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Biomedika
Published by Universitas Muhammadiyah Surakarta
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Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
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Articles 399 Documents
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PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL Muhtadi, .; Haryoto, .; Sujono, Tanti Azizah; Indaryudha, Peni; Suhendi, Andi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v5i2.266

Abstract

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 ?g / mL. The fruit contains ? avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet
UJI PENURUNAN KADAR GLUKOSA DARAH OLEH EKSTRAK ETANOL 70% DAUN BUNCIS (Phaseolus vulgaris L) PADA KELINCI JANTAN YANG DIBEBANI GLUKOSA Kurniawati, Desy; Sutrisna, EM; Wahyuni, Arifah Sri
Biomedika Vol 4, No 1 (2012): Biomedika Februari 2012
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v4i1.257

Abstract

This research aim to know the descent of blood glucose rate by extract etanol 70% of bean leaf at male rabbit which induced glucose. Research using the method test glucose tolerance of oral was including category research of sham eksperimental with complete random attempt device of unidirectional pattern. This research use 20 male rabbits which divided in 5 treatment group. Group I given by CMC Na 1% as negative control, group II given by acarbose suspensi 2,33 mg/kgBB as positive control, group III, IV and V given by extract etanol 70% bean leaf with each dose 200, 300 and 450 mg/kgBB. Treatment given at once after test animal induced glucose 50% ( 5 ml/1,5 kgBB). Glucose blood rate to define every 30 minute, 0 minute until 300 minutes by using method of enzimatik GOD PAP (Glucose Oxidase Phenol Aminoantipyrina Peroxidase), what was later then analysed with one track Anava and continued by test of LSD (Least Significant Diffeerence) with trust level 95%. Extract etanol 70% bean leaf with dose 200, 300 and 450 mg/kgBB have effect descent of blood glucose rate to negative control of CMC Na 1% (p = 0,000) with each percentage descent of blood glucose rate (% PKGD) 80,88 ± 0,93 ; 82,73 ± 0,67 and 85,32 ± 0,21.Keyword : Extract etanol 70%, bean leaf (Phaseolus vulgaris L), degradation of glucose rate
UJI PRAKLINIK ANTIHIPERURISEMIA SECARA IN VIVO PADA MENCIT PUTIH JANTAN GALUR BALB-C DARI EKSTRAK DAUN SALAM (Syzigium polyanthum Walp) DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L.) Muhtadi, .; Suhendi, Andi; Wahyuningtyas, Nurcahyanti; Sutrisna, EM.
Biomedika Vol 6, No 1 (2014): Biomedika Februari 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v6i1.283

Abstract

Antihyperuricemia activity in vivo testing has been done of single and combined extracts of Salam (Syzigium polyanthum Walp) and Belimbing Wuluh leaves (Averrhoa bilimbi L.), and also standardized extracts. Salam leaves extraction and Belimbing Wuluh leaves carried by the water solvent. Dried extract of each ingredient had been done antihyperuricemia preclinical in vivo testing against male white mice strain Balb-C induced by potassium oxonate dose of 250 mg / kg b.w. Antihyperuricemia preclinical in vivo testing results showed that the single extracts of Salam and Belimbing Wuluh at a dose of 200 mg / kg b.w. had lower activity levels of uric acid in the blood serum of male white mice, respectively 0.640 and 0.680. While the activity of the combination of extracts of Salam-Belimbing Wuluh is 1.380.Keywords: Antihyperurisemia preclinical in vivo testing; Salam leaves extract, Belimbing Wuluh leaves extract, male white mice Balb-C
HUBUNGAN DERAJAT KEPRIBADIAN INTROVERT DENGAN SINDROMA PRAMENSTRUASI Bestari, Rochmadina Suci
Biomedika Vol 3, No 2 (2011): Biomedika Agustus 2011
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v3i2.241

