868% and an atomic concentration of 49.685% of the spectrum peak at 3 KeV. AgNPs have the ability to inhibit Staphylococcus aureus as shown by the inhibitory zone diameter of 11 mm and Escherichia coli of 9.7 mm.
Quality of Life and Compliance Based On Hypertension Patient Characteristics At Krobokan Primary Health Center West Semarang District Gilang Rizki Al Farizi; Rissa Maharani Dewi; Fransica Gloria; Hartika Widiya
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.9455

Abstract

Hypertension is the chronic diseases that is a health problem in Indonesia. According to the Basic Health Research 2018 the hypertension population in Indonesia is around 34.1% at the age of ≥18 years. Every year hypertension sufferers are increasing, around 29% of adults suffer from hypertension worldwide. Patients with hypertension require long therapy even for life which certainly makes patients continuously consume antihypertensive drugs which can ultimately affect patient compliance and quality of life. The purpose of the study was to determine description of quality of life and  adherence based on hypertention patient at Krobokan Primary Health Center, West Semarang district. This study used a quantitative design with observational research and a cross-sectional approach conducted in the period March-May 2023. The instruments used were MMAS-8 and HRQOL SF-36 as many as 53 samples who met the inclusion criteria. The results showed that the highest respondent characteristics were female 36 (68%), age 56 - 65 years 26 (49%), high school 18 (34%), housewives 31 (58%), length of hypertension ≥ 2 years 27 (51%), one of hypertention drug taken 50 (94%), suffering from other illnesses 23 (43%) and moderate adherance 36 (68%). In the domains of energy, emotional role, physical role, physical function and general health had a low quality of life in most patients with moderate adherence
Evaluasi Penggunaan Kemoterapi pada Pasien Kanker Payudara di Rumah Sakit Islam Sultan Agung Semarang Tahun 2022 Nadia Zulfana Firdaus; Sri Susilowati
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 2 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i2.9902

Abstract

Kemoterapi adalah salah satu pengobatan kanker payudara. Pengobatan kemoterapi perlu dilakukan dengan tepat untuk menghindari terjadinya pemborosan, meningkatnya efek samping obat, dan kegagalan terapi. Tujuan penelitian ini untuk mengetahui pola penggunaan kemoterapi dan mengevaluasi ketepatannya yang meliputi tepat indikasi, tepat pasien, tepat regimen obat, tepat dosis, dan tepat cara pemberian pada pasien kanker payudara di Rumah Sakit Islam Sultan Agung Semarang tahun 2022. Penelitian dilakukan secara observasional dengan desain cross-sectional. Data diperoleh secara retrospektif dari rekam medis pasien. Pengambilan sampel menggunakan metode purposive sampling sehingga didapatkan 56 sampel yang memenuhi kriteria inklusi dan eksklusi. Evaluasi dilakukan menggunakan standar Pedoman Nasional Pelayanan Kedokteran Tata Laksana Kanker Payudara Kementerian Kesehatan Republik Indonesia tahun 2018 dan British Columbia Cancer Agency Clinical Pharmacy Guide kemudian data dianalisa secara deskriptif. Hasil penelitian menunjukkan bahwa regimen obat kemoterapi yang paling banyak digunakan adalah doksetaksel dan doksorubisin (64,3%), obat penunjang yang diberikan seluruhnya adalah kombinasi difenhidramin, ranitidin, ondansetron, dan deksametason (100%). Evaluasi ketepatan penggunaan obat menunjukkan tepat indikasi (100%), tepat pasien (100%), tepat regimen obat (82,2%), tepat dosis (8,8%), dan tepat rute pemberian obat (100%). Kesimpulannya bahwa penggunaan kemoterapi pada pasien kanker payudara di Rumah Sakit Islam Sultan Agung masih terdapat ketidaktepatan terkait regimen dan dosis.
Kajian Rute Alternatif Pemberian Liraglutide dalam Penanganan Diabetes dan Obesitas Immanuel, Handika
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 2 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i2.9299

Abstract

Liraglutide adalah sebuah obat peptida yang digunakan untuk menangani diabetes tipe 2 dan obesitas. Liraglutide diberikan secara injeksi subkutan setiap harinya. Rute injeksi subkutan dapat menyebabkan rasa sakit dan ketidaknyamanan bagi beberapa pasien. Oleh sebab itu, penting untuk meninjau keefektifan dan keamanan rute alternatif ini untuk memastikan bahwa pasien memiliki akses ke pilihan pengobatan yang paling tepat dan nyaman. Rute pemberian alternatif seperti oral dan subkutan yang diperlama pelepasan obatnya, serta topikal, mulai dikembangkan. Artikel review deskriptif ini dibuat dengan metode penelaahan pustaka menggunakan kriteria inklusi dan eksklusi. Beberapa penelitian telah dilakukan untuk mengevaluasi efikasi dan keamanan liraglutide yang diberikan melalui rute alternatif seperti oral dan topikal. Liraglutide yang diberikan melalui rute oral menggunakan teknologi enkapsulasi telah menunjukkan manfaat yang serupa dengan liraglutide yang diberikan melalui injeksi subkutan, ditandai dengan adanya penurunan kadar glukosa darah serta penurunan berat badan yang sebanding. Pemberian liraglutide yang telah dienkapsulasikan melalui injeksi subkutan juga telah diketahui dapat memberikan durasi efek farmakologis yang lebih panjang, sehingga meminimalkan frekuensi pemakaian liraglutide.
Potensi Senyawa Salisilanilida Dari Minyak Gandapura Sebagai Antiinflamasi dan Analgetik Secara In Vivo Dhimas Adhityasmara; Eka Susanti Hanhadyanaputri; Erwin Indriyanti
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.11751

Abstract

Administration of non-steroidal anti-inflammatory drugs (NSAIDs) is the first therapeutic choice for the treatment of pain and inflammation. Several existing amide derivatives show their properties as anti-inflammatory, antidegenerative, anticancer, antimicrobial and analgesic, one of which is salicylanilide. The precursor for salicylanilide synthesis is carboxylic acid, using natural methyl salicylate from gondopuro oil and amines sonochemically with the help of Decyclocarbodiimide (DCC) coupling reagent. The research aims to carry out the synthesis of amide derivatives using DCC coupling reagent with the sonochemical method in 7 hours. Identification of synthetic compounds by spectrum elucidation using infrared spectrophotometry (FTIR-ATR), GC-MS and in-vivo anti-inflammatory and analgesic activity tests. In this study, the mixture was sonicated for 7 hours at a temperature of ±0oC, then left in the refrigerator overnight, evaporated at a temperature of 65oC. The precipitate formed was filtered using Buchner, washed using cold distilled water and washed again using methanol. The crystals obtained were then dried in an oven at 40ºC until dry, then the % yield of the synthesized compound was determined. Tests include organoleptic tests, melting point, solubility, FTIR, GC-MS In vivo anti-inflammatory and analgesic activity tests. The research results showed that salicylanilide compounds could be synthesized in 7 hours with a % yield of 27.55%. The resulting synthesis can melt from a temperature of 218-222°C and can dissolve in methanol, ethanol, chloroform and ether but does not dissolve in distilled water. FTIR testing on salicylanilide compounds showed the presence of phenolic -OH, aromatic C-H, C=O amide and aromatic C=C groups. The synthesized compound produced an abundance of 2.43%. The highest percentage of anti-inflammatory power was at dose 3 synthesis (7.56 mg/ 200 grams of rat body weight) at 44.46% and the highest analgesic effect was at dose 4 synthesis (10.08 mg/ 200 grams Rat BW)

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