Abstract

Introvert people tend to have distress. Psicosomatic manifestation from distress on women can be appeared as premenstrual syndrome. The aim of this study is to know the correlation between social introversion stage and premenstrual syndrome. This study is an analitic observasional study with cross sectional approach, which was held on November 2006 on Medical Faculty UNS Solo. Samples were taken by purposive sampling with restriction on new university studentsclass 2006 Medical Faculty of UNS. The requirements are : (1) on premenstrual or menstrual phase, and (2) does not have reproduction organ disease. Subject  ?  lled (1) Kuesioner Riwayat Menstruasi dan Ginekologi (Gynecology and Menstrual History Questionair) to know subject?s menstrual cycle, (2) Kuesioner Skala L-MMPI (L-MMPI Scale Questionair) to state honesty in answering questions given, (3) Kuesioner Sindroma Pramenstruasi (Premenstrual Syndrome Questionair) consisted of pramenstrual syndrome?s aspects, (4) Kuesioner Skala-0 MMPI (MMPI 0-Scale Questionair) to state social introversion stage. It?s obtained 42 subjects data. Social introversion stage (SI) and premenstrual syndrome (PMS) data were then analyzed with (1) Normality test by Shapiro Wilk, and (2) Hypothetic test by Pearson correlation used SPSS 11.0 for Windows computer program.Results of this study are (1) Premenstrual subjects are bigger amount than non-premenstrual subjects (88,1% vs 11,9%), (2) there is signi?  cant positive correlation between social introversion stage and premenstrual syndrome with strong correlation (r=0,551; P<0,05). The conclusion of this study is there is signi?  cant positive correlation between social introversion stage and premenstrual syndrome.Keywords: Social introversion, premenstrual syndrome
EFEK DAMBI (DAUN JAMBU BIJI) (Psidium guajava Linn) TERHADAP PENYEMBUHAN LUKA PADA KULIT Abshor, Ulil; Basuki, Sri Wahyu
Biomedika Vol 11, No 2 (2019): Biomedika Agustus 2019
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v11i2.8546

Abstract

Kandungan senyawa daun jambu biji yang dapat membantu penyembuhan luka adalah alkaloid, saponin, tanin dan flavanoid. Penelitian ini bertujuan mengetahui khasiat daun jambu biji (Psidium guajava Linn) sebagai obat alternatif untuk pengobatan luka. Jenis penelitian ini eksperimental laboratorium dengan metode pre test &  post test only  control group design. Teknik pengambilan sampel menggunakan purposive sampling. Sampel sejumlah 24 ekor tikus dikelompokkan menjadi 4 kelompok, kelompok pertama tidak diberi perlakuan, kelompok ke dua diberi povidone iodine, kelompok ke tiga (ekstrak dengan pelarut air), kelompok ke empat (ekstrak pelarut alkohol). Data dianalisis menggunakan uji Friedman dan diakhiri post hoc uji wilcoxon. Hasil penelitian menunjukkan bahwa pemberian ekstrak daun jambu biji dengan pelarut alkohol lebih cepat mengalami penyembuhan luka dibandingkan kontrol negatif, kontrol positif, dan daun jambu biji dengan pelarut air. Hasil uji Friedman pada jumlah netrofil dan limfosit (p<0,05). Terdapat hubungan antara Efek DAMBI (Daun Jambu Biji) terhadap Penyembuhan Luka pada Kulit.Kata kunci : Daun jambu biji, Luka, Flavanoid, Alkaloid, Kulit The content of leaves of guava can help wound healing are alkaloids, saponins, tannins and flavonoids. The aim of this research is determine the efficacy of guava leaves (Psidium guajava Linn) as an alternative medicine for the treatment of wounds. This study is laboratory experimental research with pre-test research methods and post test only control group design. The sampling technique used was purposive sampling,. Sample of 24 rats were divided into 4 groups, the first group was given no treatment, the second group was given povidone iodine, a group of three (extract with water solvent), a group of four (extract peelarut alcohol). Data were analyzed using the Friedman test and ending with post hoc Wilcoxon test. The results showed that administration of guava leaf extract with alcohol solvent more rapid wound healing compared to the negative control, positive control, and guava leaves with water solvent. Friedman test results on the number of neutrophils and lymphocytes (p<0.05). There is a relationship between the effects Dambi (Leaf guava) on the Skin Wound Healing.Keywords : Guava leaves, Wound, flavonoids, alkaloids, Skin  
HUBUNGAN PENGETAHUAN TENTANG KESEHATAN REPRODUKSI TERHADAP SIKAP MENGHADAPI SINDROM PRE-MENSTRUASI PADA REMAJA PUTRI SISWI X DAN XI MAN 2 MADIUN Anggariksa, Ekki Dita; Ichsan, Burhannudin; Nirlawati, Dewi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v5i2.262

Abstract

Approximately 1 billion people or 1 out of every 6 people in the world are teenagers, where 85% of them live in developing countries. The knowledge of adolescents about reproduction health in Indonesias still very low. Adolescent reproduction problems not only give impact physically but also can affect mental health, emotion, economical condition and social welfare in long term. Pre menstrual syndrome often leads to physical and emotional disorders. The objective of this research is to know the correlation of reproduction health knowledge toward the attitude to face pre-menstrual syndrome of female students on X and XI grade in MAN 2 Madiun. The study was cross sectional using cluster sampling. As much as 32 respondents (62%) had higher reproduction knowledge compared to the mean. 27 respondents (54%) had higher values above the average of attitude values . Data analysis of the Pearson test (p = 0.000), which is statistically signi? cant and r =0,740 indicates strong correlation. There was a signi? cant correlation between reproductive health knowledge toward attitude to face pre-menstrual syndrome of female students in X and XI grade in MAN 2 Madiun.Keywords: knowledge, reproductive health, attitude, pre-menstrual syndrome.
PERBEDAAN FUNGSI KELUARGA DAN KUALITAS HIDUP ISTRI ANTARA ISTRI BEKERJA DAN TIDAK BEKERJA Candrasari, Anika; Probandari, Ari Natalia
Biomedika Vol 5, No 1 (2013): Biomedika Februari 2013
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v5i1.903

Abstract

Along economic progress and increase in women education, so many housewives today serve not only as manager of their household, but also work outside home. It will have various social implications, such as stress due to work overloads, increased teenage delinquency due to lack of parental attention, lack of marriage or family values. This study aimed to analyze the differences of family function and wife?s quality of life among wife with and without occupation. Location of study was Bolon village, District Colomadu, Karanganya, Central Java. The study used an observational analytic design, with a cross-sectional approach. The study population was wives. Sampling used 128 wives. The instruments were APGAR, SCREEM family function and WHOQOL. From t test, it showed signifi cant differences family function and wife?s quality of life among wife with and without occupation (APGAR p = 0.023, SCREEM p = 0.001 and wife?s quality of life p = 0.043).Keywords: family function, quality of life, wife, work.
EFEK ANTIINFLAMASI INFUSA RIMPANG TEMU PUTIH (Curcuma zedoaria (Berg) Roscoe) PADA TIKUS YANG DIINDUKSI KARAGENIN Sujono, Tanti Azizah; Patimah, Raudatul; Yuliani, Ratna
Biomedika Vol 4, No 2 (2012): Biomedika Agustus 2012
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v4i2.253

Abstract

In-flammation is the body’s reaction to foreign substances that enter the body with signs of redness, heat, swelling, pain, and impaired organ functions. Curcuma rhizome including medicinal plants that have properties relieve the pain and inflammation of the skin. The purpose of this research was to examine the anti-iflammation effect of Curcuma zedoaria (Berg) Roscoe Rhizome infusion on carrageenan induced paw edema in rats. This research used experimental method with completely randomized design. Twenty five healthy Wistar male rats, 2-3 months old and 150-250 g divided into five groups and each group consist of 5 rats. Rats in group I that served as negative control were given 2.5 mL/200gbw of aquadest. Rats in group II as positive control were given sodium diclofenac with dose of 6.75 mg/kgbw. Group III, IV, and V were given Curcuma zedoaria (Berg) Roscoe Rhizome infusion with dose of 0.625, 1.250 and 2.500 g/kgbw, respectively. Treatments were given per oral 1 hour before injection of 0.1 ml carrageenan 1% subplantar. Rat paw edema volume was measured before and after carrageenan injection. The measurement was done every 0.5 hour for 6 hours observation. Area Under the Curve (AUC) that is calculated from paw edema volume data, was use to calculate percentage of anti-inflammatory effect. Data were analyzed with one way Anova and Least Signifi cant Difference with confi dence level 95%. Infusion of Curcuma zedoaria Rhizome with doses of 0,625, 1,250, and 2,500 g/kgbw had anti-inflammatory effect in Wistar male rats which were induced by Carrageenan 1%. Percentage of anti-inflammation effect (44,16+5,11)%, (48,70+7,05)%, (59,09+9,61)% respectively and the effects were equivalent with positive control.Key words: Anti-inflammation, Curcuma zedoaria (Berg) Roscoe, infusion, Carrageenan.
GIANT CELL TUMOR OF THE RIGHT DISTAL FEMUR REGION IN A MALE 25 YEARS OLD WITH HIV POSITIVE (RARE CASE) Riyadli, Muhammad; Idulhaq, Mujaddid; Utomo, Pamudji
Biomedika Vol 11, No 2 (2019): Biomedika Agustus 2019
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v11i2.8279

Abstract

Giant cell tumor (GCT) with Human Immunodeficiency Virus (HIV) infection is a rare case. At present, few literatures reported about GCT with HIV positive patients and there are no effective treatments of this disease currently. The aim of this article is to report the change the surgical treatment from limb salvage (wide excision and endoprostheses) to another way limb salvage (wide excision and knee arthrodesis) to minimize risk and further complication. A case of male, 25 years old, with diagnosis GCT of the right distal femur with HIV positive. In this case we administered antiretroviral treatment (ARV) and planned to limb salvage surgery (wide excision and knee arthrodesis).We follow up this patient in the first 4 weeks. There were no complaints, good postoperative wounds, no signs of infection, and histopathological examination postoperative showed the positive results of a GCT. The conclusion the surgical treatment from limb salvage (wide excision and endoprostheses) to another way limb salvage (wide excision and knee arthrodesis) could minimize risk and further complication.Keywords: Giant Cell Tumor, HIV,Limb Salvage Surgery, Wide Excision, Arthrodesis KneeGiant Cell Tumor (GCT) disertai dengan infeksi Human Imminodeficiency Virus (HIV) merupakan kasus yang jarang terjadi. Pada saat ini hanya sedikit literatur yang melaporkan kejadian pasien GCT dengan HIV positif dan belum ada standar terapi yang efektif. Tujuan dari artikel ini adalah melaporkan penggantian penatalaksanaan operatif sebelumnya berupa limb salvage (eksisi luas dan pemasangan endoprosthesis) menjadi eksisi luas dan arthrodesis knee untuk meminimalisir risiko dan kompikasi lebih lanjut. Kasus seorang laki-laki usia 25 tahun dengan diagnosis GCT pada distal femur kanan dengan infeksi HIV positif. Pada kasus ini, terapi yang diberikan adalah Anti Retroviral (ARV) dan operatif dengan limb salvage (eksisi luas dan arthrodesis lutut). Follow up pasien ini pada 4 minggu pertama post operasi. Keluhan nyeri berkurang, luka operasi baik, tidak ada tanda infeksi dan pemeriksaan histopatologi menunjukkan hasil GCT.Kesimpulannya bahwa penatalaksanaan operatif sebelumnya berupa limb salvage (eksisi luas dan pemasangan endoprosthesis) menjadi eksisi luas dan arthrodesis knee dapat meminimalisir risiko dan kompikasi lebih lanjut. Kata Kunci: Giant Cell Tumor, Hiv, Limb Salvage, Eksisiluas, Arthrodesis Lutut
HUBUNGAN ANTARA HIPERTENSI DENGAN PREMENSTRUAL SYNDROME PADA WANITA USIA REPRODUKTIF Rahmawati, Azhim; Siryaningsih, Retno; Jatmiko, Safari Wahyu
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v6i2.279

Abstract

Premenstrual syndrome (PMS) is a cycle disorder which is commonly occured during the luteal phase of the menstrual cycle and will dissapear at the time of menstruation. Ninety percent of women on reproductive ages experience symptomps of PMS and 10% of them experience severe premenstrual symptomps that cuse physical disturbance, medical care necessity, even worst death. Hypertension is a risk factor for a PMS. The aim of this research is to find out a conection between PMS and hypertension. This research was designated using analytic observational with cross sectional approach. We used purposive sampling to get sample. Based on sample formula, we got 104 respondents which is consist of 52 women with hypertension and 52 women normotensive. To obtain data, we used shortened premenstrual syndrome assesment form (SPAF). Data collected were analyzed by chi square test. The result showed that the value of p = 0.00 (p<0.005). This result indicated that there is a conection between hypertension and PMS occurence in reproductive age. The probability of hypertension women to get PMS is 6.75.Keywords: Hypertension, Premenstrual Syndrome, reproductive age

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